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Warfarin sensitivity

MedGen UID:
392858
Concept ID:
C2608079
Disease or Syndrome
Synonyms: Warfarin Sensitivity
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: HPO, OMIM, Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
Autosomal dominant inheritance (HPO, OMIM, Orphanet)
SNOMED CT: Warfarin sensitivity (726543008)
 
OMIM®: 122700; 300746; 601130; 608547

Clinical features

Abnormality of blood and blood-forming tissues
MedGen UID:
163092
Concept ID:
C0850715
Finding
An abnormality of the hematopoietic system.
Abnormality of metabolism/homeostasis
MedGen UID:
867398
Concept ID:
C4021768
Finding

Recent clinical studies

Etiology

del Campo M, Roberts G
Ann Pharmacother 2015 Sep;49(9):962-8. Epub 2015 Jun 23 doi: 10.1177/1060028015590438. PMID: 26104049
Hirai K, Hayashi H, Ono Y, Izumiya K, Tanaka M, Suzuki T, Sakamoto T, Itoh K
Drug Metab Pharmacokinet 2013;28(2):132-7. Epub 2012 Aug 14 PMID: 22892446
Mlynarsky L, Bejarano-Achache I, Muszkat M, Caraco Y
Eur J Clin Pharmacol 2012 May;68(5):617-27. Epub 2011 Nov 10 doi: 10.1007/s00228-011-1143-z. PMID: 22071881
Lee SJ, Jang YJ, Cha EY, Kim HS, Lee SS, Shin JG
Br J Clin Pharmacol 2010 Aug;70(2):213-21. doi: 10.1111/j.1365-2125.2010.03688.x. PMID: 20653674Free PMC Article
Efrati E, Elkin H, Sprecher E, Krivoy N
Curr Drug Saf 2010 Jul 2;5(3):190-3. PMID: 20210733

Diagnosis

Saleh MI
Am J Ther 2016 Nov/Dec;23(6):e1690-e1694. doi: 10.1097/MJT.0000000000000248. PMID: 25830869
del Campo M, Roberts G
Ann Pharmacother 2015 Sep;49(9):962-8. Epub 2015 Jun 23 doi: 10.1177/1060028015590438. PMID: 26104049
Chua YA, Abdullah WZ, Yusof Z, Gan SH
Biomed Res Int 2014;2014:316310. Epub 2014 Mar 30 doi: 10.1155/2014/316310. PMID: 24790995Free PMC Article
Hirai K, Hayashi H, Ono Y, Izumiya K, Tanaka M, Suzuki T, Sakamoto T, Itoh K
Drug Metab Pharmacokinet 2013;28(2):132-7. Epub 2012 Aug 14 PMID: 22892446
Moyer TP, O'Kane DJ, Baudhuin LM, Wiley CL, Fortini A, Fisher PK, Dupras DM, Chaudhry R, Thapa P, Zinsmeister AR, Heit JA
Mayo Clin Proc 2009 Dec;84(12):1079-94. doi: 10.4065/mcp.2009.0278. PMID: 19955245Free PMC Article

Therapy

Saleh MI
Am J Ther 2016 Nov/Dec;23(6):e1690-e1694. doi: 10.1097/MJT.0000000000000248. PMID: 25830869
del Campo M, Roberts G
Ann Pharmacother 2015 Sep;49(9):962-8. Epub 2015 Jun 23 doi: 10.1177/1060028015590438. PMID: 26104049
Mlynarsky L, Bejarano-Achache I, Muszkat M, Caraco Y
Eur J Clin Pharmacol 2012 May;68(5):617-27. Epub 2011 Nov 10 doi: 10.1007/s00228-011-1143-z. PMID: 22071881
Moyer TP, O'Kane DJ, Baudhuin LM, Wiley CL, Fortini A, Fisher PK, Dupras DM, Chaudhry R, Thapa P, Zinsmeister AR, Heit JA
Mayo Clin Proc 2009 Dec;84(12):1079-94. doi: 10.4065/mcp.2009.0278. PMID: 19955245Free PMC Article
Li C, Schwarz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D
Blood 2009 Apr 23;113(17):3925-30. Epub 2008 Dec 12 doi: 10.1182/blood-2008-09-176859. PMID: 19074728Free PMC Article

Prognosis

Saleh MI
Am J Ther 2016 Nov/Dec;23(6):e1690-e1694. doi: 10.1097/MJT.0000000000000248. PMID: 25830869
Chua YA, Abdullah WZ, Yusof Z, Gan SH
Biomed Res Int 2014;2014:316310. Epub 2014 Mar 30 doi: 10.1155/2014/316310. PMID: 24790995Free PMC Article
Lee SJ, Jang YJ, Cha EY, Kim HS, Lee SS, Shin JG
Br J Clin Pharmacol 2010 Aug;70(2):213-21. doi: 10.1111/j.1365-2125.2010.03688.x. PMID: 20653674Free PMC Article
Langley MR, Booker JK, Evans JP, McLeod HL, Weck KE
J Mol Diagn 2009 May;11(3):216-25. Epub 2009 Mar 26 doi: 10.2353/jmoldx.2009.080123. PMID: 19324988Free PMC Article
Li C, Schwarz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D
Blood 2009 Apr 23;113(17):3925-30. Epub 2008 Dec 12 doi: 10.1182/blood-2008-09-176859. PMID: 19074728Free PMC Article

Clinical prediction guides

Saleh MI
Am J Ther 2016 Nov/Dec;23(6):e1690-e1694. doi: 10.1097/MJT.0000000000000248. PMID: 25830869
del Campo M, Roberts G
Ann Pharmacother 2015 Sep;49(9):962-8. Epub 2015 Jun 23 doi: 10.1177/1060028015590438. PMID: 26104049
Chua YA, Abdullah WZ, Yusof Z, Gan SH
Biomed Res Int 2014;2014:316310. Epub 2014 Mar 30 doi: 10.1155/2014/316310. PMID: 24790995Free PMC Article
Lee SJ, Jang YJ, Cha EY, Kim HS, Lee SS, Shin JG
Br J Clin Pharmacol 2010 Aug;70(2):213-21. doi: 10.1111/j.1365-2125.2010.03688.x. PMID: 20653674Free PMC Article
Li C, Schwarz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D
Blood 2009 Apr 23;113(17):3925-30. Epub 2008 Dec 12 doi: 10.1182/blood-2008-09-176859. PMID: 19074728Free PMC Article

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