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Arteriosclerosis disorder

MedGen UID:
2076
Concept ID:
C0003850
Disease or Syndrome
Synonym: Arteriosclerosis
SNOMED CT: Arteriosclerotic vascular disease (72092001); Vascular sclerosis (107671003); Arteriosclerosis (28960008)
 
HPO: HP:0002634
Monarch Initiative: MONDO:0002277

Definition

Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity. [from HPO]

Conditions with this feature

Schimke immuno-osseous dysplasia
MedGen UID:
164078
Concept ID:
C0877024
Congenital Abnormality
Schimke immunoosseous dysplasia (SIOD) is characterized by spondyloepiphyseal dysplasia (SED) resulting in short stature, nephropathy, and T-cell deficiency. Radiographic manifestations of SED include ovoid and mildly flattened vertebral bodies, small ilia with shallow dysplastic acetabular fossae, and small deformed capital femoral epiphyses. Nearly all affected individuals have progressive steroid-resistant nephropathy, usually developing within five years of the diagnosis of growth failure and terminating with end-stage renal disease. The majority of tested individuals have T-cell deficiency and an associated risk for opportunistic infection, a common cause of death. SIOD involves a spectrum that ranges from an infantile or severe early-onset form with a greater risk of death during childhood to a juvenile or milder later-onset form with likely survival into adulthood if renal disease is appropriately treated.
Arteriosclerosis, severe juvenile
MedGen UID:
395330
Concept ID:
C1859725
Disease or Syndrome
Pseudoxanthoma elasticum, forme fruste
MedGen UID:
357280
Concept ID:
C1867450
Disease or Syndrome
Pseudoxanthoma elasticum (PXE) is a systemic disorder that affects the elastic tissue of the skin, the eye, and vascular system. Individuals most commonly present with angioid streaks of the retina found on routine eye examination or associated with retinal hemorrhage and/or characteristic papules in the skin. The most frequent cause of morbidity and disability in PXE is reduced vision due to complications of subretinal neovascularizations and macular atrophy. Other manifestations include premature gastrointestinal angina and/or bleeding, intermittent claudication of arm and leg muscles, stroke, renovascular hypertension, and cardiovascular complications (angina/myocardial infarction). Most affected individuals live a normal life span.

Professional guidelines

PubMed

Goldsborough E 3rd, Osuji N, Blaha MJ
Endocrinol Metab Clin North Am 2022 Sep;51(3):483-509. Epub 2022 Jul 4 doi: 10.1016/j.ecl.2022.02.005. PMID: 35963625
Neeland IJ, Ross R, Després JP, Matsuzawa Y, Yamashita S, Shai I, Seidell J, Magni P, Santos RD, Arsenault B, Cuevas A, Hu FB, Griffin B, Zambon A, Barter P, Fruchart JC, Eckel RH; International Atherosclerosis Society; International Chair on Cardiometabolic Risk Working Group on Visceral Obesity
Lancet Diabetes Endocrinol 2019 Sep;7(9):715-725. Epub 2019 Jul 10 doi: 10.1016/S2213-8587(19)30084-1. PMID: 31301983
LeRoith D, Biessels GJ, Braithwaite SS, Casanueva FF, Draznin B, Halter JB, Hirsch IB, McDonnell ME, Molitch ME, Murad MH, Sinclair AJ
J Clin Endocrinol Metab 2019 May 1;104(5):1520-1574. doi: 10.1210/jc.2019-00198. PMID: 30903688Free PMC Article

Recent clinical studies

Etiology

Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, Prescott E, Storey RF, Deaton C, Cuisset T, Agewall S, Dickstein K, Edvardsen T, Escaned J, Gersh BJ, Svitil P, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Valgimigli M, Achenbach S, Bax JJ; ESC Scientific Document Group
Eur Heart J 2020 Jan 14;41(3):407-477. doi: 10.1093/eurheartj/ehz425. PMID: 31504439
Libby P
Nature 2002 Dec 19-26;420(6917):868-74. doi: 10.1038/nature01323. PMID: 12490960
Lusis AJ
Nature 2000 Sep 14;407(6801):233-41. doi: 10.1038/35025203. PMID: 11001066Free PMC Article
Johansson BB
Clin Exp Pharmacol Physiol 1999 Jul;26(7):563-5. doi: 10.1046/j.1440-1681.1999.03081.x. PMID: 10405790
Doyle AE
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Diagnosis

Saraste A, Knuuti J
Herz 2020 Aug;45(5):409-420. doi: 10.1007/s00059-020-04935-x. PMID: 32430520Free PMC Article
Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, Prescott E, Storey RF, Deaton C, Cuisset T, Agewall S, Dickstein K, Edvardsen T, Escaned J, Gersh BJ, Svitil P, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Valgimigli M, Achenbach S, Bax JJ; ESC Scientific Document Group
Eur Heart J 2020 Jan 14;41(3):407-477. doi: 10.1093/eurheartj/ehz425. PMID: 31504439
Qureshi AI, Caplan LR
Lancet 2014 Mar 15;383(9921):984-98. Epub 2013 Sep 2 doi: 10.1016/S0140-6736(13)61088-0. PMID: 24007975
Libby P, Ridker PM, Maseri A
Circulation 2002 Mar 5;105(9):1135-43. doi: 10.1161/hc0902.104353. PMID: 11877368
Lusis AJ
Nature 2000 Sep 14;407(6801):233-41. doi: 10.1038/35025203. PMID: 11001066Free PMC Article

