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ASCVD 10-Year Risk Estimator - Risk Score

MedGen UID:
906102
•Concept ID:
C4085920
•
Finding

Definition

Atherosclerotic Cardiovascular Disease 10-Year Risk Estimator (ASCVD 10-Year Risk Estimator) Risk score. [from NCI]

Professional guidelines

PubMed

2025 ESC/EAS Dyslipidemia Guidelines Focused Update: Intensifying Prevention, Risk Stratification, and Therapy.
Pradhan A, Thandi P, Mahajan K, Iellamo F, Perrone-Filardi P, Perrone MA
Am J Cardiol 2026 May 15;267:171-176. Epub 2026 Mar 3 doi: 10.1016/j.amjcard.2026.02.059. PMID: 41785983
Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.
Marston NA, Pirruccello JP, Melloni GEM, Koyama S, Kamanu FK, Weng LC, Roselli C, Kamatani Y, Komuro I, Aragam KG, Butterworth AS, Ito K, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT
JAMA Cardiol 2023 Feb 1;8(2):130-137. doi: 10.1001/jamacardio.2022.4466. PMID: 36576811Free PMC Article
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B
Circulation 2019 Sep 10;140(11):e563-e595. Epub 2019 Mar 17 doi: 10.1161/CIR.0000000000000677. PMID: 30879339Free PMC Article

Recent clinical studies

Etiology

Atherosclerotic Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations.
Anderson TS, Wilson LM, Sussman JB
JAMA Intern Med 2024 Aug 1;184(8):963-970. doi: 10.1001/jamainternmed.2024.1302. PMID: 38856978Free PMC Article
Development and validation of a new algorithm for improved cardiovascular risk prediction.
Hippisley-Cox J, Coupland CAC, Bafadhel M, Russell REK, Sheikh A, Brindle P, Channon KM
Nat Med 2024 May;30(5):1440-1447. Epub 2024 Apr 18 doi: 10.1038/s41591-024-02905-y. PMID: 38637635Free PMC Article
Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.
Marston NA, Pirruccello JP, Melloni GEM, Koyama S, Kamanu FK, Weng LC, Roselli C, Kamatani Y, Komuro I, Aragam KG, Butterworth AS, Ito K, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT
JAMA Cardiol 2023 Feb 1;8(2):130-137. doi: 10.1001/jamacardio.2022.4466. PMID: 36576811Free PMC Article
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B
Circulation 2019 Sep 10;140(11):e563-e595. Epub 2019 Mar 17 doi: 10.1161/CIR.0000000000000677. PMID: 30879339Free PMC Article
Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the multi-ethnic study of atherosclerosis (MESA).
Budoff MJ, Young R, Burke G, Jeffrey Carr J, Detrano RC, Folsom AR, Kronmal R, Lima JAC, Liu KJ, McClelland RL, Michos E, Post WS, Shea S, Watson KE, Wong ND
Eur Heart J 2018 Jul 1;39(25):2401-2408. doi: 10.1093/eurheartj/ehy217. PMID: 29688297Free PMC Article

