Format

Send to:

Choose Destination

Non-small cell lung cancer(NSCLC)

MedGen UID:
40104
Concept ID:
C0007131
Neoplastic Process
Synonyms: Non-small cell lung carcinoma; NSCLC
SNOMED CT: Non-small cell lung cancer (254637007); NSCLC - Non-small cell lung cancer (254637007)
 
HPO: HP:0030358
OMIM®: 211980

Definition

A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-small cell lung cancer

Conditions with this feature

Lung cancer
MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
A primary or metastatic malignant neoplasm involving the lung.
Lung carcinoma
MedGen UID:
195765
Concept ID:
C0684249
Neoplastic Process
Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008).

Professional guidelines

PubMed

Khozin S, Blumenthal GM, Jiang X, He K, Boyd K, Murgo A, Justice R, Keegan P, Pazdur R
Oncologist 2014 Jul;19(7):774-9. Epub 2014 May 27 doi: 10.1634/theoncologist.2014-0089. PMID: 24868098Free PMC Article
Kim H, Shim HS, Kim L, Kim TJ, Kwon KY, Lee GK, Chung JH; Korean Cardiopulmonary Pathology Study Group.
Korean J Pathol 2014 Feb;48(1):1-9. Epub 2014 Feb 25 doi: 10.4132/KoreanJPathol.2014.48.1.1. PMID: 24627688Free PMC Article
Shim HS, Chung JH, Kim L, Chang S, Kim WS, Lee GK, Jung SH, Jang SJ
Korean J Pathol 2013 Apr;47(2):100-6. Epub 2013 Apr 24 doi: 10.4132/KoreanJPathol.2013.47.2.100. PMID: 23667368Free PMC Article

External

EGFR-TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin

Suggested Reading

PubMed

Cooper W, Fox S, O'Toole S, Morey A, Frances G, Pavlakis N, O'Byrne K, Dettrick A, Leong T, Rathi V, Spagnolo D, Hemmings C, Singh M, Moffat D, Tsao MS, Wilner K, Buller R, Pitman Lowenthal S, Arifeen S, Binko J, Alam M
Asia Pac J Clin Oncol 2014 Apr;10 Suppl 2:11-7. doi: 10.1111/ajco.12190. PMID: 24673736

Recent clinical studies

Etiology

Provencio M, Terrasa J, Garrido P, Campelo RG, Aparisi F, Diz P, Aguiar D, García-Giron C, Hidalgo J, Aguado C, González JG, Esteban E, Gómez-Aldavarí L, Moran T, Juan O, Chara LE, Marti JL, Castro RL, Ortega AL, Moreno EM, Coves J, Sánchez Peña AM, Bosch-Barrera J, Gastaldo AS, Núñez NF, Del Barco E, Cobo M, Isla D, Majem M, Navarro F, Calvo V
BMC Cancer 2021 Mar 6;21(1):230. doi: 10.1186/s12885-021-07922-5. PMID: 33676426Free PMC Article
Mamesaya N, Muramatsu K, Yabe M, Kodama H, Nishioka N, Miyawaki T, Miyawaki E, Kobayashi H, Omori S, Wakuda K, Ono A, Kenmotsu H, Naito T, Murakami H, Harada H, Sugino T, Shimizu T, Gon Y, Takahashi T
Int J Clin Oncol 2021 Apr;26(4):659-669. Epub 2021 Jan 7 doi: 10.1007/s10147-020-01856-x. PMID: 33415571
Saka H, Nishio M, Hida T, Nakagawa K, Sakai H, Nogami N, Atagi S, Takahashi T, Horinouchi H, Takenoyama M, Katakami N, Tanaka H, Takeda K, Satouchi M, Isobe H, Maemondo M, Goto K, Hirashima T, Minato K, Yada N, Tamura T
Jpn J Clin Oncol 2021 Jan 1;51(1):106-113. doi: 10.1093/jjco/hyaa157. PMID: 33020837Free PMC Article
Li H, Liu T, Sun Z, Yang F
Thorac Cancer 2020 Nov;11(11):3213-3222. Epub 2020 Sep 18 doi: 10.1111/1759-7714.13649. PMID: 32946207Free PMC Article
Kubo T, Watanabe H, Ninomiya K, Kudo K, Minami D, Murakami E, Ochi N, Ninomiya T, Harada D, Yasugi M, Ichihara E, Ohashi K, Rai K, Fujiwara K, Hotta K, Tabata M, Maeda Y, Kiura K
Jpn J Clin Oncol 2020 Dec 16;50(12):1447-1453. doi: 10.1093/jjco/hyaa152. PMID: 32869100

