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Sustained Virologic Response

MedGen UID:
886175
•Concept ID:
C4050171
•
Finding
Synonyms: Response, Sustained Virologic; Suppression, Sustained Viral; Sustained Viral Suppression; Sustained Viral Suppressions; Sustained Virologic Responses; Virologic Response, Sustained

Definition

A finding of aviremia at a predetermined time point after the end of planned or actual treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSustained Virologic Response

Professional guidelines

PubMed

Hepatitis C: Diagnosis and Management.
Maness DL, Riley E, Studebaker G
Am Fam Physician 2021 Dec 1;104(6):626-635. PMID: 34913652
Public Health Clinic-Based Hepatitis C Treatment.
Rosecrans AM, Cheedalla A, Rives ST, Scotti LA, Harris RE, Greenbaum AH, Irvin RR, Ntiri-Reid BA, Brown HT, Alston KE, Smith JA, Page KR, Falade-Nwulia OO
Am J Prev Med 2020 Sep;59(3):420-427. Epub 2020 May 16 doi: 10.1016/j.amepre.2020.03.006. PMID: 32430222
Prevention and management of treatment failure to new oral hepatitis C drugs.
Benítez-Gutiérrez L, Barreiro P, Labarga P, de Mendoza C, Fernandez-Montero JV, Arias A, Peña JM, Soriano V
Expert Opin Pharmacother 2016 Jun;17(9):1215-23. Epub 2016 May 9 doi: 10.1080/14656566.2016.1182156. PMID: 27149603

Recent clinical studies

Etiology

Alcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy.
Cartwright EJ, Pierret C, Minassian C, Esserman DA, Tate JP, Goetz MB, Bhattacharya D, Fiellin DA, Justice AC, Lo Re V 3rd, Rentsch CT
JAMA Netw Open 2023 Sep 5;6(9):e2335715. doi: 10.1001/jamanetworkopen.2023.35715. PMID: 37751206Free PMC Article
Hepatitis C: Diagnosis and Management.
Maness DL, Riley E, Studebaker G
Am Fam Physician 2021 Dec 1;104(6):626-635. PMID: 34913652
Interferon and Hepatitis B: Current and Future Perspectives.
Ye J, Chen J
Front Immunol 2021;12:733364. Epub 2021 Sep 7 doi: 10.3389/fimmu.2021.733364. PMID: 34557195Free PMC Article
HCC surveillance after SVR in patients with F3/F4 fibrosis.
Ioannou GN
J Hepatol 2021 Feb;74(2):458-465. Epub 2020 Dec 7 doi: 10.1016/j.jhep.2020.10.016. PMID: 33303216
Hepatitis C: looking into the future.
Massoud O
Expert Rev Gastroenterol Hepatol 2020 May;14(5):367-374. Epub 2020 Mar 27 doi: 10.1080/17474124.2020.1746641. PMID: 32216467

Diagnosis

The wide spectrum of cryoglobulinemic vasculitis and an overview of therapeutic advancements.
Dammacco F, Lauletta G, Vacca A
Clin Exp Med 2023 Jun;23(2):255-272. Epub 2022 Mar 28 doi: 10.1007/s10238-022-00808-1. PMID: 35348938Free PMC Article
Hepatitis C: Diagnosis and Management.
Maness DL, Riley E, Studebaker G
Am Fam Physician 2021 Dec 1;104(6):626-635. PMID: 34913652
HCC surveillance after SVR in patients with F3/F4 fibrosis.
Ioannou GN
J Hepatol 2021 Feb;74(2):458-465. Epub 2020 Dec 7 doi: 10.1016/j.jhep.2020.10.016. PMID: 33303216
Understanding the Cryoglobulinemias.
Fuentes A, Mardones C, Burgos PI
Curr Rheumatol Rep 2019 Nov 19;21(11):60. doi: 10.1007/s11926-019-0859-0. PMID: 31741077
Targeting Hepatitis D.
Rizzetto M
Semin Liver Dis 2018 Feb;38(1):66-72. Epub 2018 Feb 22 doi: 10.1055/s-0037-1621711. PMID: 29471567

Therapy

Similar Sustained Virologic Response in Real-World and Clinical Trial Studies of Hepatitis C/Human Immunodeficiency Virus Coinfection.
Sikavi C, Najarian L, Saab S
Dig Dis Sci 2018 Nov;63(11):2829-2839. Epub 2018 Aug 9 doi: 10.1007/s10620-018-5215-0. PMID: 30094623
Clinical Pharmacokinetics of Paritaprevir.
Menon RM, Polepally AR, Khatri A, Awni WM, Dutta S
Clin Pharmacokinet 2017 Oct;56(10):1125-1137. doi: 10.1007/s40262-017-0520-x. PMID: 28236252
From HCV To HBV Cure.
Schinazi RF, Asselah T
Liver Int 2017 Jan;37 Suppl 1(Suppl 1):73-80. doi: 10.1111/liv.13324. PMID: 28052627Free PMC Article
Therapy of Delta Hepatitis.
Yurdaydin C, Idilman R
Cold Spring Harb Perspect Med 2015 Aug 7;5(10) doi: 10.1101/cshperspect.a021543. PMID: 26253093Free PMC Article
Telaprevir user's guide.
Liapakis A, Jacobson I
Clin Liver Dis 2011 Aug;15(3):555-71. doi: 10.1016/j.cld.2011.05.013. PMID: 21867936

