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Pneumonia caused by methicillin resistant Staphylococcus aureus

MedGen UID:
853161
•Concept ID:
C1142536
•
Disease or Syndrome
Synonyms: Methicillin-Resistant Staphylococcus aureus Pneumonia; MRSA Pneumonia
SNOMED CT: Pneumonia caused by methicillin resistant Staphylococcus aureus (124691000119101)

Definition

Pneumonia that is caused by Staphylococcus aureus that is resistant to methicillin treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPneumonia caused by methicillin resistant Staphylococcus aureus

Professional guidelines

PubMed

Pharmacodynamics, pharmacokinetics and clinical efficacy of telavancin in the treatment of pneumonia.
Adamantia L, Antoni T
Expert Opin Drug Metab Toxicol 2016 Jul;12(7):803-12. Epub 2016 May 30 doi: 10.1080/17425255.2016.1187599. PMID: 27158752
Current review of antimicrobial treatment of nosocomial pneumonia caused by multidrug-resistant pathogens.
Jean SS, Hsueh PR
Expert Opin Pharmacother 2011 Oct;12(14):2145-8. doi: 10.1517/14656566.2011.599320. PMID: 21895553
Treatment of hospital-acquired pneumonia caused by methicillin-resistant Staphylococcus aureus.
Ferrara AM
Int J Antimicrob Agents 2007 Jul;30(1):19-24. Epub 2007 May 1 doi: 10.1016/j.ijantimicag.2007.02.011. PMID: 17475449

Recent clinical studies

Etiology

Infectious Pulmonary Diseases.
Rafeq R, Igneri LA
Infect Dis Clin North Am 2024 Mar;38(1):1-17. doi: 10.1016/j.idc.2023.12.006. PMID: 38280758
Infectious Pulmonary Diseases.
Rafeq R, Igneri LA
Emerg Med Clin North Am 2022 Aug;40(3):503-518. Epub 2022 Jul 9 doi: 10.1016/j.emc.2022.05.005. PMID: 35953214
Staphylococcus aureus Pneumonia in the Community.
He H, Wunderink RG
Semin Respir Crit Care Med 2020 Aug;41(4):470-479. Epub 2020 Jun 10 doi: 10.1055/s-0040-1709992. PMID: 32521547
The Clinical Utility of Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Screening to Rule Out MRSA Pneumonia: A Diagnostic Meta-analysis With Antimicrobial Stewardship Implications.
Parente DM, Cunha CB, Mylonakis E, Timbrook TT
Clin Infect Dis 2018 Jun 18;67(1):1-7. doi: 10.1093/cid/ciy024. PMID: 29340593
Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus: Does Vancomycin Heteroresistance Matter?
Claeys KC, Lagnf AM, Hallesy JA, Compton MT, Gravelin AL, Davis SL, Rybak MJ
Antimicrob Agents Chemother 2016 Jan 4;60(3):1708-16. doi: 10.1128/AAC.02388-15. PMID: 26729497Free PMC Article

Diagnosis

Infectious Pulmonary Diseases.
Rafeq R, Igneri LA
Infect Dis Clin North Am 2024 Mar;38(1):1-17. doi: 10.1016/j.idc.2023.12.006. PMID: 38280758
Systematic review of ceftaroline fosamil in the management of patients with methicillin-resistant Staphylococcus aureus pneumonia.
Torres A, Kuraieva A, Stone GG, Cillóniz C
Eur Respir Rev 2023 Dec 31;32(170) Epub 2023 Oct 18 doi: 10.1183/16000617.0117-2023. PMID: 37852658Free PMC Article
Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus.
Guo Y, Song G, Sun M, Wang J, Wang Y
Front Cell Infect Microbiol 2020;10:107. Epub 2020 Mar 17 doi: 10.3389/fcimb.2020.00107. PMID: 32257966Free PMC Article
Linezolid: a review of its properties, function, and use in critical care.
Hashemian SMR, Farhadi T, Ganjparvar M
Drug Des Devel Ther 2018;12:1759-1767. Epub 2018 Jun 18 doi: 10.2147/DDDT.S164515. PMID: 29950810Free PMC Article
The Clinical Utility of Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Screening to Rule Out MRSA Pneumonia: A Diagnostic Meta-analysis With Antimicrobial Stewardship Implications.
Parente DM, Cunha CB, Mylonakis E, Timbrook TT
Clin Infect Dis 2018 Jun 18;67(1):1-7. doi: 10.1093/cid/ciy024. PMID: 29340593

Therapy

Infectious Pulmonary Diseases.
Rafeq R, Igneri LA
Infect Dis Clin North Am 2024 Mar;38(1):1-17. doi: 10.1016/j.idc.2023.12.006. PMID: 38280758
Systematic review of ceftaroline fosamil in the management of patients with methicillin-resistant Staphylococcus aureus pneumonia.
Torres A, Kuraieva A, Stone GG, Cillóniz C
Eur Respir Rev 2023 Dec 31;32(170) Epub 2023 Oct 18 doi: 10.1183/16000617.0117-2023. PMID: 37852658Free PMC Article
Staphylococcus aureus Pneumonia in the Community.
He H, Wunderink RG
Semin Respir Crit Care Med 2020 Aug;41(4):470-479. Epub 2020 Jun 10 doi: 10.1055/s-0040-1709992. PMID: 32521547
Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus.
Guo Y, Song G, Sun M, Wang J, Wang Y
Front Cell Infect Microbiol 2020;10:107. Epub 2020 Mar 17 doi: 10.3389/fcimb.2020.00107. PMID: 32257966Free PMC Article
Linezolid: a review of its properties, function, and use in critical care.
Hashemian SMR, Farhadi T, Ganjparvar M
Drug Des Devel Ther 2018;12:1759-1767. Epub 2018 Jun 18 doi: 10.2147/DDDT.S164515. PMID: 29950810Free PMC Article

