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Cytomegalovirus infection

MedGen UID:
8239
Concept ID:
C0010823
Disease or Syndrome
Synonym: CMV infection
SNOMED CT: CMV - Cytomegalovirus infection (28944009); Disease due to Cytomegalovirus (28944009); Cytomegalovirus disease (28944009); Cytomegalovirus infection (28944009); Cytomegalic inclusion disease (28944009)
 
Monarch Initiative: MONDO:0005132

Definition

A herpesvirus infection caused by Cytomegalovirus. Healthy individuals generally do not produce symptoms. However, the infection may be life-threatening in affected immunocompromised patients. The virus may cause retinitis, esophagitis, gastritis, and colitis. Morphologically, it is characterized by the presence of intranuclear inclusion bodies. [from NCI]

Recent clinical studies

Etiology

Räihä J, Ortiz F, Mannonen L, Loginov R, Lempinen M, Lautenschlager I, Helanterä I
Transpl Infect Dis 2021 Aug;23(4):e13577. Epub 2021 Feb 18 doi: 10.1111/tid.13577. PMID: 33527660
Keymeulen A, De Leenheer E, Goderis J, Dhooge I, Smets K; Flemish Society of Pediatrics’ Neonatology and Perinatal Epidemiology Working Group for cCMV infection.
Acta Clin Belg 2021 Jun;76(3):169-176. Epub 2019 Oct 23 doi: 10.1080/17843286.2019.1683262. PMID: 31645217
Billette de Villemeur A, Tattevin P, Salmi LR; French Haut Conseil de la santé publique Working Group.
BMC Infect Dis 2020 Jun 16;20(1):418. doi: 10.1186/s12879-020-05139-8. PMID: 32546244Free PMC Article
Rahmel T, Nowak H, Rump K, Koos B, Schenker P, Viebahn R, Adamzik M, Bergmann L
Front Immunol 2019;10:2871. Epub 2019 Dec 5 doi: 10.3389/fimmu.2019.02871. PMID: 31867018Free PMC Article
Michita RT, Chies JAB, Schramm S, Horn PA, Heinemann FM, Wunsch A, Viebahn R, Schenker P, Rebmann V
Int J Mol Sci 2018 Sep 4;19(9) doi: 10.3390/ijms19092618. PMID: 30181474Free PMC Article

Diagnosis

Räihä J, Ortiz F, Mannonen L, Loginov R, Lempinen M, Lautenschlager I, Helanterä I
Transpl Infect Dis 2021 Aug;23(4):e13577. Epub 2021 Feb 18 doi: 10.1111/tid.13577. PMID: 33527660
Ponz de Antonio I, Rodríguez Chaverri A, García Reyne A, Carrasco Antón N, Lora Pablos D, López Medrano F, de Dios S, Jurado A, Folgueira MD, García-Cosio Carmena MD, Arribas Ynsaurriaga F, Aguado JM, Lumbreras C, Delgado Jiménez JF
Transpl Infect Dis 2021 Apr;23(2):e13479. Epub 2020 Oct 13 doi: 10.1111/tid.13479. PMID: 32996216
Billette de Villemeur A, Tattevin P, Salmi LR; French Haut Conseil de la santé publique Working Group.
BMC Infect Dis 2020 Jun 16;20(1):418. doi: 10.1186/s12879-020-05139-8. PMID: 32546244Free PMC Article
Wang H, Peng G, Bai J, He B, Huang K, Hu X, Liu D
J Am Heart Assoc 2017 Jul 6;6(7) doi: 10.1161/JAHA.116.005025. PMID: 28684641Free PMC Article
Hong SY, Yang JJ, Li SY, Lee IC
Pediatr Neonatol 2015 Dec;56(6):408-14. Epub 2015 May 13 doi: 10.1016/j.pedneo.2015.04.002. PMID: 26073370

Therapy

Shah M, Kakar A, Gogia A, Langer S
J Postgrad Med 2021 Apr-Jun;67(2):100-102. doi: 10.4103/jpgm.JPGM_1168_20. PMID: 33942774Free PMC Article
Räihä J, Ortiz F, Mannonen L, Loginov R, Lempinen M, Lautenschlager I, Helanterä I
Transpl Infect Dis 2021 Aug;23(4):e13577. Epub 2021 Feb 18 doi: 10.1111/tid.13577. PMID: 33527660
Tanimura K, Shi Y, Uchida A, Uenaka M, Imafuku H, Ikuta T, Fujioka K, Morioka I, Deguchi M, Minematsu T, Yamada H
J Reprod Immunol 2021 Feb;143:103263. Epub 2020 Dec 16 doi: 10.1016/j.jri.2020.103263. PMID: 33422744
Zhang Y, Zhou T, Huang M, Gu G, Xia Q
Ann Clin Microbiol Antimicrob 2020 Aug 5;19(1):34. doi: 10.1186/s12941-020-00372-0. PMID: 32758225Free PMC Article
Rahmel T, Nowak H, Rump K, Koos B, Schenker P, Viebahn R, Adamzik M, Bergmann L
Front Immunol 2019;10:2871. Epub 2019 Dec 5 doi: 10.3389/fimmu.2019.02871. PMID: 31867018Free PMC Article

