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Abnormal epididymis morphology

MedGen UID:
869792
•Concept ID:
C4024222
•
Anatomical Abnormality
Synonym: Abnormality of the epididymis
 
HPO: HP:0009714

Definition

An abnormality of the epididymis. [from HPO]

Conditions with this feature

46,XY sex reversal 7
MedGen UID:
383876
•Concept ID:
C1856273
•
Congenital Abnormality
See: Condition Record
46,XY sex reversal 7

Professional guidelines

PubMed

Management of pediatric vanishing testes syndrome based on pathological diagnosis: a single-center retrospective study.
Mao CK, Yuan-Fang, Cao YS
Sci Rep 2024 Apr 24;14(1):9437. doi: 10.1038/s41598-024-59583-6. PMID: 38658594Free PMC Article
Case report: treatment of congenital vas obstruction with sperm aspiration, nonstimulated in vitro fertilization, and nonsurgical tubal embryo transfer.
Steinleitner A, Sharlip I, Lambert H, Garcia M, Nachtigall R
J Assist Reprod Genet 1992 Aug;9(4):407-9. doi: 10.1007/BF01203970. PMID: 1472823
The undescended testis. Hormonal and surgical management.
Elder JS
Surg Clin North Am 1988 Oct;68(5):983-1005. doi: 10.1016/s0039-6109(16)44633-5. PMID: 2902694

Recent clinical studies

Etiology

Complete testicular epididymal dissociation in the abdominal cryptorchid testis.
Sharma S, Sen A
J Pediatr Urol 2013 Dec;9(6 Pt B):1023-7. Epub 2013 Jun 2 doi: 10.1016/j.jpurol.2013.02.017. PMID: 23735659
Chromosome abnormalities in spermatozoa of patients with azoospermia and normal somatic karyotype.
Burrello N, Vicari E, Calogero AE
Cytogenet Genome Res 2005;111(3-4):363-5. doi: 10.1159/000086912. PMID: 16192717
Prostate gland-like epithelium in the epididymis: a case report and review of the literature.
Lee LY, Tzeng J, Grosman M, Unger PD
Arch Pathol Lab Med 2004 Apr;128(4):e60-2. PMID: 15043474
Testicular regression syndrome--a pathological study of 77 cases.
Smith NM, Byard RW, Bourne AJ
Histopathology 1991 Sep;19(3):269-72. doi: 10.1111/j.1365-2559.1991.tb00033.x. PMID: 1916702
Polyorchidism.
Hancock RA, Hodgins TE
Urology 1984 Oct;24(4):303-7. doi: 10.1016/0090-4295(84)90196-1. PMID: 6385438

Diagnosis

Imaging of seminal vesicles: a pictorial review.
Mohsen Y, Al-Kutoubi A
Abdom Radiol (NY) 2023 Nov;48(11):3469-3487. Epub 2023 Aug 25 doi: 10.1007/s00261-023-04019-4. PMID: 37624375
Epididymal Appearance in Congenital Absence of Vas Deferens.
Gokhale S, Kochhar K
J Ultrasound Med 2021 Jun;40(6):1085-1090. Epub 2020 Sep 21 doi: 10.1002/jum.15500. PMID: 32955739
von Hippel-Lindau syndrome.
Chou A, Toon C, Pickett J, Gill AJ
Front Horm Res 2013;41:30-49. Epub 2013 Mar 19 doi: 10.1159/000345668. PMID: 23652669
Physical deformities relevant to male infertility.
Singh R, Hamada AJ, Bukavina L, Agarwal A
Nat Rev Urol 2012 Feb 21;9(3):156-74. doi: 10.1038/nrurol.2012.11. PMID: 22349654
Epididymitis, orchitis, and related conditions.
Krieger JN
Sex Transm Dis 1984 Jul-Sep;11(3):173-81. doi: 10.1097/00007435-198407000-00012. PMID: 6390741

Therapy

Role of Oxidative Stress in Male Reproductive Dysfunctions with Reference to Phthalate Compounds.
Sedha S, Kumar S, Shukla S
Urol J 2015 Nov 14;12(5):2304-16. PMID: 26571312
A comparison of DNA damage in testicular and proximal epididymal spermatozoa in obstructive azoospermia.
Steele EK, McClure N, Maxwell RJ, Lewis SE
Mol Hum Reprod 1999 Sep;5(9):831-5. doi: 10.1093/molehr/5.9.831. PMID: 10460221
The undescended testis: considerations and impact on fertility.
Leissner J, Filipas D, Wolf HK, Fisch M
BJU Int 1999 May;83(8):885-91; quiz 891-2. doi: 10.1046/j.1464-410x.1999.00093.x. PMID: 10368225
Relative force of human epididymal sperm.
Araujo E Jr, Tadir Y, Patrizio P, Ord T, Silber S, Berns MW, Asch RH
Fertil Steril 1994 Sep;62(3):585-90. PMID: 8062955
Micropenis associated with testicular agenesis.
Grant DB, Dillon MJ
Arch Dis Child 1975 Mar;50(3):247-9. doi: 10.1136/adc.50.3.247. PMID: 1147662Free PMC Article

