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Reduced CSF lactate

MedGen UID:
868263
•Concept ID:
C4022655
•
Finding
Synonym: Hypolactatorachia
 
HPO: HP:0030086

Definition

Decreased concentration of lactate in the cerebrospinal fluid. [from HPO]

Professional guidelines

PubMed

Pathogenesis-driven treatment of primary pulmonary alveolar proteinosis.
Lettieri S, Bonella F, Marando VA, Franciosi AN, Corsico AG, Campo I
Eur Respir Rev 2024 Jul;33(173) Epub 2024 Aug 14 doi: 10.1183/16000617.0064-2024. PMID: 39142709Free PMC Article
Cerebro-spinal fluid glucose and lactate concentrations changes in response to therapies in patIents with primary brain injury: the START-TRIP study.
Gouvêa Bogossian E, Taleb C, Aspide R, Badenes R, Battaglini D, Bilotta F, Blandino Ortiz A, Caricato A, Castioni CA, Citerio G, Ferraro G, Martino C, Melchionda I, Montanaro F, Monleon Lopez B, Nato CG, Piagnerelli M, Picetti E, Robba C, Simonet O, Thooft A, Taccone FS
Crit Care 2023 Mar 31;27(1):130. doi: 10.1186/s13054-023-04409-6. PMID: 37004053Free PMC Article
Management of Non-Hodgkin Lymphoma: ICMR Consensus Document.
Thacker N, Bakhshi S, Chinnaswamy G, Vora T, Prasad M, Bansal D, Agarwala S, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Dhaliwal RS, Arora B
Indian J Pediatr 2017 May;84(5):382-392. Epub 2017 Apr 5 doi: 10.1007/s12098-017-2318-0. PMID: 28378140

Recent clinical studies

Etiology

Novel cerebrospinal fluid biomarkers of glucose transporter type 1 deficiency syndrome: Implications beyond the brain's energy deficit.
Peters TMA, Merx J, Kooijman PC, Noga M, de Boer S, van Gemert LA, Salden G, Engelke UFH, Lefeber DJ, van Outersterp RE, Berden G, Boltje TJ, Artuch R, Pías-Peleteiro L, García-Cazorla Á, Barić I, Thöny B, Oomens J, Martens J, Wevers RA, Verbeek MM, Coene KLM, Willemsen MAAP
J Inherit Metab Dis 2023 Jan;46(1):66-75. Epub 2022 Oct 17 doi: 10.1002/jimd.12554. PMID: 36088537Free PMC Article
Cerebrospinal fluid levels of L-glutamate signal central inflammatory neurodegeneration in multiple sclerosis.
Stampanoni Bassi M, Nuzzo T, Gilio L, Miroballo M, Casamassa A, Buttari F, Bellantonio P, Fantozzi R, Galifi G, Furlan R, Finardi A, De Rosa A, Di Maio A, Errico F, Centonze D, Usiello A
J Neurochem 2021 Dec;159(5):857-866. Epub 2021 Oct 9 doi: 10.1111/jnc.15518. PMID: 34547109
Management of Non-Hodgkin Lymphoma: ICMR Consensus Document.
Thacker N, Bakhshi S, Chinnaswamy G, Vora T, Prasad M, Bansal D, Agarwala S, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Dhaliwal RS, Arora B
Indian J Pediatr 2017 May;84(5):382-392. Epub 2017 Apr 5 doi: 10.1007/s12098-017-2318-0. PMID: 28378140
How do I perform a lumbar puncture and analyze the results to diagnose bacterial meningitis?
Straus SE, Thorpe KE, Holroyd-Leduc J
JAMA 2006 Oct 25;296(16):2012-22. doi: 10.1001/jama.296.16.2012. PMID: 17062865
Stress responsive neurohormones in depression and anxiety.
Ströhle A, Holsboer F
Pharmacopsychiatry 2003 Nov;36 Suppl 3:S207-14. doi: 10.1055/s-2003-45132. PMID: 14677081

