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Aplastic bone marrow

MedGen UID:
730446
•Concept ID:
C1368107
•
Disease or Syndrome
Synonym: Bone marrow aplasia
SNOMED CT: Aplastic bone marrow (303266002)

Definition

Depletion of stem cells in the bone marrow that results in the lack of production of hematopoietic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAplastic bone marrow

Professional guidelines

PubMed

Role of "third-look" laparotomy in the guidance of ovarian cancer treatment.
Copeland LJ, Wharton JT, Rutledge FN, Gershenson DM, Seski JC, Herson J
Gynecol Oncol 1983 Apr;15(2):145-53. doi: 10.1016/0090-8258(83)90068-9. PMID: 6572612

Recent clinical studies

Etiology

Population preference values for health states in relapsed or refractory B-precursor acute lymphoblastic leukemia in the United Kingdom.
Aristides M, Barlev A, Barber B, Gijsen M, Quinn C
Health Qual Life Outcomes 2015 Nov 16;13:181. doi: 10.1186/s12955-015-0377-3. PMID: 26573610Free PMC Article
Immunosuppressive therapy for transplant-ineligible aplastic anemia patients.
Schrezenmeier H, Körper S, Höchsmann B
Expert Rev Hematol 2015 Feb;8(1):89-99. doi: 10.1586/17474086.2015.978759. PMID: 25572607
Clonogenic assays and engraftment in allogeneic bone marrow transplantation.
Gerhartz HH, Kolb HJ, Clemm C, Wilmanns W
Bone Marrow Transplant 1986 Dec;1(2):221-6. PMID: 2901871
Hemocytopenia as initial manifestation of systemic lupus erythematosus. Prognostic significance.
Lavalle C, Hurtado R, Quezada JJ, Cabral A, Fraga A
Clin Rheumatol 1983 Sep;2(3):227-32. doi: 10.1007/BF02041395. PMID: 6687220
Role of "third-look" laparotomy in the guidance of ovarian cancer treatment.
Copeland LJ, Wharton JT, Rutledge FN, Gershenson DM, Seski JC, Herson J
Gynecol Oncol 1983 Apr;15(2):145-53. doi: 10.1016/0090-8258(83)90068-9. PMID: 6572612

Diagnosis

High-dose etoposide and cyclophosphamide in adults and children with primary refractory and multiply relapsed acute leukaemias: The Royal Marsden experience.
Carceller F, Hirsch SG, Khabra K, Petterson T, Malik R, Guerra-García P, Moreno L, Marshall LV, Taj M, Atra A, Ethell M, Potter M, Lancaster D
Leuk Res 2019 Oct;85:106217. Epub 2019 Aug 13 doi: 10.1016/j.leukres.2019.106217. PMID: 31493701
Immunosuppressive therapy for transplant-ineligible aplastic anemia patients.
Schrezenmeier H, Körper S, Höchsmann B
Expert Rev Hematol 2015 Feb;8(1):89-99. doi: 10.1586/17474086.2015.978759. PMID: 25572607
Bone marrow changes in anorexia nervosa are correlated with the amount of weight loss and not with other clinical findings.
Abella E, Feliu E, Granada I, Millá F, Oriol A, Ribera JM, Sánchez-Planell L, Berga LI, Reverter JC, Rozman C
Am J Clin Pathol 2002 Oct;118(4):582-8. doi: 10.1309/2Y7X-YDXK-006B-XLT2. PMID: 12375646
Hemocytopenia as initial manifestation of systemic lupus erythematosus. Prognostic significance.
Lavalle C, Hurtado R, Quezada JJ, Cabral A, Fraga A
Clin Rheumatol 1983 Sep;2(3):227-32. doi: 10.1007/BF02041395. PMID: 6687220
The aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome.
Conrad ME, Barton JC
Am J Hematol 1979;7(1):61-7. doi: 10.1002/ajh.2830070108. PMID: 507047

