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Chimera

MedGen UID:
727368
•Concept ID:
C1318484
•
Congenital Abnormality
SNOMED CT: Chimera (2229005)

Professional guidelines

PubMed

Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validation.
Chen S, Li B, Chen L, Jiang H
J Transl Med 2023 Jun 12;21(1):380. doi: 10.1186/s12967-023-04233-0. PMID: 37308949Free PMC Article
PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration.
Wang R, Zhong T, Bian Q, Zhang S, Ma X, Li L, Xu Y, Gu Y, Yuan A, Hu W, Qin C, Gao J
Small Methods 2023 Jan;7(1):e2201293. Epub 2022 Dec 20 doi: 10.1002/smtd.202201293. PMID: 36538748
An MDM2 degrader for treatment of acute leukemias.
Marcellino BK, Yang X, Ümit Kaniskan H, Brady C, Chen H, Chen K, Qiu X, Clementelli C, Herschbein L, Li Z, Elghaity-Beckley S, Arandela J, Kelly B, Hoffman R, Liu J, Xiong Y, Jin J, Shih AH
Leukemia 2023 Feb;37(2):370-378. Epub 2022 Oct 29 doi: 10.1038/s41375-022-01735-6. PMID: 36309559Free PMC Article

Recent clinical studies

Etiology

Ubiquitous regulation of cerebrovascular diseases by ubiquitin-modifying enzymes.
Huang J, Zhu Z, Schlüter D, Lambertsen KL, Song W, Wang X
Clin Transl Med 2024 May;14(5):e1719. doi: 10.1002/ctm2.1719. PMID: 38778460Free PMC Article
Natural human chimeras: A review.
Madan K
Eur J Med Genet 2020 Sep;63(9):103971. Epub 2020 Jun 18 doi: 10.1016/j.ejmg.2020.103971. PMID: 32565253
Frontiers of Pluripotency.
De Los Angeles A
Methods Mol Biol 2019;2005:3-27. doi: 10.1007/978-1-4939-9524-0_1. PMID: 31175642
Macrochimerism and clinical transplant tolerance.
Scandling JD, Busque S, Lowsky R, Shizuru J, Shori A, Engleman E, Jensen K, Strober S
Hum Immunol 2018 May;79(5):266-271. Epub 2018 Jan 9 doi: 10.1016/j.humimm.2018.01.002. PMID: 29330112Free PMC Article
Tolerance in clinical liver transplantation.
Levitsky J, Feng S
Hum Immunol 2018 May;79(5):283-287. Epub 2017 Oct 18 doi: 10.1016/j.humimm.2017.10.007. PMID: 29054397

Diagnosis

Novel Estrogen Receptor-Targeted Agents for Breast Cancer.
Shastry M, Hamilton E
Curr Treat Options Oncol 2023 Jul;24(7):821-844. Epub 2023 May 2 doi: 10.1007/s11864-023-01079-y. PMID: 37129836
De Novo Design of an Androgen Receptor DNA Binding Domain-Targeted peptide PROTAC for Prostate Cancer Therapy.
Ma B, Fan Y, Zhang D, Wei Y, Jian Y, Liu D, Wang Z, Gao Y, Ma J, Chen Y, Xu S, Li L
Adv Sci (Weinh) 2022 Oct;9(28):e2201859. Epub 2022 Aug 15 doi: 10.1002/advs.202201859. PMID: 35971165Free PMC Article
Prevalence of Autoimmune Diseases and Its Challenges in Diagnosis.
Chauhan R, Raina V, Nandi SP
Crit Rev Immunol 2019;39(3):189-201. doi: 10.1615/CritRevImmunol.2019031798. PMID: 32421963
A review of the biology and classification of human chimeras.
Wenk RE
Transfusion 2018 Aug;58(8):2054-2067. Epub 2018 Aug 28 doi: 10.1111/trf.14791. PMID: 30153329
Genetic disorders in primary aldosteronism-familial and somatic.
Funder JW
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):154-157. Epub 2016 Mar 21 doi: 10.1016/j.jsbmb.2016.03.020. PMID: 27013018