Diagnosis

Pathogenesis-driven treatment of primary pulmonary alveolar proteinosis.
Lettieri S, Bonella F, Marando VA, Franciosi AN, Corsico AG, Campo I
Eur Respir Rev 2024 Jul;33(173) Epub 2024 Aug 14 doi: 10.1183/16000617.0064-2024. PMID: 39142709Free PMC Article
How and when to use CSF to investigate neonates and children with possible central nervous system infection.
Winzor G, Atabani SF
Arch Dis Child Educ Pract Ed 2022 Feb;107(1):50-56. Epub 2021 Mar 19 doi: 10.1136/archdischild-2020-321242. PMID: 33741654
Management of Non-Hodgkin Lymphoma: ICMR Consensus Document.
Thacker N, Bakhshi S, Chinnaswamy G, Vora T, Prasad M, Bansal D, Agarwala S, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Dhaliwal RS, Arora B
Indian J Pediatr 2017 May;84(5):382-392. Epub 2017 Apr 5 doi: 10.1007/s12098-017-2318-0. PMID: 28378140
Barth syndrome.
Clarke SL, Bowron A, Gonzalez IL, Groves SJ, Newbury-Ecob R, Clayton N, Martin RP, Tsai-Goodman B, Garratt V, Ashworth M, Bowen VM, McCurdy KR, Damin MK, Spencer CT, Toth MJ, Kelley RI, Steward CG
Orphanet J Rare Dis 2013 Feb 12;8:23. doi: 10.1186/1750-1172-8-23. PMID: 23398819Free PMC Article
Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis.
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
J Infect 2011 Apr;62(4):255-62. Epub 2011 Mar 5 doi: 10.1016/j.jinf.2011.02.010. PMID: 21382412

Therapy

Long-term CSF responses in adult patients with spinal muscular atrophy type 2 or 3 on treatment with nusinersen.
Cebulla G, Hai L, Warnken U, Güngör C, Hoffmann DC, Korporal-Kuhnke M, Wildemann B, Wick W, Kessler T, Weiler M
J Neurol 2025 Mar 14;272(4):270. doi: 10.1007/s00415-025-12984-7. PMID: 40085221Free PMC Article
The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status.
Dumbuya JS, Chen L, Wu JY, Wang B
J Neuroinflammation 2021 Feb 21;18(1):55. doi: 10.1186/s12974-021-02084-4. PMID: 33612099Free PMC Article
Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment.
Nagpal R, Neth BJ, Wang S, Craft S, Yadav H
EBioMedicine 2019 Sep;47:529-542. Epub 2019 Aug 30 doi: 10.1016/j.ebiom.2019.08.032. PMID: 31477562Free PMC Article
Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis.
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
J Infect 2011 Apr;62(4):255-62. Epub 2011 Mar 5 doi: 10.1016/j.jinf.2011.02.010. PMID: 21382412
How do I perform a lumbar puncture and analyze the results to diagnose bacterial meningitis?
Straus SE, Thorpe KE, Holroyd-Leduc J
JAMA 2006 Oct 25;296(16):2012-22. doi: 10.1001/jama.296.16.2012. PMID: 17062865

