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Glioma

MedGen UID:
9030
Concept ID:
C0017638
Neoplastic Process
Synonyms: Glial Cell Tumor; Glial Cell Tumors; Gliomas; Tumor, Glial Cell; Tumors, Glial Cell
SNOMED CT: Glioma (393564001); Glioma (115240006)
 
Related genes: SUFU, PTCH2, ELP1, TP53, IDH1, ERBB2, CTNNB1, BRCA2
 
HPO: HP:0009733
Monarch Initiative: MONDO:0021042

Definition

The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes). [from HPO]

Term Hierarchy

Follow this link to review classifications for Glioma in Orphanet.

Conditions with this feature

Hamartoma of hypothalamus
MedGen UID:
137970
Concept ID:
C0342418
Finding
Pallister-Hall-like syndrome (PHLS) is a pleiotropic autosomal recessive disorder characterized by phenotypic variability. Patients exhibit postaxial polydactyly as well as hypothalamic hamartoma, cardiac and skeletal anomalies, and craniofacial dysmorphisms. Hirschsprung disease has also been observed (Rubino et al., 2018; Le et al., 2020). Pallister-Hall syndrome (146510) is an autosomal dominant disorder with features overlapping those of PHLS, caused by mutation in the GLI3 gene (165240).
Microcephaly, normal intelligence and immunodeficiency
MedGen UID:
140771
Concept ID:
C0398791
Disease or Syndrome
Nijmegen breakage syndrome (NBS) is characterized by progressive microcephaly, intrauterine growth retardation and short stature, recurrent sinopulmonary infections, an increased risk for cancer, and premature ovarian failure in females. Developmental milestones are attained at the usual time during the first year; however, borderline delays in development and hyperactivity may be observed in early childhood. Intellectual abilities tend to decline over time and most children tested after age seven years have mild to moderate intellectual disability. Recurrent pneumonia and bronchitis may result in respiratory failure and early death. Approximately 40% of affected individuals have developed malignancies before age 20 years, with the risk being highest for T-cell (55%) and B-cell lymphomas (45%). Other tumors include solid tumors (e.g., medulloblastoma, glioma, and rhabdomyosarcoma). Note, however, that much of what is reported about NBS is based on individuals who are homozygous for the single most common Eastern European pathogenic variant, c.657_661del5.
Osteoporosis with pseudoglioma
MedGen UID:
98480
Concept ID:
C0432252
Disease or Syndrome
Osteoporosis-pseudoglioma syndrome is a rare condition characterized by severe thinning of the bones (osteoporosis) and eye abnormalities that lead to vision loss. In people with this condition, osteoporosis is usually recognized in early childhood. It is caused by a shortage of minerals, such as calcium, in bones (decreased bone mineral density), which makes the bones brittle and prone to fracture. Affected individuals often have multiple bone fractures, including in the bones that form the spine (vertebrae). Multiple fractures can cause collapse of the affected vertebrae (compressed vertebrae), abnormal side-to-side curvature of the spine (scoliosis), short stature, and limb deformities. Decreased bone mineral density can also cause softening or thinning of the skull (craniotabes).\n\nMost affected individuals have impaired vision at birth or by early infancy and are blind by young adulthood. Vision problems are usually caused by one of several eye conditions, grouped together as pseudoglioma, that affect the light-sensitive tissue at the back of the eye (the retina), although other eye conditions have been identified in affected individuals. Pseudogliomas are so named because, on examination, the conditions resemble an eye tumor known as a retinal glioma.\n\nRarely, people with osteoporosis-pseudoglioma syndrome have additional signs or symptoms such as mild intellectual disability, weak muscle tone (hypotonia), abnormally flexible joints, or seizures.
Li-Fraumeni syndrome 2
MedGen UID:
322930
Concept ID:
C1836482
Disease or Syndrome
A rare, inherited, cancer predisposition syndrome characterized by the early-onset of multiple primary cancers including breast cancer, soft tissue and bone sarcomas, brain tumors, adrenal cortical carcinoma (ACC), leukemias, and other cancers.
Glioma susceptibility 9
MedGen UID:
908376
Concept ID:
C4225278
Finding
POT1 tumor predisposition (POT1-TPD) is characterized by an increased lifetime risk for multiple cutaneous melanomas, chronic lymphocytic leukemia (CLL), angiosarcoma (particularly cardiac angiosarcomas), and gliomas. Additional cancers (e.g., colorectal cancer, thyroid cancer, breast angiosarcomas) have been reported in individuals with POT1-TPD but with very limited evidence. The age of onset for first primary cutaneous melanoma ranges from 15 to 80 years. The majority of POT1 associated cancers are diagnosed in adulthood.