Prognosis

Keymeulen A, De Leenheer E, Goderis J, Dhooge I, Smets K; Flemish Society of Pediatrics’ Neonatology and Perinatal Epidemiology Working Group for cCMV infection.
Acta Clin Belg 2021 Jun;76(3):169-176. Epub 2019 Oct 23 doi: 10.1080/17843286.2019.1683262. PMID: 31645217
Billette de Villemeur A, Tattevin P, Salmi LR; French Haut Conseil de la santé publique Working Group.
BMC Infect Dis 2020 Jun 16;20(1):418. doi: 10.1186/s12879-020-05139-8. PMID: 32546244Free PMC Article
Michita RT, Chies JAB, Schramm S, Horn PA, Heinemann FM, Wunsch A, Viebahn R, Schenker P, Rebmann V
Int J Mol Sci 2018 Sep 4;19(9) doi: 10.3390/ijms19092618. PMID: 30181474Free PMC Article
Wang H, Peng G, Bai J, He B, Huang K, Hu X, Liu D
J Am Heart Assoc 2017 Jul 6;6(7) doi: 10.1161/JAHA.116.005025. PMID: 28684641Free PMC Article
Krakar G, Đaković I, Delin S, Bošnjak VM
J Child Neurol 2015 Jan;30(1):93-5. Epub 2014 Jan 21 doi: 10.1177/0883073813514292. PMID: 24453153

Clinical prediction guides

Rahmel T, Nowak H, Rump K, Koos B, Schenker P, Viebahn R, Adamzik M, Bergmann L
Front Immunol 2019;10:2871. Epub 2019 Dec 5 doi: 10.3389/fimmu.2019.02871. PMID: 31867018Free PMC Article
Perello R, Vergara A, Monclus E, Jimenez S, Montero M, Saubi N, Moreno A, Eto Y, Inciarte A, Mallolas J, Martínez E, Marcos MA
BMC Infect Dis 2019 Dec 4;19(1):1030. doi: 10.1186/s12879-019-4643-6. PMID: 31801482Free PMC Article
Cadena-Mota S, Monsiváis-Urenda A, Salgado-Bustamante M, Monjarás-Ávila C, Bernal-Silva S, Aranda-Romo S, Noyola DE
Microbiol Immunol 2018 Dec;62(12):755-762. doi: 10.1111/1348-0421.12661. PMID: 30461037
Michita RT, Chies JAB, Schramm S, Horn PA, Heinemann FM, Wunsch A, Viebahn R, Schenker P, Rebmann V
Int J Mol Sci 2018 Sep 4;19(9) doi: 10.3390/ijms19092618. PMID: 30181474Free PMC Article
Hong SY, Yang JJ, Li SY, Lee IC
Pediatr Neonatol 2015 Dec;56(6):408-14. Epub 2015 May 13 doi: 10.1016/j.pedneo.2015.04.002. PMID: 26073370

Recent systematic reviews

Barber V, Calvert A, Vandrevala T, Star C, Khalil A, Griffiths P, Heath PT, Jones CE
Pediatr Infect Dis J 2020 Oct;39(10):949-954. doi: 10.1097/INF.0000000000002763. PMID: 32502127
Zhang YL, Zhu Y, Xiao Q, Wang L, Liu L, Luo XH
Ann Hematol 2019 Apr;98(4):1009-1020. Epub 2019 Jan 21 doi: 10.1007/s00277-018-3585-1. PMID: 30666434
Wang H, Peng G, Bai J, He B, Huang K, Hu X, Liu D
J Am Heart Assoc 2017 Jul 6;6(7) doi: 10.1161/JAHA.116.005025. PMID: 28684641Free PMC Article
Ellington SR, Clarke KE, Kourtis AP
J Infect Dis 2016 Mar 15;213(6):891-900. Epub 2015 Nov 23 doi: 10.1093/infdis/jiv549. PMID: 26597258Free PMC Article
Marinho-Dias J, Sousa H
Acta Med Port 2013 Mar-Apr;26(2):154-60. Epub 2013 May 31 PMID: 23809748

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