Diagnosis

Provencio M, Terrasa J, Garrido P, Campelo RG, Aparisi F, Diz P, Aguiar D, García-Giron C, Hidalgo J, Aguado C, González JG, Esteban E, Gómez-Aldavarí L, Moran T, Juan O, Chara LE, Marti JL, Castro RL, Ortega AL, Moreno EM, Coves J, Sánchez Peña AM, Bosch-Barrera J, Gastaldo AS, Núñez NF, Del Barco E, Cobo M, Isla D, Majem M, Navarro F, Calvo V
BMC Cancer 2021 Mar 6;21(1):230. doi: 10.1186/s12885-021-07922-5. PMID: 33676426Free PMC Article
Imaoka K, Satoh D, Oshita K, Yano T, Kubota T, Ishida M, Choda Y, Yoshimitsu M, Nakano K, Harano M, Matsukawa H, Idani H, Shiozaki S, Okajima M
Clin J Gastroenterol 2021 Feb;14(1):351-357. Epub 2021 Jan 25 doi: 10.1007/s12328-020-01293-3. PMID: 33495974
Zemanova M, Jakopovic M, Stanic K, Łazar-Poniatowska M, Vrankar M, Rusu P, Ciuleanu T, Radosavljevic D, Bogos K, Nawrocki S
Radiol Oncol 2020 Oct 11;54(4):447-454. doi: 10.2478/raon-2020-0058. PMID: 33048837Free PMC Article
Sun C, Anraku M, Kawahara T, Karasaki T, Kitano K, Nagayama K, Sato M, Nakajima J
Lung Cancer 2020 Sep;147:71-76. Epub 2020 Jul 7 doi: 10.1016/j.lungcan.2020.07.008. PMID: 32673829
Lin S, Luo S, Zhong L, Lai S, Zeng D, Rao X, Huang P, Weng X
Int J Clin Pharm 2020 Aug;42(4):1175-1183. Epub 2020 Jun 11 doi: 10.1007/s11096-020-01076-3. PMID: 32524512

Therapy

Provencio M, Terrasa J, Garrido P, Campelo RG, Aparisi F, Diz P, Aguiar D, García-Giron C, Hidalgo J, Aguado C, González JG, Esteban E, Gómez-Aldavarí L, Moran T, Juan O, Chara LE, Marti JL, Castro RL, Ortega AL, Moreno EM, Coves J, Sánchez Peña AM, Bosch-Barrera J, Gastaldo AS, Núñez NF, Del Barco E, Cobo M, Isla D, Majem M, Navarro F, Calvo V
BMC Cancer 2021 Mar 6;21(1):230. doi: 10.1186/s12885-021-07922-5. PMID: 33676426Free PMC Article
Lin Z, Li G, Xu X, Mei J
Interact Cardiovasc Thorac Surg 2021 Jan 1;32(1):73-76. doi: 10.1093/icvts/ivaa213. PMID: 33212505
Saka H, Nishio M, Hida T, Nakagawa K, Sakai H, Nogami N, Atagi S, Takahashi T, Horinouchi H, Takenoyama M, Katakami N, Tanaka H, Takeda K, Satouchi M, Isobe H, Maemondo M, Goto K, Hirashima T, Minato K, Yada N, Tamura T
Jpn J Clin Oncol 2021 Jan 1;51(1):106-113. doi: 10.1093/jjco/hyaa157. PMID: 33020837Free PMC Article
Pal AS, Bains M, Agredo A, Kasinski AL
Biochem Pharmacol 2021 Jul;189:114154. Epub 2020 Jul 16 doi: 10.1016/j.bcp.2020.114154. PMID: 32681833Free PMC Article
Sengul Samanci N, Yılmaz U, Bedir S, Ozgur Yurttas N, Oruc K, Durak Sahin Z, Celik E, Toplutas KN, Akı H, Eskazan AE, Demirelli FH
J Oncol Pharm Pract 2020 Dec;26(8):2042-2046. Epub 2020 Apr 16 doi: 10.1177/1078155220918627. PMID: 32299317