Therapy

c-Myc-Targeting PROTAC Based on a TNA-DNA Bivalent Binder for Combination Therapy of Triple-Negative Breast Cancer.
Li X, Zhang Z, Gao F, Ma Y, Wei D, Lu Z, Chen S, Wang M, Wang Y, Xu K, Wang R, Xu F, Chen JY, Zhu C, Li Z, Yu H, Guan X
J Am Chem Soc 2023 Apr 26;145(16):9334-9342. Epub 2023 Apr 17 doi: 10.1021/jacs.3c02619. PMID: 37068218
Protein degraders enter the clinic - a new approach to cancer therapy.
Chirnomas D, Hornberger KR, Crews CM
Nat Rev Clin Oncol 2023 Apr;20(4):265-278. Epub 2023 Feb 13 doi: 10.1038/s41571-023-00736-3. PMID: 36781982
Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer.
Adams CM, Mitra R, Xiao Y, Michener P, Palazzo J, Chao A, Gour J, Cassel J, Salvino JM, Eischen CM
Cancer Discov 2023 May 4;13(5):1210-1229. doi: 10.1158/2159-8290.CD-22-1131. PMID: 36734633Free PMC Article
Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy.
Li X, Song Y
J Hematol Oncol 2020 May 13;13(1):50. doi: 10.1186/s13045-020-00885-3. PMID: 32404196Free PMC Article
RNA sequencing by direct tagmentation of RNA/DNA hybrids.
Di L, Fu Y, Sun Y, Li J, Liu L, Yao J, Wang G, Wu Y, Lao K, Lee RW, Zheng G, Xu J, Oh J, Wang D, Xie XS, Huang Y, Wang J
Proc Natl Acad Sci U S A 2020 Feb 11;117(6):2886-2893. Epub 2020 Jan 27 doi: 10.1073/pnas.1919800117. PMID: 31988135Free PMC Article

Prognosis

Targeted protein degradation for the treatment of Parkinson's disease: Advances and future perspective.
Amirian R, Badrbani MA, Derakhshankhah H, Izadi Z, Shahbazi MA
Biomed Pharmacother 2023 Oct;166:115408. Epub 2023 Aug 29 doi: 10.1016/j.biopha.2023.115408. PMID: 37651798
Prevalence of Autoimmune Diseases and Its Challenges in Diagnosis.
Chauhan R, Raina V, Nandi SP
Crit Rev Immunol 2019;39(3):189-201. doi: 10.1615/CritRevImmunol.2019031798. PMID: 32421963
Recurrent Glioblastoma Treated with Recombinant Poliovirus.
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Nonmyeloablative allogeneic hematopoietic cell transplantation.
Storb R, Sandmaier BM
Haematologica 2016 May;101(5):521-30. doi: 10.3324/haematol.2015.132860. PMID: 27132278Free PMC Article
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA
N Engl J Med 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222. PMID: 25317870Free PMC Article

Clinical prediction guides

A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation.
Fletcher A, Clift D, de Vries E, Martinez Cuesta S, Malcolm T, Meghini F, Chaerkady R, Wang J, Chiang A, Weng SHS, Tart J, Wong E, Donohoe G, Rawlins P, Gordon E, Taylor JD, James L, Hunt J
Nat Commun 2023 Nov 4;14(1):7093. doi: 10.1038/s41467-023-42546-2. PMID: 37925433Free PMC Article
Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras.
Ahn G, Riley NM, Kamber RA, Wisnovsky S, Moncayo von Hase S, Bassik MC, Banik SM, Bertozzi CR
Science 2023 Oct 20;382(6668):eadf6249. doi: 10.1126/science.adf6249. PMID: 37856615Free PMC Article
The Regulative Nature of Mammalian Embryos.
Klimczewska K, Kasperczuk A, Suwińska A
Curr Top Dev Biol 2018;128:105-149. Epub 2017 Dec 2 doi: 10.1016/bs.ctdb.2017.10.010. PMID: 29477160
On human parthenogenesis.
Jose de Carli G, Campos Pereira T
Med Hypotheses 2017 Sep;106:57-60. Epub 2017 Jul 11 doi: 10.1016/j.mehy.2017.07.008. PMID: 28818272
Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics.
Schneekloth AR, Pucheault M, Tae HS, Crews CM
Bioorg Med Chem Lett 2008 Nov 15;18(22):5904-8. Epub 2008 Jul 31 doi: 10.1016/j.bmcl.2008.07.114. PMID: 18752944Free PMC Article

Recent systematic reviews

Is it a chimera? A systematic review of the economic evaluations of CAR-T cell therapy - an update.
Petrou P
Expert Rev Pharmacoecon Outcomes Res 2023 Jul-Dec;23(6):625-650. Epub 2023 Jun 19 doi: 10.1080/14737167.2023.2214731. PMID: 37288738
Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects.
Xia J, Li J, Tian L, Ren X, Liu C, Liang C
J Med Chem 2022 May 26;65(10):7016-7043. Epub 2022 May 7 doi: 10.1021/acs.jmedchem.2c00047. PMID: 35531606
Media portrayal of ethical and social issues in brain organoid research.
Presley A, Samsa LA, Dubljević V
Philos Ethics Humanit Med 2022 Apr 13;17(1):8. doi: 10.1186/s13010-022-00119-z. PMID: 35414094Free PMC Article
Ethical arguments concerning human-animal chimera research: a systematic review.
Kwisda K, White L, Hübner D
BMC Med Ethics 2020 Mar 23;21(1):24. doi: 10.1186/s12910-020-00465-7. PMID: 32293411Free PMC Article
Systematic review of accuracy of prenatal diagnosis for abnormal chromosome diseases by microarray technology.
Xu HB, Yang H, Liu G, Chen H
Genet Mol Res 2014 Oct 31;13(4):9115-21. doi: 10.4238/2014.October.31.27. PMID: 25366803

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