Diagnosis

AHA PREVENT Equations and Cardiovascular Disease Risk in Diverse Health Care Populations.
Cho SMJ, Levin M, Chen R, Samarakoon R, Judy R, Hartmann K, Postupaka D, Viscosi V, Farber-Eger E, Fahed AC, Honigberg MC, Patel CJ, Hornsby W, Wells QS, Damrauer SM, Do R, Natarajan P
J Am Coll Cardiol 2025 Jul 22;86(3):181-192. doi: 10.1016/j.jacc.2025.04.066. PMID: 40669956Free PMC Article
10-Year and 30-Year Risks of Cardiovascular Disease in the U.S. Population.
Faridi KF, Malik D, Essa M, Yang H, Spatz ES, Krumholz HM, Lu Y
J Am Coll Cardiol 2025 Jun 17;85(23):2239-2249. doi: 10.1016/j.jacc.2025.03.546. PMID: 40499978
Predicting cardiovascular outcomes in Chinese patients with type 2 diabetes by combining risk factor trajectories and machine learning algorithm: a cohort study.
Huang Q, Zou X, Lian Z, Zhou X, Han X, Luo Y, Chen S, Wang Y, Wu S, Ji L
Cardiovasc Diabetol 2025 Feb 7;24(1):61. doi: 10.1186/s12933-025-02611-0. PMID: 39920715Free PMC Article
Hemoglobin A1c and abdominal obesity as predictors of diabetes and ASCVD in individuals with prediabetes in UK Biobank: a prospective observational study.
Pencina KM, Thanassoulis G, Pencina MJ, Toth PP, Sniderman AD
Cardiovasc Diabetol 2024 Dec 19;23(1):448. doi: 10.1186/s12933-024-02525-3. PMID: 39702291Free PMC Article
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B
Circulation 2019 Sep 10;140(11):e563-e595. Epub 2019 Mar 17 doi: 10.1161/CIR.0000000000000677. PMID: 30879339Free PMC Article

Therapy

2025 ESC/EAS Dyslipidemia Guidelines Focused Update: Intensifying Prevention, Risk Stratification, and Therapy.
Pradhan A, Thandi P, Mahajan K, Iellamo F, Perrone-Filardi P, Perrone MA
Am J Cardiol 2026 May 15;267:171-176. Epub 2026 Mar 3 doi: 10.1016/j.amjcard.2026.02.059. PMID: 41785983
PREVENT and PCE Models for Estimating ASCVD Risk Stratified by Statin Exposure.
Lee MS, Onwuzurike J, Wu YL, Palmer-Toy DE, An J, Chen W
JAMA Netw Open 2025 Sep 2;8(9):e2532164. doi: 10.1001/jamanetworkopen.2025.32164. PMID: 40956580Free PMC Article
Risk reduction of ASCVD attributed to lowering of remnant cholesterol from statins, fibrates, APOC3 inhibitors, and ANGPTL3 inhibitors: a cohort study.
Balling M, Roepstorff OG, Gerds TA, Varbo A, Mortensen MB, Langsted A, Nordestgaard BG, Afzal S
Atherosclerosis 2025 Oct;409:120471. Epub 2025 Aug 6 doi: 10.1016/j.atherosclerosis.2025.120471. PMID: 40839980
Atherosclerotic Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations.
Anderson TS, Wilson LM, Sussman JB
JAMA Intern Med 2024 Aug 1;184(8):963-970. doi: 10.1001/jamainternmed.2024.1302. PMID: 38856978Free PMC Article
Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.
Marston NA, Pirruccello JP, Melloni GEM, Koyama S, Kamanu FK, Weng LC, Roselli C, Kamatani Y, Komuro I, Aragam KG, Butterworth AS, Ito K, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT
JAMA Cardiol 2023 Feb 1;8(2):130-137. doi: 10.1001/jamacardio.2022.4466. PMID: 36576811Free PMC Article

