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Dyssynergia

MedGen UID:: 13945
•Concept ID:: C0004134
•: Sign or Symptom

Synonym:	Ataxia
SNOMED CT:	Ataxia (loss of muscle coordination) (20262006); Ataxia (20262006); Dyssynergia (39384006)

HPO:	HP:0010867

Definition

A type of ataxia characterized by the impairment of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed. With dyssynergia, a voluntary movement appears broken down into its component parts. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDyssynergia

Congenital Systemic Disorder
- Abnormality of the nervous system
  - Abnormal nervous system physiology
    - Abnormal central motor function
      - Abnormality of coordination
        Cerebellar ataxia
        Dyssynergia
        Asynergia
        Cerebellar ataxia
        Dysdiadochokinesis
        Dysmetria
        Limb dysmetria
        Hereditary episodic ataxia
        Episodic ataxia type 1
        Episodic ataxia type 2
        Episodic ataxia type 3
        Episodic ataxia type 4
        Episodic ataxia type 5
        Episodic ataxia type 6
        Episodic ataxia type 7
        Episodic ataxia type 8
        Limb ataxia
        Nonprogressive cerebellar ataxia
        Optic ataxia
        Progressive cerebellar ataxia
        Spastic ataxia
        Spasticity-ataxia-gait anomalies syndrome
        Spinocerebellar atrophy
        Ataxia with oculomotor apraxia type 3
        Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia
        Ataxia-telangiectasia syndrome
        Autosomal dominant cerebellar ataxia
        Autosomal recessive cerebellar ataxia
        Azorean disease
        Familial isolated deficiency of vitamin E
        Spinocerebellar ataxia 7
        Spinocerebellar ataxia type 1
        Spinocerebellar ataxia type 2
        Spinocerebellar ataxia type 6
        Spinocerebellar ataxia type 12
        Spinocerebellar ataxia type 17
        Spinocerebellar Ataxia Type 19/22
        Spinocerebellar ataxia type 31
        Spinocerebellar ataxia type 36
        Spinocerebellar ataxia type 42
        Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2
        Truncal ataxia
        Progressive truncal ataxia
        Charlevoix-Saguenay spastic ataxia
        COVID-19-Associated Ataxia
        Gait ataxia
        Abasia
        Progressive gait ataxia
        Hereditary cerebellar ataxia
        Friedreich ataxia
        Friedreich ataxia 1
        Friedreich ataxia 2
        Ocular dyssynergia
        Spastic ataxia 2

Professional guidelines

PubMed

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.

Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811

Pathophysiological basis, clinical assessment, investigation and management of patients with obstruction defecation syndrome.

Bunni J, Laugharne MJ
Langenbecks Arch Surg 2023 Feb 2;408(1):75. doi: 10.1007/s00423-023-02755-1. PMID: 36729157

The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function.

Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R, Chey WD, Chiarioni G, Dinning P, Emmanuel A, Farouk R, Felt-Bersma RJF, Jung KW, Lembo A, Malcolm A, Mittal RK, Mion F, Myung SJ, O'Connell PR, Pehl C, Remes-Troche JM, Reveille RM, Vaizey CJ, Vitton V, Whitehead WE, Wong RK, Scott SM; All members of the International Anorectal Physiology Working Group
Neurogastroenterol Motil 2020 Jan;32(1):e13679. Epub 2019 Aug 12 doi: 10.1111/nmo.13679. PMID: 31407463 Free PMC Article

See all (98)

Recent clinical studies

Etiology

Thoracoabdominal Wall Motion-Guided Biofeedback Treatment of Abdominal Distention: A Randomized Placebo-Controlled Trial.

Barba E, Livovsky DM, Accarino A, Azpiroz F
Gastroenterology 2024 Aug;167(3):538-546.e1. Epub 2024 Mar 11 doi: 10.1053/j.gastro.2024.03.005. PMID: 38467383

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.

Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811

The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function.

Epidemiology and pathophysiology of neurogenic bladder after spinal cord injury.

Hamid R, Averbeck MA, Chiang H, Garcia A, Al Mousa RT, Oh SJ, Patel A, Plata M, Del Popolo G
World J Urol 2018 Oct;36(10):1517-1527. Epub 2018 May 11 doi: 10.1007/s00345-018-2301-z. PMID: 29752515

Diagnosis and clinical evaluation of neurogenic bladder.

Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046

See all (485)

Diagnosis

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.

Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811

Abdominophrenic Dyssynergia: A Narrative Review.

Damianos JA, Tomar SK, Azpiroz F, Barba E
Am J Gastroenterol 2023 Jan 1;118(1):41-45. Epub 2022 Sep 30 doi: 10.14309/ajg.0000000000002044. PMID: 36191283 Free PMC Article

Solitary rectal ulcer syndrome.

Felt-Bersma RJF
Curr Opin Gastroenterol 2021 Jan;37(1):59-65. doi: 10.1097/MOG.0000000000000689. PMID: 33060396

Diagnosis and clinical evaluation of neurogenic bladder.

Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046

Constipation in Parkinson's Disease.

Stocchi F, Torti M
Int Rev Neurobiol 2017;134:811-826. Epub 2017 Jul 13 doi: 10.1016/bs.irn.2017.06.003. PMID: 28805584

See all (434)

Therapy

Management of the child with refractory constipation.

van der Zande JMJ, Lu PL
Aliment Pharmacol Ther 2024 Jul;60 Suppl 1:S42-S53. Epub 2024 Jun 25 doi: 10.1111/apt.17847. PMID: 38923030

Thoracoabdominal Wall Motion-Guided Biofeedback Treatment of Abdominal Distention: A Randomized Placebo-Controlled Trial.

