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Arteriosclerosis

MedGen UID:
2076
Concept ID:
C0003850
Disease or Syndrome
Synonym: Arterioscleroses
SNOMED CT: Arteriosclerotic vascular disease (72092001); Vascular sclerosis (107671003); Arteriosclerosis (28960008)
 
HPO: HP:0002634

Definition

Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity. [from HPO]

Conditions with this feature

Schimke immuno-osseous dysplasia
MedGen UID:
164078
Concept ID:
C0877024
Congenital Abnormality
Schimke immunoosseous dysplasia (SIOD) is characterized by spondyloepiphyseal dysplasia (SED) resulting in short stature, nephropathy, and T-cell deficiency. Radiographic manifestations of SED include ovoid and mildly flattened vertebral bodies, small ilia with shallow dysplastic acetabular fossae, and small deformed capital femoral epiphyses. Nearly all affected individuals have progressive steroid-resistant nephropathy, usually developing within five years of the diagnosis of growth failure and terminating with end-stage renal disease. The majority of tested individuals have T-cell deficiency and an associated risk for opportunistic infection, a common cause of death. SIOD involves a spectrum that ranges from an infantile or severe early-onset form with a greater risk of death during childhood to a juvenile or milder later-onset form with likely survival into adulthood if renal disease is appropriately treated.
Arteriosclerosis, severe juvenile
MedGen UID:
395330
Concept ID:
C1859725
Disease or Syndrome
Pseudoxanthoma elasticum, forme fruste
MedGen UID:
357280
Concept ID:
C1867450
Disease or Syndrome
Pseudoxanthoma elasticum (PXE) is a systemic disorder that affects the elastic tissue of the skin, the eye, and vascular system. Individuals most commonly present with angioid streaks of the retina found on routine eye examination or associated with retinal hemorrhage and/or characteristic papules in the skin. The most frequent cause of morbidity and disability in PXE is reduced vision due to complications of subretinal neovascularizations and macular atrophy. Other manifestations include premature gastrointestinal angina and/or bleeding, intermittent claudication of arm and leg muscles, stroke, renovascular hypertension, and cardiovascular complications (angina/myocardial infarction). Most affected individuals live a normal life span.

Recent clinical studies

Etiology

Ta N, Wei HC, Li MM
Technol Health Care 2022;30(6):1359-1369. doi: 10.3233/THC-220040. PMID: 35599519
Liu H, Huang W, Liu J, Zhao N, Wang H
J Vasc Res 2022;59(3):189-198. Epub 2022 Mar 24 doi: 10.1159/000520744. PMID: 35325892
Ishida K, Morimoto S, Horiuchi S, Kimura M, Ishikawa T, Kimura S, Yamashita K, Takano N, Seki Y, Bokuda K, Sasaki N, Watanabe D, Ichihara A
Hypertens Res 2022 Mar;45(3):455-463. Epub 2021 Dec 21 doi: 10.1038/s41440-021-00823-x. PMID: 34934159
Echterdiek F, Tilgener C, Dippon J, Kitterer D, Scheder-Bieschin J, Paul G, Ott M, Humke U, Schwenger V, Latus J
Langenbecks Arch Surg 2022 Mar;407(2):727-737. Epub 2021 Nov 26 doi: 10.1007/s00423-021-02383-7. PMID: 34825954
Yu L, Yan J, Yang C, Gao Y, Wang A, Huang H
Int J Environ Res Public Health 2021 Aug 25;18(17) doi: 10.3390/ijerph18178927. PMID: 34501516Free PMC Article

Diagnosis

Cheng J, Hou Y, Wang C, Guo L
Genes (Basel) 2022 Oct 8;13(10) doi: 10.3390/genes13101818. PMID: 36292702Free PMC Article
Liu H, Huang W, Liu J, Zhao N, Wang H
J Vasc Res 2022;59(3):189-198. Epub 2022 Mar 24 doi: 10.1159/000520744. PMID: 35325892
Chen T, Li Y, Wang J, Wang J
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Dec 28;46(12):1338-1345. doi: 10.11817/j.issn.1672-7347.2021.210059. PMID: 35232902
Yu L, Yan J, Yang C, Gao Y, Wang A, Huang H
Int J Environ Res Public Health 2021 Aug 25;18(17) doi: 10.3390/ijerph18178927. PMID: 34501516Free PMC Article
Mostaza JM, Pintó X, Armario P, Masana L, Ascaso JF, Valdivielso P; en nombre de la Sociedad Española de Arteriosclerosis.; Miembros de la Sociedad Española de Arteriosclerosis.
Clin Investig Arterioscler 2019 Jul;31 Suppl 1:1-43. Epub 2019 Apr 11 doi: 10.1016/j.arteri.2019.03.004. PMID: 30981542

