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Abnormality of the parathyroid physiology

MedGen UID:
868793
•Concept ID:
C4023198
•
Disease or Syndrome
Synonyms: Parathyroid dysfunction; Parathyroid issue
 
HPO: HP:0011767

Definition

A functional abnormality of the parathyroid gland. [from HPO]

Professional guidelines

PubMed

Hypoparathyroidism: diagnosis, management and emerging therapies.
Khan S, Khan AA
Nat Rev Endocrinol 2025 Jun;21(6):360-374. Epub 2025 Feb 4 doi: 10.1038/s41574-024-01075-8. PMID: 39905273
Secondary Hyperparathyroidism: Pathogenesis and Latest Treatment.
Mizobuchi M, Ogata H, Koiwa F
Ther Apher Dial 2019 Aug;23(4):309-318. Epub 2018 Dec 18 doi: 10.1111/1744-9987.12772. PMID: 30411503
Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters.
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995

Recent clinical studies

Etiology

Immune Dysfunction and Risk of Infection in Chronic Kidney Disease.
Syed-Ahmed M, Narayanan M
Adv Chronic Kidney Dis 2019 Jan;26(1):8-15. doi: 10.1053/j.ackd.2019.01.004. PMID: 30876622
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV
Nat Rev Endocrinol 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. PMID: 30443043Free PMC Article
Bone imaging in hypoparathyroidism.
Silva BC, Rubin MR, Cusano NE, Bilezikian JP
Osteoporos Int 2017 Feb;28(2):463-471. Epub 2016 Aug 30 doi: 10.1007/s00198-016-3750-0. PMID: 27577725
Pathophysiology of Calcium, Phosphorus, and Magnesium Dysregulation in Chronic Kidney Disease.
Felsenfeld AJ, Levine BS, Rodriguez M
Semin Dial 2015 Nov-Dec;28(6):564-77. Epub 2015 Aug 25 doi: 10.1111/sdi.12411. PMID: 26303319
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537

Diagnosis

Chromosome 22q11.2 Deletion Syndrome: A Comprehensive Review of Molecular Genetics in the Context of Multidisciplinary Clinical Approach.
Szczawińska-Popłonyk A, Schwartzmann E, Chmara Z, Głukowska A, Krysa T, Majchrzycki M, Olejnicki M, Ostrowska P, Babik J
Int J Mol Sci 2023 May 5;24(9) doi: 10.3390/ijms24098317. PMID: 37176024Free PMC Article
Overview of the 2022 WHO Classification of Parathyroid Tumors.
Erickson LA, Mete O, Juhlin CC, Perren A, Gill AJ
Endocr Pathol 2022 Mar;33(1):64-89. Epub 2022 Feb 17 doi: 10.1007/s12022-022-09709-1. PMID: 35175514
DiGeorge syndrome: consider the diagnosis.
Altshuler E, Saidi A, Budd J
BMJ Case Rep 2022 Feb 2;15(2) doi: 10.1136/bcr-2021-245164. PMID: 35110278Free PMC Article
Primary hyperparathyroidism.
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Nat Rev Dis Primers 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33. PMID: 27194212Free PMC Article
Parathyroid imaging.
Johnson NA, Carty SE, Tublin ME
Radiol Clin North Am 2011 May;49(3):489-509, vi. doi: 10.1016/j.rcl.2011.02.009. PMID: 21569907

Therapy

Hypoparathyroidism: diagnosis, management and emerging therapies.
Khan S, Khan AA
Nat Rev Endocrinol 2025 Jun;21(6):360-374. Epub 2025 Feb 4 doi: 10.1038/s41574-024-01075-8. PMID: 39905273
Bone Disease in Chronic Kidney Disease and Kidney Transplant.
Bellorin-Font E, Rojas E, Martin KJ
Nutrients 2022 Dec 29;15(1) doi: 10.3390/nu15010167. PMID: 36615824Free PMC Article
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV
Nat Rev Endocrinol 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. PMID: 30443043Free PMC Article
Hypoparathyroidism.
Al-Azem H, Khan AA
Best Pract Res Clin Endocrinol Metab 2012 Aug;26(4):517-22. Epub 2012 May 31 doi: 10.1016/j.beem.2012.01.004. PMID: 22863393
Hypoparathyroidism and pseudohypoparathyroidism.
Maeda SS, Fortes EM, Oliveira UM, Borba VC, Lazaretti-Castro M
Arq Bras Endocrinol Metabol 2006 Aug;50(4):664-73. doi: 10.1590/s0004-27302006000400012. PMID: 17117292

