Format

Send to:

Choose Destination

Fuchs corneal dystrophy

MedGen UID:
4800
Concept ID:
C0016781
Disease or Syndrome
Synonyms: Dystrophy, Fuch's Endothelial; Dystrophy, Fuchs' Endothelial; Endothelial Dystrophy, Fuch's; Endothelial Dystrophy, Fuchs'; Fuch Endothelial Dystrophy; Fuch's Endothelial Dystrophy; Fuchs Atrophy; Fuchs Corneal Dystrophy; Fuchs Dystrophy; Fuchs Endothelial Corneal Dystrophy; Fuchs Endothelial Dystrophy; Fuchs' Endothelial Dystrophy
SNOMED CT: Fuchs corneal dystrophy (193839007); Fuchs' corneal dystrophy (193839007); Fuchs' endothelial dystrophy (193839007); Fuch's endothelial corneal dystrophy (193839007)

Definition

An autosomal dominant, bilateral, slowly progressive degeneration of corneal endothelial cells with thickening of Descemet's membrane and accumulation of excrescences. It results in corneal edema and loss of vision. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFuchs corneal dystrophy

Recent clinical studies

Etiology

Sirp A, Leite K, Tuvikene J, Nurm K, Sepp M, Timmusk T
Sci Rep 2020 Oct 28;10(1):18424. doi: 10.1038/s41598-020-75437-3. PMID: 33116252Free PMC Article
Reed NS, Deal JA, Huddle MG, Betz JF, Bailey BE, McGlumphy EJ, Eghrari AO, Riazuddin SA, Lin FR, Gottsch JD
J Speech Lang Hear Res 2018 Oct 26;61(10):2604-2608. doi: 10.1044/2018_JSLHR-H-18-0088. PMID: 30286242Free PMC Article
Skorodumova LO, Belodedova AV, Antonova OP, Sharova EI, Akopian TA, Selezneva OV, Kostryukova ES, Malyugin BE
Invest Ophthalmol Vis Sci 2018 Sep 4;59(11):4748-4754. doi: 10.1167/iovs.18-24590. PMID: 30267097
Eghrari AO, Vahedi S, Afshari NA, Riazuddin SA, Gottsch JD
Invest Ophthalmol Vis Sci 2017 Dec 1;58(14):6046-6049. doi: 10.1167/iovs.17-21661. PMID: 29196769Free PMC Article
Yokogawa H, Sanchez PJ, Mayko ZM, Straiko MD, Terry MA
Cornea 2016 Jul;35(7):932-7. doi: 10.1097/ICO.0000000000000882. PMID: 27191667

Diagnosis

Skorodumova LO, Belodedova AV, Antonova OP, Sharova EI, Akopian TA, Selezneva OV, Kostryukova ES, Malyugin BE
Invest Ophthalmol Vis Sci 2018 Sep 4;59(11):4748-4754. doi: 10.1167/iovs.18-24590. PMID: 30267097
Eghrari AO, Vahedi S, Afshari NA, Riazuddin SA, Gottsch JD
Invest Ophthalmol Vis Sci 2017 Dec 1;58(14):6046-6049. doi: 10.1167/iovs.17-21661. PMID: 29196769Free PMC Article
Eghrari AO, Garrett BS, Mumtaz AA, Edalati AE, Meadows DN, McGlumphy EJ, Iliff BW, Gottsch JD
Cornea 2015 Dec;34(12):1623-6. doi: 10.1097/ICO.0000000000000656. PMID: 26488628Free PMC Article
Kim YW, Kim MK, Wee WR
Korean J Ophthalmol 2013 Dec;27(6):409-15. Epub 2013 Nov 15 doi: 10.3341/kjo.2013.27.6.409. PMID: 24311925Free PMC Article
Koizumi N, Okumura N, Ueno M, Nakagawa H, Hamuro J, Kinoshita S
Cornea 2013 Aug;32(8):1167-70. doi: 10.1097/ICO.0b013e318285475d. PMID: 23715376

