U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cerebellar ataxia

MedGen UID:
849
•Concept ID:
C0007758
•
Disease or Syndrome
Synonyms: Ataxia, Cerebellar; Ataxias, Cerebellar; Cerebellar Ataxia; Cerebellar Ataxias; Cerebellar Incoordination; Cerebellar Incoordinations; Incoordination, Cerebellar; Incoordinations, Cerebellar
SNOMED CT: Cerebellar ataxia (85102008); Cerebellar ataxia (loss of muscle coordination) (85102008)
 
Monarch Initiative: MONDO:0000437
Orphanet: ORPHA102002

Definition

A neurological syndrome characterized by clumsy and uncoordinated movement of the limbs, trunk, and cranial muscles. It results from pathology in the cerebellum and its connections, or in the proprioceptive sensory pathways. [from MONDO]

Term Hierarchy

Professional guidelines

PubMed

CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options.
Indelicato E, Boesch S
Handb Exp Pharmacol 2023;279:227-248. doi: 10.1007/164_2022_625. PMID: 36592223
Cerebellar Dizziness and Vertigo: Etiologies, Diagnostic Assessment, and Treatment.
Zwergal A, Feil K, Schniepp R, Strupp M
Semin Neurol 2020 Feb;40(1):87-96. Epub 2019 Dec 30 doi: 10.1055/s-0039-3400315. PMID: 31887755
Acute cerebellar ataxia: differential diagnosis and clinical approach.
Pedroso JL, Vale TC, Braga-Neto P, Dutra LA, França MC Jr, Teive HAG, Barsottini OGP
Arq Neuropsiquiatr 2019 Mar;77(3):184-193. doi: 10.1590/0004-282X20190020. PMID: 30970132

Recent clinical studies

Etiology

Acute Cerebellitis or Postinfectious Cerebellar Ataxia? Clinical and Imaging Features in Acute Cerebellitis.
Yildirim M, Gocmen R, Konuskan B, Parlak S, Yalnizoglu D, Anlar B
J Child Neurol 2020 May;35(6):380-388. Epub 2020 Mar 12 doi: 10.1177/0883073820901407. PMID: 32160830
Acute cerebellar ataxia: differential diagnosis and clinical approach.
Pedroso JL, Vale TC, Braga-Neto P, Dutra LA, França MC Jr, Teive HAG, Barsottini OGP
Arq Neuropsiquiatr 2019 Mar;77(3):184-193. doi: 10.1590/0004-282X20190020. PMID: 30970132
A systematic review of the gait characteristics associated with Cerebellar Ataxia.
Buckley E, Mazzà C, McNeill A
Gait Posture 2018 Feb;60:154-163. Epub 2017 Dec 1 doi: 10.1016/j.gaitpost.2017.11.024. PMID: 29220753
Drug-induced cerebellar ataxia: a systematic review.
van Gaalen J, Kerstens FG, Maas RP, Härmark L, van de Warrenburg BP
CNS Drugs 2014 Dec;28(12):1139-53. doi: 10.1007/s40263-014-0200-4. PMID: 25391707
Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases.
Miyai I, Ito M, Hattori N, Mihara M, Hatakenaka M, Yagura H, Sobue G, Nishizawa M; Cerebellar Ataxia Rehabilitation Trialists Collaboration
Neurorehabil Neural Repair 2012 Jun;26(5):515-22. Epub 2011 Dec 2 doi: 10.1177/1545968311425918. PMID: 22140200

Diagnosis

CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options.
Indelicato E, Boesch S
Handb Exp Pharmacol 2023;279:227-248. doi: 10.1007/164_2022_625. PMID: 36592223
Evaluation of Cerebellar Ataxic Patients.
Radmard S, Zesiewicz TA, Kuo SH
Neurol Clin 2023 Feb;41(1):21-44. Epub 2022 Aug 31 doi: 10.1016/j.ncl.2022.05.002. PMID: 36400556Free PMC Article
Neurodegenerative Cerebellar Ataxia.
Rosenthal LS
Continuum (Minneap Minn) 2022 Oct 1;28(5):1409-1434. doi: 10.1212/CON.0000000000001180. PMID: 36222772
Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS): genetic and clinical aspects.
Cortese A, Curro' R, Vegezzi E, Yau WY, Houlden H, Reilly MM
Pract Neurol 2022 Feb;22(1):14-18. Epub 2021 Aug 13 doi: 10.1136/practneurol-2020-002822. PMID: 34389644
Acute cerebellar ataxia: differential diagnosis and clinical approach.
Pedroso JL, Vale TC, Braga-Neto P, Dutra LA, França MC Jr, Teive HAG, Barsottini OGP
Arq Neuropsiquiatr 2019 Mar;77(3):184-193. doi: 10.1590/0004-282X20190020. PMID: 30970132