Prognosis

Community-genotype methicillin-resistant Staphylococcus aureus skin and soft tissue infections in Latin America: a systematic review.
Leme RCP, Bispo PJM, Salles MJ
Braz J Infect Dis 2021 Jan-Feb;25(1):101539. Epub 2021 Feb 16 doi: 10.1016/j.bjid.2021.101539. PMID: 33607082Free PMC Article
Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics.
Rao GG, Konicki R, Cattaneo D, Alffenaar JW, Marriott DJE, Neely M; IATDMCT Antimicrobial Scientific Committee
Ther Drug Monit 2020 Feb;42(1):83-92. doi: 10.1097/FTD.0000000000000710. PMID: 31652190
The Clinical Utility of Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Screening to Rule Out MRSA Pneumonia: A Diagnostic Meta-analysis With Antimicrobial Stewardship Implications.
Parente DM, Cunha CB, Mylonakis E, Timbrook TT
Clin Infect Dis 2018 Jun 18;67(1):1-7. doi: 10.1093/cid/ciy024. PMID: 29340593
Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus: Does Vancomycin Heteroresistance Matter?
Claeys KC, Lagnf AM, Hallesy JA, Compton MT, Gravelin AL, Davis SL, Rybak MJ
Antimicrob Agents Chemother 2016 Jan 4;60(3):1708-16. doi: 10.1128/AAC.02388-15. PMID: 26729497Free PMC Article
Epidemiology and outcome of pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) in Canadian hospitals.
Tadros M, Williams V, Coleman BL, McGeer AJ, Haider S, Lee C, Iacovides H, Rubinstein E, John M, Johnston L, McNeil S, Katz K, Laffin N, Suh KN, Powis J, Smith S, Taylor G, Watt C, Simor AE
PLoS One 2013;8(9):e75171. Epub 2013 Sep 17 doi: 10.1371/journal.pone.0075171. PMID: 24069391Free PMC Article

Clinical prediction guides

Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics.
Rao GG, Konicki R, Cattaneo D, Alffenaar JW, Marriott DJE, Neely M; IATDMCT Antimicrobial Scientific Committee
Ther Drug Monit 2020 Feb;42(1):83-92. doi: 10.1097/FTD.0000000000000710. PMID: 31652190
The Clinical Utility of Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Screening to Rule Out MRSA Pneumonia: A Diagnostic Meta-analysis With Antimicrobial Stewardship Implications.
Parente DM, Cunha CB, Mylonakis E, Timbrook TT
Clin Infect Dis 2018 Jun 18;67(1):1-7. doi: 10.1093/cid/ciy024. PMID: 29340593
The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis.
Klein EY, Monteforte B, Gupta A, Jiang W, May L, Hsieh YH, Dugas A
Influenza Other Respir Viruses 2016 Sep;10(5):394-403. Epub 2016 Jun 24 doi: 10.1111/irv.12398. PMID: 27232677Free PMC Article
Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus: Does Vancomycin Heteroresistance Matter?
Claeys KC, Lagnf AM, Hallesy JA, Compton MT, Gravelin AL, Davis SL, Rybak MJ
Antimicrob Agents Chemother 2016 Jan 4;60(3):1708-16. doi: 10.1128/AAC.02388-15. PMID: 26729497Free PMC Article
Cefditoren pivoxil.
Darkes MJ, Plosker GL
Drugs 2002;62(2):319-36; discussion 337-8. doi: 10.2165/00003495-200262020-00006. PMID: 11817976

Recent systematic reviews

Systematic review of ceftaroline fosamil in the management of patients with methicillin-resistant Staphylococcus aureus pneumonia.
Torres A, Kuraieva A, Stone GG, Cillóniz C
Eur Respir Rev 2023 Dec 31;32(170) Epub 2023 Oct 18 doi: 10.1183/16000617.0117-2023. PMID: 37852658Free PMC Article
Community-genotype methicillin-resistant Staphylococcus aureus skin and soft tissue infections in Latin America: a systematic review.
Leme RCP, Bispo PJM, Salles MJ
Braz J Infect Dis 2021 Jan-Feb;25(1):101539. Epub 2021 Feb 16 doi: 10.1016/j.bjid.2021.101539. PMID: 33607082Free PMC Article
Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics.
Rao GG, Konicki R, Cattaneo D, Alffenaar JW, Marriott DJE, Neely M; IATDMCT Antimicrobial Scientific Committee
Ther Drug Monit 2020 Feb;42(1):83-92. doi: 10.1097/FTD.0000000000000710. PMID: 31652190
Community-acquired pneumonia caused by methicillin-resistant Staphylococcus aureus in critically-ill patients: systematic review.
Carballo N, De Antonio-Cuscó M, Echeverría-Esnal D, Luque S, Salas E, Grau S
Farm Hosp 2017 Mar 1;41(2):187-203. doi: 10.7399/fh.2017.41.2.10591. PMID: 28236797
The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis.
Klein EY, Monteforte B, Gupta A, Jiang W, May L, Hsieh YH, Dugas A
Influenza Other Respir Viruses 2016 Sep;10(5):394-403. Epub 2016 Jun 24 doi: 10.1111/irv.12398. PMID: 27232677Free PMC Article

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