Prognosis

Atherosclerotic Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations.
Anderson TS, Wilson LM, Sussman JB
JAMA Intern Med 2024 Aug 1;184(8):963-970. doi: 10.1001/jamainternmed.2024.1302. PMID: 38856978Free PMC Article
Development and validation of a new algorithm for improved cardiovascular risk prediction.
Hippisley-Cox J, Coupland CAC, Bafadhel M, Russell REK, Sheikh A, Brindle P, Channon KM
Nat Med 2024 May;30(5):1440-1447. Epub 2024 Apr 18 doi: 10.1038/s41591-024-02905-y. PMID: 38637635Free PMC Article
Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.
Marston NA, Pirruccello JP, Melloni GEM, Koyama S, Kamanu FK, Weng LC, Roselli C, Kamatani Y, Komuro I, Aragam KG, Butterworth AS, Ito K, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT
JAMA Cardiol 2023 Feb 1;8(2):130-137. doi: 10.1001/jamacardio.2022.4466. PMID: 36576811Free PMC Article
Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease: the updated SMART2 algorithm.
Hageman SHJ, McKay AJ, Ueda P, Gunn LH, Jernberg T, Hagström E, Bhatt DL, Steg PG, Läll K, Mägi R, Gynnild MN, Ellekjær H, Saltvedt I, Tuñón J, Mahíllo I, Aceña Á, Kaminski K, Chlabicz M, Sawicka E, Tillman T, McEvoy JW, Di Angelantonio E, Graham I, De Bacquer D, Ray KK, Dorresteijn JAN, Visseren FLJ
Eur Heart J 2022 May 7;43(18):1715-1727. doi: 10.1093/eurheartj/ehac056. PMID: 35165703Free PMC Article
Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the multi-ethnic study of atherosclerosis (MESA).
Budoff MJ, Young R, Burke G, Jeffrey Carr J, Detrano RC, Folsom AR, Kronmal R, Lima JAC, Liu KJ, McClelland RL, Michos E, Post WS, Shea S, Watson KE, Wong ND
Eur Heart J 2018 Jul 1;39(25):2401-2408. doi: 10.1093/eurheartj/ehy217. PMID: 29688297Free PMC Article

Clinical prediction guides

Atherosclerotic Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations.
Anderson TS, Wilson LM, Sussman JB
JAMA Intern Med 2024 Aug 1;184(8):963-970. doi: 10.1001/jamainternmed.2024.1302. PMID: 38856978Free PMC Article
Development and validation of a new algorithm for improved cardiovascular risk prediction.
Hippisley-Cox J, Coupland CAC, Bafadhel M, Russell REK, Sheikh A, Brindle P, Channon KM
Nat Med 2024 May;30(5):1440-1447. Epub 2024 Apr 18 doi: 10.1038/s41591-024-02905-y. PMID: 38637635Free PMC Article
Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.
Marston NA, Pirruccello JP, Melloni GEM, Koyama S, Kamanu FK, Weng LC, Roselli C, Kamatani Y, Komuro I, Aragam KG, Butterworth AS, Ito K, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT
JAMA Cardiol 2023 Feb 1;8(2):130-137. doi: 10.1001/jamacardio.2022.4466. PMID: 36576811Free PMC Article
Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease: the updated SMART2 algorithm.
Hageman SHJ, McKay AJ, Ueda P, Gunn LH, Jernberg T, Hagström E, Bhatt DL, Steg PG, Läll K, Mägi R, Gynnild MN, Ellekjær H, Saltvedt I, Tuñón J, Mahíllo I, Aceña Á, Kaminski K, Chlabicz M, Sawicka E, Tillman T, McEvoy JW, Di Angelantonio E, Graham I, De Bacquer D, Ray KK, Dorresteijn JAN, Visseren FLJ
Eur Heart J 2022 May 7;43(18):1715-1727. doi: 10.1093/eurheartj/ehac056. PMID: 35165703Free PMC Article
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B
Circulation 2019 Sep 10;140(11):e563-e595. Epub 2019 Mar 17 doi: 10.1161/CIR.0000000000000677. PMID: 30879339Free PMC Article

Recent systematic reviews

Association between carotid-femoral pulse wave velocity and cardiovascular disease in individuals with moderate blood pressure: a systematic review and individual participant meta-analysis.
Pavey H, Wood A, Mceniery CM, AlGhatrif M, Arshi B, Brunner E, Chen CH, Cheng HM, Hansen TW, Ikram MK, Kavousi M, Kuh D, Kuipers AL, Lakatta EG, Linneberg A, Mattace Raso F, Mitchell GF, Maldonado J, Newman AB, Pereira T, Maki-Petaja K, Shipley M, Vasan RS, Wong A, Ben-Shlomo Y, Wilkinson IB
BMJ Open 2025 Dec 15;15(12):e101368. doi: 10.1136/bmjopen-2025-101368. PMID: 41401986Free PMC Article

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