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Left heart failure

MedGen UID:
7287
•Concept ID:
C0023212
•
Disease or Syndrome
Synonyms: Heart Failure, Left Sided; Heart Failure, Left-Sided; Left Sided Heart Failure; Left-Sided Heart Failure
SNOMED CT: LVF - Left ventricular failure (85232009); Left heart failure (85232009); Left ventricular failure (85232009); Left-sided heart failure (85232009)

Definition

Failure of adequate output by the left ventricle despite an increase in distending pressure and in end-diastolic volume, with dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeft heart failure

Professional guidelines

PubMed

Emergency Department Evaluation and Management of Patients with Left Ventricular Assist Devices.
Honasoge A, Hu KM
Emerg Med Clin North Am 2022 Nov;40(4):755-770. doi: 10.1016/j.emc.2022.06.011. PMID: 36396220
Atrial Fibrillation in Heart Failure: Left Atrial Appendage Management.
Ellis CR, Kanagasundram AN
Cardiol Clin 2019 May;37(2):241-249. Epub 2019 Feb 13 doi: 10.1016/j.ccl.2019.01.009. PMID: 30926025
Treatment of advanced group 2 PH.
Barnett CF, De Marco T
Prog Cardiovasc Dis 2016 Jul-Aug;59(1):78-86. Epub 2016 Jul 11 doi: 10.1016/j.pcad.2016.07.002. PMID: 27417251

Recent clinical studies

Etiology

Group 2 pulmonary hypertension: from diagnosis to treatment.
Frantz RP
Curr Opin Pulm Med 2023 Sep 1;29(5):391-398. Epub 2023 Jul 17 doi: 10.1097/MCP.0000000000001002. PMID: 37461857
Right heart failure in left heart disease: imaging, functional, and biochemical aspects of right ventricular dysfunction.
Ghio S, Acquaro M, Agostoni P, Ambrosio G, Carluccio E, Castiglione V, Colombo D, D'Alto M, Delle Grottaglie S, Dini FL, Emdin M, Fortunato M, Guaricci AI, Jacoangeli F, Marra AM, Paolillo S, Papa S, Scajola LV, Correale M, Palazzuoli A
Heart Fail Rev 2023 Jul;28(4):1009-1022. Epub 2022 Nov 16 doi: 10.1007/s10741-022-10276-0. PMID: 36385328
Use of β-Blockers in Pulmonary Hypertension.
Perros F, de Man FS, Bogaard HJ, Antigny F, Simonneau G, Bonnet S, Provencher S, Galiè N, Humbert M
Circ Heart Fail 2017 Apr;10(4) doi: 10.1161/CIRCHEARTFAILURE.116.003703. PMID: 28364092
Treatment of advanced group 2 PH.
Barnett CF, De Marco T
Prog Cardiovasc Dis 2016 Jul-Aug;59(1):78-86. Epub 2016 Jul 11 doi: 10.1016/j.pcad.2016.07.002. PMID: 27417251
Definitions and diagnosis of pulmonary hypertension.
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641

Diagnosis

Right heart failure in left heart disease: imaging, functional, and biochemical aspects of right ventricular dysfunction.
Ghio S, Acquaro M, Agostoni P, Ambrosio G, Carluccio E, Castiglione V, Colombo D, D'Alto M, Delle Grottaglie S, Dini FL, Emdin M, Fortunato M, Guaricci AI, Jacoangeli F, Marra AM, Paolillo S, Papa S, Scajola LV, Correale M, Palazzuoli A
Heart Fail Rev 2023 Jul;28(4):1009-1022. Epub 2022 Nov 16 doi: 10.1007/s10741-022-10276-0. PMID: 36385328
EANM guideline for ventilation/perfusion single-photon emission computed tomography (SPECT) for diagnosis of pulmonary embolism and beyond.
Bajc M, Schümichen C, Grüning T, Lindqvist A, Le Roux PY, Alatri A, Bauer RW, Dilic M, Neilly B, Verberne HJ, Delgado Bolton RC, Jonson B
Eur J Nucl Med Mol Imaging 2019 Nov;46(12):2429-2451. Epub 2019 Aug 13 doi: 10.1007/s00259-019-04450-0. PMID: 31410539Free PMC Article
Use of β-Blockers in Pulmonary Hypertension.
Perros F, de Man FS, Bogaard HJ, Antigny F, Simonneau G, Bonnet S, Provencher S, Galiè N, Humbert M
Circ Heart Fail 2017 Apr;10(4) doi: 10.1161/CIRCHEARTFAILURE.116.003703. PMID: 28364092
Definitions and diagnosis of pulmonary hypertension.
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641
Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.
Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel NF, Hassoun PM
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D22-33. doi: 10.1016/j.jacc.2013.10.027. PMID: 24355638

