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Lack of Efficacy

MedGen UID:
68623
Concept ID:
C0235828
Finding
Synonym: Efficacy Lack

Definition

The lack of expected or desired effect related to a therapy. [from NCI]

Professional guidelines

PubMed

Sarris J, Ravindran A, Yatham LN, Marx W, Rucklidge JJ, McIntyre RS, Akhondzadeh S, Benedetti F, Caneo C, Cramer H, Cribb L, de Manincor M, Dean O, Deslandes AC, Freeman MP, Gangadhar B, Harvey BH, Kasper S, Lake J, Lopresti A, Lu L, Metri NJ, Mischoulon D, Ng CH, Nishi D, Rahimi R, Seedat S, Sinclair J, Su KP, Zhang ZJ, Berk M
World J Biol Psychiatry 2022 Jul;23(6):424-455. Epub 2022 Mar 21 doi: 10.1080/15622975.2021.2013041. PMID: 35311615
García-Gutiérrez MS, Navarrete F, Gasparyan A, Austrich-Olivares A, Sala F, Manzanares J
Biomolecules 2020 Nov 19;10(11) doi: 10.3390/biom10111575. PMID: 33228239Free PMC Article
Joseph MM, Edwards A
Pediatr Emerg Med Pract 2019 Oct;16(10):1-24. Epub 2019 Oct 2 PMID: 31557431

Recent clinical studies

Etiology

Mortaja M, Demehri S
Cancer Lett 2023 Oct 28;575:216406. Epub 2023 Sep 19 doi: 10.1016/j.canlet.2023.216406. PMID: 37734530
Baquero F
Int Microbiol 2021 Nov;24(4):499-506. Epub 2021 May 24 doi: 10.1007/s10123-021-00184-y. PMID: 34028624Free PMC Article
Corrêa TD, Amorim EG, Tomazelli JAG, Corrêa MD Júnior
Rev Bras Ginecol Obstet 2019 Jan;41(1):53-58. Epub 2019 Feb 4 doi: 10.1055/s-0038-1676511. PMID: 30716786Free PMC Article
Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN; Haemato-oncology Task Force of British Committee for Standards in Haematology; British Society for Blood and Marrow Transplantation
Br J Haematol 2013 Nov;163(4):444-57. Epub 2013 Sep 17 doi: 10.1111/bjh.12558. PMID: 24102514
Ebeling PR
Curr Opin Endocrinol Diabetes Obes 2010 Jun;17(3):284-92. doi: 10.1097/MED.0b013e328339658c. PMID: 20375885

Diagnosis

Joseph MM, Edwards A
Pediatr Emerg Med Pract 2019 Oct;16(10):1-24. Epub 2019 Oct 2 PMID: 31557431
Apóstolo J, Cooke R, Bobrowicz-Campos E, Santana S, Marcucci M, Cano A, Vollenbroek-Hutten M, Germini F, D'Avanzo B, Gwyther H, Holland C
JBI Database System Rev Implement Rep 2018 Jan;16(1):140-232. doi: 10.11124/JBISRIR-2017-003382. PMID: 29324562Free PMC Article
Gubler MC
Pediatr Nephrol 2014 Jan;29(1):51-9. Epub 2013 May 1 doi: 10.1007/s00467-013-2480-1. PMID: 23636579
Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN; Haemato-oncology Task Force of British Committee for Standards in Haematology; British Society for Blood and Marrow Transplantation
Br J Haematol 2013 Nov;163(4):444-57. Epub 2013 Sep 17 doi: 10.1111/bjh.12558. PMID: 24102514
Kwan P, Brodie MJ
N Engl J Med 2000 Feb 3;342(5):314-9. doi: 10.1056/NEJM200002033420503. PMID: 10660394

Therapy

Santos FF, Lourenço BM, Souza MB, Maia LB, Oliveira VC, Oliveira MX
Physiotherapy 2023 Mar;118:1-11. Epub 2022 Sep 15 doi: 10.1016/j.physio.2022.09.004. PMID: 36288631
Baribeau D, Vorstman J, Anagnostou E
Curr Opin Psychiatry 2022 Mar 1;35(2):101-110. doi: 10.1097/YCO.0000000000000775. PMID: 35044968
Tsai YC, Tsai TF
Expert Rev Clin Pharmacol 2020 May;13(5):493-503. Epub 2020 May 27 doi: 10.1080/17512433.2020.1767590. PMID: 32394765
Mücke M, Phillips T, Radbruch L, Petzke F, Häuser W
Cochrane Database Syst Rev 2018 Mar 7;3(3):CD012182. doi: 10.1002/14651858.CD012182.pub2. PMID: 29513392Free PMC Article
O'Leary B, Finn RS, Turner NC
Nat Rev Clin Oncol 2016 Jul;13(7):417-30. Epub 2016 Mar 31 doi: 10.1038/nrclinonc.2016.26. PMID: 27030077

