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Celiac disease(CELIAC1)

MedGen UID:
3291
Concept ID:
C0007570
Disease or Syndrome
Synonyms: Celiac sprue; CELIAC SPRUE, SUSCEPTIBILITY TO, 1; CELIAC1; Gluten-sensitive enteropathy; GLUTEN-SENSITIVE ENTEROPATHY, SUSCEPTIBILITY TO, 1
Modes of inheritance:
Heterogeneous
MedGen UID:
67020
Concept ID:
C0242960
Organism Attribute
Source: HPO
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Sources: HPO, OMIM, Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
Multifactorial inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Sources: HPO, Orphanet
A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases.
Autosomal recessive inheritance (HPO, OMIM, Orphanet)
SNOMED CT: Celiac disease (396331005); CD - Celiac disease (396331005); Idiopathic steatorrhea (396331005); Celiac sprue (396331005); CS - Celiac sprue (396331005); Celiac syndrome (396331005); Wheat-sensitive enteropathy (396331005); Gluten enteropathy (396331005); Gluten-responsive sprue (396331005); GSE - Gluten-sensitive enteropathy (396331005); Gluten-sensitive enteropathy (396331005); Non-tropical sprue (396331005); Gluten-induced enteropathy syndrome (396331005); Nontropical sprue (396331005)
 
Genes (locations): HLA-DQA1 (6p21.32); HLA-DQB1 (6p21.32)
Related genes: MYO9B, CTLA4
OMIM®: 212750
HPO: HP:0002608

Disease characteristics

Excerpted from the GeneReview: Celiac Disease
Celiac disease is a systemic autoimmune disease that can be associated with gastrointestinal findings (diarrhea, weight loss, abdominal pain, anorexia, lactose intolerance, abdominal distention, and irritability) and/or highly variable non-gastrointestinal findings (iron deficiency anemia, dermatitis herpetiformis, chronic fatigue, joint pain/inflammation, migraines, depression, attention-deficit disorder, epilepsy, osteoporosis/osteopenia, infertility and/or recurrent fetal loss, vitamin deficiencies, short stature, failure to thrive, delayed puberty, dental enamel defects, and autoimmune disorders). Classic celiac disease, characterized by mild to severe gastrointestinal symptoms, is less common than non-classic celiac disease, characterized by absence of gastrointestinal symptoms. [from GeneReviews]
Authors:
Annette K Taylor  |  Benjamin Lebwohl  |  Cara L Snyder, et. al.   view full author information

Additional descriptions

From OMIM
Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy (GSE), is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). Long regarded as gastrointestinal disorder of childhood, the disease is now considered to be a chronic systemic autoimmune disease and is more often diagnosed in adults than in children (Monsuur et al., 2005). For a discussion of genetic heterogeneity of celiac disease, see MAPPING.  http://www.omim.org/entry/212750
From GHR
Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.Celiac disease can develop at any age after an individual starts eating foods containing gluten. The classic symptoms of the condition result from inflammation affecting the gastrointestinal tract. This inflammation damages the villi, which are small, finger-like projections that line the small intestine and provide a greatly increased surface area to absorb nutrients. In celiac disease, the villi become shortened and eventually flatten out. Intestinal damage causes diarrhea and poor absorption of nutrients, which may lead to weight loss. Abdominal pain, swelling (distention), and food intolerances are common in celiac disease. Inflammation associated with celiac disease may lead to an increased risk of developing certain gastrointestinal cancers such as cancers of the small intestine or esophagus.Inflammation and poor nutrient absorption may lead to problems affecting many other organs and systems of the body in affected individuals. These health problems may include iron deficiency that results in a low number of red blood cells (anemia), vitamin deficiencies, low bone mineral density (osteoporosis), itchy skin rashes (dermatitis herpetiformis), defects in the enamel of the teeth, chronic fatigue, joint pain, poor growth, delayed puberty, infertility, or repeated miscarriages. Neurological problems have also been associated with celiac disease; these include migraine headaches, depression, attention deficit hyperactivity disorder (ADHD), and recurrent seizures (epilepsy). Many people with celiac disease have one or more of these varied health problems but do not have gastrointestinal symptoms. This form of the condition is called nonclassic celiac disease. Researchers now believe that nonclassic celiac disease is actually more common than the classic form.Celiac disease often goes undiagnosed because many of its signs and symptoms are nonspecific, which means they may occur in many disorders. Most people who have one or more of these nonspecific health problems do not have celiac disease. On average, a diagnosis of celiac disease is not made until 6 to 10 years after symptoms begin.Some people have silent celiac disease, in which they have no symptoms of the disorder. However, people with silent celiac disease do have immune proteins in their blood (antibodies) that are common in celiac disease. They also have inflammatory damage to their small intestine that can be detected with a biopsy.In a small number of cases, celiac disease does not improve with a gluten-free diet and progresses to a condition called refractory sprue. Refractory sprue is characterized by chronic inflammation of the gastrointestinal tract, poor absorption of nutrients, and an increased risk of developing a type of cancer of the immune cells called T-cell lymphoma.  https://ghr.nlm.nih.gov/condition/celiac-disease

