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Infection due to Mycobacterium tuberculosis

MedGen UID:
22513
Concept ID:
C0041296
Disease or Syndrome
Synonyms: Infection, Mycobacterium tuberculosis; Infections, Mycobacterium tuberculosis; Koch Disease; Koch's Disease; Kochs Disease; Mycobacterium tuberculosis Infection; Mycobacterium tuberculosis Infections; Tuberculoses; Tuberculosis
Modes of inheritance:
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
not inherited (Orphanet)
SNOMED CT: Tuberculous (371569005); Infection due to Mycobacterium tuberculosis (373576009); Infection caused by Mycobacterium tuberculosis (373576009); TB - Tuberculosis (56717001); Tuberculosis (56717001)
 
Orphanet: ORPHA3389

Definition

A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. [from NCI]

Recent clinical studies

Etiology

Lin SH, Lai CC, Huang SH, Hung CC, Hsueh PR
Epidemiol Infect 2014 Jul;142(7):1524-32. Epub 2013 Oct 29 doi: 10.1017/S0950268813002707. PMID: 24168831
Sagar T, Singh NP, Kashyap B, Kaur IR
J Postgrad Med 2013 Jul-Sep;59(3):173-6. doi: 10.4103/0022-3859.118031. PMID: 24029192
Ullah K, Raza S, Ahmed P, Satti TM, Ikram A, Chaudhry QU, Kamal MK, Akhtar FM
J Pak Med Assoc 2007 Nov;57(11):567-9. PMID: 18062526
De Rosa FG, Shaz D, Campagna AC, Dellaripa PE, Khettry U, Craven DE
Infect Control Hosp Epidemiol 2003 Jul;24(7):477-82. doi: 10.1086/502250. PMID: 12887234
Berbari EF, Hanssen AD, Duffy MC, Steckelberg JM, Osmon DR
Am J Orthop (Belle Mead NJ) 1998 Mar;27(3):219-27. PMID: 9544364

Diagnosis

Lin SH, Lai CC, Huang SH, Hung CC, Hsueh PR
Epidemiol Infect 2014 Jul;142(7):1524-32. Epub 2013 Oct 29 doi: 10.1017/S0950268813002707. PMID: 24168831
Safdar A, Brown AE, Kraus DH, Malkin M
Clin Infect Dis 2000 Mar;30(3):625-7. doi: 10.1086/313731. PMID: 10722470
Berbari EF, Hanssen AD, Duffy MC, Steckelberg JM, Osmon DR
Am J Orthop (Belle Mead NJ) 1998 Mar;27(3):219-27. PMID: 9544364
Tokumoto JI, Follansbee SE, Jacobs RA
Clin Infect Dis 1995 Jul;21(1):134-6. PMID: 7578722
Bassiri A, Chan NB, McLeod A, Rossi S, Phillips P
CMAJ 1993 Feb 15;148(4):577-8. PMID: 8431819Free PMC Article

Therapy

Ullah K, Raza S, Ahmed P, Satti TM, Ikram A, Chaudhry QU, Kamal MK, Akhtar FM
J Pak Med Assoc 2007 Nov;57(11):567-9. PMID: 18062526
De Rosa FG, Shaz D, Campagna AC, Dellaripa PE, Khettry U, Craven DE
Infect Control Hosp Epidemiol 2003 Jul;24(7):477-82. doi: 10.1086/502250. PMID: 12887234
Safdar A, Brown AE, Kraus DH, Malkin M
Clin Infect Dis 2000 Mar;30(3):625-7. doi: 10.1086/313731. PMID: 10722470
Tokumoto JI, Follansbee SE, Jacobs RA
Clin Infect Dis 1995 Jul;21(1):134-6. PMID: 7578722
Bassiri A, Chan NB, McLeod A, Rossi S, Phillips P
CMAJ 1993 Feb 15;148(4):577-8. PMID: 8431819Free PMC Article

Prognosis

Gurjar M, Aggarwal SK, Saigal S, Singh RK
Indian J Tuberc 2012 Apr;59(2):103-6. PMID: 22838209
Quaglio G, Lugoboni F, Talamini G, Lechi A, Mezzelani P
Scand J Infect Dis 2002;34(8):574-6. PMID: 12238571

Clinical prediction guides

Quaglio G, Lugoboni F, Talamini G, Lechi A, Mezzelani P
Scand J Infect Dis 2002;34(8):574-6. PMID: 12238571
Nolan CM
Clin Infect Dis 1999 Oct;29(4):880-7. doi: 10.1086/520453. PMID: 10589907

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