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Leukoplakia of Lip

MedGen UID:
98317
•Concept ID:
C0399602
•
Neoplastic Process
Synonyms: Leucokeratosis of lip; Leukokeratosis of lip; Leukoplakia of lips
SNOMED CT: Leukokeratosis of lip (17531008); Leucokeratosis of lip (17531008); Leukoplakia of lips (17531008)

Definition

A clinical term that indicates the presence of a white patch on the surface of the lip which cannot be characterized as any other disease. It may be a precancerous condition and in most cases histologic examination reveals keratosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukoplakia of Lip

Professional guidelines

PubMed

Oral cancer detection. The importance of routine screening for prolongation of survival.
Chiodo GT, Eigner T, Rosenstein DI
Postgrad Med 1986 Aug;80(2):231-6. doi: 10.1080/00325481.1986.11699497. PMID: 3526308
Evaluation of 5-fluorouracil in the treatment of actinic keratosis of the lip.
Warnock GR, Fuller RP Jr, Pelleu GB Jr
Oral Surg Oral Med Oral Pathol 1981 Nov;52(5):501-5. doi: 10.1016/0030-4220(81)90362-5. PMID: 6946379
Yttrium 90 in the treatment of oral leukoplakia.
Vickery IM
Br J Oral Surg 1972 Nov;10(2):158-67. doi: 10.1016/s0007-117x(72)80032-5. PMID: 4509979

Recent clinical studies

Etiology

Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Cryosurgery cure rate of premalignant leukoplakia of the lower lip.
Lubritz RR, Smolewski SA
J Dermatol Surg Oncol 1983 Mar;9(3):235-7. doi: 10.1111/j.1524-4725.1983.tb00794.x. PMID: 6826879
Invasive carcinoma of the lower lip.
Hendricks JL, Mendelson BC, Woods JE
Surg Clin North Am 1977 Aug;57(4):837-44. doi: 10.1016/s0039-6109(16)41293-4. PMID: 897970
Carcinoma of the lip.
Wurman LH, Adams GL, Meyerhoff WL
Am J Surg 1975 Oct;130(4):470-4. doi: 10.1016/0002-9610(75)90486-9. PMID: 1101725
Cancer of the lip at risk.
Wilson JS, Kemble JV
Br J Oral Surg 1972 Mar;9(3):186-94. doi: 10.1016/s0007-117x(71)80033-1. PMID: 4558235

Diagnosis

Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Oral Biopsy Techniques.
Shanti RM, Tanaka T, Stanton DC
Dermatol Clin 2020 Oct;38(4):421-427. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.003. PMID: 32892851
Prominent inferior labial artery.
Howell JB, Freeman RG
Arch Dermatol 1973 Mar;107(3):386-7. PMID: 4692128
Problems of verrucose squamous carcinoma.
Elliott GB, Macdougall JA, Elliott JD
Ann Surg 1973 Jan;177(1):21-9. doi: 10.1097/00000658-197301000-00005. PMID: 4566093Free PMC Article
Cancer and leukoplakia of the lip.
Kleitsch WP, Taricco A
Nebr State Med J 1969 Jul;54(7):458-70. PMID: 4241040

Therapy

Oral leukoplakia-epidemiological survey and histochemical analysis of 107 cases in Brazil.
Dogenski LC, de Figueiredo Ribeiro S, Gambin DJ, Maso PC, Linden MSS, Trentin MS, Zoehler B, Crivelini MM, De Carli JP
Clin Oral Investig 2021 Apr;25(4):1859-1867. Epub 2020 Aug 6 doi: 10.1007/s00784-020-03488-x. PMID: 32761445
Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients.
Petti S, Polimeni A, Berloco PB, Scully C
Oral Dis 2013 Jan;19(1):18-36. Epub 2012 Mar 28 doi: 10.1111/j.1601-0825.2012.01925.x. PMID: 22458357
Carcinoma of the lip.
Wurman LH, Adams GL, Meyerhoff WL
Am J Surg 1975 Oct;130(4):470-4. doi: 10.1016/0002-9610(75)90486-9. PMID: 1101725
Cancer of the lip at risk.
Wilson JS, Kemble JV
Br J Oral Surg 1972 Mar;9(3):186-94. doi: 10.1016/s0007-117x(71)80033-1. PMID: 4558235
Oral lesions.
Hinds EC, Kent JN
Am J Gastroenterol 1971 Mar;55(3):225-36. PMID: 4931041