Clinical features

Abdominal distention
MedGen UID:
34
Concept ID:
C0000731
Finding
Distention of the abdomen.
Abdominal pain
MedGen UID:
7803
Concept ID:
C0000737
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
Alopecia
MedGen UID:
7982
Concept ID:
C0002170
Finding
Absence of hair from areas where it is normally present.
Macrocytic anemia
MedGen UID:
1920
Concept ID:
C0002886
Disease or Syndrome
A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).
Anxiety
MedGen UID:
1613
Concept ID:
C0003467
Finding
Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.
Arthralgia
MedGen UID:
13917
Concept ID:
C0003862
Sign or Symptom
Joint pain.
Celiac disease
MedGen UID:
3291
Concept ID:
C0007570
Disease or Syndrome
Celiac disease is a systemic autoimmune disease that can be associated with gastrointestinal findings (diarrhea, weight loss, abdominal pain, anorexia, lactose intolerance, abdominal distention, and irritability) and/or highly variable non-gastrointestinal findings (iron deficiency anemia, dermatitis herpetiformis, chronic fatigue, joint pain/inflammation, migraines, depression, attention-deficit disorder, epilepsy, osteoporosis/osteopenia, infertility and/or recurrent fetal loss, vitamin deficiencies, short stature, failure to thrive, delayed puberty, dental enamel defects, and autoimmune disorders). Classic celiac disease, characterized by mild to severe gastrointestinal symptoms, is less common than non-classic celiac disease, characterized by absence of gastrointestinal symptoms.
Ataxia
MedGen UID:
849
Concept ID:
C0007758
Sign or Symptom
Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of elementary neurological deficits including asynergy (lack of coordination between muscles, limbs and joints), dysmetria (lack of ability to judge distances that can lead to under- oder overshoot in grasping movements), and dysdiadochokinesia (inability to perform rapid movements requiring antagonizing muscle groups to be switched on and off repeatedly).
Hypoplasia of dental enamel
MedGen UID:
3730
Concept ID:
C0011351
Disease or Syndrome
A form of amelogenesis imperfecta characterized by incomplete formation of the dental enamel and transmitted as an X-linked or autosomal dominant trait.
Depressivity
MedGen UID:
4229
Concept ID:
C0011581
Mental or Behavioral Dysfunction
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
Diabetes mellitus type 1
MedGen UID:
41522
Concept ID:
C0011854
Disease or Syndrome
The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. It is a genetically heterogeneous autoimmune disease affecting about 0.3% of Caucasian populations (Todd, 1990). Genetic studies of IDDM have focused on the identification of loci associated with increased susceptibility to this multifactorial phenotype. The classical phenotype of diabetes mellitus is polydipsia, polyphagia, and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Diarrhea
MedGen UID:
8360
Concept ID:
C0011991
Sign or Symptom
Abnormally increased frequency of loose or watery bowel movements.
Eczematous rash
MedGen UID:
3968
Concept ID:
C0013595
Disease or Syndrome
A form of dermatitis characterized by red, itchy, scaly, or crusty patches that can be chronic or intermittent.(NICHD)
Folate deficiency
MedGen UID:
42057
Concept ID:
C0016412
Disease or Syndrome
A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
Hypocalcemia
MedGen UID:
5705
Concept ID:
C0020598
Disease or Syndrome
An abnormally decreased calcium concentration in the blood.
Infertility
MedGen UID:
43876
Concept ID:
C0021359
Finding
A reduced or absent capacity to reproduce.
Lymphoma
MedGen UID:
44223
Concept ID:
C0024299
Neoplastic Process
A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells.
Generalized osteoporosis
MedGen UID:
14535
Concept ID:
C0029456
Disease or Syndrome
A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).
Delayed Puberty
MedGen UID:
46203
Concept ID:
C0034012
Pathologic Function
Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.
Rickets
MedGen UID:
48470