Prognosis

HCC surveillance after SVR in patients with F3/F4 fibrosis.
Ioannou GN
J Hepatol 2021 Feb;74(2):458-465. Epub 2020 Dec 7 doi: 10.1016/j.jhep.2020.10.016. PMID: 33303216
Hepatic benefits of HCV cure.
Calvaruso V, Craxì A
J Hepatol 2020 Dec;73(6):1548-1556. Epub 2020 Aug 7 doi: 10.1016/j.jhep.2020.08.006. PMID: 32777323
The Epidemiology of Hepatocellular Carcinoma in the USA.
Kim HS, El-Serag HB
Curr Gastroenterol Rep 2019 Apr 11;21(4):17. doi: 10.1007/s11894-019-0681-x. PMID: 30976932
Similar Sustained Virologic Response in Real-World and Clinical Trial Studies of Hepatitis C/Human Immunodeficiency Virus Coinfection.
Sikavi C, Najarian L, Saab S
Dig Dis Sci 2018 Nov;63(11):2829-2839. Epub 2018 Aug 9 doi: 10.1007/s10620-018-5215-0. PMID: 30094623
Chemopreventive strategies in hepatocellular carcinoma.
Singh S, Singh PP, Roberts LR, Sanchez W
Nat Rev Gastroenterol Hepatol 2014 Jan;11(1):45-54. Epub 2013 Aug 13 doi: 10.1038/nrgastro.2013.143. PMID: 23938452Free PMC Article

Clinical prediction guides

Risk of hepatocellular carcinoma after hepatitis C virus cure.
Luna-Cuadros MA, Chen HW, Hanif H, Ali MJ, Khan MM, Lau DT
World J Gastroenterol 2022 Jan 7;28(1):96-107. doi: 10.3748/wjg.v28.i1.96. PMID: 35125821Free PMC Article
HCC surveillance after SVR in patients with F3/F4 fibrosis.
Ioannou GN
J Hepatol 2021 Feb;74(2):458-465. Epub 2020 Dec 7 doi: 10.1016/j.jhep.2020.10.016. PMID: 33303216
Hepatic benefits of HCV cure.
Calvaruso V, Craxì A
J Hepatol 2020 Dec;73(6):1548-1556. Epub 2020 Aug 7 doi: 10.1016/j.jhep.2020.08.006. PMID: 32777323
Similar Sustained Virologic Response in Real-World and Clinical Trial Studies of Hepatitis C/Human Immunodeficiency Virus Coinfection.
Sikavi C, Najarian L, Saab S
Dig Dis Sci 2018 Nov;63(11):2829-2839. Epub 2018 Aug 9 doi: 10.1007/s10620-018-5215-0. PMID: 30094623
Liver transplantation.
Brown KA
Curr Opin Gastroenterol 2005 May;21(3):331-6. doi: 10.1097/01.mog.0000159830.36793.2b. PMID: 15818154

Recent systematic reviews

Risk of Hepatocellular Carcinoma After Spontaneous Clearance of Hepatitis C Virus and in Noncirrhosis Chronic Hepatitis C Patients With Sustained Virological Response: A Systematic Review.
Hsu CC, Gopalakrishna H, Mironova M, Lee MH, Chen CJ, Yang HI, Wiese M, Chang KM, Wright EC, Abijo T, Feld JJ, Kaplan DE
Clin Infect Dis 2023 Aug 14;77(Suppl 3):S245-S256. doi: 10.1093/cid/ciad380. PMID: 37579210Free PMC Article
Treatment Outcomes of Sofosbuvir/Velpatasvir/Voxilaprevir in Direct-Acting Antiviral-Experienced Hepatitis C Virus Patients: A Systematic Review and Meta-Analysis.
Devan P, Tiong KLA, Neo JE, Mohan BP, Wijarnpreecha K, Tam YCS, Coppola N, Preda CM, Wong YJ
Viruses 2023 Jun 30;15(7) doi: 10.3390/v15071489. PMID: 37515176Free PMC Article
Sustained Virological Response in Special Populations with Chronic Hepatitis C Using Interferon-Free Treatments: A Systematic Review and Meta-analysis of Observational Cohort Studies.
Ferreira VL, Leonart LP, Tonin FS, Borba HHL, Pontarolo R
Clin Drug Investig 2018 May;38(5):389-400. doi: 10.1007/s40261-018-0624-6. PMID: 29435907
A systematic review and meta-analysis of HCV clearance.
Gauthiez E, Habfast-Robertson I, Rüeger S, Kutalik Z, Aubert V, Berg T, Cerny A, Gorgievski M, George J, Heim MH, Malinverni R, Moradpour D, Müllhaupt B, Negro F, Semela D, Semmo N, Villard J, Bibert S, Bochud PY; Swiss Hepatitis C Cohort Study
Liver Int 2017 Oct;37(10):1431-1445. Epub 2017 Mar 30 doi: 10.1111/liv.13401. PMID: 28261910
Achieving sustained virologic response in hepatitis C: a systematic review of the clinical, economic and quality of life benefits.
Smith-Palmer J, Cerri K, Valentine W
BMC Infect Dis 2015 Jan 17;15:19. doi: 10.1186/s12879-015-0748-8. PMID: 25596623Free PMC Article

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