U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Difficulty walking

MedGen UID:
86319
•Concept ID:
C0311394
•
Finding
Synonyms: Ambulation Difficulties; Ambulation Difficulty; Ambulatory Difficulties; Ambulatory Difficulty; Difficulties, Ambulation; Difficulties, Ambulatory; Difficulty Ambulation; Difficulty Walking; Difficulty, Ambulation; Walking, Difficulty
SNOMED CT: Difficulty walking (719232003)

Definition

Any persistent problem with walking. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDifficulty walking

Professional guidelines

PubMed

Eteplirsen Treatment for Duchenne Muscular Dystrophy: A Qualitative Patient Experience Study.
Iff J, Carmichael C, McKee S, Sehinovych I, McNeill C, Tesi-Rocha C, Henricson E, Muntoni F, Kitchen H
Adv Ther 2024 Aug;41(8):3278-3298. Epub 2024 Jul 3 doi: 10.1007/s12325-024-02915-9. PMID: 38958840Free PMC Article
Screening for Chemotherapy-induced Peripheral Neuropathy and Utilization of Physical Therapy in Pediatric Patients Receiving Treatment for Hematologic Malignancies.
Wang CP, Syrkin-Nikolau M, Farnaes L, Shen D, Kanegaye M, Kuo DJ
J Pediatr Hematol Oncol 2022 Mar 1;44(2):e358-e361. doi: 10.1097/MPH.0000000000002202. PMID: 34001791
Disease course and treatment patterns in progressive supranuclear palsy: A real-world study.
Morgan JC, Ye X, Mellor JA, Golden KJ, Zamudio J, Chiodo LA, Bao Y, Xie T
J Neurol Sci 2021 Feb 15;421:117293. Epub 2020 Dec 25 doi: 10.1016/j.jns.2020.117293. PMID: 33385754

Recent clinical studies

Etiology

Development and External Validation of a Mortality Prediction Model for Community-Dwelling Older Adults With Dementia.
Deardorff WJ, Barnes DE, Jeon SY, Boscardin WJ, Langa KM, Covinsky KE, Mitchell SL, Whitlock EL, Smith AK, Lee SJ
JAMA Intern Med 2022 Nov 1;182(11):1161-1170. doi: 10.1001/jamainternmed.2022.4326. PMID: 36156062Free PMC Article
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD
Drugs Aging 2022 Jul;39(7):523-550. Epub 2022 Jun 27 doi: 10.1007/s40266-022-00946-x. PMID: 35754070
Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke.
Barclay RE, Stevenson TJ, Poluha W, Semenko B, Schubert J
Cochrane Database Syst Rev 2020 May 25;5(5):CD005950. doi: 10.1002/14651858.CD005950.pub5. PMID: 32449959Free PMC Article
Stroke.
Mansfield A, Inness EL, Mcilroy WE
Handb Clin Neurol 2018;159:205-228. doi: 10.1016/B978-0-444-63916-5.00013-6. PMID: 30482315
Locomotive syndrome: clinical perspectives.
Ikemoto T, Arai YC
Clin Interv Aging 2018;13:819-827. Epub 2018 Apr 30 doi: 10.2147/CIA.S148683. PMID: 29750024Free PMC Article