Prognosis

Oral lichen planus and related lesions. What should we accept based on the available evidence?
González-Moles MÁ, Ramos-García P
Oral Dis 2023 Oct;29(7):2624-2637. Epub 2022 Dec 8 doi: 10.1111/odi.14438. PMID: 36371653
Oral leukoplakia-epidemiological survey and histochemical analysis of 107 cases in Brazil.
Dogenski LC, de Figueiredo Ribeiro S, Gambin DJ, Maso PC, Linden MSS, Trentin MS, Zoehler B, Crivelini MM, De Carli JP
Clin Oral Investig 2021 Apr;25(4):1859-1867. Epub 2020 Aug 6 doi: 10.1007/s00784-020-03488-x. PMID: 32761445
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Cryosurgery cure rate of premalignant leukoplakia of the lower lip.
Lubritz RR, Smolewski SA
J Dermatol Surg Oncol 1983 Mar;9(3):235-7. doi: 10.1111/j.1524-4725.1983.tb00794.x. PMID: 6826879
Surgical treatment of non-traumatic lower lip lesions with special reference to the step technique. A follow-up on 149 patients.
Johanson B, Aspelund E, Breine U, Holmström H
Scand J Plast Reconstr Surg 1974;8(3):232-40. doi: 10.3109/02844317409084399. PMID: 4617298

Clinical prediction guides

Oral leukoplakia-epidemiological survey and histochemical analysis of 107 cases in Brazil.
Dogenski LC, de Figueiredo Ribeiro S, Gambin DJ, Maso PC, Linden MSS, Trentin MS, Zoehler B, Crivelini MM, De Carli JP
Clin Oral Investig 2021 Apr;25(4):1859-1867. Epub 2020 Aug 6 doi: 10.1007/s00784-020-03488-x. PMID: 32761445
Development and validation of nomogram for prediction of malignant transformation in oral leukoplakia: A large-scale cohort study.
Wang T, Wang L, Yang H, Lu H, Zhang J, Li N, Guo CB
J Oral Pathol Med 2019 Jul;48(6):491-498. Epub 2019 May 15 doi: 10.1111/jop.12862. PMID: 30980769
Potentially malignant oral lesions: clinicopathological correlations.
Maia HC, Pinto NA, Pereira Jdos S, de Medeiros AM, da Silveira ÉJ, Miguel MC
Einstein (Sao Paulo) 2016 Jan-Mar;14(1):35-40. doi: 10.1590/S1679-45082016AO3578. PMID: 27074232Free PMC Article
Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients.
Petti S, Polimeni A, Berloco PB, Scully C
Oral Dis 2013 Jan;19(1):18-36. Epub 2012 Mar 28 doi: 10.1111/j.1601-0825.2012.01925.x. PMID: 22458357
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Souza-Lima NC, Jaime-Paiva LG, Junqueira-Kipnis AP, Silva TA, Mendonça EF, Batista AC
J Oral Pathol Med 2011 May;40(5):380-4. Epub 2011 Feb 22 doi: 10.1111/j.1600-0714.2011.01014.x. PMID: 21342273

Recent systematic reviews

Prevalence of human papillomavirus (HPV) in oral mucosal lesions in Iran: A systematic review and meta-analysis.
Aghaeipour F, Salehiniya H, Abbaszadeh H
J Med Virol 2021 Nov;93(11):6089-6099. Epub 2021 Jul 6 doi: 10.1002/jmv.27161. PMID: 34180541

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