Concept ID:
C0035579
Disease or Syndrome
Bone softening and weakening usually caused by deficiency or impaired metabolism of vitamin D. Deficiency of calcium, magnesium, or phosphorus may also cause rickets. It predominantly affects children who suffer from severe malnutrition. It manifests with bone pain, fractures, muscle weakness, and skeletal deformities.
Seizures
MedGen UID:
20693
Concept ID:
C0036572
Sign or Symptom
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Steatorrhea
MedGen UID:
20948
Concept ID:
C0038238
Finding
A condition that is characterized by chronic fatty DIARRHEA, a result of abnormal DIGESTION and/or INTESTINAL ABSORPTION of FATS.
Vitamin D deficiency
MedGen UID:
12114
Concept ID:
C0042870
Disease or Syndrome
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Vitamin K deficiency
MedGen UID:
22672
Concept ID:
C0042880
Disease or Syndrome
A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)
Vomiting
MedGen UID:
12124
Concept ID:
C0042963
Sign or Symptom
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
Prolonged prothrombin time
MedGen UID:
56249
Concept ID:
C0151872
Finding
Increased time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation.
Polyneuropathy
MedGen UID:
57502
Concept ID:
C0152025
Disease or Syndrome
A disease or disorder affecting more than one nerve.
Iron deficiency anemia
MedGen UID:
57668
Concept ID:
C0162316
Disease or Syndrome
Anemia caused by low iron intake, inefficient iron absorption in the gastrointestinal tract, or chronic blood loss.
Selective IgA deficiency
MedGen UID:
57934
Concept ID:
C0162538
Disease or Syndrome
Immunoglobulin (Ig) A deficiency (IGAD) is characterized by decreased or absent levels of serum IgA in the presence of normal serum levels of IgG and IgM in a patient older than 4 years of age in whom other causes of hypogammaglobulinemia have been excluded. IgA in the dimeric form is the dominant immunoglobulin in luminal secretions, such as saliva, tears, bronchial secretions, nasal mucosal secretions, and mucous secretions of the small intestine. Individuals with selective IgA deficiency may be asymptomatic or have recurrent sinopulmonary and gastrointestinal infections, allergic disorders, and autoimmune disorders. The diagnosis of IgA deficiency depends on the measurement of monomeric IgA concentrations in serum; thus individuals with IgA deficiency may have IgA in mucosal systems, which may offer some protection (review by Yel, 2010). Genetic Heterogeneity of IgA Deficiency The IGAD1 locus maps to chromosome 6p21. See also IGAD2 (609529), which is caused by mutation in the TNFRSF13B gene (604907) on chromosome 17p11.
Prolonged partial thromboplastin time
MedGen UID:
66815
Concept ID:
C0240671
Finding
An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment.
Cerebral calcification
MedGen UID:
124360
Concept ID:
C0270685
Finding
Abnormal deposits of calcium in the cerebral tissue.
Short stature
MedGen UID:
87607
Concept ID:
C0349588
Finding
A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).
Thrombocytosis
MedGen UID:
163397
Concept ID:
C0836924
Disease or Syndrome
A hematology test result that indicates the presence of higher than normal platelet counts in the peripheral blood.
Weight loss
MedGen UID:
853198
Concept ID:
C1262477
Finding
A reduction in total body weight.
Elevated hepatic transaminases
MedGen UID:
338525
Concept ID:
C1848701
Finding
Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage.
Postnatal growth retardation
MedGen UID:
395343
Concept ID:
C1859778
Finding
Slow or limited growth after birth.
Failure to thrive
MedGen UID:
746019
Concept ID:
C2315100
Disease or Syndrome
Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.
Recurrent aphthous stomatitis
MedGen UID:
445425
Concept ID:
C2937365
Disease or Syndrome
Aphthous ulcers of the mouth that are recurrent.
Abnormality of the abdominal wall
MedGen UID:
867301
Concept ID:
C4021664
Anatomical Abnormality
The presence of any abnormality affecting the abdominal wall.