Professional guidelines

PubMed

Febbo PG, Ladanyi M, Aldape KD, De Marzo AM, Hammond ME, Hayes DF, Iafrate AJ, Kelley RK, Marcucci G, Ogino S, Pao W, Sgroi DC, Birkeland ML
J Natl Compr Canc Netw 2011 Nov;9 Suppl 5:S1-32; quiz S33. doi: 10.6004/jnccn.2011.0137. PMID: 22138009

Recent clinical studies

Etiology

Su C, Xu S, Lin D, He H, Chen Z, Damen FC, Ke C, Lv X, Cai K
Eur Radiol 2022 Jan;32(1):101-111. Epub 2021 Jul 17 doi: 10.1007/s00330-021-08175-3. PMID: 34272981
Chen J, Zhao Y, Hou X, Gao X, Shi Q, Li S, Huang H
Ann Palliat Med 2021 Dec;10(12):12650-12656. doi: 10.21037/apm-21-3382. PMID: 35016422
Li N, Shi H, Hou P, Gao L, Shi Y, Mi W, Zhang G, Wang N, Dai W, Wei L, Jin T, Shi Y, Guo S
Int J Cancer 2021 Dec 1;149(11):1910-1915. Epub 2021 Aug 28 doi: 10.1002/ijc.33755. PMID: 34319593
Derks J, Kulik SD, Numan T, de Witt Hamer PC, Noske DP, Klein M, Geurts JJG, Reijneveld JC, Stam CJ, Schoonheim MM, Hillebrand A, Douw L
Brain Connect 2021 Dec;11(10):865-874. Epub 2021 Jun 17 doi: 10.1089/brain.2020.0801. PMID: 33947274
Wang Z, Su G, Dai Z, Meng M, Zhang H, Fan F, Liu Z, Zhang L, Weygant N, He F, Fang N, Zhang L, Cheng Q
Cell Prolif 2021 Mar;54(3):e12988. Epub 2021 Jan 13 doi: 10.1111/cpr.12988. PMID: 33442944Free PMC Article

Diagnosis

Gao X, Jiang W, Ke Z, Huang Q, Chen L, Zhang G, Li C, Yu X
Biochem Biophys Res Commun 2022 Jan 1;586:34-41. Epub 2021 Nov 19 doi: 10.1016/j.bbrc.2021.11.061. PMID: 34826698
Miklja Z, Gabel N, Altshuler D, Wang L, Hervey-Jumper SL, Smith S
Support Care Cancer 2022 Feb;30(2):1493-1500. Epub 2021 Sep 16 doi: 10.1007/s00520-021-06566-2. PMID: 34532753
Su C, Xu S, Lin D, He H, Chen Z, Damen FC, Ke C, Lv X, Cai K
Eur Radiol 2022 Jan;32(1):101-111. Epub 2021 Jul 17 doi: 10.1007/s00330-021-08175-3. PMID: 34272981
Liu Y, Chen G, Tang H, Hong L, Peng W, Zhang X
Ann Palliat Med 2021 Dec;10(12):12488-12497. doi: 10.21037/apm-21-3319. PMID: 35016424
Wang Z, Su G, Dai Z, Meng M, Zhang H, Fan F, Liu Z, Zhang L, Weygant N, He F, Fang N, Zhang L, Cheng Q
Cell Prolif 2021 Mar;54(3):e12988. Epub 2021 Jan 13 doi: 10.1111/cpr.12988. PMID: 33442944Free PMC Article

Therapy

Chen J, Zhao Y, Hou X, Gao X, Shi Q, Li S, Huang H
Ann Palliat Med 2021 Dec;10(12):12650-12656. doi: 10.21037/apm-21-3382. PMID: 35016422
Nie S, Zhu Y, Yang J, Xin T, Xue S, Sun J, Mu D, Chen Z, Sun P, Yu J, Hu M
BMC Med 2021 Nov 17;19(1):269. doi: 10.1186/s12916-021-02143-w. PMID: 34784919Free PMC Article
Zhou K, Jiang T, Liu Y, Zhao Z, Huang L, Li G
BMC Neurol 2021 Nov 9;21(1):438. doi: 10.1186/s12883-021-02476-2. PMID: 34753441Free PMC Article
Narita Y, Muragaki Y, Kagawa N, Asai K, Nagane M, Matsuda M, Ueki K, Kuroda J, Date I, Kobayashi H, Kumabe T, Beppu T, Kanamori M, Kasai S, Nishimura Y, Xiong H, Ocampo C, Yamada M, Mishima K
Cancer Sci 2021 Dec;112(12):5020-5033. Epub 2021 Oct 30 doi: 10.1111/cas.15153. PMID: 34609773Free PMC Article
Mair MJ, Ilhan-Mutlu A, Pajenda S, Kiesel B, Wöhrer A, Widhalm G, Dieckmann K, Marosi C, Wagner L, Preusser M, Berghoff AS
Cancer Immunol Immunother 2021 Dec;70(12):3643-3650. Epub 2021 May 6 doi: 10.1007/s00262-021-02951-2. PMID: 33956203Free PMC Article

