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Metabolic syndrome X

MedGen UID:
99356
Concept ID:
C0524620
Disease or Syndrome
Synonyms: Cardiovascular Syndrome, Metabolic; Cardiovascular Syndromes, Metabolic; Dysmetabolic Syndrome X; Insulin Resistance Syndrome X; Metabolic Cardiovascular Syndrome; Metabolic Syndrome; Metabolic Syndrome X; Metabolic Syndromes; Metabolic X Syndrome; Reaven Syndrome X; Syndrome X, Dysmetabolic; Syndrome X, Insulin Resistance; Syndrome X, Metabolic; Syndrome X, Reaven; Syndrome, Metabolic; Syndrome, Metabolic Cardiovascular; Syndrome, Metabolic X; Syndromes, Metabolic; X Syndrome, Metabolic
SNOMED CT: Insulin resistance syndrome (237602007); Metabolic syndrome (237602007); Dysmetabolic syndrome X (237602007); Metabolic syndrome X (237602007); Reaven's syndrome (237602007)
 
OMIM®: 605552

Definition

A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetabolic syndrome X

Recent clinical studies

Etiology

Das UN
J Assoc Physicians India 2006 Aug;54:637-49. PMID: 16941796
Hurwitz BE, Klimas NG, Llabre MM, Maher KJ, Skyler JS, Bilsker MS, McPherson-Baker S, Lawrence PJ, Laperriere AR, Greeson JM, Klaus JR, Lawrence R, Schneiderman N
Cardiovasc Toxicol 2004;4(3):303-16. PMID: 15470277
Das UN
Curr Hypertens Rep 2004 Feb;6(1):66-73. PMID: 14972097
Frontini MG, Srinivasan SR, Berenson GS
Int J Obes Relat Metab Disord 2003 Nov;27(11):1398-404. doi: 10.1038/sj.ijo.0802422. PMID: 14574352
López-Candales A
J Med 2001;32(5-6):283-300. PMID: 11958275

Diagnosis

Kranjcec D, Pinter A, Birtić T, Cabrijan T, Halle J, Tomicić D, Halle Z, Pintarić H, Radacić M, Novak N
Coll Antropol 2002 Jun;26(1):23-9. PMID: 12137304
López-Candales A
J Med 2001;32(5-6):283-300. PMID: 11958275
Timar O, Sestier F, Levy E
Can J Cardiol 2000 Jun;16(6):779-89. PMID: 10863169
Hansen BC
Ann N Y Acad Sci 1999 Nov 18;892:1-24. doi: 10.1111/j.1749-6632.1999.tb07782.x. PMID: 10842649
Komers R, Vrána A
Physiol Res 1998;47(4):215-25. PMID: 9803467

Therapy

Hurwitz BE, Klimas NG, Llabre MM, Maher KJ, Skyler JS, Bilsker MS, McPherson-Baker S, Lawrence PJ, Laperriere AR, Greeson JM, Klaus JR, Lawrence R, Schneiderman N
Cardiovasc Toxicol 2004;4(3):303-16. PMID: 15470277
Kranjcec D, Pinter A, Birtić T, Cabrijan T, Halle J, Tomicić D, Halle Z, Pintarić H, Radacić M, Novak N
Coll Antropol 2002 Jun;26(1):23-9. PMID: 12137304
De Luca N, Izzo R, Fontana D, Iovino G, Argenziano L, Vecchione C, Trimarco B
J Hypertens 2000 Oct;18(10):1515-22. doi: 10.1097/00004872-200018100-00021. PMID: 11057441
Marceau P, Biron S, Hould FS, Marceau S, Simard S, Thung SN, Kral JG
J Clin Endocrinol Metab 1999 May;84(5):1513-7. doi: 10.1210/jcem.84.5.5661. PMID: 10323371
Christensen JO, Svendsen OL, Hassager C, Christiansen C
Int J Obes Relat Metab Disord 1998 Mar;22(3):195-9. PMID: 9539185

Prognosis

Mora-Rodriguez R, Ortega JF, Morales-Palomo F, Ramirez-Jimenez M
Nutr Metab Cardiovasc Dis 2018 Dec;28(12):1267-1274. Epub 2018 Aug 23 doi: 10.1016/j.numecd.2018.08.004. PMID: 30459053
Saloojee S, Burns JK, Motala AA
Early Interv Psychiatry 2018 Dec;12(6):1137-1143. Epub 2017 Apr 12 doi: 10.1111/eip.12428. PMID: 28402033Free PMC Article
Zohal M, Ghorbani A, Esmailzadehha N, Ziaee A, Mohammadi Z
Diabetes Metab Syndr 2017 Nov;11 Suppl 1:S377-S380. Epub 2017 Mar 6 doi: 10.1016/j.dsx.2017.03.020. PMID: 28284911
Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo' A, Paolisso G
Mol Aspects Med 2003 Feb-Jun;24(1-3):39-52. PMID: 12537988
Christensen JO, Svendsen OL, Hassager C, Christiansen C
Int J Obes Relat Metab Disord 1998 Mar;22(3):195-9. PMID: 9539185

Clinical prediction guides

Mora-Rodriguez R, Ortega JF, Morales-Palomo F, Ramirez-Jimenez M
Nutr Metab Cardiovasc Dis 2018 Dec;28(12):1267-1274. Epub 2018 Aug 23 doi: 10.1016/j.numecd.2018.08.004. PMID: 30459053
Zohal M, Ghorbani A, Esmailzadehha N, Ziaee A, Mohammadi Z
Diabetes Metab Syndr 2017 Nov;11 Suppl 1:S377-S380. Epub 2017 Mar 6 doi: 10.1016/j.dsx.2017.03.020. PMID: 28284911
Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo' A, Paolisso G
Mol Aspects Med 2003 Feb-Jun;24(1-3):39-52. PMID: 12537988
Christensen JO, Svendsen OL, Hassager C, Christiansen C
Int J Obes Relat Metab Disord 1998 Mar;22(3):195-9. PMID: 9539185
Friedman TC, Mastorakos G, Newman TD, Mullen NM, Horton EG, Costello R, Papadopoulos NM, Chrousos GP
Endocr J 1996 Dec;43(6):645-55. doi: 10.1507/endocrj.43.645. PMID: 9075604

Recent systematic reviews

Zhang D, Liu X, Liu Y, Sun X, Wang B, Ren Y, Zhao Y, Zhou J, Han C, Yin L, Zhao J, Shi Y, Zhang M, Hu D
Metabolism 2017 Oct;75:36-44. Epub 2017 Aug 15 doi: 10.1016/j.metabol.2017.08.001. PMID: 28927737
Cardona Velásquez S, Guzmán Vivares L, Cardona-Arias JA
Endocrinol Diabetes Nutr 2017 Feb;64(2):82-91. Epub 2017 Feb 4 doi: 10.1016/j.endinu.2016.09.002. PMID: 28440782
Kim J, Lee I, Lim S
J Clin Nurs 2017 Dec;26(23-24):3869-3880. Epub 2017 May 23 doi: 10.1111/jocn.13802. PMID: 28295797
Li R, Li W, Lun Z, Zhang H, Sun Z, Kanu JS, Qiu S, Cheng Y, Liu Y
BMC Public Health 2016 Apr 1;16:296. doi: 10.1186/s12889-016-2870-y. PMID: 27039079Free PMC Article
Kelishadi R, Mansourian M, Heidari-Beni M
Nutrition 2014 May;30(5):503-10. doi: 10.1016/j.nut.2013.08.014. PMID: 24698343

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