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Arteriosclerosis

MedGen UID:
2076
Concept ID:
C0003850
Disease or Syndrome
Synonym: Hardened artery wall
SNOMED CT: Arteriosclerotic vascular disease (72092001); Vascular sclerosis (107671003); Arteriosclerosis (28960008)
 
HPO: HP:0002634

Definition

Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity. [from HPO]

Conditions with this feature

Schimke immuno-osseous dysplasia
MedGen UID:
164078
Concept ID:
C0877024
Congenital Abnormality
Schimke immunoosseous dysplasia (SIOD) is an autosomal recessive multisystem disorder characterized by spondyloepiphyseal dysplasia (SED) resulting in short stature, nephropathy, and T-cell deficiency. Radiographic manifestations of SED include ovoid and mildly flattened vertebral bodies, small deformed capital femoral epiphyses, and shallow dysplastic acetabular fossae. Adult height is 136-157 cm for men and 98.5-143 cm for women. Nearly all affected individuals have progressive steroid-resistant nephropathy, usually developing within five years of the diagnosis of growth failure and terminating with end-stage renal disease (ESRD). The majority of tested individuals have T-cell deficiency and an associated risk for opportunistic infection, a common cause of death. SIOD involves a spectrum that ranges from an infantile or severe early-onset form with death early in life to a juvenile or milder later-onset form with survival into adulthood if renal disease is appropriately treated.
Arteriosclerosis, severe juvenile
MedGen UID:
395330
Concept ID:
C1859725
Disease or Syndrome
Pseudoxanthoma elasticum, forme fruste
MedGen UID:
357280
Concept ID:
C1867450
Disease or Syndrome
Pseudoxanthoma elasticum (PXE) is a systemic disorder that affects the elastic tissue of the skin, the eye, and vascular system. Individuals most commonly present with angioid streaks of the retina found on routine eye examination or associated with retinal hemorrhage and/or characteristic papules in the skin. The most frequent cause of morbidity and disability in PXE is reduced vision due to complications of subretinal neovascularizations and macular atrophy. Other manifestations include premature gastrointestinal angina and/or bleeding, intermittent claudication of arm and leg muscles, stroke, renovascular hypertension, and cardiovascular complications (angina/myocardial infarction). Most affected individuals live a normal life span.

Recent clinical studies

Etiology

Ohta H, Liu X, Maeda M
Stem Cell Res Ther 2020 Dec 11;11(1):538. doi: 10.1186/s13287-020-02067-x. PMID: 33308301Free PMC Article
De Vusser K, Martens D, Lerut E, Kuypers D, Nawrot TS, Naesens M
Nephrol Dial Transplant 2020 Nov 1;35(11):1984-1995. doi: 10.1093/ndt/gfaa151. PMID: 33067610
Liu H, Liu J, Huang W, Zhao H, Zhao N, Wang H
Cardiovasc Ultrasound 2020 Aug 1;18(1):30. doi: 10.1186/s12947-020-00212-3. PMID: 32738905Free PMC Article
Kakuta Y, Okumi M, Kanzawa T, Unagami K, Iizuka J, Takagi T, Ishida H, Tanabe K
Int J Urol 2020 May;27(5):423-430. Epub 2020 Mar 11 doi: 10.1111/iju.14212. PMID: 32162399
Mostaza JM, Pintó X, Armario P, Masana L, Ascaso JF, Valdivielso P; en nombre de la Sociedad Española de Arteriosclerosis.; Miembros de la Sociedad Española de Arteriosclerosis.
Clin Investig Arterioscler 2019 Jul;31 Suppl 1:1-43. Epub 2019 Apr 11 doi: 10.1016/j.arteri.2019.03.004. PMID: 30981542

Diagnosis

Liu H, Liu J, Huang W, Zhao H, Zhao N, Wang H
Cardiovasc Ultrasound 2020 Aug 1;18(1):30. doi: 10.1186/s12947-020-00212-3. PMID: 32738905Free PMC Article
Liu Q, Liu C, Gao Y, Zhang X, Yi N, Cao J, Wang Y, Jiang Y, Tang Z
Sci Rep 2020 May 25;10(1):8595. doi: 10.1038/s41598-020-65575-z. PMID: 32451435Free PMC Article
Kakuta Y, Okumi M, Kanzawa T, Unagami K, Iizuka J, Takagi T, Ishida H, Tanabe K
Int J Urol 2020 May;27(5):423-430. Epub 2020 Mar 11 doi: 10.1111/iju.14212. PMID: 32162399
Mostaza JM, Pintó X, Armario P, Masana L, Ascaso JF, Valdivielso P; en nombre de la Sociedad Española de Arteriosclerosis.; Miembros de la Sociedad Española de Arteriosclerosis.
Clin Investig Arterioscler 2019 Jul;31 Suppl 1:1-43. Epub 2019 Apr 11 doi: 10.1016/j.arteri.2019.03.004. PMID: 30981542
Weir-McCall JR, Lambert M, Gandy SJ, Belch JJF, Cavin I, Henderson SA, Littleford R, Macfarlane JA, Matthew SZ, Stephen Nicholas R, Struthers AD, Sullivan F, White RD, Graeme Houston J
J Cardiovasc Magn Reson 2018 Jan 30;20(1):7. doi: 10.1186/s12968-018-0428-0. PMID: 29382349Free PMC Article

