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Non-small cell lung carcinoma(NSCLC)

MedGen UID:
40104
Concept ID:
C0007131
Neoplastic Process
Synonyms: Non-small cell lung cancer; NSCLC
SNOMED CT: Non-small cell lung cancer (254637007); NSCLC - Non-small cell lung cancer (254637007)
 
HPO: HP:0030358
Monarch Initiative: MONDO:0005233
OMIM®: 211980

Definition

A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-small cell lung carcinoma

Conditions with this feature

Lung cancer
MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
A primary or metastatic malignant neoplasm involving the lung.

Professional guidelines

PubMed

Shin DH, Shim HS, Kim TJ, Park HS, Choi Y, Kim WS, Kim L, Chang SH, Song JS, Kim HJ, Han JH, Lee CH, Lee GK, Jang SJ
J Pathol Transl Med 2019 May;53(3):153-158. Epub 2019 Feb 28 doi: 10.4132/jptm.2019.02.22. PMID: 30813707Free PMC Article
Khozin S, Blumenthal GM, Jiang X, He K, Boyd K, Murgo A, Justice R, Keegan P, Pazdur R
Oncologist 2014 Jul;19(7):774-9. Epub 2014 May 27 doi: 10.1634/theoncologist.2014-0089. PMID: 24868098Free PMC Article
Kim H, Shim HS, Kim L, Kim TJ, Kwon KY, Lee GK, Chung JH; Korean Cardiopulmonary Pathology Study Group.
Korean J Pathol 2014 Feb;48(1):1-9. Epub 2014 Feb 25 doi: 10.4132/KoreanJPathol.2014.48.1.1. PMID: 24627688Free PMC Article
Shim HS, Chung JH, Kim L, Chang S, Kim WS, Lee GK, Jung SH, Jang SJ
Korean J Pathol 2013 Apr;47(2):100-6. Epub 2013 Apr 24 doi: 10.4132/KoreanJPathol.2013.47.2.100. PMID: 23667368Free PMC Article

External

EGFR-TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Suggested Reading

PubMed

Cooper W, Fox S, O'Toole S, Morey A, Frances G, Pavlakis N, O'Byrne K, Dettrick A, Leong T, Rathi V, Spagnolo D, Hemmings C, Singh M, Moffat D, Tsao MS, Wilner K, Buller R, Pitman Lowenthal S, Arifeen S, Binko J, Alam M
Asia Pac J Clin Oncol 2014 Apr;10 Suppl 2:11-7. doi: 10.1111/ajco.12190. PMID: 24673736

Recent clinical studies

Etiology

Rezaei H, Mostaghimi H, Mehdizadeh AR
J Cancer Res Ther 2022 Jul-Sep;18(4):946-952. doi: 10.4103/jcrt.JCRT_689_20. PMID: 36149145
Bahnassy AA, Ismail H, Mohanad M, El-Bastawisy A, Yousef HF
J Egypt Natl Canc Inst 2022 May 30;34(1):23. doi: 10.1186/s43046-022-00121-8. PMID: 35644823
Wadowska K, Błasiak P, Rzechonek A, Bil-Lula I, Śliwińska-Mossoń M
Biomolecules 2021 Aug 13;11(8) doi: 10.3390/biom11081208. PMID: 34439874Free PMC Article
Zhou YJ, Zheng W, Zeng QH, Ye Y, Wang C, Fang C, Liu CJ, Niu L, Wu LM
Hum Genomics 2021 Apr 12;15(1):21. doi: 10.1186/s40246-021-00320-9. PMID: 33845897Free PMC Article
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article

Diagnosis

Kazdal D, Hofman V, Christopoulos P, Ilié M, Stenzinger A, Hofman P
Genes Chromosomes Cancer 2022 May;61(5):244-260. Epub 2022 Jan 22 doi: 10.1002/gcc.23022. PMID: 34997651
Sun T, Wang X, Wang M, Minerowicz C, Sanchez H, Laskin W, Cohen P, Zhong M
Int J Surg Pathol 2022 Aug;30(5):512-519. Epub 2021 Dec 31 doi: 10.1177/10668969211070179. PMID: 34970936
Wadowska K, Błasiak P, Rzechonek A, Bil-Lula I, Śliwińska-Mossoń M
Biomolecules 2021 Aug 13;11(8) doi: 10.3390/biom11081208. PMID: 34439874Free PMC Article
Miyamoto A, Kawakami T, Kakinuma M, Sato R, Fukuoka K, Karube M, Komagata Y, Kaname S
CEN Case Rep 2021 May;10(2):194-198. Epub 2020 Oct 15 doi: 10.1007/s13730-020-00541-2. PMID: 33058004Free PMC Article
Ijsseldijk MA, Shoni M, Siegert C, Wiering B, van Engelenburg AKC, Tsai TC, Ten Broek RPG, Lebenthal A
Clin Lung Cancer 2021 May;22(3):e235-e292. Epub 2020 May 7 doi: 10.1016/j.cllc.2020.04.017. PMID: 32912754

