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Wasting disease

MedGen UID:
22696
Concept ID:
C0043046
Disease or Syndrome
Synonyms: Wasting Disease; Wasting Diseases; Wasting Syndrome; Wasting Syndromes
SNOMED CT: Wasting disease (288517002)
 

Definition

A condition of involuntary weight loss of greater then 10% of baseline body weight. It is characterized by atrophy of muscles and depletion of lean body mass. Wasting is a sign of MALNUTRITION as a result of inadequate dietary intake, malabsorption, or hypermetabolism. [from MeSH]

Recent clinical studies

Etiology

Gavin C, Henderson D, Benestad SL, Simmons M, Adkin A
Prev Vet Med 2019 May 1;166:28-38. Epub 2019 Mar 6 doi: 10.1016/j.prevetmed.2019.02.016. PMID: 30935503
Hannaoui S, Schatzl HM, Gilch S
PLoS Pathog 2017 Nov;13(11):e1006619. Epub 2017 Nov 2 doi: 10.1371/journal.ppat.1006619. PMID: 29095921Free PMC Article
Taschuk R, Scruten E, Woodbury M, Cashman N, Potter A, Griebel P, Tikoo SK, Napper S
Prion 2017 Sep 3;11(5):368-380. doi: 10.1080/19336896.2017.1367083. PMID: 28968152Free PMC Article
Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ
J Clin Invest 2015 Apr;125(4):1485-96. Epub 2015 Feb 23 doi: 10.1172/JCI79408. PMID: 25705888Free PMC Article
Magle SB, Samuel MD, Van Deelen TR, Robinson SJ, Mathews NE
PLoS One 2013;8(2):e56568. Epub 2013 Feb 20 doi: 10.1371/journal.pone.0056568. PMID: 23437171Free PMC Article

Diagnosis

Race B, Williams K, Chesebro B
Vet Res 2019 Jan 22;50(1):6. doi: 10.1186/s13567-019-0626-2. PMID: 30670087Free PMC Article
van Erp RJ, Schröppel B, Barth TF, Seufferlein T, Schmidt SA, Meining A, Kleger A
Gut 2016 May;65(5):787, 881. Epub 2015 Oct 28 doi: 10.1136/gutjnl-2015-310404. PMID: 26511796
Potapov A, Merrill E, Pybus M, Lewis MA
PLoS One 2015;10(10):e0140024. Epub 2015 Oct 9 doi: 10.1371/journal.pone.0140024. PMID: 26452231Free PMC Article
Gilch S, Chitoor N, Taguchi Y, Stuart M, Jewell JE, Schätzl HM
Top Curr Chem 2011;305:51-77. doi: 10.1007/128_2011_159. PMID: 21598099
Prcina M, Bardon J, Kontseková E
Acta Virol 2008;52(4):209-18. PMID: 19143476

Therapy

Taschuk R, Scruten E, Woodbury M, Cashman N, Potter A, Griebel P, Tikoo SK, Napper S
Prion 2017 Sep 3;11(5):368-380. doi: 10.1080/19336896.2017.1367083. PMID: 28968152Free PMC Article
Darmon P
Curr Opin Clin Nutr Metab Care 2013 May;16(3):284-9. doi: 10.1097/MCO.0b013e32835f503f. PMID: 23429407
Wisniewski T, Goñi F
Expert Rev Anti Infect Ther 2012 Mar;10(3):307-17. doi: 10.1586/eri.11.177. PMID: 22397565Free PMC Article
Kamiji MM, Inui A
Curr Opin Clin Nutr Metab Care 2008 Jul;11(4):443-51. doi: 10.1097/MCO.0b013e328303dee4. PMID: 18542005
Angers RC, Browning SR, Seward TS, Sigurdson CJ, Miller MW, Hoover EA, Telling GC
Science 2006 Feb 24;311(5764):1117. Epub 2006 Jan 26 doi: 10.1126/science.1122864. PMID: 16439622

Prognosis

Chiu A, Goddard E, Parlee B
J Toxicol Environ Health A 2016;79(16-17):762-97. doi: 10.1080/15287394.2016.1174011. PMID: 27556568
Olszowy KM, Lavelle J, Rachfal K, Hempstead S, Drouin K, Darcy JM 2nd, Reiber C, Garruto RM
Public Health 2014 Sep;128(9):860-8. Epub 2014 Sep 13 doi: 10.1016/j.puhe.2014.06.012. PMID: 25225155
Heikens GT, Manary M
Malawi Med J 2009 Sep;21(3):101-5. PMID: 20345017Free PMC Article
Kong Q, Huang S, Zou W, Vanegas D, Wang M, Wu D, Yuan J, Zheng M, Bai H, Deng H, Chen K, Jenny AL, O'Rourke K, Belay ED, Schonberger LB, Petersen RB, Sy MS, Chen SG, Gambetti P
J Neurosci 2005 Aug 31;25(35):7944-9. doi: 10.1523/JNEUROSCI.2467-05.2005. PMID: 16135751Free PMC Article
Morrissey PJ, Charrier K
Res Immunol 1994 Jun;145(5):357-62. PMID: 7701115

Clinical prediction guides

Race B, Williams K, Chesebro B
Vet Res 2019 Jan 22;50(1):6. doi: 10.1186/s13567-019-0626-2. PMID: 30670087Free PMC Article
Sikorska B, Gajos A, Bogucki A, Zielonka E, Sigurdson C, Liberski PP
Prion 2017 Nov 2;11(6):431-439. doi: 10.1080/19336896.2017.1384109. PMID: 29105545Free PMC Article
Zimmer N, Boxall PC, Adamowicz WL
J Toxicol Environ Health A 2011;74(22-24):1621-35. doi: 10.1080/15287394.2011.618988. PMID: 22043918
Sandberg MK, Al-Doujaily H, Sigurdson CJ, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J
J Gen Virol 2010 Oct;91(Pt 10):2651-7. Epub 2010 Jul 7 doi: 10.1099/vir.0.024380-0. PMID: 20610667Free PMC Article
Miller MW, Williams ES
Curr Top Microbiol Immunol 2004;284:193-214. doi: 10.1007/978-3-662-08441-0_8. PMID: 15148993

Recent systematic reviews

Waddell L, Greig J, Mascarenhas M, Otten A, Corrin T, Hierlihy K
Transbound Emerg Dis 2018 Feb;65(1):37-49. Epub 2017 Jan 30 doi: 10.1111/tbed.12612. PMID: 28139079
Prousky JE
Altern Med Rev 2003 May;8(2):180-5. PMID: 12777163

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