Therapy

Maier AB, Pilger D, Gundlach E, Winterhalter S, Torun N
Cornea 2021 Jan;40(1):26-32. doi: 10.1097/ICO.0000000000002363. PMID: 32558736
Lau LC, Ma L, Young AL, Rong SS, Jhanji V, Brelen ME, Pang CP, Chen LJ
PLoS One 2014;9(10):e109142. Epub 2014 Oct 9 doi: 10.1371/journal.pone.0109142. PMID: 25299301Free PMC Article
Koizumi N, Okumura N, Ueno M, Nakagawa H, Hamuro J, Kinoshita S
Cornea 2013 Aug;32(8):1167-70. doi: 10.1097/ICO.0b013e318285475d. PMID: 23715376
Seitzman GD, Gottsch JD, Stark WJ
Ophthalmology 2005 Mar;112(3):441-6. doi: 10.1016/j.ophtha.2004.10.044. PMID: 15745771
Alaa M, Waring GO 3rd, Malaty A, Grossniklaus H
J Refract Surg 1997 May-Jun;13(3):308-10. PMID: 9183764

Prognosis

Eghrari AO, Vahedi S, Afshari NA, Riazuddin SA, Gottsch JD
Invest Ophthalmol Vis Sci 2017 Dec 1;58(14):6046-6049. doi: 10.1167/iovs.17-21661. PMID: 29196769Free PMC Article
Vasanth S, Eghrari AO, Gapsis BC, Wang J, Haller NF, Stark WJ, Katsanis N, Riazuddin SA, Gottsch JD
Invest Ophthalmol Vis Sci 2015 Jul;56(8):4531-6. doi: 10.1167/iovs.14-16122. PMID: 26200491Free PMC Article
Xing C, Gong X, Hussain I, Khor CC, Tan DT, Aung T, Mehta JS, Vithana EN, Mootha VV
Invest Ophthalmol Vis Sci 2014 Oct 8;55(11):7073-8. doi: 10.1167/iovs.14-15390. PMID: 25298419Free PMC Article
Kim YW, Kim MK, Wee WR
Korean J Ophthalmol 2013 Dec;27(6):409-15. Epub 2013 Nov 15 doi: 10.3341/kjo.2013.27.6.409. PMID: 24311925Free PMC Article
Baratz KH, McLaren JW, Maguire LJ, Patel SV
Arch Ophthalmol 2012 Jul;130(7):868-74. doi: 10.1001/archophthalmol.2012.73. PMID: 22410629

Clinical prediction guides

Tang H, Zhang W, Yan XM, Wang LP, Dong H, Shou T, Lei H, Guo Q
Int J Mol Med 2016 Jun;37(6):1487-500. Epub 2016 Apr 20 doi: 10.3892/ijmm.2016.2570. PMID: 27121161Free PMC Article
Eghrari AO, Garrett BS, Mumtaz AA, Edalati AE, Meadows DN, McGlumphy EJ, Iliff BW, Gottsch JD
Cornea 2015 Dec;34(12):1623-6. doi: 10.1097/ICO.0000000000000656. PMID: 26488628Free PMC Article
Vasanth S, Eghrari AO, Gapsis BC, Wang J, Haller NF, Stark WJ, Katsanis N, Riazuddin SA, Gottsch JD
Invest Ophthalmol Vis Sci 2015 Jul;56(8):4531-6. doi: 10.1167/iovs.14-16122. PMID: 26200491Free PMC Article
Koizumi N, Okumura N, Ueno M, Nakagawa H, Hamuro J, Kinoshita S
Cornea 2013 Aug;32(8):1167-70. doi: 10.1097/ICO.0b013e318285475d. PMID: 23715376
Eghrari AO, McGlumphy EJ, Iliff BW, Wang J, Emmert D, Riazuddin SA, Katsanis N, Gottsch JD
Am J Ophthalmol 2012 Jun;153(6):1067-72. Epub 2012 Feb 8 doi: 10.1016/j.ajo.2011.11.033. PMID: 22321803Free PMC Article

Recent systematic reviews

Lau LC, Ma L, Young AL, Rong SS, Jhanji V, Brelen ME, Pang CP, Chen LJ
PLoS One 2014;9(10):e109142. Epub 2014 Oct 9 doi: 10.1371/journal.pone.0109142. PMID: 25299301Free PMC Article

Supplemental Content

Table of contents

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    Support Center