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Episodic hypersomnia

MedGen UID:
870479
•Concept ID:
C4024925
•
Disease or Syndrome
Synonyms: Idiopathic hypersomnia; Recurrent hypersomnia
 
HPO: HP:0007200

Definition

Recurrent episodes of severe hypersomnia are accompanied by cognitive and behavioral disturbances, including confusion, derealization, apathy, compulsive eating, and hypersexuality. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpisodic hypersomnia

Conditions with this feature

Kleine-Levin syndrome
MedGen UID:
61511
•Concept ID:
C0206085
•
Disease or Syndrome
The Kleine-Levin hibernation syndrome, a rare disorder that occurs predominantly in males, is characterized by episodic attacks of aberrant behavior, hypersomnia, and increased feeding (megaphagia) and sex drives (Kleine, 1925; Levin, 1929).
See: Condition Record
Kleine-Levin syndrome

Professional guidelines

PubMed

Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depressive Disorder: A Living Clinical Guideline From the American College of Physicians.
Qaseem A, Owens DK, Etxeandia-Ikobaltzeta I, Tufte J, Cross JT Jr, Wilt TJ; Clinical Guidelines Committee of the American College of Physicians, Crandall CJ, Balk E, Cooney TG, Fitterman N, Hicks LA, Lin JS, Maroto M, Obley AJ, Tice JA, Yost J
Ann Intern Med 2023 Feb;176(2):239-252. Epub 2023 Jan 24 doi: 10.7326/M22-2056. PMID: 36689752
Pharmacological treatment for Kleine-Levin syndrome.
de Oliveira MM, Conti C, Prado GF
Cochrane Database Syst Rev 2016 May 6;2016(5):CD006685. doi: 10.1002/14651858.CD006685.pub4. PMID: 27153153Free PMC Article
Diagnosis, disease course, and management of patients with Kleine-Levin syndrome.
Arnulf I, Rico TJ, Mignot E
Lancet Neurol 2012 Oct;11(10):918-28. doi: 10.1016/S1474-4422(12)70187-4. PMID: 22995695

Recent clinical studies

Etiology

Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.
Ambati A, Hillary R, Leu-Semenescu S, Ollila HM, Lin L, During EH, Farber N, Rico TJ, Faraco J, Leary E, Goldstein-Piekarski AN, Huang YS, Han F, Sivan Y, Lecendreux M, Dodet P, Honda M, Gadoth N, Nevsimalova S, Pizza F, Kanbayashi T, Peraita-Adrados R, Leschziner GD, Hasan R, Canellas F, Kume K, Daniilidou M, Bourgin P, Rye D, Vicario JL, Hogl B, Hong SC, Plazzi G, Mayer G, Landtblom AM, Dauvilliers Y, Arnulf I, Mignot EJ
Proc Natl Acad Sci U S A 2021 Mar 23;118(12) doi: 10.1073/pnas.2005753118. PMID: 33737391Free PMC Article

Diagnosis

Kleine-Levin Syndrome: An Overview and Relevance to Nursing Practice.
Arnone JM, Conti RP
J Psychosoc Nurs Ment Health Serv 2016 Mar;54(3):41-7. doi: 10.3928/02793695-20160219-07. PMID: 26935190
Episodic hypersomnia and unusual behaviors in a 14-year old adolescent.
Hirst J, Mignot E, Stein MT
J Dev Behav Pediatr 2007 Dec;28(6):475-7. doi: 10.1097/DBP.0b013e31815d4c60. PMID: 18091094
The Kleine-Levin syndrome. Report of a case and review of the literature.
Papacostas SS, Hadjivasilis V
Eur Psychiatry 2000 Jun;15(4):231-5. doi: 10.1016/s0924-9338(00)00239-x. PMID: 10951606
Slit ventricle syndrome presenting with paroxysmal hypersomnia in an adult: case report.
Korfali E, Aksoy K, Safi I
Neurosurgery 1988 Mar;22(3):594-5. doi: 10.1227/00006123-198803000-00028. PMID: 3258965

Therapy

Slit ventricle syndrome presenting with paroxysmal hypersomnia in an adult: case report.
Korfali E, Aksoy K, Safi I
Neurosurgery 1988 Mar;22(3):594-5. doi: 10.1227/00006123-198803000-00028. PMID: 3258965

Prognosis

Kleine-Levin Syndrome: An Overview and Relevance to Nursing Practice.
Arnone JM, Conti RP
J Psychosoc Nurs Ment Health Serv 2016 Mar;54(3):41-7. doi: 10.3928/02793695-20160219-07. PMID: 26935190
The Kleine-Levin syndrome. Report of a case and review of the literature.
Papacostas SS, Hadjivasilis V
Eur Psychiatry 2000 Jun;15(4):231-5. doi: 10.1016/s0924-9338(00)00239-x. PMID: 10951606

Clinical prediction guides

Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.
Ambati A, Hillary R, Leu-Semenescu S, Ollila HM, Lin L, During EH, Farber N, Rico TJ, Faraco J, Leary E, Goldstein-Piekarski AN, Huang YS, Han F, Sivan Y, Lecendreux M, Dodet P, Honda M, Gadoth N, Nevsimalova S, Pizza F, Kanbayashi T, Peraita-Adrados R, Leschziner GD, Hasan R, Canellas F, Kume K, Daniilidou M, Bourgin P, Rye D, Vicario JL, Hogl B, Hong SC, Plazzi G, Mayer G, Landtblom AM, Dauvilliers Y, Arnulf I, Mignot EJ
Proc Natl Acad Sci U S A 2021 Mar 23;118(12) doi: 10.1073/pnas.2005753118. PMID: 33737391Free PMC Article
Slit ventricle syndrome presenting with paroxysmal hypersomnia in an adult: case report.
Korfali E, Aksoy K, Safi I
Neurosurgery 1988 Mar;22(3):594-5. doi: 10.1227/00006123-198803000-00028. PMID: 3258965

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