Conditions with this feature

Celiac disease
MedGen UID:
3291
Concept ID:
C0007570
Disease or Syndrome
Celiac disease is a systemic autoimmune disease that can be associated with gastrointestinal findings (diarrhea, weight loss, abdominal pain, anorexia, lactose intolerance, abdominal distention, and irritability) and/or highly variable non-gastrointestinal findings (iron deficiency anemia, dermatitis herpetiformis, chronic fatigue, joint pain/inflammation, migraines, depression, attention-deficit disorder, epilepsy, osteoporosis/osteopenia, infertility and/or recurrent fetal loss, vitamin deficiencies, short stature, failure to thrive, delayed puberty, dental enamel defects, and autoimmune disorders). Classic celiac disease, characterized by mild to severe gastrointestinal symptoms, is less common than non-classic celiac disease, characterized by absence of gastrointestinal symptoms.
Floating-Harbor syndrome
MedGen UID:
152667
Concept ID:
C0729582
Disease or Syndrome
Floating-Harbor syndrome (FHS) is characterized by typical craniofacial features; low birth weight, normal head circumference, and short stature; bone age delay that normalizes between ages six and 12 years; skeletal anomalies (brachydactyly, clubbing, clinodactyly, short thumbs, prominent joints, clavicular abnormalities); severe receptive and expressive language impairment; hypernasality and high-pitched voice; and intellectual disability that is typically mild to moderate. Difficulties with temperament and behavior that are present in many children tend to improve in adulthood. Other features can include: hyperopia and/or strabismus; conductive hearing loss; seizures; gastroesophageal reflux; renal anomalies (e.g., hydronephrosis/renal pelviectasis, cysts, and/or agenesis) and genital anomalies (e.g., hypospadias and/or undescended testes).
Epilepsy occipital calcifications
MedGen UID:
341654
Concept ID:
C1856930
Disease or Syndrome
Autoimmune disease, multisystem, infantile-onset, 1
MedGen UID:
863232
Concept ID:
C4014795
Disease or Syndrome
Infantile-onset multisystem autoimmune disease-1 is characterized by early childhood onset of a spectrum of autoimmune disorders affecting multiple organs. Common manifestations include insulin-dependent diabetes mellitus and autoimmune enteropathy, or celiac disease, and autoimmune hematologic disorders. Other features include short stature and nonspecific dermatitis. More variable features include hypothyroidism, autoimmune arthritis, and delayed puberty. Some patients may show recurrent infections. The disorder results from an inborn error of cytokine signaling (summary by Flanagan et al., 2014 and Milner et al., 2015). Genetic Heterogeneity of Infantile-Onset Multisystem Autoimmune Disease See also ADMIO2 (617006), caused by mutation in the ZAP70 gene (176947) on chromosome 2q12.

