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Cerebral sinovenous thrombosis

MedGen UID:
798152
•Concept ID:
CN204195
•
Finding
Synonyms: cerebral sinovenous thrombosis; CSVT
 
Monarch Initiative: MONDO:0017993
Orphanet: ORPHA329217

Definition

A rare, potentially life-threatening, circulatory system disease characterized by variable signs and symptoms which may include headache, seizures, altered mental status, intracranial hypertension and cavernous sinus syndrome, among others. [from ORDO]

Professional guidelines

PubMed

Management of thrombosis in children and neonates: practical use of anticoagulants in children.
Monagle P, Newall F
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):399-404. doi: 10.1182/asheducation-2018.1.399. PMID: 30504338Free PMC Article
Perinatal stroke: mechanisms, management, and outcomes of early cerebrovascular brain injury.
Dunbar M, Kirton A
Lancet Child Adolesc Health 2018 Sep;2(9):666-676. Epub 2018 Jul 27 doi: 10.1016/S2352-4642(18)30173-1. PMID: 30119760
Consensus statement on abusive head trauma in infants and young children.
Choudhary AK, Servaes S, Slovis TL, Palusci VJ, Hedlund GL, Narang SK, Moreno JA, Dias MS, Christian CW, Nelson MD Jr, Silvera VM, Palasis S, Raissaki M, Rossi A, Offiah AC
Pediatr Radiol 2018 Aug;48(8):1048-1065. Epub 2018 May 23 doi: 10.1007/s00247-018-4149-1. PMID: 29796797

Recent clinical studies

Etiology

Pediatric Cerebral Sinovenous Thrombosis and Risk for Epilepsy.
Karlin AR, Kumar NK, Vossough A, Abend NS, Ichord RN, Beslow LA
Pediatr Neurol 2023 Sep;146:85-94. Epub 2023 May 25 doi: 10.1016/j.pediatrneurol.2023.05.014. PMID: 37453223
Perinatal stroke.
Whitaker EE, Cipolla MJ
Handb Clin Neurol 2020;171:313-326. doi: 10.1016/B978-0-444-64239-4.00016-3. PMID: 32736758
Perinatal Stroke.
Dunbar M, Kirton A
Semin Pediatr Neurol 2019 Dec;32:100767. Epub 2019 Aug 7 doi: 10.1016/j.spen.2019.08.003. PMID: 31813521
Perinatal stroke: mechanisms, management, and outcomes of early cerebrovascular brain injury.
Dunbar M, Kirton A
Lancet Child Adolesc Health 2018 Sep;2(9):666-676. Epub 2018 Jul 27 doi: 10.1016/S2352-4642(18)30173-1. PMID: 30119760
Neonatal stroke.
Ramenghi LA, Bassi L, Fumagalli M, Ometto A, Groppo M, De Carli A, Pisoni S, Dessimone F, Farè P, Mosca F
Minerva Pediatr 2010 Jun;62(3 Suppl 1):177-9. PMID: 21089737

Diagnosis

Pediatric abusive head trauma.
Hung KL
Biomed J 2020 Jun;43(3):240-250. Epub 2020 Apr 21 doi: 10.1016/j.bj.2020.03.008. PMID: 32330675Free PMC Article
Perinatal Stroke.
Dunbar M, Kirton A
Semin Pediatr Neurol 2019 Dec;32:100767. Epub 2019 Aug 7 doi: 10.1016/j.spen.2019.08.003. PMID: 31813521
Management of thrombosis in children and neonates: practical use of anticoagulants in children.
Monagle P, Newall F
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):399-404. doi: 10.1182/asheducation-2018.1.399. PMID: 30504338Free PMC Article
Perinatal stroke: mechanisms, management, and outcomes of early cerebrovascular brain injury.
Dunbar M, Kirton A
Lancet Child Adolesc Health 2018 Sep;2(9):666-676. Epub 2018 Jul 27 doi: 10.1016/S2352-4642(18)30173-1. PMID: 30119760
Consensus statement on abusive head trauma in infants and young children.
Choudhary AK, Servaes S, Slovis TL, Palusci VJ, Hedlund GL, Narang SK, Moreno JA, Dias MS, Christian CW, Nelson MD Jr, Silvera VM, Palasis S, Raissaki M, Rossi A, Offiah AC
Pediatr Radiol 2018 Aug;48(8):1048-1065. Epub 2018 May 23 doi: 10.1007/s00247-018-4149-1. PMID: 29796797

Therapy

Post traumatic cerebral sinovenous thrombosis in children: A retrospective and multicenter study.
Roth H, Ränsch R, Kossorotoff M, Chahine A, Tirel O, Brossier D, Wroblewski I, Orliaguet G, Chabrier S, Mortamet G
Eur J Paediatr Neurol 2023 Mar;43:12-15. Epub 2023 Jan 25 doi: 10.1016/j.ejpn.2023.01.009. PMID: 36746017
Cerebral Sinovenous Thrombosis in Infants and Children: A Practical Approach to Management.
Mandel-Shorer N, Sabapathy CA, Krishnan P, Sharma M, Goldenberg NA, Brandão LR, Moharir MD
Semin Pediatr Neurol 2022 Dec;44:100993. Epub 2022 Sep 10 doi: 10.1016/j.spen.2022.100993. PMID: 36456034
Neonatal cerebral sinovenous thrombosis.
Ramenghi LA, Cardiello V, Rossi A
Handb Clin Neurol 2019;162:267-280. doi: 10.1016/B978-0-444-64029-1.00012-6. PMID: 31324314
Management of thrombosis in children and neonates: practical use of anticoagulants in children.
Monagle P, Newall F
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):399-404. doi: 10.1182/asheducation-2018.1.399. PMID: 30504338Free PMC Article
Cerebral sinovenous thrombosis in children: diagnosis and treatment.
Jackson BF, Porcher FK, Zapton DT, Losek JD
Pediatr Emerg Care 2011 Sep;27(9):874-80; quiz 881-3. doi: 10.1097/PEC.0b013e31822c9ccc. PMID: 21926891