Prognosis

Xu L, Wu Q, Yan H, Shu C, Fan W, Tong X, Li Q
Cancer Lett 2022 Jan 28;525:33-45. Epub 2021 Oct 30 doi: 10.1016/j.canlet.2021.10.033. PMID: 34728310
Chu YH, Liao WC, Ho YJ, Huang CH, Tseng TJ, Liu CH
Cells 2021 Dec 20;10(12) doi: 10.3390/cells10123594. PMID: 34944101Free PMC Article
Ji LY, Wei M, Liu YY, Di ZL, Li SZ
Oncol Rep 2021 Dec;46(6) Epub 2021 Oct 19 doi: 10.3892/or.2021.8206. PMID: 34664678Free PMC Article
Wang Z, Su G, Dai Z, Meng M, Zhang H, Fan F, Liu Z, Zhang L, Weygant N, He F, Fang N, Zhang L, Cheng Q
Cell Prolif 2021 Mar;54(3):e12988. Epub 2021 Jan 13 doi: 10.1111/cpr.12988. PMID: 33442944Free PMC Article
Zhang L, Liu F, Weygant N, Zhang J, Hu P, Qin Z, Yang J, Cheng Q, Fan F, Zeng Y, Tang Y, Li Y, Tang A, He F, Peng J, Liao W, Hu Z, Li M, Liu Z
Cancer Lett 2021 Mar 1;500:87-97. Epub 2020 Dec 10 doi: 10.1016/j.canlet.2020.12.013. PMID: 33309780

Clinical prediction guides

Chu YH, Liao WC, Ho YJ, Huang CH, Tseng TJ, Liu CH
Cells 2021 Dec 20;10(12) doi: 10.3390/cells10123594. PMID: 34944101Free PMC Article
Hou Z, Zhang K, Liu X, Fang S, Li L, Wang Y, Jiang T
Cancer Lett 2021 Dec 1;522:14-21. Epub 2021 Sep 10 doi: 10.1016/j.canlet.2021.09.008. PMID: 34517083
Mair MJ, Ilhan-Mutlu A, Pajenda S, Kiesel B, Wöhrer A, Widhalm G, Dieckmann K, Marosi C, Wagner L, Preusser M, Berghoff AS
Cancer Immunol Immunother 2021 Dec;70(12):3643-3650. Epub 2021 May 6 doi: 10.1007/s00262-021-02951-2. PMID: 33956203Free PMC Article
Wang Z, Su G, Dai Z, Meng M, Zhang H, Fan F, Liu Z, Zhang L, Weygant N, He F, Fang N, Zhang L, Cheng Q
Cell Prolif 2021 Mar;54(3):e12988. Epub 2021 Jan 13 doi: 10.1111/cpr.12988. PMID: 33442944Free PMC Article
Zhang L, Liu F, Weygant N, Zhang J, Hu P, Qin Z, Yang J, Cheng Q, Fan F, Zeng Y, Tang Y, Li Y, Tang A, He F, Peng J, Liao W, Hu Z, Li M, Liu Z
Cancer Lett 2021 Mar 1;500:87-97. Epub 2020 Dec 10 doi: 10.1016/j.canlet.2020.12.013. PMID: 33309780

Recent systematic reviews

Liu Y, Chen G, Tang H, Hong L, Peng W, Zhang X
Ann Palliat Med 2021 Dec;10(12):12488-12497. doi: 10.21037/apm-21-3319. PMID: 35016424
Buchlak QD, Esmaili N, Leveque JC, Bennett C, Farrokhi F, Piccardi M
J Clin Neurosci 2021 Jul;89:177-198. Epub 2021 May 13 doi: 10.1016/j.jocn.2021.04.043. PMID: 34119265
De Witt Hamer PC, De Witt Hamer PC, Klein M, Hervey-Jumper SL, Wefel JS, Berger MS
Neurosurgery 2021 Mar 15;88(4):720-732. doi: 10.1093/neuros/nyaa365. PMID: 33517431Free PMC Article
Shi S, Lu S, Jing X, Liao J, Li Q
World Neurosurg 2021 Apr;148:e565-e571. Epub 2021 Jan 19 doi: 10.1016/j.wneu.2021.01.024. PMID: 33476781
Lasocki A, Anjari M, Ӧrs Kokurcan S, Thust SC
Neuroradiology 2021 Mar;63(3):353-362. Epub 2020 Aug 25 doi: 10.1007/s00234-020-02532-7. PMID: 32840682

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