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Abnormal posterior eye segment morphology

MedGen UID:
870893
•Concept ID:
C4025354
•
Anatomical Abnormality
Synonyms: Abnormal morphology of the posterior segment of the globe; Abnormality of the posterior segment of the eye; Abnormality of the posterior segment of the eyeball; Abnormality of the posterior segment of the globe
 
HPO: HP:0004329

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal posterior eye segment morphology

Professional guidelines

PubMed

Hereditary Vitreoretinopathies: Molecular Diagnosis, Clinical Presentation and Management.
Ghoraba HH, Sears J, Traboulsi EI
Clin Exp Ophthalmol 2025 Apr;53(3):281-291. Epub 2025 Jan 21 doi: 10.1111/ceo.14494. PMID: 39837650Free PMC Article
Clinical Classification and Management Outcomes of Anterior Segment-Dominated Persistent Fetal Vasculature: The CCPMOH Report.
Chen H, Chen W, Zhou F, Luo C, Lin Z, Li X, Lin Y, Lin H, Chen W
Am J Ophthalmol 2025 Mar;271:316-328. Epub 2024 Dec 7 doi: 10.1016/j.ajo.2024.11.024. PMID: 39647568
The differential diagnosis of leukokoria.
Cheng KP, Hiles DA, Biglan AW
Pediatr Ann 1990 Jun;19(6):376-83, 386. doi: 10.3928/0090-4481-19900601-07. PMID: 2200999

Recent clinical studies

Etiology

Axenfeld-Rieger syndrome: a novel histopathologic finding associated with corneal abnormalities.
Yu T, Dai Z, Peng R, Xiao G, Zhang P, Ma S, Hong J
BMC Ophthalmol 2022 Dec 28;22(1):514. doi: 10.1186/s12886-022-02754-8. PMID: 36577962Free PMC Article
Ocular Phenotype of Peters-Plus Syndrome.
Shah PR, Chauhan B, Chu CT, Kofler J, Nischal KK
Cornea 2022 Feb 1;41(2):219-223. doi: 10.1097/ICO.0000000000002889. PMID: 34629439
Vascular abnormalities in uveitis.
Ebrahimiadib N, Maleki A, Fadakar K, Manhapra A, Ghassemi F, Foster CS
Surv Ophthalmol 2021 Jul-Aug;66(4):653-667. Epub 2021 Jan 5 doi: 10.1016/j.survophthal.2020.12.006. PMID: 33412171
Interocular Comparison of Anterior and Posterior Segment Findings and Laterality in Hyperopic Anisometropia.
Cankurtaran V, Tekin K, Şimşek M, Elgin U, Yilmazbaş P
Eye Contact Lens 2018 Jan;44(1):29-34. doi: 10.1097/ICL.0000000000000296. PMID: 27541970
Exfoliation syndrome and exfoliation glaucoma.
Vesti E, Kivelä T
Prog Retin Eye Res 2000 May;19(3):345-68. doi: 10.1016/s1350-9462(99)00019-1. PMID: 10749381

Diagnosis

Vitreomacular traction - a review.
Ketkar M, Dave VP, de Ribot FM, Sallam AB, Shettigar MP, Hsieh YT, Lai TT, Soedarman S, Liu L, Wu L, Hattenbach LO, Pathengay A, Pappuru RR
Eye (Lond) 2025 Mar;39(4):710-717. Epub 2025 Jan 20 doi: 10.1038/s41433-024-03576-2. PMID: 39833579Free PMC Article
Anterior segment optical coherence tomography in ocular surface tumours and simulating lesions.
Gündüz AK, Mirzayev I, Okcu Heper A, Kuzu I, Gahramanli Z, Cansiz Ersöz C, Gündüz ÖÖ, Ataoğlu Ö
Eye (Lond) 2023 Apr;37(5):925-937. Epub 2022 Dec 13 doi: 10.1038/s41433-022-02339-1. PMID: 36513855Free PMC Article
Vascular abnormalities in uveitis.
Ebrahimiadib N, Maleki A, Fadakar K, Manhapra A, Ghassemi F, Foster CS
Surv Ophthalmol 2021 Jul-Aug;66(4):653-667. Epub 2021 Jan 5 doi: 10.1016/j.survophthal.2020.12.006. PMID: 33412171
Simple microphthalmos.
Weiss AH, Kousseff BG, Ross EA, Longbottom J
Arch Ophthalmol 1989 Nov;107(11):1625-30. doi: 10.1001/archopht.1989.01070020703032. PMID: 2818284
The vitreous.
Jaffe NS
Arch Ophthalmol 1973 Jul;90(1):69-82. doi: 10.1001/archopht.1973.01000050071016. PMID: 4577008

