U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Delayed puberty (males)

MedGen UID:
893076
•Concept ID:
C2367046
•
Finding

Professional guidelines

PubMed

Hypogonadism in male and female: which is the best treatment?
Bertelli E, DI Frenna M, Cappa M, Salerno M, Wasniewska M, Bizzarri C, DE Sanctis L
Minerva Pediatr (Torino) 2021 Dec;73(6):572-587. Epub 2021 Jul 26 doi: 10.23736/S2724-5276.21.06534-4. PMID: 34309345
Clinical Management of Congenital Hypogonadotropic Hypogonadism.
Young J, Xu C, Papadakis GE, Acierno JS, Maione L, Hietamäki J, Raivio T, Pitteloud N
Endocr Rev 2019 Apr 1;40(2):669-710. doi: 10.1210/er.2018-00116. PMID: 30698671
Disorders of Puberty: An Approach to Diagnosis and Management.
Klein DA, Emerick JE, Sylvester JE, Vogt KS
Am Fam Physician 2017 Nov 1;96(9):590-599. PMID: 29094880

Recent clinical studies

Etiology

New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-depth Review of the Literature.
Federici S, Goggi G, Quinton R, Giovanelli L, Persani L, Cangiano B, Bonomi M
Endocr Rev 2022 Sep 26;43(5):824-851. doi: 10.1210/endrev/bnab043. PMID: 34864951
Genetic and Epigenetic Control of Puberty.
Manotas MC, González DM, Céspedes C, Forero C, Rojas Moreno AP
Sex Dev 2022;16(1):1-10. Epub 2021 Oct 14 doi: 10.1159/000519039. PMID: 34649256Free PMC Article
Puberty in cystic fibrosis.
Goldsweig B, Kaminski B, Sidhaye A, Blackman SM, Kelly A
J Cyst Fibros 2019 Oct;18 Suppl 2:S88-S94. doi: 10.1016/j.jcf.2019.08.013. PMID: 31679734
Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries.
Howard SR, Dunkel L
Endocr Rev 2019 Oct 1;40(5):1285-1317. doi: 10.1210/er.2018-00248. PMID: 31220230Free PMC Article
Coeliac disease in children.
Paul SP, Kirkham EN, Pidgeon S, Sandmann S
Nurs Stand 2015 Aug 5;29(49):36-41. doi: 10.7748/ns.29.49.36.e10022. PMID: 26243121

Diagnosis

Delayed Puberty.
Mohanraj S, Prasad HK
Indian J Pediatr 2023 Jun;90(6):590-597. Epub 2023 May 2 doi: 10.1007/s12098-023-04577-x. PMID: 37127825
An Approach to the Patient With Delayed Puberty.
Harrington J, Palmert MR
J Clin Endocrinol Metab 2022 May 17;107(6):1739-1750. doi: 10.1210/clinem/dgac054. PMID: 35100608
Delayed puberty.
Butler G, Purushothaman P
Minerva Pediatr 2020 Dec;72(6):484-490. Epub 2020 Aug 4 doi: 10.23736/S0026-4946.20.05968-X. PMID: 32748610
Clinical Management of Congenital Hypogonadotropic Hypogonadism.
Young J, Xu C, Papadakis GE, Acierno JS, Maione L, Hietamäki J, Raivio T, Pitteloud N
Endocr Rev 2019 Apr 1;40(2):669-710. doi: 10.1210/er.2018-00116. PMID: 30698671
Adolescent growth and development.
Chulani VL, Gordon LP
Prim Care 2014 Sep;41(3):465-87. doi: 10.1016/j.pop.2014.05.002. PMID: 25124201

Therapy

Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline.
Nordenström A, Ahmed SF, van den Akker E, Blair J, Bonomi M, Brachet C, Broersen LHA, Claahsen-van der Grinten HL, Dessens AB, Gawlik A, Gravholt CH, Juul A, Krausz C, Raivio T, Smyth A, Touraine P, Vitali D, Dekkers OM
Eur J Endocrinol 2022 Apr 21;186(6):G9-G49. doi: 10.1530/EJE-22-0073. PMID: 35353710Free PMC Article
New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-depth Review of the Literature.
Federici S, Goggi G, Quinton R, Giovanelli L, Persani L, Cangiano B, Bonomi M
Endocr Rev 2022 Sep 26;43(5):824-851. doi: 10.1210/endrev/bnab043. PMID: 34864951
Delayed pubarche.
Baldo F, Barbi E, Tornese G
Ital J Pediatr 2021 Sep 6;47(1):180. doi: 10.1186/s13052-021-01134-0. PMID: 34488834Free PMC Article
Hypogonadism in male and female: which is the best treatment?
Bertelli E, DI Frenna M, Cappa M, Salerno M, Wasniewska M, Bizzarri C, DE Sanctis L
Minerva Pediatr (Torino) 2021 Dec;73(6):572-587. Epub 2021 Jul 26 doi: 10.23736/S2724-5276.21.06534-4. PMID: 34309345
Clinical Management of Congenital Hypogonadotropic Hypogonadism.
Young J, Xu C, Papadakis GE, Acierno JS, Maione L, Hietamäki J, Raivio T, Pitteloud N
Endocr Rev 2019 Apr 1;40(2):669-710. doi: 10.1210/er.2018-00116. PMID: 30698671