Therapy

Zhang, Deng T, Yuan W, Chen T, Jiang S
Clin Exp Pharmacol Physiol 2022 Aug;49(8):797-804. Epub 2022 Jun 2 doi: 10.1111/1440-1681.13667. PMID: 35576104
Liu N, Mao J, Tao P, Chi H, Jia W, Dong C
Medicine (Baltimore) 2022 Jan 21;101(3):e28617. doi: 10.1097/MD.0000000000028617. PMID: 35060536Free PMC Article
Kazdal D, Hofman V, Christopoulos P, Ilié M, Stenzinger A, Hofman P
Genes Chromosomes Cancer 2022 May;61(5):244-260. Epub 2022 Jan 22 doi: 10.1002/gcc.23022. PMID: 34997651
Makri OE, Dimitrakopoulos FI, Tsapardoni F, Tsekouras I, Argyriou AA, Kalofonos H, Georgakopoulos CD
Int J Neurosci 2022 Jul;132(7):643-648. Epub 2020 Oct 14 doi: 10.1080/00207454.2020.1831489. PMID: 32998608
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article

Prognosis

Pan T, Wang H, Wang S, Liu F
Br J Biomed Sci 2022;79:10598. Epub 2022 Jul 14 doi: 10.3389/bjbs.2022.10598. PMID: 35996496Free PMC Article
Bahnassy AA, Ismail H, Mohanad M, El-Bastawisy A, Yousef HF
J Egypt Natl Canc Inst 2022 May 30;34(1):23. doi: 10.1186/s43046-022-00121-8. PMID: 35644823
Liu N, Mao J, Tao P, Chi H, Jia W, Dong C
Medicine (Baltimore) 2022 Jan 21;101(3):e28617. doi: 10.1097/MD.0000000000028617. PMID: 35060536Free PMC Article
Hofman P
Cells 2021 Aug 21;10(8) doi: 10.3390/cells10082157. PMID: 34440926Free PMC Article
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article

Clinical prediction guides

Pan T, Wang H, Wang S, Liu F
Br J Biomed Sci 2022;79:10598. Epub 2022 Jul 14 doi: 10.3389/bjbs.2022.10598. PMID: 35996496Free PMC Article
Bahnassy AA, Ismail H, Mohanad M, El-Bastawisy A, Yousef HF
J Egypt Natl Canc Inst 2022 May 30;34(1):23. doi: 10.1186/s43046-022-00121-8. PMID: 35644823
Zhang, Deng T, Yuan W, Chen T, Jiang S
Clin Exp Pharmacol Physiol 2022 Aug;49(8):797-804. Epub 2022 Jun 2 doi: 10.1111/1440-1681.13667. PMID: 35576104
Makri OE, Dimitrakopoulos FI, Tsapardoni F, Tsekouras I, Argyriou AA, Kalofonos H, Georgakopoulos CD
Int J Neurosci 2022 Jul;132(7):643-648. Epub 2020 Oct 14 doi: 10.1080/00207454.2020.1831489. PMID: 32998608
Hofman P
Cells 2021 Aug 21;10(8) doi: 10.3390/cells10082157. PMID: 34440926Free PMC Article

Recent systematic reviews

Ran R, Jin JW, Zhang WP
Dis Markers 2021;2021:5424623. Epub 2021 Nov 23 doi: 10.1155/2021/5424623. PMID: 34858541Free PMC Article
Ijsseldijk MA, Shoni M, Siegert C, Wiering B, van Engelenburg AKC, Tsai TC, Ten Broek RPG, Lebenthal A
Clin Lung Cancer 2021 May;22(3):e235-e292. Epub 2020 May 7 doi: 10.1016/j.cllc.2020.04.017. PMID: 32912754
Liu J, Li C, Seery S, Yu J, Meng X
Oncoimmunology 2020;9(1):1746112. Epub 2020 Apr 7 doi: 10.1080/2162402X.2020.1746112. PMID: 32313723Free PMC Article
Xiao Z, Jiang Y, Wang CQ, Hu SS, Huang XR, Chen XF, Huang J, Shan LJ, Tang YH, Wang YH, Gong QH, Feng JH, Xiao X, Li XF
Pharmacol Res 2020 Mar;153:104637. Epub 2020 Jan 11 doi: 10.1016/j.phrs.2020.104637. PMID: 31935454
Zhou Y, Chen C, Zhang X, Fu S, Xue C, Ma Y, Fang W, Yang Y, Hou X, Huang Y, Zhao H, Hong S, Zhang L
J Immunother Cancer 2018 Dec 22;6(1):155. doi: 10.1186/s40425-018-0477-9. PMID: 30577837Free PMC Article

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