Therapy

Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Nakanishi S, Mune T, Kaku K
Int J Mol Sci 2021 Jul 24;22(15) doi: 10.3390/ijms22157917. PMID: 34360682Free PMC Article
Keijbeck A, Veenstra R, Pol RA, Konijn C, Jansen N, van Goor H, Hoitsma AJ, Peutz-Kootstra CJ, Moers C
Transplantation 2020 Dec;104(12):2567-2574. doi: 10.1097/TP.0000000000003189. PMID: 33215902Free PMC Article
De Vusser K, Martens D, Lerut E, Kuypers D, Nawrot TS, Naesens M
Nephrol Dial Transplant 2020 Nov 1;35(11):1984-1995. doi: 10.1093/ndt/gfaa151. PMID: 33067610
Liu H, Liu J, Huang W, Zhao H, Zhao N, Wang H
Cardiovasc Ultrasound 2020 Aug 1;18(1):30. doi: 10.1186/s12947-020-00212-3. PMID: 32738905Free PMC Article
Kakuta Y, Okumi M, Kanzawa T, Unagami K, Iizuka J, Takagi T, Ishida H, Tanabe K
Int J Urol 2020 May;27(5):423-430. Epub 2020 Mar 11 doi: 10.1111/iju.14212. PMID: 32162399

Prognosis

Liu H, Liu J, Huang W, Zhao H, Zhao N, Wang H
Cardiovasc Ultrasound 2020 Aug 1;18(1):30. doi: 10.1186/s12947-020-00212-3. PMID: 32738905Free PMC Article
Nakatsu Y, Niida S, Tanaka K, Takenaka S, Kuwabara A
J Nutr Sci Vitaminol (Tokyo) 2020;66(3):213-218. doi: 10.3177/jnsv.66.213. PMID: 32612082
Dong R, Lv Q, Gao Y, He C, Tan S, Zhang M, Zhou T
Echocardiography 2019 Dec;36(12):2234-2240. Epub 2019 Nov 22 doi: 10.1111/echo.14540. PMID: 31755583
Weir-McCall JR, Lambert M, Gandy SJ, Belch JJF, Cavin I, Henderson SA, Littleford R, Macfarlane JA, Matthew SZ, Stephen Nicholas R, Struthers AD, Sullivan F, White RD, Graeme Houston J
J Cardiovasc Magn Reson 2018 Jan 30;20(1):7. doi: 10.1186/s12968-018-0428-0. PMID: 29382349Free PMC Article
Aoyama T, Fukumoto A, Shigita K, Asayama N, Mukai S, Nagata S
Dig Dis Sci 2018 Mar;63(3):723-730. Epub 2018 Jan 25 doi: 10.1007/s10620-018-4930-x. PMID: 29372478

Clinical prediction guides

Ohta H, Liu X, Maeda M
Stem Cell Res Ther 2020 Dec 11;11(1):538. doi: 10.1186/s13287-020-02067-x. PMID: 33308301Free PMC Article
De Vusser K, Martens D, Lerut E, Kuypers D, Nawrot TS, Naesens M
Nephrol Dial Transplant 2020 Nov 1;35(11):1984-1995. doi: 10.1093/ndt/gfaa151. PMID: 33067610
Liu H, Liu J, Huang W, Zhao H, Zhao N, Wang H
Cardiovasc Ultrasound 2020 Aug 1;18(1):30. doi: 10.1186/s12947-020-00212-3. PMID: 32738905Free PMC Article
De Vusser K, Winckelmans E, Martens D, Lerut E, Kuypers D, Nawrot T, Naesens M
Aging (Albany NY) 2020 Apr 30;12(9):7830-7847. doi: 10.18632/aging.103098. PMID: 32353828Free PMC Article
Kakuta Y, Okumi M, Kanzawa T, Unagami K, Iizuka J, Takagi T, Ishida H, Tanabe K
Int J Urol 2020 May;27(5):423-430. Epub 2020 Mar 11 doi: 10.1111/iju.14212. PMID: 32162399

Recent systematic reviews

Villarruz-Sulit MV, Forster R, Dans AL, Tan FN, Sulit DV
Cochrane Database Syst Rev 2020 May 5;5:CD002785. doi: 10.1002/14651858.CD002785.pub2. PMID: 32367513Free PMC Article
Knowles L, Nadeem N, Chowienczyk PJ
Br J Clin Pharmacol 2020 May;86(5):837-851. Epub 2020 Mar 8 doi: 10.1111/bcp.14215. PMID: 31957052Free PMC Article
Seyedsaadat SM, Yolcu YU, Neuhaus A, Rizvi A, Alzuabi M, Murad MH, Brinjikji W, Bydon M, Kallmes DF
J Neurointerv Surg 2020 Apr;12(4):380-385. Epub 2019 Nov 20 doi: 10.1136/neurintsurg-2019-015451. PMID: 31748381
Tsirimiagkou C, Basdeki ED, Argyris A, Manios Y, Yannakoulia M, Protogerou AD, Karatzi K
Nutrients 2019 Dec 18;12(1) doi: 10.3390/nu12010005. PMID: 31861381Free PMC Article
Andras A, Stansby G, Hansrani M
Cochrane Database Syst Rev 2013 Jul 19;(7):CD003285. doi: 10.1002/14651858.CD003285.pub2. PMID: 23881650Free PMC Article

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