Prognosis

Pediatric Cerebral Sinovenous Thrombosis and Risk for Epilepsy.
Karlin AR, Kumar NK, Vossough A, Abend NS, Ichord RN, Beslow LA
Pediatr Neurol 2023 Sep;146:85-94. Epub 2023 May 25 doi: 10.1016/j.pediatrneurol.2023.05.014. PMID: 37453223
Perinatal stroke.
Whitaker EE, Cipolla MJ
Handb Clin Neurol 2020;171:313-326. doi: 10.1016/B978-0-444-64239-4.00016-3. PMID: 32736758
Pediatric abusive head trauma.
Hung KL
Biomed J 2020 Jun;43(3):240-250. Epub 2020 Apr 21 doi: 10.1016/j.bj.2020.03.008. PMID: 32330675Free PMC Article
Neonatal cerebral sinovenous thrombosis.
Ramenghi LA, Cardiello V, Rossi A
Handb Clin Neurol 2019;162:267-280. doi: 10.1016/B978-0-444-64029-1.00012-6. PMID: 31324314
Neonatal stroke.
Ramenghi LA, Bassi L, Fumagalli M, Ometto A, Groppo M, De Carli A, Pisoni S, Dessimone F, Farè P, Mosca F
Minerva Pediatr 2010 Jun;62(3 Suppl 1):177-9. PMID: 21089737

Clinical prediction guides

Pediatric Cerebral Sinovenous Thrombosis and Risk for Epilepsy.
Karlin AR, Kumar NK, Vossough A, Abend NS, Ichord RN, Beslow LA
Pediatr Neurol 2023 Sep;146:85-94. Epub 2023 May 25 doi: 10.1016/j.pediatrneurol.2023.05.014. PMID: 37453223
Post traumatic cerebral sinovenous thrombosis in children: A retrospective and multicenter study.
Roth H, Ränsch R, Kossorotoff M, Chahine A, Tirel O, Brossier D, Wroblewski I, Orliaguet G, Chabrier S, Mortamet G
Eur J Paediatr Neurol 2023 Mar;43:12-15. Epub 2023 Jan 25 doi: 10.1016/j.ejpn.2023.01.009. PMID: 36746017
Incidence and risk factors of cerebral sinovenous thrombosis in infants.
Sorg AL, Von Kries R, Klemme M, Gerstl L, Beyerlein A, Lack N, Felderhoff-Müser U, Dzietko M
Dev Med Child Neurol 2021 Jun;63(6):697-704. Epub 2021 Jan 27 doi: 10.1111/dmcn.14816. PMID: 33506500
Clinical and neuroimaging characteristics of cerebral sinovenous thrombosis in neonates undergoing cardiac surgery.
Claessens NHP, Algra SO, Jansen NJG, Groenendaal F, de Wit E, Wilbrink AA, Haas F, Schouten ANJ, Nievelstein RAJ, Benders MJNL, de Vries LS
J Thorac Cardiovasc Surg 2018 Mar;155(3):1150-1158. Epub 2017 Nov 8 doi: 10.1016/j.jtcvs.2017.10.083. PMID: 29221746
Cerebral sinovenous thrombosis (CSVT) in children: what the pediatric radiologists need to know.
Carducci C, Colafati GS, Figà-Talamanca L, Longo D, Lunardi T, Randisi F, Bernardi B
Radiol Med 2016 May;121(5):329-41. Epub 2016 Mar 30 doi: 10.1007/s11547-016-0630-9. PMID: 27025499

Recent systematic reviews

Epidemiology and pathogenesis of stroke in preterm infants: A systematic review.
Roy B, Walker K, Morgan C, Finch-Edmondson M, Galea C, Epi M, Badawi N, Novak I
J Neonatal Perinatal Med 2022;15(1):11-18. doi: 10.3233/NPM-200597. PMID: 34219672Free PMC Article
Neurological complications in childhood nephrotic syndrome: A systematic review.
Stabouli S, Chrysaidou K, Kupferman JC, Zafeiriou DI
Eur J Paediatr Neurol 2019 May;23(3):384-391. Epub 2019 Feb 22 doi: 10.1016/j.ejpn.2019.02.007. PMID: 30837193
Anticoagulation in the management of neonatal cerebral sinovenous thrombosis: a systematic review and meta-analysis.
Rossor T, Arichi T, Bhate S, Hart AR, Raman Singh R
Dev Med Child Neurol 2018 Sep;60(9):884-891. Epub 2018 Apr 19 doi: 10.1111/dmcn.13760. PMID: 29675941
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies.
Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Günther G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen CH, Raffini L, Rostásy K, Simioni P, Sträter RD, Young G, Nowak-Göttl U
Circulation 2010 Apr 27;121(16):1838-47. Epub 2010 Apr 12 doi: 10.1161/CIRCULATIONAHA.109.913673. PMID: 20385928

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