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Chronic fatigue syndrome

MedGen UID:
5130
Concept ID:
C0015674
Disease or Syndrome
Synonyms: Chronic Fatigue and Immune Dysfunction Syndrome; Chronic Fatigue Disorder; Chronic Fatigue Disorders; Chronic Fatigue Fibromyalgia Syndrome; Chronic Fatigue Syndrome; Chronic Fatigue Syndromes; Chronic Fatigue-Fibromyalgia Syndrome; Chronic Fatigue-Fibromyalgia Syndromes; Encephalomyelitis, Myalgic; Fatigue Disorder, Chronic; Fatigue Disorders, Chronic; Fatigue Syndrome, Chronic; Fatigue Syndrome, Postviral; Fatigue Syndromes, Chronic; Fatigue Syndromes, Postviral; Fatigue-Fibromyalgia Syndrome, Chronic; Fatigue-Fibromyalgia Syndromes, Chronic; Infectious Mononucleosis Like Syndrome, Chronic; Infectious Mononucleosis-Like Syndrome, Chronic; Myalgic Encephalomyelitis; Postviral Fatigue Syndrome; Postviral Fatigue Syndromes; Royal Free Disease; Systemic Exertion Intolerance Disease
SNOMED CT: Myalgic encephalomyelitis syndrome (52702003); ME - Myalgic encephalomyelitis (52702003); Myalgic encephalomyelitis (52702003); CFS - Chronic fatigue syndrome (52702003); Postviral fatigue syndrome (51771007); Iceland disease (52702003); Benign myalgic encephalomyelitis (52702003); Chronic fatigue syndrome (52702003)
 

Definition

A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic fatigue syndrome

Recent clinical studies

Etiology

Groven N, Fors EA, Iversen VC, White LR, Reitan SK
Nord J Psychiatry 2018 Nov;72(8):556-560. Epub 2018 Jul 31 doi: 10.1080/08039488.2018.1493747. PMID: 30063870
Crawley EM, Gaunt DM, Garfield K, Hollingworth W, Sterne JAC, Beasant L, Collin SM, Mills N, Montgomery AA
Arch Dis Child 2018 Feb;103(2):155-164. Epub 2017 Sep 20 doi: 10.1136/archdischild-2017-313375. PMID: 28931531Free PMC Article
Unger ER, Lin JS, Tian H, Natelson BH, Lange G, Vu D, Blate M, Klimas NG, Balbin EG, Bateman L, Allen A, Lapp CW, Springs W, Kogelnik AM, Phan CC, Danver J, Podell RN, Fitzpatrick T, Peterson DL, Gottschalk CG, Rajeevan MS; MCAM Study Group.
Am J Epidemiol 2017 Apr 15;185(8):617-626. doi: 10.1093/aje/kwx029. PMID: 28338983Free PMC Article
Williams TE, Chalder T, Sharpe M, White PD
Psychol Med 2017 Jun;47(8):1454-1465. Epub 2017 Jan 23 doi: 10.1017/S0033291716003615. PMID: 28112075
Roberts E, Wessely S, Chalder T, Chang CK, Hotopf M
Lancet 2016 Apr 16;387(10028):1638-43. Epub 2016 Feb 10 doi: 10.1016/S0140-6736(15)01223-4. PMID: 26873808

Diagnosis

Baos S, Brigden A, Anderson E, Hollingworth W, Price S, Mills N, Beasant L, Gaunt D, Garfield K, Metcalfe C, Parslow R, Downing H, Kessler D, Macleod J, Stallard P, Knoop H, Van de Putte E, Nijhof S, Bleijenberg G, Crawley E
Trials 2018 Feb 22;19(1):136. doi: 10.1186/s13063-018-2500-3. PMID: 29471861Free PMC Article
Monro JA, Puri BK
Mol Neurobiol 2018 Sep;55(9):7377-7388. Epub 2018 Feb 6 doi: 10.1007/s12035-018-0928-9. PMID: 29411266Free PMC Article
Higgins JNP, Pickard JD, Lever AML
Med Hypotheses 2017 Aug;105:6-9. Epub 2017 Jun 24 doi: 10.1016/j.mehy.2017.06.014. PMID: 28735654
Unger ER, Lin JS, Tian H, Natelson BH, Lange G, Vu D, Blate M, Klimas NG, Balbin EG, Bateman L, Allen A, Lapp CW, Springs W, Kogelnik AM, Phan CC, Danver J, Podell RN, Fitzpatrick T, Peterson DL, Gottschalk CG, Rajeevan MS; MCAM Study Group.
Am J Epidemiol 2017 Apr 15;185(8):617-626. doi: 10.1093/aje/kwx029. PMID: 28338983Free PMC Article
Roberts E, Wessely S, Chalder T, Chang CK, Hotopf M
Lancet 2016 Apr 16;387(10028):1638-43. Epub 2016 Feb 10 doi: 10.1016/S0140-6736(15)01223-4. PMID: 26873808

