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Feline Infectious Peritonitides

MedGen UID:
88378
•Concept ID:
C0085306
•
Disease or Syndrome
Synonyms: Feline Infectious Peritonitis; Infectious Peritonitides, Feline; Infectious Peritonitis, Feline; Peritonitis, Feline Infectious; Peritonitis, Infectious, Feline

Definition

Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFeline Infectious Peritonitides

Professional guidelines

PubMed

Outcomes of treatment of cats with feline infectious peritonitis using parenterally administered remdesivir, with or without transition to orally administered GS-441524.
Coggins SJ, Norris JM, Malik R, Govendir M, Hall EJ, Kimble B, Thompson MF
J Vet Intern Med 2023 Sep-Oct;37(5):1772-1783. Epub 2023 Jul 13 doi: 10.1111/jvim.16803. PMID: 37439383Free PMC Article

Recent clinical studies

Etiology

Bicavitary effusion in cats: retrospective analysis of signalment, clinical investigations, diagnosis and outcome.
Hardwick JJ, Ioannides-Hoey CSFK, Finch N, Black V
J Feline Med Surg 2024 Mar;26(3):1098612X241227122. doi: 10.1177/1098612X241227122. PMID: 38506622Free PMC Article
Enhanced decay of coronaviruses in sewers with domestic wastewater.
Shi J, Li X, Zhang S, Sharma E, Sivakumar M, Sherchan SP, Jiang G
Sci Total Environ 2022 Mar 20;813:151919. Epub 2021 Nov 24 doi: 10.1016/j.scitotenv.2021.151919. PMID: 34826473Free PMC Article
Conservation of substrate specificities among coronavirus main proteases.
Hegyi A, Ziebuhr J
J Gen Virol 2002 Mar;83(Pt 3):595-599. doi: 10.1099/0022-1317-83-3-595. PMID: 11842254
Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I.
Tresnan DB, Levis R, Holmes KV
J Virol 1996 Dec;70(12):8669-74. doi: 10.1128/JVI.70.12.8669-8674.1996. PMID: 8970993Free PMC Article
Experimental inoculation of cats with human coronavirus 229E and subsequent challenge with feline infectious peritonitis virus.
Barlough JE, Johnson-Lussenburg CM, Stoddart CA, Jacobson RH, Scott FW
Can J Comp Med 1985 Jul;49(3):303-7. PMID: 2994865Free PMC Article

Diagnosis

Serologic, Virologic and Pathologic Features of Cats with Naturally Occurring Feline Infectious Peritonitis Enrolled in Antiviral Clinical Trials.
Murphy BG, Castillo D, Neely NE, Kol A, Brostoff T, Grant CK, Reagan KL
Viruses 2024 Mar 17;16(3) doi: 10.3390/v16030462. PMID: 38543827Free PMC Article
AN OUTBREAK OF FELINE INFECTIOUS PERITONITIS IN THREE RELATED SAND CATS (FELIS MARGARITA) IN HUMAN CARE.
Aplasca AC, Martinez MP, Evans SJM, Martinez ME, Cianciolo RE, Bundschuh M, Puchulu-Campanella E, Chen X, Yan P, Bundschuh R, Seeley KE, Bapodra-Villaverde P, Garner MM, Junge RE
J Zoo Wildl Med 2023 Oct;54(3):628-638. doi: 10.1638/2022-0159. PMID: 37817630
Thirty-two cats with effusive or non-effusive feline infectious peritonitis treated with a combination of remdesivir and GS-441524.
Green J, Syme H, Tayler S
J Vet Intern Med 2023 Sep-Oct;37(5):1784-1793. Epub 2023 Jul 4 doi: 10.1111/jvim.16804. PMID: 37403259Free PMC Article
Animal Coronavirus Diseases: Parallels with COVID-19 in Humans.
Lin CN, Chan KR, Ooi EE, Chiou MT, Hoang M, Hsueh PR, Ooi PT
Viruses 2021 Jul 30;13(8) doi: 10.3390/v13081507. PMID: 34452372Free PMC Article
Feline infectious peritonitis.
Barr F
J Small Anim Pract 1998 Oct;39(10):501-4. doi: 10.1111/j.1748-5827.1998.tb03691.x. PMID: 9816576Free PMC Article

