Format

Send to:

Choose Destination

Mental depression

MedGen UID:
8325
Concept ID:
C0011570
Mental or Behavioral Dysfunction
Synonym: Depressive Disorder
 
Monarch Initiative: MONDO:0002050

Definition

Depression (also known as major depression or major depressive disorder) is a psychiatric disorder that affects mood, behavior, and overall health. It causes prolonged feelings of sadness, emptiness, or hopelessness, and a loss of interest in activities that were once enjoyed. People with depression may also have changes in appetite (leading to overeating or not eating enough), changes in sleeping patterns (sleeping too much or not being able to sleep), loss of energy, and difficulty concentrating. Although depression is considered primarily a mental health disorder, it can also have physical features including headaches, other unexplained aches and pains, unusually slow or fast movements, and digestive problems. To be diagnosed with depression, an individual must have signs and symptoms nearly every day for at least 2 weeks. However, the features of this condition vary widely.\n\nDepression most commonly begins in late adolescence or early adulthood, although it can appear at any age. If untreated, episodes of depression can last for weeks, months, or years, and can go away and come back (recur). Affected individuals may have difficulty functioning in their daily lives, including at school or work. People with depression have a higher risk of substance abuse problems and dying by suicide than the general population.\n\nSeveral health conditions are closely related to depression or have depression as a characteristic feature. These include dysthymia (which has long-lasting signs and symptoms that are similar to, but not as severe as, those of depression), perinatal or postpartum depression (which occurs around or following the birth of a child), seasonal affective disorder (which is triggered by the changing of the seasons), bipolar disorder (which can include both "highs," or manic episodes, and depressive episodes), and generalized anxiety disorder. In people with schizoaffective disorder, depression or another mood disorder occurs together with features of schizophrenia (a brain disorder that affects a person's thinking, sense of self, and perceptions). [from MedlinePlus Genetics]

Recent clinical studies

Etiology

Salakari M, Nurminen R, Sillanmäki L, Pylkkänen L, Suominen S
Support Care Cancer 2020 Aug;28(8):3847-3854. Epub 2019 Dec 14 doi: 10.1007/s00520-019-05228-8. PMID: 31836939Free PMC Article
Salakari M, Pylkkänen L, Sillanmäki L, Nurminen R, Rautava P, Koskenvuo M, Suominen S
Breast 2017 Oct;35:85-90. Epub 2017 Jun 28 doi: 10.1016/j.breast.2017.06.017. PMID: 28667868
Patel SK, Saggurti N, Pachauri S, Prabhakar P
Asia Pac J Public Health 2015 Nov;27(8):809-19. Epub 2015 Aug 25 doi: 10.1177/1010539515601480. PMID: 26307144
Lippi G, Montagnana M, Favaloro EJ, Franchini M
Semin Thromb Hemost 2009 Apr;35(3):325-36. Epub 2009 May 18 doi: 10.1055/s-0029-1222611. PMID: 19452408
He Q, Zhang J, Tang Y
J Tradit Chin Med 2007 Sep;27(3):166-9. PMID: 17955648

Diagnosis

Salakari M, Nurminen R, Sillanmäki L, Pylkkänen L, Suominen S
Support Care Cancer 2020 Aug;28(8):3847-3854. Epub 2019 Dec 14 doi: 10.1007/s00520-019-05228-8. PMID: 31836939Free PMC Article
Lippi G, Montagnana M, Favaloro EJ, Franchini M
Semin Thromb Hemost 2009 Apr;35(3):325-36. Epub 2009 May 18 doi: 10.1055/s-0029-1222611. PMID: 19452408
Zhang G, Ruan J
J Tradit Chin Med 2004 Mar;24(1):20-1. PMID: 15119163
Ledochowski M, Sperner-Unterweger B, Fuchs D
Dig Dis Sci 1998 Nov;43(11):2513-7. doi: 10.1023/a:1026654820461. PMID: 9824144
Capurro PU, Capurro C
Clin Toxicol 1979;15(2):193-5. doi: 10.3109/15563657908989866. PMID: 509886

Therapy

Ginter E, Simko V
Bratisl Lek Listy 2010;111(12):680-5. PMID: 21384741
He Q, Zhang J, Tang Y
J Tradit Chin Med 2007 Sep;27(3):166-9. PMID: 17955648
Zhang C
J Tradit Chin Med 2005 Dec;25(4):243-6. PMID: 16447661
Han C, Li X, Luo H, Zhao X, Li X
J Tradit Chin Med 2004 Sep;24(3):172-6. PMID: 15510791
Zhang G, Ruan J
J Tradit Chin Med 2004 Mar;24(1):20-1. PMID: 15119163

Prognosis

Tang CZ, Zhang DF, Yang JT, Liu QH, Wang YR, Wang WS
Cell Death Dis 2019 Apr 8;10(4):316. doi: 10.1038/s41419-019-1522-4. PMID: 30962417Free PMC Article
Zhang X, Norton J, Carrière I, Ritchie K, Chaudieu I, Ancelin ML
Transl Psychiatry 2015 Mar 31;5:e536. doi: 10.1038/tp.2015.31. PMID: 25826111Free PMC Article
Lippi G, Montagnana M, Favaloro EJ, Franchini M
Semin Thromb Hemost 2009 Apr;35(3):325-36. Epub 2009 May 18 doi: 10.1055/s-0029-1222611. PMID: 19452408
Takeida K, Nishi M, Miyake H
J Epidemiol 1997 Dec;7(4):210-3. doi: 10.2188/jea.7.210. PMID: 9465545
Deberdt R, Van Hooren J, Biesbrouck M, Amery W
Biol Psychiatry 1976 Feb;11(1):69-74. PMID: 1083254

Clinical prediction guides

He Q, Zhang J, Tang Y
J Tradit Chin Med 2007 Sep;27(3):166-9. PMID: 17955648
Zhang C
J Tradit Chin Med 2005 Dec;25(4):243-6. PMID: 16447661
Han C, Li X, Luo H, Zhao X, Li X
J Tradit Chin Med 2004 Sep;24(3):172-6. PMID: 15510791
Ledochowski M, Widner B, Sperner-Unterweger B, Propst T, Vogel W, Fuchs D
Dig Dis Sci 2000 Jul;45(7):1255-9. doi: 10.1023/a:1005527230346. PMID: 10961700
Ledochowski M, Sperner-Unterweger B, Fuchs D
Dig Dis Sci 1998 Nov;43(11):2513-7. doi: 10.1023/a:1026654820461. PMID: 9824144

Supplemental Content

Table of contents

    Clinical resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    Support Center