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Keratolytic agent

MedGen UID:
7202
Concept ID:
C0022585
Pharmacologic Substance
Synonyms: Agents, Desquamating; Agents, Keratolytic; Agents, Skin-Peeling; Desquamating Agents; Keratolytic Agents; Skin Peeling Agents; Skin-Peeling Agents
SNOMED CT: Keratolytic agent (280906005)
 

Definition

Agents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKeratolytic agent

Recent clinical studies

Etiology

Abdel Meguid AM, Elaziz Ahmed Attallah DA, Omar H
Dermatol Surg 2015 Dec;41(12):1398-404. doi: 10.1097/DSS.0000000000000522. PMID: 26551771
Akamine KL, Gustafson CJ, Yentzer BA, Edison BL, Green BA, Davis SA, Feldman SR
J Drugs Dermatol 2013 Aug;12(8):855-9. PMID: 23986157
Wolf SL, Qin R, Menon SP, Rowland KM Jr, Thomas S, Delaune R, Christian D, Pajon ER Jr, Satele DV, Berenberg JL, Loprinzi CL; North Central Cancer Treatment Group Study N05C5.
J Clin Oncol 2010 Dec 10;28(35):5182-7. Epub 2010 Nov 8 doi: 10.1200/JCO.2010.31.1431. PMID: 21060036Free PMC Article
Arenas R, Fernández G, Domínguez L
Int J Dermatol 1991 Aug;30(8):586-9. doi: 10.1111/j.1365-4362.1991.tb02648.x. PMID: 1657803

Diagnosis

Celleno L
Dermatol Ther 2018 Nov;31(6):e12690. Epub 2018 Oct 30 doi: 10.1111/dth.12690. PMID: 30378232
Bliziotis I, Rafailidis P, Vergidis P, Falagas ME
J Infect 2005 Aug;51(2):E31-4. doi: 10.1016/j.jinf.2004.08.009. PMID: 16038746

Therapy

Celleno L
Dermatol Ther 2018 Nov;31(6):e12690. Epub 2018 Oct 30 doi: 10.1111/dth.12690. PMID: 30378232
Abdel Meguid AM, Elaziz Ahmed Attallah DA, Omar H
Dermatol Surg 2015 Dec;41(12):1398-404. doi: 10.1097/DSS.0000000000000522. PMID: 26551771
Wolf SL, Qin R, Menon SP, Rowland KM Jr, Thomas S, Delaune R, Christian D, Pajon ER Jr, Satele DV, Berenberg JL, Loprinzi CL; North Central Cancer Treatment Group Study N05C5.
J Clin Oncol 2010 Dec 10;28(35):5182-7. Epub 2010 Nov 8 doi: 10.1200/JCO.2010.31.1431. PMID: 21060036Free PMC Article
Burkhart CG, Burkhart CN
Skinmed 2008 Jan-Feb;7(1):15-8. doi: 10.1111/j.1540-9740.2007.07221.x. PMID: 18174808
Arenas R, Fernández G, Domínguez L
Int J Dermatol 1991 Aug;30(8):586-9. doi: 10.1111/j.1365-4362.1991.tb02648.x. PMID: 1657803

Prognosis

Akamine KL, Gustafson CJ, Yentzer BA, Edison BL, Green BA, Davis SA, Feldman SR
J Drugs Dermatol 2013 Aug;12(8):855-9. PMID: 23986157

Clinical prediction guides

Wolf SL, Qin R, Menon SP, Rowland KM Jr, Thomas S, Delaune R, Christian D, Pajon ER Jr, Satele DV, Berenberg JL, Loprinzi CL; North Central Cancer Treatment Group Study N05C5.
J Clin Oncol 2010 Dec 10;28(35):5182-7. Epub 2010 Nov 8 doi: 10.1200/JCO.2010.31.1431. PMID: 21060036Free PMC Article
Elie R, Durocher LP, Kavalec EC
J Int Med Res 1983;11(2):108-12. doi: 10.1177/030006058301100208. PMID: 6852357

Recent systematic reviews

Pan M, Heinecke G, Bernardo S, Tsui C, Levitt J
Dermatol Online J 2013 Nov 15;19(11):20392. PMID: 24314769

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