Barba E, Livovsky DM, Accarino A, Azpiroz F
Gastroenterology 2024 Aug;167(3):538-546.e1. Epub 2024 Mar 11 doi: 10.1053/j.gastro.2024.03.005. PMID: 38467383

Non-pharmacologic approach to pediatric constipation.

Santucci NR, Chogle A, Leiby A, Mascarenhas M, Borlack RE, Lee A, Perez M, Russell A, Yeh AM
Complement Ther Med 2021 Jun;59:102711. Epub 2021 Mar 15 doi: 10.1016/j.ctim.2021.102711. PMID: 33737146

Constipation in Parkinson's Disease.

Stocchi F, Torti M
Int Rev Neurobiol 2017;134:811-826. Epub 2017 Jul 13 doi: 10.1016/bs.irn.2017.06.003. PMID: 28805584

Urologic applications of botulinum toxin.

King A, Quirouet A, Moore CK
Cleve Clin J Med 2015 Jul;82(7):456-64. doi: 10.3949/ccjm.82a.13166. PMID: 26185945

See all (328)

Prognosis

Constipation in Parkinson's Disease.

Quigley EMM
Semin Neurol 2023 Aug;43(4):562-571. Epub 2023 Aug 14 doi: 10.1055/s-0043-1771457. PMID: 37579786

Pelvic floor investigations for anal incontinence: Are they useful to predict outcomes from conservative treatment?

Cuinas K, Ferrari L, Igbedioh C, Solanki D, Williams A, Schizas A, Hainsworth A
Neurourol Urodyn 2023 Jun;42(5):1122-1131. Epub 2023 Apr 3 doi: 10.1002/nau.25182. PMID: 37010063

Inadequate Rectal Pressure and Insufficient Relaxation and Abdominopelvic Coordination in Defecatory Disorders.

Deb B, Sharma M, Fletcher JG, Srinivasan SG, Chronopoulou A, Chen J, Bailey KR, Feuerhak KJ, Bharucha AE
Gastroenterology 2022 Apr;162(4):1111-1122.e2. Epub 2021 Dec 22 doi: 10.1053/j.gastro.2021.12.257. PMID: 34951994 Free PMC Article

Role of permanent stents.

Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859

Female urinary retention.

Wheeler JS Jr, Culkin DJ, Walter JS, Flanigan RC
Urology 1990 May;35(5):428-32. doi: 10.1016/0090-4295(90)80086-3. PMID: 1970915

See all (255)

Clinical prediction guides

Thoracoabdominal Wall Motion-Guided Biofeedback Treatment of Abdominal Distention: A Randomized Placebo-Controlled Trial.

Barba E, Livovsky DM, Accarino A, Azpiroz F
Gastroenterology 2024 Aug;167(3):538-546.e1. Epub 2024 Mar 11 doi: 10.1053/j.gastro.2024.03.005. PMID: 38467383

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.

Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811

Abdomino-anal Dyscoordination in Defecatory Disorders.

Srinivasan SG, Muthyala A, Sharma M, Feuerhak K, Boon A, Bailey KR, Bharucha AE
Clin Gastroenterol Hepatol 2022 Sep;20(9):2091-2101.e5. Epub 2021 Dec 8 doi: 10.1016/j.cgh.2021.11.040. PMID: 34896282 Free PMC Article

Symptomatic myoclonus.

Borg M
Neurophysiol Clin 2006 Sep-Dec;36(5-6):309-18. Epub 2007 Jan 17 doi: 10.1016/j.neucli.2006.12.006. PMID: 17336775

Detrusor-urethral sphincter dyssynergia.

Yalla SV, Blunt KJ, Fam BA, Constantinople NL, Gittes RF
J Urol 1977 Dec;118(6):1026-9. doi: 10.1016/s0022-5347(17)58286-5. PMID: 926242

See all (289)

Recent systematic reviews

Botulinum toxin type A for the treatment of dyssynergic defaecation in adults: a systematic review.

Chaichanavichkij P, Vollebregt PF, Scott SM, Knowles CH
Colorectal Dis 2020 Dec;22(12):1832-1841. Epub 2020 Jun 11 doi: 10.1111/codi.15120. PMID: 32403161

Use of Botulinum Toxin A (BoNT-A) in Detrusor External Sphincter Dyssynergia (DESD): A Systematic Review and Meta-analysis.

Goel S, Pierce H, Pain K, Christos P, Dmochowski R, Chughtai B
Urology 2020 Jun;140:7-13. Epub 2020 Mar 19 doi: 10.1016/j.urology.2020.03.007. PMID: 32197987

Biomarkers to distinguish functional constipation from irritable bowel syndrome with constipation.

Whitehead WE, Palsson OS, Simrén M
Neurogastroenterol Motil 2016 Jun;28(6):783-92. doi: 10.1111/nmo.12852. PMID: 27214096

Iatrogenic urological triggers of autonomic dysreflexia: a systematic review.

Liu N, Zhou M, Biering-Sørensen F, Krassioukov AV
Spinal Cord 2015 Jul;53(7):500-9. Epub 2015 Mar 24 doi: 10.1038/sc.2015.39. PMID: 25800696

An updated systematic review and statistical comparison of standardised mean outcomes for the use of botulinum toxin in the management of lower urinary tract disorders.

Mangera A, Apostolidis A, Andersson KE, Dasgupta P, Giannantoni A, Roehrborn C, Novara G, Chapple C
Eur Urol 2014 May;65(5):981-90. Epub 2013 Nov 1 doi: 10.1016/j.eururo.2013.10.033. PMID: 24239446

See all (15)

MedGen

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Dyssynergia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

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