Therapy

Group 2 pulmonary hypertension: from diagnosis to treatment.
Frantz RP
Curr Opin Pulm Med 2023 Sep 1;29(5):391-398. Epub 2023 Jul 17 doi: 10.1097/MCP.0000000000001002. PMID: 37461857
Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions.
Friedrich EE, Hong Z, Xiong S, Zhong M, Di A, Rehman J, Komarova YA, Malik AB
Proc Natl Acad Sci U S A 2019 Jun 25;116(26):12980-12985. Epub 2019 Jun 11 doi: 10.1073/pnas.1902165116. PMID: 31186359Free PMC Article
Medical Therapy for Heart Failure Associated With Pulmonary Hypertension.
Zelt JGE, Chaudhary KR, Cadete VJ, Mielniczuk LM, Stewart DJ
Circ Res 2019 May 24;124(11):1551-1567. doi: 10.1161/CIRCRESAHA.118.313650. PMID: 31120820
Hemodynamic Phenotyping of Pulmonary Hypertension in Left Heart Failure.
Naeije R, Gerges M, Vachiery JL, Caravita S, Gerges C, Lang IM
Circ Heart Fail 2017 Sep;10(9) doi: 10.1161/CIRCHEARTFAILURE.117.004082. PMID: 28912263
Use of β-Blockers in Pulmonary Hypertension.
Perros F, de Man FS, Bogaard HJ, Antigny F, Simonneau G, Bonnet S, Provencher S, Galiè N, Humbert M
Circ Heart Fail 2017 Apr;10(4) doi: 10.1161/CIRCHEARTFAILURE.116.003703. PMID: 28364092

Prognosis

Right Heart Failure: A Hemodynamic Review.
El Hajj MC, Viray MC, Tedford RJ
Cardiol Clin 2020 May;38(2):161-173. Epub 2020 Feb 20 doi: 10.1016/j.ccl.2020.01.001. PMID: 32284094
Use of β-Blockers in Pulmonary Hypertension.
Perros F, de Man FS, Bogaard HJ, Antigny F, Simonneau G, Bonnet S, Provencher S, Galiè N, Humbert M
Circ Heart Fail 2017 Apr;10(4) doi: 10.1161/CIRCHEARTFAILURE.116.003703. PMID: 28364092
Definitions and diagnosis of pulmonary hypertension.
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641
Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.
Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel NF, Hassoun PM
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D22-33. doi: 10.1016/j.jacc.2013.10.027. PMID: 24355638
Describing right ventricular function.
Vonk-Noordegraaf A, Westerhof N
Eur Respir J 2013 Jun;41(6):1419-23. Epub 2013 Jan 11 doi: 10.1183/09031936.00160712. PMID: 23314901

Clinical prediction guides

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions.
Friedrich EE, Hong Z, Xiong S, Zhong M, Di A, Rehman J, Komarova YA, Malik AB
Proc Natl Acad Sci U S A 2019 Jun 25;116(26):12980-12985. Epub 2019 Jun 11 doi: 10.1073/pnas.1902165116. PMID: 31186359Free PMC Article
Medical Therapy for Heart Failure Associated With Pulmonary Hypertension.
Zelt JGE, Chaudhary KR, Cadete VJ, Mielniczuk LM, Stewart DJ
Circ Res 2019 May 24;124(11):1551-1567. doi: 10.1161/CIRCRESAHA.118.313650. PMID: 31120820
Hemodynamic Phenotyping of Pulmonary Hypertension in Left Heart Failure.
Naeije R, Gerges M, Vachiery JL, Caravita S, Gerges C, Lang IM
Circ Heart Fail 2017 Sep;10(9) doi: 10.1161/CIRCHEARTFAILURE.117.004082. PMID: 28912263
Use of β-Blockers in Pulmonary Hypertension.
Perros F, de Man FS, Bogaard HJ, Antigny F, Simonneau G, Bonnet S, Provencher S, Galiè N, Humbert M
Circ Heart Fail 2017 Apr;10(4) doi: 10.1161/CIRCHEARTFAILURE.116.003703. PMID: 28364092
Definitions and diagnosis of pulmonary hypertension.
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641

Recent systematic reviews

Effect of Levosimendan on B-type Natriuretic Peptide Levels in Patients with Heart Failure: A Systematic Review and Meta-Analysis.
Liu G, Lin X
Altern Ther Health Med 2023 Oct;29(7):184-190. PMID: 37471659
The association between pulmonary hypertension and stroke: A systematic review and meta-analysis.
Shah TG, Sutaria JM, Vyas MV
Int J Cardiol 2019 Nov 15;295:21-24. Epub 2019 Jul 31 doi: 10.1016/j.ijcard.2019.07.085. PMID: 31402157
Pulmonary hypertension-targeted therapies in heart failure: A systematic review and meta-analysis.
Guay CA, Morin-Thibault LV, Bonnet S, Lacasse Y, Lambert C, Lega JC, Provencher S
PLoS One 2018;13(10):e0204610. Epub 2018 Oct 11 doi: 10.1371/journal.pone.0204610. PMID: 30307953Free PMC Article

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