Professional guidelines

PubMed

Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, Green PH, Hadjivassiliou M, Holdoway A, van Heel DA, Kaukinen K, Leffler DA, Leonard JN, Lundin KE, McGough N, Davidson M, Murray JA, Swift GL, Walker MM, Zingone F, Sanders DS; BSG Coeliac Disease Guidelines Development Group.; British Society of Gastroenterology.
Gut 2014 Aug;63(8):1210-28. Epub 2014 Jun 10 doi: 10.1136/gutjnl-2013-306578. PMID: 24917550Free PMC Article
Bai JC, Fried M, Corazza GR, Schuppan D, Farthing M, Catassi C, Greco L, Cohen H, Ciacci C, Eliakim R, Fasano A, González A, Krabshuis JH, LeMair A; World Gastroenterology Organization.
J Clin Gastroenterol 2013 Feb;47(2):121-6. doi: 10.1097/MCG.0b013e31827a6f83. PMID: 23314668

Recent clinical studies

Etiology

Simons M, Scott-Sheldon LAJ, Risech-Neyman Y, Moss SF, Ludvigsson JF, Green PHR
Am J Med 2018 Jan;131(1):83-89. Epub 2017 Aug 8 doi: 10.1016/j.amjmed.2017.07.021. PMID: 28801224
Lebwohl B, Nobel YR, Green PHR, Blaser MJ, Ludvigsson JF
Am J Gastroenterol 2017 Dec;112(12):1878-1884. Epub 2017 Oct 31 doi: 10.1038/ajg.2017.400. PMID: 29087398Free PMC Article
Alaedini A, Lebwohl B, Wormser GP, Green PH, Ludvigsson JF
BMC Med 2017 Sep 15;15(1):169. doi: 10.1186/s12916-017-0926-1. PMID: 28911326Free PMC Article
Paez MA, Gramelspacher AM, Sinacore J, Winterfield L, Venu M
Am J Med 2017 Nov;130(11):1318-1323. Epub 2017 Jun 13 doi: 10.1016/j.amjmed.2017.05.027. PMID: 28623177
Hoerter NA, Shannahan SE, Suarez J, Lewis SK, Green PHR, Leffler DA, Lebwohl B
Dig Dis Sci 2017 May;62(5):1272-1276. Epub 2017 Feb 4 doi: 10.1007/s10620-017-4474-5. PMID: 28161854

Diagnosis

Lebwohl B, Nobel YR, Green PHR, Blaser MJ, Ludvigsson JF
Am J Gastroenterol 2017 Dec;112(12):1878-1884. Epub 2017 Oct 31 doi: 10.1038/ajg.2017.400. PMID: 29087398Free PMC Article
Alaedini A, Lebwohl B, Wormser GP, Green PH, Ludvigsson JF
BMC Med 2017 Sep 15;15(1):169. doi: 10.1186/s12916-017-0926-1. PMID: 28911326Free PMC Article
Paez MA, Gramelspacher AM, Sinacore J, Winterfield L, Venu M
Am J Med 2017 Nov;130(11):1318-1323. Epub 2017 Jun 13 doi: 10.1016/j.amjmed.2017.05.027. PMID: 28623177
Zhou T, Han G, Li BN, Lin Z, Ciaccio EJ, Green PH, Qin J
Comput Biol Med 2017 Jun 1;85:1-6. Epub 2017 Apr 8 doi: 10.1016/j.compbiomed.2017.03.031. PMID: 28412572
Hoerter NA, Shannahan SE, Suarez J, Lewis SK, Green PHR, Leffler DA, Lebwohl B
Dig Dis Sci 2017 May;62(5):1272-1276. Epub 2017 Feb 4 doi: 10.1007/s10620-017-4474-5. PMID: 28161854

