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Colorectal carcinoma(CRC)

MedGen UID:
3170
Concept ID:
C0009402
Neoplastic Process
Synonyms: Cancer, Colorectal; Cancers, Colorectal; Carcinoma, Colorectal; Carcinomas, Colorectal; Colorectal Cancer; Colorectal Cancers; Colorectal Carcinoma; Colorectal Carcinomas
 
Monarch Initiative: MONDO:0024331
OMIM®: 114500; 172411; 191170; 516000; 516004; 516020; 516030; 516040

Definition

A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

García-Alfonso P, García-Carbonero R, García-Foncillas J, Pérez-Segura P, Salazar R, Vera R, Ramón Y Cajal S, Hernández-Losa J, Landolfi S, Musulén E, Cuatrecasas M, Navarro S
Clin Transl Oncol 2020 Nov;22(11):1976-1991. Epub 2020 May 16 doi: 10.1007/s12094-020-02357-z. PMID: 32418154Free PMC Article

Recent clinical studies

Etiology

Kajsik M, Chovancova B, Liskova V, Babula P, Krizanova O
Eur J Pharmacol 2022 May 5;922:174875. Epub 2022 Mar 18 doi: 10.1016/j.ejphar.2022.174875. PMID: 35314158
Zhu G, Wu C, Shen X
Medicine (Baltimore) 2020 Nov 6;99(45):e22857. doi: 10.1097/MD.0000000000022857. PMID: 33157927Free PMC Article
Chittleborough TJ, Gutlic I, Pearson JF, Watson A, Bhatti LA, Buchwald P, Potter JD, Wakeman C, Eglinton T, Frizelle F
Dis Colon Rectum 2020 Jul;63(7):903-910. doi: 10.1097/DCR.0000000000001631. PMID: 32109915
Jia W, Zeng L, Luo S, Bai F, Zhong R, Wu L, Huang GL, Pu X
Medicine (Baltimore) 2018 Feb;97(6):e9846. doi: 10.1097/MD.0000000000009846. PMID: 29419695Free PMC Article
Utsumi M, Tanakaya K, Mushiake Y, Kunitomo T, Yasuhara I, Taniguchi F, Arata T, Katsuda K, Aoki H, Takeuchi H
World J Surg Oncol 2017 Aug 1;15(1):140. doi: 10.1186/s12957-017-1207-3. PMID: 28764791Free PMC Article

Diagnosis

Kajsik M, Chovancova B, Liskova V, Babula P, Krizanova O
Eur J Pharmacol 2022 May 5;922:174875. Epub 2022 Mar 18 doi: 10.1016/j.ejphar.2022.174875. PMID: 35314158
Lawan AI, Ogunbiyi JO
West Afr J Med 2020 Apr-Jun;37(2):100-105. PMID: 32150626
Malvicini M, Gutierrez-Moraga A, Rodriguez MM, Gomez-Bustillo S, Salazar L, Sunkel C, Nozal L, Salgado A, Hidalgo M, Lopez-Casas PP, Novella JL, Vaquero JJ, Alvarez-Builla J, Mora A, Gidekel M, Mazzolini G
Mol Cancer Ther 2018 May;17(5):966-976. Epub 2018 Feb 26 doi: 10.1158/1535-7163.MCT-17-0193. PMID: 29483221
Li L, Luo HS
Oncol Res 2018 Jan 19;26(1):27-35. Epub 2017 Mar 23 doi: 10.3727/096504017X14900515946914. PMID: 28337960Free PMC Article
Gu S, Feng J, Jin Q, Wang W, Zhang S
Histol Histopathol 2017 May;32(5):491-497. Epub 2016 Sep 21 doi: 10.14670/HH-11-815. PMID: 27651378

Therapy

Caldiran FY, Cacan E
Pathol Res Pract 2022 Aug;236:154007. Epub 2022 Jul 3 doi: 10.1016/j.prp.2022.154007. PMID: 35810565
Kajsik M, Chovancova B, Liskova V, Babula P, Krizanova O
Eur J Pharmacol 2022 May 5;922:174875. Epub 2022 Mar 18 doi: 10.1016/j.ejphar.2022.174875. PMID: 35314158
Ray SK, Meshram Y, Mukherjee S
Curr Mol Med 2021;21(3):221-236. doi: 10.2174/1566524020666200824103749. PMID: 32838717
Zhu G, Wu C, Shen X
Medicine (Baltimore) 2020 Nov 6;99(45):e22857. doi: 10.1097/MD.0000000000022857. PMID: 33157927Free PMC Article
Kuan SF, Ren B, Brand R, Dudley B, Pai RK
Hum Pathol 2017 May;63:33-39. Epub 2017 Feb 21 doi: 10.1016/j.humpath.2017.02.003. PMID: 28232158

