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Lemierre syndrome

MedGen UID:
83364
•Concept ID:
C0343525
•
Disease or Syndrome
Synonyms: Disease, Lemierre; Disease, Lemierre's; Lemierre Disease; Lemierre Syndrome; Lemierre's Disease; Lemierre's Syndrome; Lemierres Disease; Lemierres Syndrome; Postanginal Sepses; Postanginal Sepsis; Sepses, Postanginal; Sepsis, Postanginal; Syndrome, Lemierre; Syndrome, Lemierre's
SNOMED CT: Septic phlebitis of internal jugular vein (1231140009); Lemierre syndrome (1231140009); Postanginal sepsis secondary to oropharyngeal infection (1231140009); Lemierre postanginal sepsis (1231140009)

Definition

A rare potentially lethal oropharyngeal infectious disease occurring in immunocompetent adolescents and young adults that is mainly due to Fusobacterium necrophorum and with characteristics of septic thrombophlebitis of the internal jugular vein that leads to septic usually pulmonary embolism, associated with ENT (ear, nose, and throat) infection that manifests with fever, neck pain and tonsillopharyngitis. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLemierre syndrome
Follow this link to review classifications for Lemierre syndrome in Orphanet.

Professional guidelines

PubMed

Management of Lemierre Syndrome.
Valerio L, Pleming W, Pecci A, Barco S
Minerva Med 2021 Dec;112(6):726-739. Epub 2021 May 14 doi: 10.23736/S0026-4806.21.07497-8. PMID: 33988011
Management of pediatric head and neck infections in the emergency department.
Abudinen-Vasquez S, Marin MN
Pediatr Emerg Med Pract 2020 Nov;17(11):1-24. Epub 2020 Nov 2 PMID: 33105074
Lemierre's syndrome in the pediatric population: Trends in disease presentation and management in literature.
Patel PN, Levi JR, Cohen MB
Int J Pediatr Otorhinolaryngol 2020 Sep;136:110213. Epub 2020 Jun 23 doi: 10.1016/j.ijporl.2020.110213. PMID: 32797805

Recent clinical studies

Etiology

High risk and low prevalence diseases: Lemierre's syndrome.
Carius BM, Koyfman A, Long B
Am J Emerg Med 2022 Nov;61:98-104. Epub 2022 Aug 30 doi: 10.1016/j.ajem.2022.08.050. PMID: 36058204
Fusobacterium necrophorum oral infections - A need for guidance.
Centor RM, Atkinson TP, Xiao L
Anaerobe 2022 Jun;75:102532. Epub 2022 Feb 2 doi: 10.1016/j.anaerobe.2022.102532. PMID: 35122953
Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death: an analysis of 712 cases.
Valerio L, Zane F, Sacco C, Granziera S, Nicoletti T, Russo M, Corsi G, Holm K, Hotz MA, Righini C, Karkos PD, Mahmoudpour SH, Kucher N, Verhamme P, Di Nisio M, Centor RM, Konstantinides SV, Pecci A, Barco S
J Intern Med 2021 Mar;289(3):325-339. Epub 2020 Jun 18 doi: 10.1111/joim.13114. PMID: 32445216
Lemierre's syndrome in the pediatric population: Trends in disease presentation and management in literature.
Patel PN, Levi JR, Cohen MB
Int J Pediatr Otorhinolaryngol 2020 Sep;136:110213. Epub 2020 Jun 23 doi: 10.1016/j.ijporl.2020.110213. PMID: 32797805
The role of Fusobacterium necrophorum in pharyngotonsillitis - A review.
Holm K, Bank S, Nielsen H, Kristensen LH, Prag J, Jensen A
Anaerobe 2016 Dec;42:89-97. Epub 2016 Sep 28 doi: 10.1016/j.anaerobe.2016.09.006. PMID: 27693542

Diagnosis

Lemierre's syndrome.
Foo EC, Tanti M, Cliffe H, Randall M
Pract Neurol 2021 Oct;21(5):442-444. Epub 2021 May 7 doi: 10.1136/practneurol-2021-002928. PMID: 33963085
Lemierre's syndrome: A forgotten and re-emerging infection.
Lee WS, Jean SS, Chen FL, Hsieh SM, Hsueh PR
J Microbiol Immunol Infect 2020 Aug;53(4):513-517. Epub 2020 Apr 4 doi: 10.1016/j.jmii.2020.03.027. PMID: 32303484
Lemierre's Syndrome.
Walkty A, Embil J
N Engl J Med 2019 Mar 21;380(12):e16. doi: 10.1056/NEJMicm1808378. PMID: 30893539
Lemierre's syndrome due to Fusobacterium necrophorum.
Kuppalli K, Livorsi D, Talati NJ, Osborn M
Lancet Infect Dis 2012 Oct;12(10):808-15. Epub 2012 May 25 doi: 10.1016/S1473-3099(12)70089-0. PMID: 22633566
Lemierre syndrome.
Wright WF, Shiner CN, Ribes JA
South Med J 2012 May;105(5):283-8. doi: 10.1097/SMJ.0b013e31825581ef. PMID: 22561543