Therapy

Simons M, Scott-Sheldon LAJ, Risech-Neyman Y, Moss SF, Ludvigsson JF, Green PHR
Am J Med 2018 Jan;131(1):83-89. Epub 2017 Aug 8 doi: 10.1016/j.amjmed.2017.07.021. PMID: 28801224
Silvester JA, Graff LA, Rigaux L, Bernstein CN, Leffler DA, Kelly CP, Walker JR, Duerksen DR
Dig Dis Sci 2017 Sep;62(9):2449-2454. Epub 2017 Jul 7 doi: 10.1007/s10620-017-4666-z. PMID: 28687943Free PMC Article
Werkstetter KJ, Korponay-Szabó IR, Popp A, Villanacci V, Salemme M, Heilig G, Lillevang ST, Mearin ML, Ribes-Koninckx C, Thomas A, Troncone R, Filipiak B, Mäki M, Gyimesi J, Najafi M, Dolinšek J, Dydensborg Sander S, Auricchio R, Papadopoulou A, Vécsei A, Szitanyi P, Donat E, Nenna R, Alliet P, Penagini F, Garnier-Lengliné H, Castillejo G, Kurppa K, Shamir R, Hauer AC, Smets F, Corujeira S, van Winckel M, Buderus S, Chong S, Husby S, Koletzko S; ProCeDE study group.
Gastroenterology 2017 Oct;153(4):924-935. Epub 2017 Jun 15 doi: 10.1053/j.gastro.2017.06.002. PMID: 28624578
Paez MA, Gramelspacher AM, Sinacore J, Winterfield L, Venu M
Am J Med 2017 Nov;130(11):1318-1323. Epub 2017 Jun 13 doi: 10.1016/j.amjmed.2017.05.027. PMID: 28623177
Alshiekh S, Zhao LP, Lernmark Å, Geraghty DE, Naluai ÅT, Agardh D
HLA 2017 Aug;90(2):95-101. Epub 2017 Jun 5 doi: 10.1111/tan.13065. PMID: 28585303

Prognosis

Lebwohl B, Nobel YR, Green PHR, Blaser MJ, Ludvigsson JF
Am J Gastroenterol 2017 Dec;112(12):1878-1884. Epub 2017 Oct 31 doi: 10.1038/ajg.2017.400. PMID: 29087398Free PMC Article
Werkstetter KJ, Korponay-Szabó IR, Popp A, Villanacci V, Salemme M, Heilig G, Lillevang ST, Mearin ML, Ribes-Koninckx C, Thomas A, Troncone R, Filipiak B, Mäki M, Gyimesi J, Najafi M, Dolinšek J, Dydensborg Sander S, Auricchio R, Papadopoulou A, Vécsei A, Szitanyi P, Donat E, Nenna R, Alliet P, Penagini F, Garnier-Lengliné H, Castillejo G, Kurppa K, Shamir R, Hauer AC, Smets F, Corujeira S, van Winckel M, Buderus S, Chong S, Husby S, Koletzko S; ProCeDE study group.
Gastroenterology 2017 Oct;153(4):924-935. Epub 2017 Jun 15 doi: 10.1053/j.gastro.2017.06.002. PMID: 28624578
Björck S, Brundin C, Karlsson M, Agardh D
J Pediatr Gastroenterol Nutr 2017 Nov;65(5):526-532. doi: 10.1097/MPG.0000000000001568. PMID: 28319607
Dowd AJ, Jung ME
Appetite 2017 Jun 1;113:293-300. Epub 2017 Feb 20 doi: 10.1016/j.appet.2017.02.023. PMID: 28223238
Hoerter NA, Shannahan SE, Suarez J, Lewis SK, Green PHR, Leffler DA, Lebwohl B
Dig Dis Sci 2017 May;62(5):1272-1276. Epub 2017 Feb 4 doi: 10.1007/s10620-017-4474-5. PMID: 28161854