Therapy

Tang B, Bai Y, Zhao J, Yang H, Avolio A, Zuo J
Rev Cardiovasc Med 2022 Mar 9;23(3):94. doi: 10.31083/j.rcm2303094. PMID: 35345261
Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Nakanishi S, Mune T, Kaku K
Int J Mol Sci 2021 Jul 24;22(15) doi: 10.3390/ijms22157917. PMID: 34360682Free PMC Article
De Vusser K, Martens D, Lerut E, Kuypers D, Nawrot TS, Naesens M
Nephrol Dial Transplant 2020 Nov 1;35(11):1984-1995. doi: 10.1093/ndt/gfaa151. PMID: 33067610
Liu H, Liu J, Huang W, Zhao H, Zhao N, Wang H
Cardiovasc Ultrasound 2020 Aug 1;18(1):30. doi: 10.1186/s12947-020-00212-3. PMID: 32738905Free PMC Article
Kakuta Y, Okumi M, Kanzawa T, Unagami K, Iizuka J, Takagi T, Ishida H, Tanabe K
Int J Urol 2020 May;27(5):423-430. Epub 2020 Mar 11 doi: 10.1111/iju.14212. PMID: 32162399

Prognosis

Cheng J, Hou Y, Wang C, Guo L
Genes (Basel) 2022 Oct 8;13(10) doi: 10.3390/genes13101818. PMID: 36292702Free PMC Article
Echterdiek F, Tilgener C, Dippon J, Kitterer D, Scheder-Bieschin J, Paul G, Ott M, Humke U, Schwenger V, Latus J
Langenbecks Arch Surg 2022 Mar;407(2):727-737. Epub 2021 Nov 26 doi: 10.1007/s00423-021-02383-7. PMID: 34825954
Yu L, Yan J, Yang C, Gao Y, Wang A, Huang H
Int J Environ Res Public Health 2021 Aug 25;18(17) doi: 10.3390/ijerph18178927. PMID: 34501516Free PMC Article
Misaki T, Fukunaga A, Nakano K
Clin Exp Nephrol 2021 Jan;25(1):87-93. Epub 2020 Sep 11 doi: 10.1007/s10157-020-01966-w. PMID: 32918134
Liu H, Liu J, Huang W, Zhao H, Zhao N, Wang H
Cardiovasc Ultrasound 2020 Aug 1;18(1):30. doi: 10.1186/s12947-020-00212-3. PMID: 32738905Free PMC Article

Clinical prediction guides

Liu H, Huang W, Liu J, Zhao N, Wang H
J Vasc Res 2022;59(3):189-198. Epub 2022 Mar 24 doi: 10.1159/000520744. PMID: 35325892
Ishida K, Morimoto S, Horiuchi S, Kimura M, Ishikawa T, Kimura S, Yamashita K, Takano N, Seki Y, Bokuda K, Sasaki N, Watanabe D, Ichihara A
Hypertens Res 2022 Mar;45(3):455-463. Epub 2021 Dec 21 doi: 10.1038/s41440-021-00823-x. PMID: 34934159
Echterdiek F, Tilgener C, Dippon J, Kitterer D, Scheder-Bieschin J, Paul G, Ott M, Humke U, Schwenger V, Latus J
Langenbecks Arch Surg 2022 Mar;407(2):727-737. Epub 2021 Nov 26 doi: 10.1007/s00423-021-02383-7. PMID: 34825954
Yu L, Yan J, Yang C, Gao Y, Wang A, Huang H
Int J Environ Res Public Health 2021 Aug 25;18(17) doi: 10.3390/ijerph18178927. PMID: 34501516Free PMC Article
Ohta H, Liu X, Maeda M
Stem Cell Res Ther 2020 Dec 11;11(1):538. doi: 10.1186/s13287-020-02067-x. PMID: 33308301Free PMC Article

Recent systematic reviews

Yang R, Yuan J, Chen X, Xie X, Ye Z, Qin C
Clin Imaging 2022 Oct;90:90-96. Epub 2022 Aug 4 doi: 10.1016/j.clinimag.2022.08.001. PMID: 35952437
Villarruz-Sulit MV, Forster R, Dans AL, Tan FN, Sulit DV
Cochrane Database Syst Rev 2020 May 5;5:CD002785. doi: 10.1002/14651858.CD002785.pub2. PMID: 32367513Free PMC Article
Knowles L, Nadeem N, Chowienczyk PJ
Br J Clin Pharmacol 2020 May;86(5):837-851. Epub 2020 Mar 8 doi: 10.1111/bcp.14215. PMID: 31957052Free PMC Article
Seyedsaadat SM, Yolcu YU, Neuhaus A, Rizvi A, Alzuabi M, Murad MH, Brinjikji W, Bydon M, Kallmes DF
J Neurointerv Surg 2020 Apr;12(4):380-385. Epub 2019 Nov 20 doi: 10.1136/neurintsurg-2019-015451. PMID: 31748381
Tsirimiagkou C, Basdeki ED, Argyris A, Manios Y, Yannakoulia M, Protogerou AD, Karatzi K
Nutrients 2019 Dec 18;12(1) doi: 10.3390/nu12010005. PMID: 31861381Free PMC Article

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