Therapy

High-dose etoposide and cyclophosphamide in adults and children with primary refractory and multiply relapsed acute leukaemias: The Royal Marsden experience.
Carceller F, Hirsch SG, Khabra K, Petterson T, Malik R, Guerra-García P, Moreno L, Marshall LV, Taj M, Atra A, Ethell M, Potter M, Lancaster D
Leuk Res 2019 Oct;85:106217. Epub 2019 Aug 13 doi: 10.1016/j.leukres.2019.106217. PMID: 31493701
Eltrombopag: a review of its use in patients with severe aplastic anaemia.
McCormack PL
Drugs 2015 Apr;75(5):525-31. doi: 10.1007/s40265-015-0363-4. PMID: 25700916
Immunosuppressive therapy for transplant-ineligible aplastic anemia patients.
Schrezenmeier H, Körper S, Höchsmann B
Expert Rev Hematol 2015 Feb;8(1):89-99. doi: 10.1586/17474086.2015.978759. PMID: 25572607
Autologous peripheral stem cell transplantation of the blastic phase of chronic myeloid leukemia following sequential high-dose cytosine arabinoside and melphalan.
Matulonis UA, Griffin JD, Canellos GP
Am J Hematol 1994 Apr;45(4):283-7. doi: 10.1002/ajh.2830450403. PMID: 7909981
Secondary leukemia after severe aplastic anemia.
Tichelli A, Gratwohl A, Würsch A, Nissen C, Speck B
Blut 1988 Feb;56(2):79-81. doi: 10.1007/BF00633468. PMID: 3422575

Prognosis

Severe refractory anemia with ringed sideroblasts and bone marrow aplasia in a child.
Castañeda VL, Williams TE, Harper JL, Graham-Pole J, Parmley RT
Am J Pediatr Hematol Oncol 1992 Spring;14(1):70-6. doi: 10.1097/00043426-199221000-00011. PMID: 1550266
Secondary leukemia after severe aplastic anemia.
Tichelli A, Gratwohl A, Würsch A, Nissen C, Speck B
Blut 1988 Feb;56(2):79-81. doi: 10.1007/BF00633468. PMID: 3422575
Hemocytopenia as initial manifestation of systemic lupus erythematosus. Prognostic significance.
Lavalle C, Hurtado R, Quezada JJ, Cabral A, Fraga A
Clin Rheumatol 1983 Sep;2(3):227-32. doi: 10.1007/BF02041395. PMID: 6687220
Role of "third-look" laparotomy in the guidance of ovarian cancer treatment.
Copeland LJ, Wharton JT, Rutledge FN, Gershenson DM, Seski JC, Herson J
Gynecol Oncol 1983 Apr;15(2):145-53. doi: 10.1016/0090-8258(83)90068-9. PMID: 6572612

Clinical prediction guides

Eltrombopag: a review of its use in patients with severe aplastic anaemia.
McCormack PL
Drugs 2015 Apr;75(5):525-31. doi: 10.1007/s40265-015-0363-4. PMID: 25700916
Bone marrow changes in anorexia nervosa are correlated with the amount of weight loss and not with other clinical findings.
Abella E, Feliu E, Granada I, Millá F, Oriol A, Ribera JM, Sánchez-Planell L, Berga LI, Reverter JC, Rozman C
Am J Clin Pathol 2002 Oct;118(4):582-8. doi: 10.1309/2Y7X-YDXK-006B-XLT2. PMID: 12375646
Severe refractory anemia with ringed sideroblasts and bone marrow aplasia in a child.
Castañeda VL, Williams TE, Harper JL, Graham-Pole J, Parmley RT
Am J Pediatr Hematol Oncol 1992 Spring;14(1):70-6. doi: 10.1097/00043426-199221000-00011. PMID: 1550266
Secondary leukemia after severe aplastic anemia.
Tichelli A, Gratwohl A, Würsch A, Nissen C, Speck B
Blut 1988 Feb;56(2):79-81. doi: 10.1007/BF00633468. PMID: 3422575
Hemocytopenia as initial manifestation of systemic lupus erythematosus. Prognostic significance.
Lavalle C, Hurtado R, Quezada JJ, Cabral A, Fraga A
Clin Rheumatol 1983 Sep;2(3):227-32. doi: 10.1007/BF02041395. PMID: 6687220

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