Diagnosis

Neurocysticercosis: diagnosis via metagenomic next-generation sequencing.
Pedrosa DA, Bruniera Peres Fernandes G, Filipe de Souza Godoy L, C Felício A, Pinho JR, Mário Doi A, de Araújo Gleizer R
Pract Neurol 2023 Nov 23;23(6):509-511. doi: 10.1136/pn-2023-003795. PMID: 37468299
Conceptual assessment of HRQOL among Japanese non-metastatic castration-resistant prostate cancer (nmCRPC) patients.
Nishimura K, Shiota M, Eto M, Satoh T, Stroupe A, Seo C, Uzumcu A, Ledesma DA
Cancer Med 2023 Jan;12(2):1762-1778. Epub 2022 Jun 30 doi: 10.1002/cam4.4955. PMID: 35770744Free PMC Article
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD
Drugs Aging 2022 Jul;39(7):523-550. Epub 2022 Jun 27 doi: 10.1007/s40266-022-00946-x. PMID: 35754070
Phosphaturic Mesenchymal Tumor.
Benson JC, Trejo-Lopez JA, Nassiri AM, Eschbacher K, Link MJ, Driscoll CL, Tiegs RD, Sfeir J, DeLone DR
AJNR Am J Neuroradiol 2022 Jun;43(6):817-822. Epub 2022 May 19 doi: 10.3174/ajnr.A7513. PMID: 35589138Free PMC Article
Locomotive syndrome: clinical perspectives.
Ikemoto T, Arai YC
Clin Interv Aging 2018;13:819-827. Epub 2018 Apr 30 doi: 10.2147/CIA.S148683. PMID: 29750024Free PMC Article

Therapy

Covid-19 vaccines and neurological complications: a systematic review.
Allahyari F, Molaee H, Hosseini Nejad J
Z Naturforsch C J Biosci 2023 Jan 27;78(1-2):1-8. Epub 2022 Sep 12 doi: 10.1515/znc-2022-0092. PMID: 36087300
Tantali fibromyalgic supplicium: Is there any relief with the antidepressant employment? A systematic review.
Ilari S, Passacatini LC, Malafoglia V, Oppedisano F, Maiuolo J, Gliozzi M, Palma E, Tomino C, Fini M, Raffaeli W, Mollace V, Muscoli C
Pharmacol Res 2022 Dec;186:106547. Epub 2022 Nov 4 doi: 10.1016/j.phrs.2022.106547. PMID: 36336218
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD
Drugs Aging 2022 Jul;39(7):523-550. Epub 2022 Jun 27 doi: 10.1007/s40266-022-00946-x. PMID: 35754070
Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke.
Barclay RE, Stevenson TJ, Poluha W, Semenko B, Schubert J
Cochrane Database Syst Rev 2020 May 25;5(5):CD005950. doi: 10.1002/14651858.CD005950.pub5. PMID: 32449959Free PMC Article
Carbofuran-induced delayed neuropathy.
Yang PY, Tsao TC, Lin JL, Lyu RK, Chiang PC
J Toxicol Clin Toxicol 2000;38(1):43-6. doi: 10.1081/clt-100100914. PMID: 10696923

Prognosis

Development and External Validation of a Mortality Prediction Model for Community-Dwelling Older Adults With Dementia.
Deardorff WJ, Barnes DE, Jeon SY, Boscardin WJ, Langa KM, Covinsky KE, Mitchell SL, Whitlock EL, Smith AK, Lee SJ
JAMA Intern Med 2022 Nov 1;182(11):1161-1170. doi: 10.1001/jamainternmed.2022.4326. PMID: 36156062Free PMC Article
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD
Drugs Aging 2022 Jul;39(7):523-550. Epub 2022 Jun 27 doi: 10.1007/s40266-022-00946-x. PMID: 35754070
A Narrative Review on Measurement Properties of Fixed-distance Walk Tests Up to 40 Meters for Adults With Knee Osteoarthritis.
Master H, Coleman G, Dobson F, Bennell K, Hinman RS, Jakiela JT, White DK
J Rheumatol 2021 May;48(5):638-647. Epub 2020 Oct 15 doi: 10.3899/jrheum.200771. PMID: 33060316
Impact of Osteoarthritis on Difficulty Walking: A Population-Based Study.
King LK, Kendzerska T, Waugh EJ, Hawker GA
Arthritis Care Res (Hoboken) 2018 Jan;70(1):71-79. Epub 2017 Dec 15 doi: 10.1002/acr.23250. PMID: 28513082
Septic sacroiliitis.
Osman AA, Govender S
Clin Orthop Relat Res 1995 Apr;(313):214-9. PMID: 7641483