Prognosis

Delayed Puberty.
Mohanraj S, Prasad HK
Indian J Pediatr 2023 Jun;90(6):590-597. Epub 2023 May 2 doi: 10.1007/s12098-023-04577-x. PMID: 37127825
Should Skeletal Maturation Be Manipulated for Extra Height Gain?
Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
Delayed puberty.
Butler G, Purushothaman P
Minerva Pediatr 2020 Dec;72(6):484-490. Epub 2020 Aug 4 doi: 10.23736/S0026-4946.20.05968-X. PMID: 32748610
The age of adolescence.
Sawyer SM, Azzopardi PS, Wickremarathne D, Patton GC
Lancet Child Adolesc Health 2018 Mar;2(3):223-228. Epub 2018 Jan 30 doi: 10.1016/S2352-4642(18)30022-1. PMID: 30169257
Delayed puberty.
Fenichel P
Endocr Dev 2012;22:138-159. Epub 2012 Jul 25 doi: 10.1159/000326686. PMID: 22846526

Clinical prediction guides

Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism.
Aung Y, Kokotsis V, Yin KN, Banerjee K, Butler G, Dattani MT, Dimitri P, Dunkel L, Hughes C, McGuigan M, Korbonits M, Paltoglou G, Sakka S, Shah P, Storr HL, Willemsen RH, Howard SR
Front Endocrinol (Lausanne) 2023;14:1226839. Epub 2023 Aug 28 doi: 10.3389/fendo.2023.1226839. PMID: 37701896Free PMC Article
Delayed puberty.
Butler G, Purushothaman P
Minerva Pediatr 2020 Dec;72(6):484-490. Epub 2020 Aug 4 doi: 10.23736/S0026-4946.20.05968-X. PMID: 32748610
Management of hypogonadism from birth to adolescence.
Howard SR, Dunkel L
Best Pract Res Clin Endocrinol Metab 2018 Aug;32(4):355-372. Epub 2018 Jun 6 doi: 10.1016/j.beem.2018.05.011. PMID: 30086863
Sex Steroid and Gonadotropin Treatment in Male Delayed Puberty.
Howard S, Dunkel L
Endocr Dev 2016;29:185-97. Epub 2015 Dec 17 doi: 10.1159/000438891. PMID: 26680579
Nutritional and Pubertal Disorders.
Muñoz-Calvo MT, Argente J
Endocr Dev 2016;29:153-73. Epub 2015 Dec 17 doi: 10.1159/000438884. PMID: 26680577

Recent systematic reviews

Abnormalities of pubertal development and gonadal function in Noonan syndrome.
Patti G, Scaglione M, Maiorano NG, Rosti G, Divizia MT, Camia T, De Rose EL, Zucconi A, Casalini E, Napoli F, Di Iorgi N, Maghnie M
Front Endocrinol (Lausanne) 2023;14:1213098. Epub 2023 Jul 28 doi: 10.3389/fendo.2023.1213098. PMID: 37576960Free PMC Article
Effect of hypertensive disorders of pregnancy on pubertal development in daughters and sons: a systematic review and meta-analysis.
Yang Z, Zhou X, Gong Z, Zhang S, Liu X, Chen Y, Ye C, Chen L, Wang T
J Hum Hypertens 2023 Jan;37(1):20-27. Epub 2022 Jun 23 doi: 10.1038/s41371-022-00715-8. PMID: 35739340
Genotype and phenotypic spectrum of vitamin D dependent rickets type 1A: our experience and systematic review.
Dodamani MH, Sehemby M, Memon SS, Sarathi V, Lila AR, Chapla A, Bhandare VV, Patil VA, Shah NS, Thomas N, Kunwar A, Bandgar TR
J Pediatr Endocrinol Metab 2021 Dec 20;34(12):1505-1513. Epub 2021 Sep 8 doi: 10.1515/jpem-2021-0403. PMID: 34492747
Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.
Oliveira FRK, Gustavo AFSE, Gonçalves RB, Bolfi F, Mendes AL, Nunes-Nogueira VDS
PLoS One 2021;16(5):e0251241. Epub 2021 May 18 doi: 10.1371/journal.pone.0251241. PMID: 34003856Free PMC Article
Kisspeptins in human reproduction-future therapeutic potential.
Kaur KK, Allahbadia G, Singh M
J Assist Reprod Genet 2012 Oct;29(10):999-1011. Epub 2012 Sep 27 doi: 10.1007/s10815-012-9856-1. PMID: 23015158Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...