Prognosis

Bone Disease in Chronic Kidney Disease and Kidney Transplant.
Bellorin-Font E, Rojas E, Martin KJ
Nutrients 2022 Dec 29;15(1) doi: 10.3390/nu15010167. PMID: 36615824Free PMC Article
Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV
Nat Rev Endocrinol 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. PMID: 30443043Free PMC Article
Primary hyperparathyroidism.
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Nat Rev Dis Primers 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33. PMID: 27194212Free PMC Article
Hyperparathyroidism.
Fraser WD
Lancet 2009 Jul 11;374(9684):145-58. doi: 10.1016/S0140-6736(09)60507-9. PMID: 19595349

Clinical prediction guides

Inflammation and gut dysbiosis as drivers of CKD-MBD.
Evenepoel P, Stenvinkel P, Shanahan C, Pacifici R
Nat Rev Nephrol 2023 Oct;19(10):646-657. Epub 2023 Jul 24 doi: 10.1038/s41581-023-00736-7. PMID: 37488276
Calcium homeostasis and hyperparathyroidism: Nephrologic and endocrinologic points of view.
Lemoine S, Figueres L, Bacchetta J, Frey S, Dubourg L
Ann Endocrinol (Paris) 2022 Aug;83(4):237-243. Epub 2022 May 19 doi: 10.1016/j.ando.2022.05.003. PMID: 35598638
Mineral Bone Abnormalities and Vascular Calcifications.
Ray M, Jovanovich A
Adv Chronic Kidney Dis 2019 Nov;26(6):409-416. doi: 10.1053/j.ackd.2019.09.004. PMID: 31831119
Primary hyperparathyroidism.
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Nat Rev Dis Primers 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33. PMID: 27194212Free PMC Article
Clinical uses of 1-alpha-hydroxycholecalciferol.
Vervloet M
Curr Vasc Pharmacol 2014 Mar;12(2):300-5. doi: 10.2174/15701611113119990132. PMID: 23713871

Recent systematic reviews

The effects of vitamin D and calcium on primary dysmenorrhea: a systematic review.
Donayeva A, Amanzholkyzy A, Abdelazim I, Saparbayev S, Nurgaliyeva R, Kaldybayeva A, Zhexenova A, Gubasheva G, Ayaganov D, Samaha I
J Med Life 2023 Nov;16(11):1597-1605. doi: 10.25122/jml-2023-0248. PMID: 38406773Free PMC Article
Restless Legs Syndrome in Chronic Kidney Disease- a Systematic Review.
Safarpour Y, Vaziri ND, Jabbari B
Tremor Other Hyperkinet Mov (N Y) 2023;13:10. Epub 2023 Mar 29 doi: 10.5334/tohm.752. PMID: 37008995Free PMC Article
Expanding the Phenotypic Spectrum of Kenny-Caffey Syndrome.
Schigt H, Bald M, van der Eerden BCJ, Gal L, Ilenwabor BP, Konrad M, Levine MA, Li D, Mache CJ, Mackin S, Perry C, Rios FJ, Schlingmann KP, Storey B, Trapp CM, Verkerk AJMH, Zillikens MC, Touyz RM, Hoorn EJ, Hoenderop JGJ, de Baaij JHF
J Clin Endocrinol Metab 2023 Aug 18;108(9):e754-e768. doi: 10.1210/clinem/dgad147. PMID: 36916904Free PMC Article
Mineral bone disorders in chronic kidney disease.
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Parathyroid hormone, cognitive function and dementia: a systematic review.
Lourida I, Thompson-Coon J, Dickens CM, Soni M, Kuźma E, Kos K, Llewellyn DJ
PLoS One 2015;10(5):e0127574. Epub 2015 May 26 doi: 10.1371/journal.pone.0127574. PMID: 26010883Free PMC Article

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