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Thrombocytopenia due to immune destruction

MedGen UID:
75778
•Concept ID:
C0272286
•
Disease or Syndrome
Synonym: Immune thrombocytopenia
SNOMED CT: Immune thrombocytopenia (2897005); ITP - immune thrombocytopenia (2897005); Thrombocytopenia due to immune destruction (2897005)
 
Monarch Initiative: MONDO:0002048

Definition

Thrombocytopenia that results from immune destruction of platelets. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThrombocytopenia due to immune destruction

Professional guidelines

PubMed

Immune thrombocytopenia: Pathophysiology and impacts of Romiplostim treatment.
Semple JW, Schifferli A, Cooper N, Saad H, Mytych DT, Chea LS, Newland A
Blood Rev 2024 Sep;67:101222. Epub 2024 Jun 20 doi: 10.1016/j.blre.2024.101222. PMID: 38942688
Current approaches for the diagnosis and management of immune thrombocytopenia.
Gafter-Gvili A
Eur J Intern Med 2023 Feb;108:18-24. Epub 2022 Nov 21 doi: 10.1016/j.ejim.2022.11.022. PMID: 36424271
Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009

Recent clinical studies

Etiology

Immune thrombocytopenia: Pathophysiology and impacts of Romiplostim treatment.
Semple JW, Schifferli A, Cooper N, Saad H, Mytych DT, Chea LS, Newland A
Blood Rev 2024 Sep;67:101222. Epub 2024 Jun 20 doi: 10.1016/j.blre.2024.101222. PMID: 38942688
How we treat primary immune thrombocytopenia in adults.
Liu XG, Hou Y, Hou M
J Hematol Oncol 2023 Jan 19;16(1):4. doi: 10.1186/s13045-023-01401-z. PMID: 36658588Free PMC Article
Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Immune thrombocytopenia.
Cuker A, Cines DB
Hematology Am Soc Hematol Educ Program 2010;2010:377-84. doi: 10.1182/asheducation-2010.1.377. PMID: 21239822
Drug-induced immune thrombocytopenia.
van den Bemt PM, Meyboom RH, Egberts AC
Drug Saf 2004;27(15):1243-52. doi: 10.2165/00002018-200427150-00007. PMID: 15588119

Diagnosis

Platelet transfusion refractoriness due to HLA alloimmunization: Evolving paradigms in mechanisms and management.
Panch SR, Guo L, Vassallo R
Blood Rev 2023 Nov;62:101135. Epub 2023 Oct 2 doi: 10.1016/j.blre.2023.101135. PMID: 37805287
How we treat primary immune thrombocytopenia in adults.
Liu XG, Hou Y, Hou M
J Hematol Oncol 2023 Jan 19;16(1):4. doi: 10.1186/s13045-023-01401-z. PMID: 36658588Free PMC Article
Current approaches for the diagnosis and management of immune thrombocytopenia.
Gafter-Gvili A
Eur J Intern Med 2023 Feb;108:18-24. Epub 2022 Nov 21 doi: 10.1016/j.ejim.2022.11.022. PMID: 36424271
Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Immune thrombocytopenia.
Cuker A, Cines DB
Hematology Am Soc Hematol Educ Program 2010;2010:377-84. doi: 10.1182/asheducation-2010.1.377. PMID: 21239822

Therapy

Immune thrombocytopenia: Pathophysiology and impacts of Romiplostim treatment.
Semple JW, Schifferli A, Cooper N, Saad H, Mytych DT, Chea LS, Newland A
Blood Rev 2024 Sep;67:101222. Epub 2024 Jun 20 doi: 10.1016/j.blre.2024.101222. PMID: 38942688
Platelet transfusion refractoriness due to HLA alloimmunization: Evolving paradigms in mechanisms and management.
Panch SR, Guo L, Vassallo R
Blood Rev 2023 Nov;62:101135. Epub 2023 Oct 2 doi: 10.1016/j.blre.2023.101135. PMID: 37805287
Current approaches for the diagnosis and management of immune thrombocytopenia.
Gafter-Gvili A
Eur J Intern Med 2023 Feb;108:18-24. Epub 2022 Nov 21 doi: 10.1016/j.ejim.2022.11.022. PMID: 36424271
Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
A Review of Romiplostim Mechanism of Action and Clinical Applicability.
Bussel JB, Soff G, Balduzzi A, Cooper N, Lawrence T, Semple JW
Drug Des Devel Ther 2021;15:2243-2268. Epub 2021 May 26 doi: 10.2147/DDDT.S299591. PMID: 34079225Free PMC Article