Prognosis

Long-term CSF responses in adult patients with spinal muscular atrophy type 2 or 3 on treatment with nusinersen.
Cebulla G, Hai L, Warnken U, Güngör C, Hoffmann DC, Korporal-Kuhnke M, Wildemann B, Wick W, Kessler T, Weiler M
J Neurol 2025 Mar 14;272(4):270. doi: 10.1007/s00415-025-12984-7. PMID: 40085221Free PMC Article
Cerebrospinal fluid levels of L-glutamate signal central inflammatory neurodegeneration in multiple sclerosis.
Stampanoni Bassi M, Nuzzo T, Gilio L, Miroballo M, Casamassa A, Buttari F, Bellantonio P, Fantozzi R, Galifi G, Furlan R, Finardi A, De Rosa A, Di Maio A, Errico F, Centonze D, Usiello A
J Neurochem 2021 Dec;159(5):857-866. Epub 2021 Oct 9 doi: 10.1111/jnc.15518. PMID: 34547109
Could Cerebrospinal Fluid Biomarkers Offer Better Predictive Value for Spinal Cord Ischaemia Than Current Neuromonitoring Techniques During Thoracoabdominal Aortic Aneurysm Repair - A Systematic Review.
Harky A, Fok M, Fraser H, Howard C, Rimmer L, Bashir M
Braz J Cardiovasc Surg 2019 Aug 27;34(4):464-471. doi: 10.21470/1678-9741-2018-0375. PMID: 31454201Free PMC Article
A systematic literature review of cerebrospinal fluid biomarkers in delirium.
Hall RJ, Shenkin SD, Maclullich AM
Dement Geriatr Cogn Disord 2011;32(2):79-93. Epub 2011 Aug 26 doi: 10.1159/000330757. PMID: 21876357
Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis.
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
J Infect 2011 Apr;62(4):255-62. Epub 2011 Mar 5 doi: 10.1016/j.jinf.2011.02.010. PMID: 21382412

Clinical prediction guides

Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer.
Naik A, Thomas R, Al-Khalifa A, Qasem H, Decock J
Cell Commun Signal 2025 Mar 19;23(1):145. doi: 10.1186/s12964-025-02139-6. PMID: 40108668Free PMC Article
Cerebrospinal Fluid and Arterial Acid-Base Equilibrium of Spontaneously Breathing Patients with Aneurismal Subarachnoid Hemorrhage.
Langer T, Zadek F, Carbonara M, Caccioppola A, Brusatori S, Zoerle T, Bottazzini F, Ferraris Fusarini C, di Modugno A, Zanella A, Zanier ER, Fumagalli R, Pesenti A, Stocchetti N
Neurocrit Care 2022 Aug;37(1):102-110. Epub 2022 Feb 23 doi: 10.1007/s12028-022-01450-1. PMID: 35199305Free PMC Article
Could Cerebrospinal Fluid Biomarkers Offer Better Predictive Value for Spinal Cord Ischaemia Than Current Neuromonitoring Techniques During Thoracoabdominal Aortic Aneurysm Repair - A Systematic Review.
Harky A, Fok M, Fraser H, Howard C, Rimmer L, Bashir M
Braz J Cardiovasc Surg 2019 Aug 27;34(4):464-471. doi: 10.21470/1678-9741-2018-0375. PMID: 31454201Free PMC Article
A systematic literature review of cerebrospinal fluid biomarkers in delirium.
Hall RJ, Shenkin SD, Maclullich AM
Dement Geriatr Cogn Disord 2011;32(2):79-93. Epub 2011 Aug 26 doi: 10.1159/000330757. PMID: 21876357
Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis.
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
J Infect 2011 Apr;62(4):255-62. Epub 2011 Mar 5 doi: 10.1016/j.jinf.2011.02.010. PMID: 21382412

Recent systematic reviews

Could Cerebrospinal Fluid Biomarkers Offer Better Predictive Value for Spinal Cord Ischaemia Than Current Neuromonitoring Techniques During Thoracoabdominal Aortic Aneurysm Repair - A Systematic Review.
Harky A, Fok M, Fraser H, Howard C, Rimmer L, Bashir M
Braz J Cardiovasc Surg 2019 Aug 27;34(4):464-471. doi: 10.21470/1678-9741-2018-0375. PMID: 31454201Free PMC Article
A systematic literature review of cerebrospinal fluid biomarkers in delirium.
Hall RJ, Shenkin SD, Maclullich AM
Dement Geriatr Cogn Disord 2011;32(2):79-93. Epub 2011 Aug 26 doi: 10.1159/000330757. PMID: 21876357

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