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LGR5 Gene Mutation
A change in the nucleotide sequence of the LGR5 gene. [from NCI]
G Protein-Coupled Receptor Signaling
A cellular process that initiates with the binding of a G protein-associated transmembrane receptor to its cognate ligand,and results in a specific cellular response. This process is involved in signaling related to neurotranmission, immune responses, and cellular metabolism, differentiation and proliferation. [from NCI]
Activating LGR5 Gene Mutation
A change in the nucleotide sequence of the LGR5 gene that that results in constitutive activation of both leucine-rich repeat-containing G-protein coupled receptor 5 and its downstream signaling pathways. [from NCI]
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