Therapy

Glaucoma With Crouzon Syndrome.
Alshamrani AA, Al-Shahwan S
J Glaucoma 2018 Jun;27(6):e110-e112. doi: 10.1097/IJG.0000000000000946. PMID: 29557836
Non-invasive anterior segment and posterior segment optical coherence tomography and phenotypic characterization of aniridia.
Gregory-Evans K, Cheong-Leen R, George SM, Xie J, Moosajee M, Colapinto P, Gregory-Evans CY
Can J Ophthalmol 2011 Aug;46(4):337-44. Epub 2011 Jul 7 doi: 10.1016/j.jcjo.2011.06.011. PMID: 21816254
Talc retinopathy.
Tse DT, Ober RR
Am J Ophthalmol 1980 Nov;90(5):624-40. doi: 10.1016/s0002-9394(14)75129-3. PMID: 6160767
The vitreous.
Jaffe NS
Arch Ophthalmol 1973 Jul;90(1):69-82. doi: 10.1001/archopht.1973.01000050071016. PMID: 4577008
Malignant glaucoma.
Simmons RJ
Br J Ophthalmol 1972 Mar;56(3):263-72. doi: 10.1136/bjo.56.3.263. PMID: 5032764Free PMC Article

Prognosis

Ocular Changes in Cystic Fibrosis: A Review.
Liberski S, Confalonieri F, Cofta S, Petrovski G, Kocięcki J
Int J Mol Sci 2024 Jun 18;25(12) doi: 10.3390/ijms25126692. PMID: 38928397Free PMC Article
Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration.
Romaus-Sanjurjo D, Regueiro U, López-López M, Vázquez-Vázquez L, Ouro A, Lema I, Sobrino T
Int J Mol Sci 2022 Feb 24;23(5) doi: 10.3390/ijms23052486. PMID: 35269629Free PMC Article
Pigment dispersion syndrome and pigmentary glaucoma: a review and update.
Scuderi G, Contestabile MT, Scuderi L, Librando A, Fenicia V, Rahimi S
Int Ophthalmol 2019 Jul;39(7):1651-1662. Epub 2018 May 2 doi: 10.1007/s10792-018-0938-7. PMID: 29721842
Interocular Comparison of Anterior and Posterior Segment Findings and Laterality in Hyperopic Anisometropia.
Cankurtaran V, Tekin K, Şimşek M, Elgin U, Yilmazbaş P
Eye Contact Lens 2018 Jan;44(1):29-34. doi: 10.1097/ICL.0000000000000296. PMID: 27541970
Stickler's syndrome.
Nielsen CE
Acta Ophthalmol (Copenh) 1981 Apr;59(2):286-95. doi: 10.1111/j.1755-3768.1981.tb02991.x. PMID: 7257747

Clinical prediction guides

Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration.
Romaus-Sanjurjo D, Regueiro U, López-López M, Vázquez-Vázquez L, Ouro A, Lema I, Sobrino T
Int J Mol Sci 2022 Feb 24;23(5) doi: 10.3390/ijms23052486. PMID: 35269629Free PMC Article
Ocular Phenotype of Peters-Plus Syndrome.
Shah PR, Chauhan B, Chu CT, Kofler J, Nischal KK
Cornea 2022 Feb 1;41(2):219-223. doi: 10.1097/ICO.0000000000002889. PMID: 34629439
Tears and Eyewear in Forensic Investigation-A Review.
Aparna R, Shanti Iyer R
Forensic Sci Int 2020 Jan;306:110055. Epub 2019 Nov 15 doi: 10.1016/j.forsciint.2019.110055. PMID: 31785512
Glaucoma With Crouzon Syndrome.
Alshamrani AA, Al-Shahwan S
J Glaucoma 2018 Jun;27(6):e110-e112. doi: 10.1097/IJG.0000000000000946. PMID: 29557836
Clinical and molecular aspects of aniridia.
Kokotas H, Petersen MB
Clin Genet 2010 May;77(5):409-20. Epub 2010 Jan 6 doi: 10.1111/j.1399-0004.2010.01372.x. PMID: 20132240

Recent systematic reviews

Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta-analysis.
Møller-Lorentzen TB, Eckmann-Hansen C, Faber C, Larsen M, Subhi Y
Acta Ophthalmol 2020 Dec;98(8):755-762. Epub 2020 May 15 doi: 10.1111/aos.14465. PMID: 32410360
Tears and Eyewear in Forensic Investigation-A Review.
Aparna R, Shanti Iyer R
Forensic Sci Int 2020 Jan;306:110055. Epub 2019 Nov 15 doi: 10.1016/j.forsciint.2019.110055. PMID: 31785512
Ocular involvement in systemic sclerosis: A systematic literature review, it's not all scleroderma that meets the eye.
Kreps EO, Carton C, Cutolo M, Cutolo CA, Vanhaecke A, Leroy BP, Smith V
Semin Arthritis Rheum 2019 Aug;49(1):119-125. Epub 2018 Dec 28 doi: 10.1016/j.semarthrit.2018.12.007. PMID: 30660382

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