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Adenocarcinoma

MedGen UID:
122
Concept ID:
C0001418
Neoplastic Process
Synonyms: Adenocarcinomas; Adenoma, Malignant; Adenomas, Malignant; Malignant Adenoma; Malignant Adenomas
SNOMED CT: Adenocarcinoma, no subtype (35917007); Adenocarcinoma (443961001); Malignant adenomatous neoplasm (443961001); Adenocarcinoma (35917007)

Definition

A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma

Recent clinical studies

Etiology

Wu Y, Lv M, Qian T, Shen Y
Ann Palliat Med 2021 Sep;10(9):9544-9552. doi: 10.21037/apm-21-1974. PMID: 34628880
Tagkalos E, van der Sluis PC, Berlth F, Poplawski A, Hadzijusufovic E, Lang H, van Berge Henegouwen MI, Gisbertz SS, Müller-Stich BP, Ruurda JP, Schiesser M, Schneider PM, van Hillegersberg R, Grimminger PP
BMC Cancer 2021 Sep 26;21(1):1060. doi: 10.1186/s12885-021-08780-x. PMID: 34565343Free PMC Article
Chen X, Hu J, Xu L, Chen J, Lin Y, Chi Z, He X, Lan P
Int J Colorectal Dis 2021 Sep;36(9):1965-1979. Epub 2021 Jul 23 doi: 10.1007/s00384-021-03997-5. PMID: 34297196
Lindner V, Waydelich A, Chen CC, Jones C, Stratton SP
Virchows Arch 2021 Aug;479(2):337-343. Epub 2021 Apr 3 doi: 10.1007/s00428-021-03088-4. PMID: 33811532
Civantos AM, Viswanathan S, Prasad A, Maldonado ST, Brody RM, Cannady SB, Newman JG, Shanti RM, Brant JA, Rajasekaran K
Eur Arch Otorhinolaryngol 2021 Sep;278(9):3459-3466. Epub 2021 Jan 3 doi: 10.1007/s00405-020-06539-x. PMID: 33388976

Diagnosis

Wang L, Zhang S, Li H, Xu Y, Wu Q, Shen J, Li T, Xu Y
BMC Cancer 2021 Jul 31;21(1):876. doi: 10.1186/s12885-021-08550-9. PMID: 34332578Free PMC Article
Suzuki K, Nagao S, Narita M, Nakazawa H, Shibutani T, Yamamoto K, Jimi T, Yano H, Kitai M, Shiozaki T, Matsuoka K, Yamaguchi S
Int J Clin Oncol 2021 Jul;26(7):1322-1329. Epub 2021 Apr 6 doi: 10.1007/s10147-021-01904-0. PMID: 33825085
Lindner V, Waydelich A, Chen CC, Jones C, Stratton SP
Virchows Arch 2021 Aug;479(2):337-343. Epub 2021 Apr 3 doi: 10.1007/s00428-021-03088-4. PMID: 33811532
Civantos AM, Viswanathan S, Prasad A, Maldonado ST, Brody RM, Cannady SB, Newman JG, Shanti RM, Brant JA, Rajasekaran K
Eur Arch Otorhinolaryngol 2021 Sep;278(9):3459-3466. Epub 2021 Jan 3 doi: 10.1007/s00405-020-06539-x. PMID: 33388976
Kawashima H, Ohno E, Ishikawa T, Iida T, Tanaka H, Furukawa K, Nakamura M, Honda T, Hashimoto S, Itoh A, Ishigami M, Hirooka Y, Fujishiro M
Dig Endosc 2021 Jul;33(5):858-869. Epub 2020 Dec 28 doi: 10.1111/den.13881. PMID: 33107134

Therapy

Tagkalos E, van der Sluis PC, Berlth F, Poplawski A, Hadzijusufovic E, Lang H, van Berge Henegouwen MI, Gisbertz SS, Müller-Stich BP, Ruurda JP, Schiesser M, Schneider PM, van Hillegersberg R, Grimminger PP
BMC Cancer 2021 Sep 26;21(1):1060. doi: 10.1186/s12885-021-08780-x. PMID: 34565343Free PMC Article
Amano T, Iijima H, Shinzaki S, Tashiro T, Iwatani S, Tani M, Otake Y, Yoshihara T, Sugimoto A, Egawa S, Yamaguchi S, Kinoshita K, Araki M, Hirao M, Sakakibara Y, Hiyama S, Ogawa H, Nagaike K, Murata J, Komori M, Okuda Y, Kizu T, Tsujii Y, Hayashi Y, Inoue T, Takahashi H, Mizushima T, Morii E, Takehara T
BMC Cancer 2021 Aug 31;21(1):978. doi: 10.1186/s12885-021-08724-5. PMID: 34465291Free PMC Article
Song L, Zhu Z, Wu H, Han W, Cheng X, Li J, Du H, Lei J, Sui X, Song W, Jin ZY
Eur Radiol 2021 Apr;31(4):2034-2047. Epub 2020 Nov 4 doi: 10.1007/s00330-020-07331-5. PMID: 33146791
Shi H, Shao Y, Lu W, Lu B
J Pathol Clin Res 2021 Jan;7(1):86-95. Epub 2020 Oct 22 doi: 10.1002/cjp2.184. PMID: 33089969Free PMC Article
Tian T, Gao X, Ju Y, Ding X, Ai Y
Arch Gynecol Obstet 2021 Mar;303(3):793-801. Epub 2020 Oct 3 doi: 10.1007/s00404-020-05826-6. PMID: 33009996