Prognosis

Hypoplastic form of myelodysplastic neoplasm.
Votavová H, Lenertová Z, Votava T, Beličková M
Klin Onkol 2023 Spring;36(3):206-214. doi: 10.48095/ccko2023206. PMID: 37353349
Thrombocytopenia in pregnant women.
Ruszala M, Poniedziałek-Czajkowska E, Mierzynski R, Wankowicz A, Zamojska A, Grzechnik M, Golubka I, Leszczynska-Gorzelak B, Gogacz M
Ginekol Pol 2021;92(8):587-590. doi: 10.5603/GP.a2021.0147. PMID: 34541631
HIV-related thrombocytopenia.
Scaradavou A
Blood Rev 2002 Mar;16(1):73-6. doi: 10.1054/blre.2001.0188. PMID: 11914001
HIV-related thrombocytopenia.
Blockmans D, Vermylen J
Acta Clin Belg 1992;47(2):117-23. doi: 10.1080/17843286.1992.11718217. PMID: 1321536
HIV-related thrombocytopenia.
Oksenhendler E, Seligmann M
Immunodefic Rev 1990;2(3):221-31. PMID: 2150312

Clinical prediction guides

Adiponectin Assists Thrombopoietic Agents in ITP Treatment by Enhancing Myosin-9/Rab6A-Mediated Trafficking of c-Mpl in MKs.
Zhao X, Ma H, Li G, Xiao J, Shi Z, Li M, Liu X, Sun T, Ji C
Adv Sci (Weinh) 2025 Sep;12(34):e03008. Epub 2025 Jun 25 doi: 10.1002/advs.202503008. PMID: 40558825Free PMC Article
Sustained response off-treatment in eltrombopag-treated adult patients with ITP who are refractory or relapsed after first-line steroids: Primary, final, and ad-hoc analyses of the Phase II TAPER trial.
Cooper N, Ghanima W, Vianelli N, Valcárcel D, Yavaşoğlu İ, Melikyan A, Ruiz EY, Haenig J, Somenzi O, Lee J, Clark J, Zhang Y, Zaja F
Am J Hematol 2024 Jan;99(1):57-67. Epub 2023 Nov 28 doi: 10.1002/ajh.27131. PMID: 38014779
Hypoplastic form of myelodysplastic neoplasm.
Votavová H, Lenertová Z, Votava T, Beličková M
Klin Onkol 2023 Spring;36(3):206-214. doi: 10.48095/ccko2023206. PMID: 37353349
Thrombocytopenia and thrombosis in hospitalized patients with COVID-19.
Mei H, Luo L, Hu Y
J Hematol Oncol 2020 Dec 1;13(1):161. doi: 10.1186/s13045-020-01003-z. PMID: 33261634Free PMC Article
Phenytoin-induced thrombocytopenia.
Holtzer CD, Reisner-Keller LA
Ann Pharmacother 1997 Apr;31(4):435-7. doi: 10.1177/106002809703100409. PMID: 9101005

Recent systematic reviews

The diagnostic accuracy of mean platelet volume in differentiating immune thrombocytopenic purpura from hypo-productive thrombocytopenia: A systematic review and meta-analysis.
Walle M, Arkew M, Asmerom H, Tesfaye A, Getu F
PLoS One 2023;18(11):e0295011. Epub 2023 Nov 30 doi: 10.1371/journal.pone.0295011. PMID: 38033118Free PMC Article
Pediatric refractory immune thrombocytopenia: A systematic review.
Ibrahim L, Dong SX, O'Hearn K, Grimes AB, Kaicker S, FritchLilla S, Breakey VR, Grace RF, Lebensburger JD, Klaassen RJ, Lambert M
Pediatr Blood Cancer 2023 Mar;70(3):e30173. Epub 2022 Dec 29 doi: 10.1002/pbc.30173. PMID: 36579787
COVID-19 and Immune-Mediated RBC Destruction.
Jacobs JW, Booth GS
Am J Clin Pathol 2022 Jun 7;157(6):844-851. doi: 10.1093/ajcp/aqab210. PMID: 34919640Free PMC Article
Risk of infection in adult patients with primary immune thrombocytopenia (ITP): a systematic review.
Sandvad M, Pedersen EA, Frederiksen H, Mannering N
Expert Rev Hematol 2021 Oct;14(10):961-974. Epub 2021 Sep 16 doi: 10.1080/17474086.2021.1976635. PMID: 34487679
Efficacy and safety of thrombopoietin receptor agonists in patients with primary immune thrombocytopenia: A systematic review and meta-analysis.
Wang L, Gao Z, Chen XP, Zhang HY, Yang N, Wang FY, Guan LX, Gu ZY, Zhao SS, Luo L, Wei HP, Gao CJ
Sci Rep 2016 Dec 19;6:39003. doi: 10.1038/srep39003. PMID: 27991534Free PMC Article

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