Therapy

Davidson LJ, Cleveland JC, Welt FG, Anwaruddin S, Bonow RO, Firstenberg MS, Gaudino MF, Gersh BJ, Grubb KJ, Kirtane AJ, Tamis-Holland JE, Truesdell AG, Windecker S, Taha RA, Malaisrie SC
J Am Coll Cardiol 2022 Nov 29;80(22):2119-2134. doi: 10.1016/j.jacc.2022.09.034. PMID: 36423996
Barry AR, Dixon DL
Pharmacotherapy 2021 Dec;41(12):1056-1065. Epub 2021 Aug 30 doi: 10.1002/phar.2615. PMID: 34431129
Butt AK, Cave B, Maturana M, Towers WF, Khouzam RN
Curr Probl Cardiol 2021 Mar;46(3):100690. Epub 2020 Aug 28 doi: 10.1016/j.cpcardiol.2020.100690. PMID: 32994053
Muhlestein JB
Curr Opin Lipidol 2003 Dec;14(6):605-14. doi: 10.1097/00041433-200312000-00009. PMID: 14624138
Blankenhorn DH, Hodis HN
West J Med 1993 Aug;159(2):172-9. PMID: 8212682Free PMC Article

Prognosis

Thuijs DJFM, Kappetein AP, Serruys PW, Mohr FW, Morice MC, Mack MJ, Holmes DR Jr, Curzen N, Davierwala P, Noack T, Milojevic M, Dawkins KD, da Costa BR, Jüni P, Head SJ; SYNTAX Extended Survival Investigators
Lancet 2019 Oct 12;394(10206):1325-1334. Epub 2019 Sep 2 doi: 10.1016/S0140-6736(19)31997-X. PMID: 31488373
Makani H, Bangalore S, Halpern D, Makwana HG, Chaudhry FA
J Am Coll Cardiol 2012 Oct 9;60(15):1393-401. Epub 2012 Sep 12 doi: 10.1016/j.jacc.2012.05.041. PMID: 22981557
Bonetti PO, Lerman LO, Lerman A
Arterioscler Thromb Vasc Biol 2003 Feb 1;23(2):168-75. doi: 10.1161/01.atv.0000051384.43104.fc. PMID: 12588755
Elhadd TA, Abdu TA, Clayton R
Ann Med 2001 Oct;33(7):477-85. doi: 10.3109/07853890109002097. PMID: 11680796
Lääperi T, Pohjolainen T, Alaranta H, Kärkkäinen M
Ann Chir Gynaecol 1993;82(3):183-7. PMID: 8285573

Clinical prediction guides

Bell KJL, White S, Hassan O, Zhu L, Scott AM, Clark J, Glasziou P
JAMA Intern Med 2022 Jun 1;182(6):634-642. doi: 10.1001/jamainternmed.2022.1262. PMID: 35467692Free PMC Article
Koulouri A, Darioli R, Dine Qanadli S, Katz E, Eeckhout E, Mazzolai L, Depairon M
Vasa 2021 Jul;50(4):280-285. Epub 2021 Apr 1 doi: 10.1024/0301-1526/a000949. PMID: 33789435
Serra R, Bracale UM, Jiritano F, Ielapi N, Licastro N, Provenzano M, Andreucci M, Pingitore A, de Franciscis S, Mastroroberto P, Serraino GF
Ann Vasc Surg 2021 Jan;70:528-541. Epub 2020 Aug 13 doi: 10.1016/j.avsg.2020.08.009. PMID: 32800889
Cury RC, Abbara S, Achenbach S, Agatston A, Berman DS, Budoff MJ, Dill KE, Jacobs JE, Maroules CD, Rubin GD, Rybicki FJ, Schoepf UJ, Shaw LJ, Stillman AE, White CS, Woodard PK, Leipsic JA
J Cardiovasc Comput Tomogr 2016 Jul-Aug;10(4):269-81. Epub 2016 Jun 15 doi: 10.1016/j.jcct.2016.04.005. PMID: 27318587
Fishbein MC, Fishbein GA
Cardiovasc Pathol 2015 Nov-Dec;24(6):335-42. Epub 2015 Aug 5 doi: 10.1016/j.carpath.2015.07.007. PMID: 26365806

Recent systematic reviews

Wang C, Xing J, Zhao B, Wang Y, Zhang L, Wang Y, Zheng M, Liu G
Cardiovasc Ther 2022;2022:4273809. Epub 2022 Jun 9 doi: 10.1155/2022/4273809. PMID: 35801132Free PMC Article
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Xu S, Kamato D, Little PJ, Nakagawa S, Pelisek J, Jin ZG
Pharmacol Ther 2019 Apr;196:15-43. Epub 2018 Nov 13 doi: 10.1016/j.pharmthera.2018.11.003. PMID: 30439455Free PMC Article
Madhavan MV, Gersh BJ, Alexander KP, Granger CB, Stone GW
J Am Coll Cardiol 2018 May 8;71(18):2015-2040. doi: 10.1016/j.jacc.2017.12.068. PMID: 29724356
Head SJ, Milojevic M, Daemen J, Ahn JM, Boersma E, Christiansen EH, Domanski MJ, Farkouh ME, Flather M, Fuster V, Hlatky MA, Holm NR, Hueb WA, Kamalesh M, Kim YH, Mäkikallio T, Mohr FW, Papageorgiou G, Park SJ, Rodriguez AE, Sabik JF 3rd, Stables RH, Stone GW, Serruys PW, Kappetein AP
Lancet 2018 Mar 10;391(10124):939-948. Epub 2018 Feb 23 doi: 10.1016/S0140-6736(18)30423-9. PMID: 29478841

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