Therapy

Serologic, Virologic and Pathologic Features of Cats with Naturally Occurring Feline Infectious Peritonitis Enrolled in Antiviral Clinical Trials.
Murphy BG, Castillo D, Neely NE, Kol A, Brostoff T, Grant CK, Reagan KL
Viruses 2024 Mar 17;16(3) doi: 10.3390/v16030462. PMID: 38543827Free PMC Article
Outcomes of treatment of cats with feline infectious peritonitis using parenterally administered remdesivir, with or without transition to orally administered GS-441524.
Coggins SJ, Norris JM, Malik R, Govendir M, Hall EJ, Kimble B, Thompson MF
J Vet Intern Med 2023 Sep-Oct;37(5):1772-1783. Epub 2023 Jul 13 doi: 10.1111/jvim.16803. PMID: 37439383Free PMC Article
Clinical Follow-Up and Postmortem Findings in a Cat That Was Cured of Feline Infectious Peritonitis with an Oral Antiviral Drug Containing GS-441524.
Krentz D, Zwicklbauer K, Felten S, Bergmann M, Dorsch R, Hofmann-Lehmann R, Meli ML, Spiri AM, von Both U, Alberer M, Hönl A, Matiasek K, Hartmann K
Viruses 2022 Sep 14;14(9) doi: 10.3390/v14092040. PMID: 36146845Free PMC Article
Investigation of monotherapy and combined anticoronaviral therapies against feline coronavirus serotype II in vitro.
Cook SE, Vogel H, Castillo D, Olsen M, Pedersen N, Murphy BG
J Feline Med Surg 2022 Oct;24(10):943-953. Epub 2021 Oct 22 doi: 10.1177/1098612X211048647. PMID: 34676775Free PMC Article
The Improbability of the Rapid Development of a Vaccine for SARS-CoV-2.
Morris KV
Mol Ther 2020 Jul 8;28(7):1548-1549. Epub 2020 Jun 12 doi: 10.1016/j.ymthe.2020.06.005. PMID: 32533920Free PMC Article

Prognosis

Bicavitary effusion in cats: retrospective analysis of signalment, clinical investigations, diagnosis and outcome.
Hardwick JJ, Ioannides-Hoey CSFK, Finch N, Black V
J Feline Med Surg 2024 Mar;26(3):1098612X241227122. doi: 10.1177/1098612X241227122. PMID: 38506622Free PMC Article
Acute phase proteins in cats: Diagnostic and prognostic role, future directions, and analytical challenges.
Rossi G
Vet Clin Pathol 2023 Feb;52 Suppl 1:37-49. Epub 2023 Feb 5 doi: 10.1111/vcp.13238. PMID: 36740231
Artificial intelligence approach fighting COVID-19 with repurposing drugs.
Ke YY, Peng TT, Yeh TK, Huang WZ, Chang SE, Wu SH, Hung HC, Hsu TA, Lee SJ, Song JS, Lin WH, Chiang TJ, Lin JH, Sytwu HK, Chen CT
Biomed J 2020 Aug;43(4):355-362. Epub 2020 May 15 doi: 10.1016/j.bj.2020.05.001. PMID: 32426387Free PMC Article
Apoptosis and T-cell depletion during feline infectious peritonitis.
Haagmans BL, Egberink HF, Horzinek MC
J Virol 1996 Dec;70(12):8977-83. doi: 10.1128/JVI.70.12.8977-8983.1996. PMID: 8971027Free PMC Article
Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I.
Tresnan DB, Levis R, Holmes KV
J Virol 1996 Dec;70(12):8669-74. doi: 10.1128/JVI.70.12.8669-8674.1996. PMID: 8970993Free PMC Article

Clinical prediction guides

Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics.
Tortorici MA, Choi A, Gibson CA, Lee J, Brown JT, Stewart C, Joshi A, Harari S, Willoughby I, Treichel C, Leaf EM, Bloom JD, King NP, Tait-Burkard C, Whittaker GR, Veesler D
Nature 2025 Sep;645(8079):235-243. Epub 2025 Jul 9 doi: 10.1038/s41586-025-09155-z. PMID: 40634609Free PMC Article
Feline infectious peritonitis epizootic caused by a recombinant coronavirus.
Attipa C, Warr AS, Epaminondas D, O'Shea M, Hanton AJ, Fletcher S, Malbon A, Lyraki M, Hammond R, Hardas A, Zanti A, Loukaidou S, Gentil M, Gunn-Moore D, Lycett SJ, Mazeri S, Tait-Burkard C
Nature 2025 Sep;645(8079):228-234. Epub 2025 Jul 9 doi: 10.1038/s41586-025-09340-0. PMID: 40633571Free PMC Article
Thirty-two cats with effusive or non-effusive feline infectious peritonitis treated with a combination of remdesivir and GS-441524.
Green J, Syme H, Tayler S
J Vet Intern Med 2023 Sep-Oct;37(5):1784-1793. Epub 2023 Jul 4 doi: 10.1111/jvim.16804. PMID: 37403259Free PMC Article
Artificial intelligence approach fighting COVID-19 with repurposing drugs.
Ke YY, Peng TT, Yeh TK, Huang WZ, Chang SE, Wu SH, Hung HC, Hsu TA, Lee SJ, Song JS, Lin WH, Chiang TJ, Lin JH, Sytwu HK, Chen CT
Biomed J 2020 Aug;43(4):355-362. Epub 2020 May 15 doi: 10.1016/j.bj.2020.05.001. PMID: 32426387Free PMC Article
The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages.
Hohdatsu T, Tokunaga J, Koyama H
Arch Virol 1994;139(3-4):273-85. doi: 10.1007/BF01310791. PMID: 7832635Free PMC Article

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