Clinical prediction guides

Kowalski K, Mulak A, Jasińska M, Paradowski L
Adv Clin Exp Med 2017 Jul;26(4):729-737. doi: 10.17219/acem/62452. PMID: 28691413
Silvester JA, Graff LA, Rigaux L, Bernstein CN, Leffler DA, Kelly CP, Walker JR, Duerksen DR
Dig Dis Sci 2017 Sep;62(9):2449-2454. Epub 2017 Jul 7 doi: 10.1007/s10620-017-4666-z. PMID: 28687943Free PMC Article
Werkstetter KJ, Korponay-Szabó IR, Popp A, Villanacci V, Salemme M, Heilig G, Lillevang ST, Mearin ML, Ribes-Koninckx C, Thomas A, Troncone R, Filipiak B, Mäki M, Gyimesi J, Najafi M, Dolinšek J, Dydensborg Sander S, Auricchio R, Papadopoulou A, Vécsei A, Szitanyi P, Donat E, Nenna R, Alliet P, Penagini F, Garnier-Lengliné H, Castillejo G, Kurppa K, Shamir R, Hauer AC, Smets F, Corujeira S, van Winckel M, Buderus S, Chong S, Husby S, Koletzko S; ProCeDE study group.
Gastroenterology 2017 Oct;153(4):924-935. Epub 2017 Jun 15 doi: 10.1053/j.gastro.2017.06.002. PMID: 28624578
Cook L, Munier CML, Seddiki N, van Bockel D, Ontiveros N, Hardy MY, Gillies JK, Levings MK, Reid HH, Petersen J, Rossjohn J, Anderson RP, Zaunders JJ, Tye-Din JA, Kelleher AD
J Allergy Clin Immunol 2017 Dec;140(6):1592-1603.e8. Epub 2017 Mar 8 doi: 10.1016/j.jaci.2017.02.015. PMID: 28283419
Hoerter NA, Shannahan SE, Suarez J, Lewis SK, Green PHR, Leffler DA, Lebwohl B
Dig Dis Sci 2017 May;62(5):1272-1276. Epub 2017 Feb 4 doi: 10.1007/s10620-017-4474-5. PMID: 28161854

Recent systematic reviews

Simons M, Scott-Sheldon LAJ, Risech-Neyman Y, Moss SF, Ludvigsson JF, Green PHR
Am J Med 2018 Jan;131(1):83-89. Epub 2017 Aug 8 doi: 10.1016/j.amjmed.2017.07.021. PMID: 28801224
Silvester JA, Kurada S, Szwajcer A, Kelly CP, Leffler DA, Duerksen DR
Gastroenterology 2017 Sep;153(3):689-701.e1. Epub 2017 May 22 doi: 10.1053/j.gastro.2017.05.015. PMID: 28545781Free PMC Article
Pinto-Sánchez MI, Causada-Calo N, Bercik P, Ford AC, Murray JA, Armstrong D, Semrad C, Kupfer SS, Alaedini A, Moayyedi P, Leffler DA, Verdú EF, Green P
Gastroenterology 2017 Aug;153(2):395-409.e3. Epub 2017 Apr 18 doi: 10.1053/j.gastro.2017.04.009. PMID: 28431885
US Preventive Services Task Force., Bibbins-Domingo K, Grossman DC, Curry SJ, Barry MJ, Davidson KW, Doubeni CA, Ebell M, Epling JW Jr, Herzstein J, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Phipps MG, Silverstein M, Simon MA, Tseng CW
JAMA 2017 Mar 28;317(12):1252-1257. doi: 10.1001/jama.2017.1462. PMID: 28350936
Chou R, Bougatsos C, Blazina I, Mackey K, Grusing S, Selph S
JAMA 2017 Mar 28;317(12):1258-1268. doi: 10.1001/jama.2016.10395. PMID: 28350935

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