Prognosis

Proximal Hypospadias and Acquired Cryptorchidism: Incidence, Morphology and Potential Clinical Implications.
D'Oro A, Rosoklija I, Yerkes EB, Lindgren BW, Rychlik K, Cheng EY
J Urol 2021 Nov;206(5):1291-1299. Epub 2021 Jul 12 doi: 10.1097/JU.0000000000001944. PMID: 34251872
Smooth muscle hyperplasia of the testicular adnexa: a clinicopathologic study of 12 cases.
Alruwaii F, Grignon DJ, Idrees MT
Hum Pathol 2020 May;99:27-35. Epub 2020 Mar 24 doi: 10.1016/j.humpath.2020.03.003. PMID: 32220606
Complete testicular epididymal dissociation in the abdominal cryptorchid testis.
Sharma S, Sen A
J Pediatr Urol 2013 Dec;9(6 Pt B):1023-7. Epub 2013 Jun 2 doi: 10.1016/j.jpurol.2013.02.017. PMID: 23735659
Papillary cystadenoma of the epididymis.
Odrzywolski KJ, Mukhopadhyay S
Arch Pathol Lab Med 2010 Apr;134(4):630-3. doi: 10.5858/134.4.630. PMID: 20367315
Incidence and structure of the appendices of the testis and epididymis.
Sahni D, Jit I, Joshi K, Sanjeev
J Anat 1996 Oct;189 ( Pt 2)(Pt 2):341-8. PMID: 8886956Free PMC Article

Clinical prediction guides

Proximal Hypospadias and Acquired Cryptorchidism: Incidence, Morphology and Potential Clinical Implications.
D'Oro A, Rosoklija I, Yerkes EB, Lindgren BW, Rychlik K, Cheng EY
J Urol 2021 Nov;206(5):1291-1299. Epub 2021 Jul 12 doi: 10.1097/JU.0000000000001944. PMID: 34251872
Ontogeny of estrogen receptors in human male and female fetal reproductive tracts.
Cunha GR, Li Y, Mei C, Derpinghaus A, Baskin LS
Differentiation 2021 Mar-Apr;118:107-131. Epub 2020 Oct 17 doi: 10.1016/j.diff.2020.10.001. PMID: 33176961Free PMC Article
Considerations in evaluating human spermatogenesis on the basis of total sperm per ejaculate.
Amann RP
J Androl 2009 Nov-Dec;30(6):626-41. Epub 2009 May 14 doi: 10.2164/jandrol.108.006817. PMID: 19443909
Genotype-phenotype correlations in families with deletions in the von Hippel-Lindau (VHL) gene.
Hes F, Zewald R, Peeters T, Sijmons R, Links T, Verheij J, Matthijs G, Leguis E, Mortier G, van der Torren K, Rosman M, Lips C, Pearson P, van der Luijt R
Hum Genet 2000 Apr;106(4):425-31. doi: 10.1007/s004390000265. PMID: 10830910
Clinical findings in congenital absence of the vasa deferentia.
Weiske WH, Sälzler N, Schroeder-Printzen I, Weidner W
Andrologia 2000 Jan;32(1):13-8. PMID: 10702861

Recent systematic reviews

Primary cilia: biosensors of the male reproductive tract.
Girardet L, Augière C, Asselin MP, Belleannée C
Andrology 2019 Sep;7(5):588-602. Epub 2019 May 26 doi: 10.1111/andr.12650. PMID: 31131532
Ultrasound of the male genital tract in relation to male reproductive health.
Lotti F, Maggi M
Hum Reprod Update 2015 Jan-Feb;21(1):56-83. Epub 2014 Jul 19 doi: 10.1093/humupd/dmu042. PMID: 25038770
WITHDRAWN: Androgens versus placebo or no treatment for idiopathic oligo/asthenospermia.
Vandekerckhove P, Lilford R, Vail A, Hughes E
Cochrane Database Syst Rev 2007 Jul 18;(4):CD000150. doi: 10.1002/14651858.CD000150. PMID: 17636603
Androgens versus placebo or no treatment for idiopathic oligo/asthenospermia.
Vandekerckhove P, Lilford R, Vail A, Hughes E
Cochrane Database Syst Rev 2000;1996(2):CD000150. doi: 10.1002/14651858.CD000150. PMID: 10796496Free PMC Article

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