Prognosis

Baribeau D, Vorstman J, Anagnostou E
Curr Opin Psychiatry 2022 Mar 1;35(2):101-110. doi: 10.1097/YCO.0000000000000775. PMID: 35044968
Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA
Clin Lung Cancer 2021 May;22(3):170-177. Epub 2020 Oct 14 doi: 10.1016/j.cllc.2020.09.013. PMID: 33221175Free PMC Article
Gómez-Revuelta M, Pelayo-Terán JM, Juncal-Ruiz M, Vázquez-Bourgon J, Suárez-Pinilla P, Romero-Jiménez R, Setién Suero E, Ayesa-Arriola R, Crespo-Facorro B
Int J Neuropsychopharmacol 2020 Apr 23;23(4):217-229. doi: 10.1093/ijnp/pyaa004. PMID: 31974576Free PMC Article
Sargent DJ, Marsoni S, Monges G, Thibodeau SN, Labianca R, Hamilton SR, French AJ, Kabat B, Foster NR, Torri V, Ribic C, Grothey A, Moore M, Zaniboni A, Seitz JF, Sinicrope F, Gallinger S
J Clin Oncol 2010 Jul 10;28(20):3219-26. Epub 2010 May 24 doi: 10.1200/JCO.2009.27.1825. PMID: 20498393Free PMC Article
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Clinical prediction guides

Bacci ED, Correll JR, Pierce EJ, Atwater AR, Dawson Z, Begolka WS, Butler L
J Dermatolog Treat 2023 Dec;34(1):2202288. doi: 10.1080/09546634.2023.2202288. PMID: 37042571
Rodríguez Sánchez-Laulhé P, Luque-Romero LG, Barrero-García FJ, Biscarri-Carbonero Á, Blanquero J, Suero-Pineda A, Heredia-Rizo AM
JMIR Mhealth Uhealth 2022 Apr 7;10(4):e35462. doi: 10.2196/35462. PMID: 35389367Free PMC Article
Baribeau D, Vorstman J, Anagnostou E
Curr Opin Psychiatry 2022 Mar 1;35(2):101-110. doi: 10.1097/YCO.0000000000000775. PMID: 35044968
Tariot PN, Cummings JL, Soto-Martin ME, Ballard C, Erten-Lyons D, Sultzer DL, Devanand DP, Weintraub D, McEvoy B, Youakim JM, Stankovic S, Foff EP
N Engl J Med 2021 Jul 22;385(4):309-319. doi: 10.1056/NEJMoa2034634. PMID: 34289275
Stover NP, Watts RL
Semin Neurol 2001;21(1):49-58. doi: 10.1055/s-2001-13119. PMID: 11346025

Recent systematic reviews

Santos FF, Lourenço BM, Souza MB, Maia LB, Oliveira VC, Oliveira MX
Physiotherapy 2023 Mar;118:1-11. Epub 2022 Sep 15 doi: 10.1016/j.physio.2022.09.004. PMID: 36288631
Maguire MJ, Marson AG, Nevitt SJ
Cochrane Database Syst Rev 2021 Apr 16;4(4):CD010682. doi: 10.1002/14651858.CD010682.pub3. PMID: 33860531Free PMC Article
Mücke M, Phillips T, Radbruch L, Petzke F, Häuser W
Cochrane Database Syst Rev 2018 Mar 7;3(3):CD012182. doi: 10.1002/14651858.CD012182.pub2. PMID: 29513392Free PMC Article
Derry S, Rice AS, Cole P, Tan T, Moore RA
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD007393. doi: 10.1002/14651858.CD007393.pub4. PMID: 28085183Free PMC Article
Ng L, Khan F, Young CA, Galea M
Cochrane Database Syst Rev 2017 Jan 10;1(1):CD011776. doi: 10.1002/14651858.CD011776.pub2. PMID: 28072907Free PMC Article

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