Prognosis

Wu Y, Lv M, Qian T, Shen Y
Ann Palliat Med 2021 Sep;10(9):9544-9552. doi: 10.21037/apm-21-1974. PMID: 34628880
Amano T, Iijima H, Shinzaki S, Tashiro T, Iwatani S, Tani M, Otake Y, Yoshihara T, Sugimoto A, Egawa S, Yamaguchi S, Kinoshita K, Araki M, Hirao M, Sakakibara Y, Hiyama S, Ogawa H, Nagaike K, Murata J, Komori M, Okuda Y, Kizu T, Tsujii Y, Hayashi Y, Inoue T, Takahashi H, Mizushima T, Morii E, Takehara T
BMC Cancer 2021 Aug 31;21(1):978. doi: 10.1186/s12885-021-08724-5. PMID: 34465291Free PMC Article
Chen X, Hu J, Xu L, Chen J, Lin Y, Chi Z, He X, Lan P
Int J Colorectal Dis 2021 Sep;36(9):1965-1979. Epub 2021 Jul 23 doi: 10.1007/s00384-021-03997-5. PMID: 34297196
Lv D, Luo X, Chen Z, Liu J, Liu M, Li Y, Huang S, Tang M, Yang L, Lu L, Jiang J, Zhou Q, Xie F, Zhong C, Li L, Chen L
Life Sci 2021 Sep 15;281:119763. Epub 2021 Jun 26 doi: 10.1016/j.lfs.2021.119763. PMID: 34186050
Lindner V, Waydelich A, Chen CC, Jones C, Stratton SP
Virchows Arch 2021 Aug;479(2):337-343. Epub 2021 Apr 3 doi: 10.1007/s00428-021-03088-4. PMID: 33811532

Clinical prediction guides

Amano T, Iijima H, Shinzaki S, Tashiro T, Iwatani S, Tani M, Otake Y, Yoshihara T, Sugimoto A, Egawa S, Yamaguchi S, Kinoshita K, Araki M, Hirao M, Sakakibara Y, Hiyama S, Ogawa H, Nagaike K, Murata J, Komori M, Okuda Y, Kizu T, Tsujii Y, Hayashi Y, Inoue T, Takahashi H, Mizushima T, Morii E, Takehara T
BMC Cancer 2021 Aug 31;21(1):978. doi: 10.1186/s12885-021-08724-5. PMID: 34465291Free PMC Article
Chen X, Hu J, Xu L, Chen J, Lin Y, Chi Z, He X, Lan P
Int J Colorectal Dis 2021 Sep;36(9):1965-1979. Epub 2021 Jul 23 doi: 10.1007/s00384-021-03997-5. PMID: 34297196
Lv D, Luo X, Chen Z, Liu J, Liu M, Li Y, Huang S, Tang M, Yang L, Lu L, Jiang J, Zhou Q, Xie F, Zhong C, Li L, Chen L
Life Sci 2021 Sep 15;281:119763. Epub 2021 Jun 26 doi: 10.1016/j.lfs.2021.119763. PMID: 34186050
Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
Lindner V, Waydelich A, Chen CC, Jones C, Stratton SP
Virchows Arch 2021 Aug;479(2):337-343. Epub 2021 Apr 3 doi: 10.1007/s00428-021-03088-4. PMID: 33811532

Recent systematic reviews

Burasakarn P, Higuchi R, Nunobe S, Kanaji S, Eguchi H, Okada KI, Fujii T, Nagakawa Y, Kanetaka K, Yamashita H, Yamada S, Kuroda S, Aoyama T, Akahori T, Nakagawa K, Yamamoto M, Yamaue H, Sho M, Kodera Y; Japan Duodenal Cancer Guideline Committee.
Int J Clin Oncol 2021 Mar;26(3):450-460. Epub 2021 Jan 1 doi: 10.1007/s10147-020-01840-5. PMID: 33386555
Anker CJ, Dragovic J, Herman JM, Bianchi NA, Goodman KA, Jones WE 3rd, Kennedy TJ, Kumar R, Lee P, Russo S, Sharma N, Small W, Suh WW, Tchelebi LT, Jabbour SK
Int J Radiat Oncol Biol Phys 2021 Jan 1;109(1):186-200. Epub 2020 Aug 25 doi: 10.1016/j.ijrobp.2020.08.050. PMID: 32858113
Kundel Y, Sternschuss M, Moore A, Perl G, Brenner B, Goldvaser H
Cancer Med 2020 Oct;9(20):7613-7625. Epub 2020 Sep 1 doi: 10.1002/cam4.3417. PMID: 32869544Free PMC Article
Wu H, Shang L, Du F, Fu M, Liu J, Fang Z, Li L
Expert Rev Gastroenterol Hepatol 2020 Nov;14(11):1107-1117. Epub 2020 Aug 20 doi: 10.1080/17474124.2020.1806710. PMID: 32757864
Chen D, Mao Y, Ding Q, Wang W, Zhu F, Chen C, Chen Y
Eur J Cardiothorac Surg 2020 Nov 1;58(5):888-898. doi: 10.1093/ejcts/ezaa172. PMID: 32596715

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