Prognosis

Provencio M, Terrasa J, Garrido P, Campelo RG, Aparisi F, Diz P, Aguiar D, García-Giron C, Hidalgo J, Aguado C, González JG, Esteban E, Gómez-Aldavarí L, Moran T, Juan O, Chara LE, Marti JL, Castro RL, Ortega AL, Moreno EM, Coves J, Sánchez Peña AM, Bosch-Barrera J, Gastaldo AS, Núñez NF, Del Barco E, Cobo M, Isla D, Majem M, Navarro F, Calvo V
BMC Cancer 2021 Mar 6;21(1):230. doi: 10.1186/s12885-021-07922-5. PMID: 33676426Free PMC Article
Mamesaya N, Muramatsu K, Yabe M, Kodama H, Nishioka N, Miyawaki T, Miyawaki E, Kobayashi H, Omori S, Wakuda K, Ono A, Kenmotsu H, Naito T, Murakami H, Harada H, Sugino T, Shimizu T, Gon Y, Takahashi T
Int J Clin Oncol 2021 Apr;26(4):659-669. Epub 2021 Jan 7 doi: 10.1007/s10147-020-01856-x. PMID: 33415571
Saka H, Nishio M, Hida T, Nakagawa K, Sakai H, Nogami N, Atagi S, Takahashi T, Horinouchi H, Takenoyama M, Katakami N, Tanaka H, Takeda K, Satouchi M, Isobe H, Maemondo M, Goto K, Hirashima T, Minato K, Yada N, Tamura T
Jpn J Clin Oncol 2021 Jan 1;51(1):106-113. doi: 10.1093/jjco/hyaa157. PMID: 33020837Free PMC Article
Sun S, Han Q, Liang M, Zhang Q, Zhang J, Cao J
Thorac Cancer 2020 Nov;11(11):3269-3279. Epub 2020 Sep 21 doi: 10.1111/1759-7714.13667. PMID: 32956555Free PMC Article
Li H, Liu T, Sun Z, Yang F
Thorac Cancer 2020 Nov;11(11):3213-3222. Epub 2020 Sep 18 doi: 10.1111/1759-7714.13649. PMID: 32946207Free PMC Article

Clinical prediction guides

Shahriari M, Taghdisi SM, Abnous K, Ramezani M, Alibolandi M
J Control Release 2021 Jul 10;335:369-388. Epub 2021 May 28 doi: 10.1016/j.jconrel.2021.05.039. PMID: 34058270
Mamesaya N, Muramatsu K, Yabe M, Kodama H, Nishioka N, Miyawaki T, Miyawaki E, Kobayashi H, Omori S, Wakuda K, Ono A, Kenmotsu H, Naito T, Murakami H, Harada H, Sugino T, Shimizu T, Gon Y, Takahashi T
Int J Clin Oncol 2021 Apr;26(4):659-669. Epub 2021 Jan 7 doi: 10.1007/s10147-020-01856-x. PMID: 33415571
Saka H, Nishio M, Hida T, Nakagawa K, Sakai H, Nogami N, Atagi S, Takahashi T, Horinouchi H, Takenoyama M, Katakami N, Tanaka H, Takeda K, Satouchi M, Isobe H, Maemondo M, Goto K, Hirashima T, Minato K, Yada N, Tamura T
Jpn J Clin Oncol 2021 Jan 1;51(1):106-113. doi: 10.1093/jjco/hyaa157. PMID: 33020837Free PMC Article
Sun S, Han Q, Liang M, Zhang Q, Zhang J, Cao J
Thorac Cancer 2020 Nov;11(11):3269-3279. Epub 2020 Sep 21 doi: 10.1111/1759-7714.13667. PMID: 32956555Free PMC Article
Kubo T, Watanabe H, Ninomiya K, Kudo K, Minami D, Murakami E, Ochi N, Ninomiya T, Harada D, Yasugi M, Ichihara E, Ohashi K, Rai K, Fujiwara K, Hotta K, Tabata M, Maeda Y, Kiura K
Jpn J Clin Oncol 2020 Dec 16;50(12):1447-1453. doi: 10.1093/jjco/hyaa152. PMID: 32869100

Recent systematic reviews

Chao D, Hu G, Li Q
Medicine (Baltimore) 2021 Feb 19;100(7):e24748. doi: 10.1097/MD.0000000000024748. PMID: 33607820Free PMC Article
Yang J, Zhu X, Yuan P, Liu J, Wang B, Wang G
Support Care Cancer 2020 Aug;28(8):3571-3579. Epub 2020 Apr 7 doi: 10.1007/s00520-020-05433-w. PMID: 32266566
Franek J, Cappelleri JC, Larkin-Kaiser KA, Wilner KD, Sandin R
Future Oncol 2019 Aug;15(24):2857-2871. Epub 2019 Jul 12 doi: 10.2217/fon-2019-0270. PMID: 31298572
Ng CSH, MacDonald JK, Gilbert S, Khan AZ, Kim YT, Louie BE, Blair Marshall M, Santos RS, Scarci M, Shargal Y, Fernando HC
Innovations (Phila) 2019 Apr;14(2):90-116. doi: 10.1177/1556984519837027. PMID: 31039680
Iqbal MS, Vashisht G, McMenemin R, Atherton P, McDonald F, Simmons T, Bradshaw A, Kovarik J, Turnbull H, Dodd L, Mulvenna P, Greystoke A
Clin Oncol (R Coll Radiol) 2019 Feb;31(2):e1-e10. Epub 2018 Nov 8 doi: 10.1016/j.clon.2018.10.006. PMID: 30415784

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center