Therapy

High risk and low prevalence diseases: Lemierre's syndrome.
Carius BM, Koyfman A, Long B
Am J Emerg Med 2022 Nov;61:98-104. Epub 2022 Aug 30 doi: 10.1016/j.ajem.2022.08.050. PMID: 36058204
Lemierre's syndrome: A forgotten and re-emerging infection.
Lee WS, Jean SS, Chen FL, Hsieh SM, Hsueh PR
J Microbiol Immunol Infect 2020 Aug;53(4):513-517. Epub 2020 Apr 4 doi: 10.1016/j.jmii.2020.03.027. PMID: 32303484
Lemierre's syndrome due to Fusobacterium necrophorum.
Kuppalli K, Livorsi D, Talati NJ, Osborn M
Lancet Infect Dis 2012 Oct;12(10):808-15. Epub 2012 May 25 doi: 10.1016/S1473-3099(12)70089-0. PMID: 22633566
Lemierre syndrome.
Wright WF, Shiner CN, Ribes JA
South Med J 2012 May;105(5):283-8. doi: 10.1097/SMJ.0b013e31825581ef. PMID: 22561543
Necrobacillosis in humans.
Dahlén G, Ebenfelt A
Expert Rev Anti Infect Ther 2011 Feb;9(2):227-36. doi: 10.1586/eri.10.172. PMID: 21342070

Prognosis

Ophthalmic complications of Lemierre syndrome.
Kreuzpointner R, Valerio L, Corsi G, Zane F, Sacco C, Holm K, Righini C, Pecci A, Zweifel S, Barco S
Acta Ophthalmol 2022 Feb;100(1):e314-e320. Epub 2021 Apr 8 doi: 10.1111/aos.14871. PMID: 33829646
Lemierre's syndrome.
Foo EC, Tanti M, Cliffe H, Randall M
Pract Neurol 2021 Oct;21(5):442-444. Epub 2021 May 7 doi: 10.1136/practneurol-2021-002928. PMID: 33963085
Lemierre's syndrome in the pediatric population: Trends in disease presentation and management in literature.
Patel PN, Levi JR, Cohen MB
Int J Pediatr Otorhinolaryngol 2020 Sep;136:110213. Epub 2020 Jun 23 doi: 10.1016/j.ijporl.2020.110213. PMID: 32797805
Incomplete Lemierre syndrome.
Shiber J, Fontane E, Rabinowitz R, Gens D, Habashi N, Scalea T
Pediatr Emerg Care 2015 Jan;31(1):39-41. doi: 10.1097/PEC.0000000000000327. PMID: 25560619
Lemierre's syndrome due to Fusobacterium necrophorum.
Kuppalli K, Livorsi D, Talati NJ, Osborn M
Lancet Infect Dis 2012 Oct;12(10):808-15. Epub 2012 May 25 doi: 10.1016/S1473-3099(12)70089-0. PMID: 22633566

Clinical prediction guides

Management of Lemierre Syndrome.
Valerio L, Pleming W, Pecci A, Barco S
Minerva Med 2021 Dec;112(6):726-739. Epub 2021 May 14 doi: 10.23736/S0026-4806.21.07497-8. PMID: 33988011
Head, Neck, and Abdominopelvic Septic Thrombophlebitis: Current Evidence and Challenges in Diagnosis and Treatment.
Valerio L, Riva N
Hamostaseologie 2020 Aug;40(3):301-310. Epub 2020 Jul 29 doi: 10.1055/a-1177-5127. PMID: 32726825
Imaging of the cavernous sinus lesions.
Korchi AM, Cuvinciuc V, Caetano J, Becker M, Lovblad KO, Vargas MI
Diagn Interv Imaging 2014 Sep;95(9):849-59. Epub 2013 Jun 12 doi: 10.1016/j.diii.2013.04.013. PMID: 23763988
Lemierre's and Lemierre's-like syndromes in association with infectious mononucleosis.
Chacko EM, Krilov LR, Patten W, Lee PJ
J Laryngol Otol 2010 Dec;124(12):1257-62. Epub 2010 Jul 6 doi: 10.1017/S0022215110001568. PMID: 20602850
Lemierre syndrome: a pediatric case series and review of literature.
Ridgway JM, Parikh DA, Wright R, Holden P, Armstrong W, Camilon F, Wong BJ
Am J Otolaryngol 2010 Jan-Feb;31(1):38-45. Epub 2009 Mar 26 doi: 10.1016/j.amjoto.2008.09.006. PMID: 19944898

Recent systematic reviews

Cardiac and Cerebral Arterial Complications of Lemierre Syndrome: Results from a Systematic Review and Individual Patient Data Meta-analysis.
Pleming W, Barco S, Voci D, Sacco C, Zane F, Granziera S, Corsi G, Konstantinides SV, Kucher N, Pecci A, Valerio L
Hamostaseologie 2022 Aug;42(4):261-267. Epub 2022 Mar 7 doi: 10.1055/a-1694-8723. PMID: 35255510Free PMC Article
Anticoagulation Strategies in the Management of Lemierre Syndrome: A Systematic Review of the Literature.
Adedeji A, Chukwura O, Obafemi T, McNulty SB, Reinert JP
Ann Pharmacother 2021 May;55(5):658-665. Epub 2020 Sep 10 doi: 10.1177/1060028020957620. PMID: 32909436
Lemierre's syndrome in adulthood, a case report and systematic review.
Moretti M, De Geyter D, Goethal L, Allard SD
Acta Clin Belg 2021 Aug;76(4):324-334. Epub 2020 Feb 29 doi: 10.1080/17843286.2020.1731661. PMID: 32116143
Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis.
Sacco C, Zane F, Granziera S, Holm K, Creemers-Schild D, Hotz MA, Turpini E, Valentini A, Righini C, Karkos PD, Verhamme P, Di Nisio M, Konstantinides S, Pecci A, Barco S; Lemierre Study Group
Hamostaseologie 2019 Feb;39(1):76-86. Epub 2018 Aug 2 doi: 10.1055/s-0038-1654720. PMID: 30071559

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