Prognosis

Yi X, Hu C, Zhang C, Shao K, Sun H, Jiang Y, Sun N, Zhi X
Cell Signal 2022 Feb;90:110202. Epub 2021 Nov 23 doi: 10.1016/j.cellsig.2021.110202. PMID: 34826587
Srivastava P, Husain N, Shukla S, Chauhan S, Pandey A, Masood S
Indian J Pathol Microbiol 2021 Jul-Sep;64(3):490-496. doi: 10.4103/IJPM.IJPM_521_20. PMID: 34341259
Wang Y, Wang J, Yang C, Wang Y, Liu J, Shi Z, Chen Y, Feng Y, Ma X, Qiao S
World J Surg Oncol 2021 Mar 29;19(1):91. doi: 10.1186/s12957-021-02195-5. PMID: 33781288Free PMC Article
Escobar D, Jones R, Gao J, Sun L, Liao J, Yang GY
Hum Pathol 2020 Nov;105:37-46. Epub 2020 Sep 9 doi: 10.1016/j.humpath.2020.08.002. PMID: 32916163
Wang YQ, Jiang DM, Hu SS, Zhao L, Wang L, Yang MH, Ai ML, Jiang HJ, Han Y, Ding YQ, Wang S
Cancer Res 2019 Jul 15;79(14):3542-3556. Epub 2019 Mar 11 doi: 10.1158/0008-5472.CAN-18-2900. PMID: 30858153

Clinical prediction guides

Kajsik M, Chovancova B, Liskova V, Babula P, Krizanova O
Eur J Pharmacol 2022 May 5;922:174875. Epub 2022 Mar 18 doi: 10.1016/j.ejphar.2022.174875. PMID: 35314158
Yi X, Hu C, Zhang C, Shao K, Sun H, Jiang Y, Sun N, Zhi X
Cell Signal 2022 Feb;90:110202. Epub 2021 Nov 23 doi: 10.1016/j.cellsig.2021.110202. PMID: 34826587
Srivastava P, Husain N, Shukla S, Chauhan S, Pandey A, Masood S
Indian J Pathol Microbiol 2021 Jul-Sep;64(3):490-496. doi: 10.4103/IJPM.IJPM_521_20. PMID: 34341259
Wang Y, Wang J, Yang C, Wang Y, Liu J, Shi Z, Chen Y, Feng Y, Ma X, Qiao S
World J Surg Oncol 2021 Mar 29;19(1):91. doi: 10.1186/s12957-021-02195-5. PMID: 33781288Free PMC Article
Malvicini M, Gutierrez-Moraga A, Rodriguez MM, Gomez-Bustillo S, Salazar L, Sunkel C, Nozal L, Salgado A, Hidalgo M, Lopez-Casas PP, Novella JL, Vaquero JJ, Alvarez-Builla J, Mora A, Gidekel M, Mazzolini G
Mol Cancer Ther 2018 May;17(5):966-976. Epub 2018 Feb 26 doi: 10.1158/1535-7163.MCT-17-0193. PMID: 29483221

Recent systematic reviews

Franco Valle K, Lubner MG, Pickhardt PJ
J Comput Assist Tomogr 2022 Mar-Apr 01;46(2):157-162. doi: 10.1097/RCT.0000000000001281. PMID: 35297571
Xu C, Guo X, Zhou C, Zhang H
Medicine (Baltimore) 2020 Jul 2;99(27):e21155. doi: 10.1097/MD.0000000000021155. PMID: 32629751Free PMC Article
Peng Y, Li Q, Zhang J, Shen W, Zhang X, Sun C, Cui H
Biosci Trends 2019 Jan 22;12(6):537-552. Epub 2018 Dec 17 doi: 10.5582/bst.2018.01246. PMID: 30555112
Tsitsias T, Toufektzian L, Routledge T, Pilling J
Interact Cardiovasc Thorac Surg 2016 Dec;23(6):962-969. Epub 2016 Aug 29 doi: 10.1093/icvts/ivw273. PMID: 27572615
Borstlap WA, Stellingwerf ME, Moolla Z, Musters GD, Buskens CJ, Tanis PJ, Bemelman WA
Colorectal Dis 2015 Dec;17(12):1044-54. doi: 10.1111/codi.13110. PMID: 26342151

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