Clinical prediction guides

Current status and challenges of percutaneous vertebroplasty (PVP).
Noguchi T, Yamashita K, Kamei R, Maehara J
Jpn J Radiol 2023 Jan;41(1):1-13. Epub 2022 Aug 9 doi: 10.1007/s11604-022-01322-w. PMID: 35943687Free PMC Article
Development and External Validation of a Mortality Prediction Model for Community-Dwelling Older Adults With Dementia.
Deardorff WJ, Barnes DE, Jeon SY, Boscardin WJ, Langa KM, Covinsky KE, Mitchell SL, Whitlock EL, Smith AK, Lee SJ
JAMA Intern Med 2022 Nov 1;182(11):1161-1170. doi: 10.1001/jamainternmed.2022.4326. PMID: 36156062Free PMC Article
Improvement in walking impairment following surgical and endovascular revascularization: Insights from VOYAGER PAD.
Hogan SE, Nehler MR, Anand S, Patel MR, Debus S, Jackson MT, Buchanan C, King RW, Hess C, Muehlhofer E, Haskell LP, Bauersachs RM, Berkowitz SD, Hsia J, Bonaca MP
Vasc Med 2022 Aug;27(4):343-349. Epub 2022 Apr 25 doi: 10.1177/1358863X221085606. PMID: 35467452
Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke.
Barclay RE, Stevenson TJ, Poluha W, Semenko B, Schubert J
Cochrane Database Syst Rev 2020 May 25;5(5):CD005950. doi: 10.1002/14651858.CD005950.pub5. PMID: 32449959Free PMC Article
Osteoarthritis-related difficulty walking and risk for diabetes complications.
Hawker GA, Croxford R, Bierman AS, Harvey P, Ravi B, Kendzerska T, Stanaitis I, King LK, Lipscombe L
Osteoarthritis Cartilage 2017 Jan;25(1):67-75. Epub 2016 Aug 16 doi: 10.1016/j.joca.2016.08.003. PMID: 27539890

Recent systematic reviews

Safety and efficacy of unilateral focused ultrasound pallidotomy on motor complications in Parkinson's disease (PD): a systematic review and meta-analysis.
Abbas A, Hassan MA, Shaheen RS, Hussein A, Moawad MHED, Meshref M, Raslan AM
Neurol Sci 2024 Oct;45(10):4687-4698. Epub 2024 Jun 6 doi: 10.1007/s10072-024-07617-2. PMID: 38842771Free PMC Article
Covid-19 vaccines and neurological complications: a systematic review.
Allahyari F, Molaee H, Hosseini Nejad J
Z Naturforsch C J Biosci 2023 Jan 27;78(1-2):1-8. Epub 2022 Sep 12 doi: 10.1515/znc-2022-0092. PMID: 36087300
Tantali fibromyalgic supplicium: Is there any relief with the antidepressant employment? A systematic review.
Ilari S, Passacatini LC, Malafoglia V, Oppedisano F, Maiuolo J, Gliozzi M, Palma E, Tomino C, Fini M, Raffaeli W, Mollace V, Muscoli C
Pharmacol Res 2022 Dec;186:106547. Epub 2022 Nov 4 doi: 10.1016/j.phrs.2022.106547. PMID: 36336218
Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke.
Barclay RE, Stevenson TJ, Poluha W, Semenko B, Schubert J
Cochrane Database Syst Rev 2020 May 25;5(5):CD005950. doi: 10.1002/14651858.CD005950.pub5. PMID: 32449959Free PMC Article
Feasibility of designing, manufacturing and delivering 3D printed ankle-foot orthoses: a systematic review.
Wojciechowski E, Chang AY, Balassone D, Ford J, Cheng TL, Little D, Menezes MP, Hogan S, Burns J
J Foot Ankle Res 2019;12:11. Epub 2019 Feb 7 doi: 10.1186/s13047-019-0321-6. PMID: 30774718Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...