Therapy

An update on multiple system atrophy.
Stankovic I, Kuijpers M, Kaufmann H
Curr Opin Neurol 2024 Aug 1;37(4):400-408. Epub 2024 Jun 3 doi: 10.1097/WCO.0000000000001285. PMID: 38828714Free PMC Article
Ataxia.
Kuo SH
Continuum (Minneap Minn) 2019 Aug;25(4):1036-1054. doi: 10.1212/CON.0000000000000753. PMID: 31356292Free PMC Article
A systematic review of the gait characteristics associated with Cerebellar Ataxia.
Buckley E, Mazzà C, McNeill A
Gait Posture 2018 Feb;60:154-163. Epub 2017 Dec 1 doi: 10.1016/j.gaitpost.2017.11.024. PMID: 29220753
The assessment and treatment of postural disorders in cerebellar ataxia: a systematic review.
Marquer A, Barbieri G, Pérennou D
Ann Phys Rehabil Med 2014 Mar;57(2):67-78. Epub 2014 Feb 6 doi: 10.1016/j.rehab.2014.01.002. PMID: 24582474
Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases.
Miyai I, Ito M, Hattori N, Mihara M, Hatakenaka M, Yagura H, Sobue G, Nishizawa M; Cerebellar Ataxia Rehabilitation Trialists Collaboration
Neurorehabil Neural Repair 2012 Jun;26(5):515-22. Epub 2011 Dec 2 doi: 10.1177/1545968311425918. PMID: 22140200

Prognosis

The inherited cerebellar ataxias: an update.
Coarelli G, Wirth T, Tranchant C, Koenig M, Durr A, Anheim M
J Neurol 2023 Jan;270(1):208-222. Epub 2022 Sep 24 doi: 10.1007/s00415-022-11383-6. PMID: 36152050Free PMC Article
Neurodegenerative Cerebellar Ataxia.
Rosenthal LS
Continuum (Minneap Minn) 2022 Oct 1;28(5):1409-1434. doi: 10.1212/CON.0000000000001180. PMID: 36222772
Neurological Syndromes Associated with Anti-GAD Antibodies.
Dade M, Berzero G, Izquierdo C, Giry M, Benazra M, Delattre JY, Psimaras D, Alentorn A
Int J Mol Sci 2020 May 24;21(10) doi: 10.3390/ijms21103701. PMID: 32456344Free PMC Article
Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases.
Miyai I, Ito M, Hattori N, Mihara M, Hatakenaka M, Yagura H, Sobue G, Nishizawa M; Cerebellar Ataxia Rehabilitation Trialists Collaboration
Neurorehabil Neural Repair 2012 Jun;26(5):515-22. Epub 2011 Dec 2 doi: 10.1177/1545968311425918. PMID: 22140200

Clinical prediction guides

The inherited cerebellar ataxias: an update.
Coarelli G, Wirth T, Tranchant C, Koenig M, Durr A, Anheim M
J Neurol 2023 Jan;270(1):208-222. Epub 2022 Sep 24 doi: 10.1007/s00415-022-11383-6. PMID: 36152050Free PMC Article
Update on Cerebellar Ataxia with Neuropathy and Bilateral Vestibular Areflexia Syndrome (CANVAS).
Dupré M, Hermann R, Froment Tilikete C
Cerebellum 2021 Oct;20(5):687-700. Epub 2020 Oct 4 doi: 10.1007/s12311-020-01192-w. PMID: 33011895Free PMC Article
Acute Cerebellitis or Postinfectious Cerebellar Ataxia? Clinical and Imaging Features in Acute Cerebellitis.
Yildirim M, Gocmen R, Konuskan B, Parlak S, Yalnizoglu D, Anlar B
J Child Neurol 2020 May;35(6):380-388. Epub 2020 Mar 12 doi: 10.1177/0883073820901407. PMID: 32160830
Functional recovery and rehabilitation of postural impairment and gait ataxia in patients with acute cerebellar stroke.
Bultmann U, Pierscianek D, Gizewski ER, Schoch B, Fritsche N, Timmann D, Maschke M, Frings M
Gait Posture 2014;39(1):563-9. Epub 2013 Sep 24 doi: 10.1016/j.gaitpost.2013.09.011. PMID: 24119775
Intensive coordinative training improves motor performance in degenerative cerebellar disease.
Ilg W, Synofzik M, Brötz D, Burkard S, Giese MA, Schöls L
Neurology 2009 Dec 1;73(22):1823-30. Epub 2009 Oct 28 doi: 10.1212/WNL.0b013e3181c33adf. PMID: 19864636

Recent systematic reviews

Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches.
Hassan A
Tremor Other Hyperkinet Mov (N Y) 2023;13:9. Epub 2023 Mar 28 doi: 10.5334/tohm.747. PMID: 37008993Free PMC Article
Effects of therapeutic exercise on disease severity, balance, and functional Independence among individuals with cerebellar ataxia: A systematic review with meta-analysis.
Winser S, Chan HK, Chen WK, Hau CY, Leung SH, Leung YH, Bello UM
Physiother Theory Pract 2023 Jul 3;39(7):1355-1375. Epub 2022 Feb 25 doi: 10.1080/09593985.2022.2037115. PMID: 35212247
A systematic review of the gait characteristics associated with Cerebellar Ataxia.
Buckley E, Mazzà C, McNeill A
Gait Posture 2018 Feb;60:154-163. Epub 2017 Dec 1 doi: 10.1016/j.gaitpost.2017.11.024. PMID: 29220753
Drug-induced cerebellar ataxia: a systematic review.
van Gaalen J, Kerstens FG, Maas RP, Härmark L, van de Warrenburg BP
CNS Drugs 2014 Dec;28(12):1139-53. doi: 10.1007/s40263-014-0200-4. PMID: 25391707
The assessment and treatment of postural disorders in cerebellar ataxia: a systematic review.
Marquer A, Barbieri G, Pérennou D
Ann Phys Rehabil Med 2014 Mar;57(2):67-78. Epub 2014 Feb 6 doi: 10.1016/j.rehab.2014.01.002. PMID: 24582474

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...