Therapy

Bjørklund G, Dadar M, Pen JJ, Chirumbolo S, Aaseth J
Biomed Pharmacother 2019 Jan;109:1000-1007. Epub 2018 Nov 5 doi: 10.1016/j.biopha.2018.10.076. PMID: 30551349
Baos S, Brigden A, Anderson E, Hollingworth W, Price S, Mills N, Beasant L, Gaunt D, Garfield K, Metcalfe C, Parslow R, Downing H, Kessler D, Macleod J, Stallard P, Knoop H, Van de Putte E, Nijhof S, Bleijenberg G, Crawley E
Trials 2018 Feb 22;19(1):136. doi: 10.1186/s13063-018-2500-3. PMID: 29471861Free PMC Article
Crawley EM, Gaunt DM, Garfield K, Hollingworth W, Sterne JAC, Beasant L, Collin SM, Mills N, Montgomery AA
Arch Dis Child 2018 Feb;103(2):155-164. Epub 2017 Sep 20 doi: 10.1136/archdischild-2017-313375. PMID: 28931531Free PMC Article
Daniels J, Brigden A, Kacorova A
Psychol Psychother 2017 Sep;90(3):502-509. Epub 2017 Feb 28 doi: 10.1111/papt.12118. PMID: 28244209
Williams TE, Chalder T, Sharpe M, White PD
Psychol Med 2017 Jun;47(8):1454-1465. Epub 2017 Jan 23 doi: 10.1017/S0033291716003615. PMID: 28112075

Prognosis

Coetzee N, Maree DJF, Smit BN
Int J Occup Med Environ Health 2019 Feb 27;32(1):75-85. Epub 2019 Feb 20 doi: 10.13075/ijomeh.1896.01274. PMID: 30855100
McBride RL, Horsfield S, Sandler CX, Cassar J, Casson S, Cvejic E, Vollmer-Conna U, Lloyd AR
Psychiatry Res 2017 Nov;257:400-405. Epub 2017 Aug 18 doi: 10.1016/j.psychres.2017.08.035. PMID: 28830024
Unger ER, Lin JS, Tian H, Natelson BH, Lange G, Vu D, Blate M, Klimas NG, Balbin EG, Bateman L, Allen A, Lapp CW, Springs W, Kogelnik AM, Phan CC, Danver J, Podell RN, Fitzpatrick T, Peterson DL, Gottschalk CG, Rajeevan MS; MCAM Study Group.
Am J Epidemiol 2017 Apr 15;185(8):617-626. doi: 10.1093/aje/kwx029. PMID: 28338983Free PMC Article
Daniels J, Brigden A, Kacorova A
Psychol Psychother 2017 Sep;90(3):502-509. Epub 2017 Feb 28 doi: 10.1111/papt.12118. PMID: 28244209
van der Schaaf ME, De Lange FP, Schmits IC, Geurts DEM, Roelofs K, van der Meer JWM, Toni I, Knoop H
Biol Psychiatry 2017 Feb 15;81(4):358-365. Epub 2016 Aug 31 doi: 10.1016/j.biopsych.2016.07.016. PMID: 27817843

Clinical prediction guides

Coetzee N, Maree DJF, Smit BN
Int J Occup Med Environ Health 2019 Feb 27;32(1):75-85. Epub 2019 Feb 20 doi: 10.13075/ijomeh.1896.01274. PMID: 30855100
Higgins JNP, Pickard JD, Lever AML
Med Hypotheses 2017 Aug;105:6-9. Epub 2017 Jun 24 doi: 10.1016/j.mehy.2017.06.014. PMID: 28735654
de Vega WC, Herrera S, Vernon SD, McGowan PO
BMC Med Genomics 2017 Feb 23;10(1):11. doi: 10.1186/s12920-017-0248-3. PMID: 28231836Free PMC Article
Williams TE, Chalder T, Sharpe M, White PD
Psychol Med 2017 Jun;47(8):1454-1465. Epub 2017 Jan 23 doi: 10.1017/S0033291716003615. PMID: 28112075
Roberts E, Wessely S, Chalder T, Chang CK, Hotopf M
Lancet 2016 Apr 16;387(10028):1638-43. Epub 2016 Feb 10 doi: 10.1016/S0140-6736(15)01223-4. PMID: 26873808

Recent systematic reviews

Galeoto G, Sansoni J, Valenti D, Mollica R, Valente D, Parente M, Servadio A
Clin Ter 2018 Jul-Aug;169(4):e184-e188. doi: 10.7417/T.2018.2076. PMID: 30151552
Jones K, Probst Y
Aust N Z J Public Health 2017 Aug;41(4):338-344. Epub 2017 Jun 14 doi: 10.1111/1753-6405.12670. PMID: 28616881
Loades ME, Sheils EA, Crawley E
BMJ Open 2016 Oct 11;6(10):e012271. doi: 10.1136/bmjopen-2016-012271. PMID: 27729349Free PMC Article
Vergauwen K, Huijnen IP, Kos D, Van de Velde D, van Eupen I, Meeus M
Disabil Rehabil 2015;37(19):1706-16. Epub 2014 Nov 3 doi: 10.3109/09638288.2014.978507. PMID: 25365699
Meeus M, Nijs J, Vanderheiden T, Baert I, Descheemaeker F, Struyf F
Clin Rehabil 2015 Mar;29(3):221-33. Epub 2014 Sep 8 doi: 10.1177/0269215514542635. PMID: 25200878

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