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Benzoic acid adverse reaction

MedGen UID:
653600
•Concept ID:
C0569805
•
Pathologic Function
SNOMED CT: Benzoic acid adverse reaction (292644009)

Professional guidelines

PubMed

Silk fibroin-capped metal-organic framework for tumor-specific redox dyshomeostasis treatment synergized by deoxygenation-driven chemotherapy.
Yu H, Li Y, Zhang Z, Ren J, Zhang L, Xu Z, Kang Y, Xue P
Acta Biomater 2022 Jan 15;138:545-560. Epub 2021 Nov 12 doi: 10.1016/j.actbio.2021.11.009. PMID: 34775125
Product selection criteria for intravascular ionic contrast media.
Swanson DP, Dick TJ, Simms SM, Thrall JH
Clin Pharm 1985 Sep-Oct;4(5):527-38. PMID: 3902331

Recent clinical studies

Etiology

Beyond antimicrobial efficacy: Complex interactions of sodium benzoate, potassium sorbate, and citrate alter the rat gut microbiome.
Rezaei A, Habibabad FS, Bina S, Khoshnoud MJ, Haghshenas M, Rashedinia M
J Sci Food Agric 2026 Aug 15;106(10):5903-5909. Epub 2026 May 1 doi: 10.1002/jsfa.70703. PMID: 42066053
Vitamin C and Benzoic Acid Intake in Patients with Kidney Disease: Is There Risk of Benzene Exposure?
Yepes-Calderón M, Doorenbos CSE, Corpeleijn E, Franssen CFM, Vos MJ, Touw DJ, Mariat C, de Weerd AE, Bakker SJL
Nutrients 2025 Dec 31;18(1) doi: 10.3390/nu18010132. PMID: 41515248Free PMC Article
Sodium Benzoate as an Emerging but Problematic Allergen: Retrospective Analysis of Patch Test Results in 3198 Cases Underlines the Need for an Improved Test Preparation, as Even Dubious Reactions May Be Clinically Relevant.
Lawrance NJ, Holden CR, Gawkrodger DJ
Contact Dermatitis 2025 Aug;93(2):114-118. Epub 2025 May 7 doi: 10.1111/cod.14803. PMID: 40342057Free PMC Article
Adverse reactions to food additives in children: A retrospective study and a prospective survey.
Lemoine A, Pauliat-Desbordes S, Challier P, Tounian P
Arch Pediatr 2020 Oct;27(7):368-371. Epub 2020 Aug 15 doi: 10.1016/j.arcped.2020.07.005. PMID: 32807620
Safety and Activity of UR-1505 in Atopic Dermatitis: A Randomized, Double-blind Phase II Exploratory Trial.
Vives R, Pontes C, Sarasa M, Millier A
Clin Ther 2015 Sep 1;37(9):1955-65. Epub 2015 Jul 7 doi: 10.1016/j.clinthera.2015.06.005. PMID: 26163200

Diagnosis

Determination of benvitimod in cosmetics by HPLC with pre-column fluorescence derivatization using 2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)oxy)benzoic acid (NBD-SA).
Ke-Yan Z, Qi R, Hai-Wen Z, Yun-Wei W, Hua-Jin Z, Bo-Zhi X, Gan-Jun Y, Lu-Yao Y, Chun-Mei G, Da-Yong P
Anal Methods 2026 Mar 12;18(10):1986-1995. doi: 10.1039/d5ay02067k. PMID: 41706528
Sodium Benzoate as an Emerging but Problematic Allergen: Retrospective Analysis of Patch Test Results in 3198 Cases Underlines the Need for an Improved Test Preparation, as Even Dubious Reactions May Be Clinically Relevant.
Lawrance NJ, Holden CR, Gawkrodger DJ
Contact Dermatitis 2025 Aug;93(2):114-118. Epub 2025 May 7 doi: 10.1111/cod.14803. PMID: 40342057Free PMC Article
Adverse reactions to food additives in children: A retrospective study and a prospective survey.
Lemoine A, Pauliat-Desbordes S, Challier P, Tounian P
Arch Pediatr 2020 Oct;27(7):368-371. Epub 2020 Aug 15 doi: 10.1016/j.arcped.2020.07.005. PMID: 32807620
Cytotoxicity of monomers, plasticizer and degradation by-products released from dental hard chairside reline resins.
Chaves CA, Machado AL, Carlos IZ, Giampaolo ET, Pavarina AC, Vergani CE
Dent Mater 2010 Oct;26(10):1017-23. Epub 2010 Jul 22 doi: 10.1016/j.dental.2010.06.008. PMID: 20650509
Allergic contact dermatitis to sodium benzoate chloroacetamide in a sorbolene lotion.
Sutton T, Nixon R
Australas J Dermatol 2006 Aug;47(3):209-10. doi: 10.1111/j.1440-0960.2006.00276.x. PMID: 16867007

Therapy

Beyond antimicrobial efficacy: Complex interactions of sodium benzoate, potassium sorbate, and citrate alter the rat gut microbiome.
Rezaei A, Habibabad FS, Bina S, Khoshnoud MJ, Haghshenas M, Rashedinia M
J Sci Food Agric 2026 Aug 15;106(10):5903-5909. Epub 2026 May 1 doi: 10.1002/jsfa.70703. PMID: 42066053
Mint condition? A survey of allergenic ingredients in UK toothpastes.
Phillips PF, Rogers A, Soriano LF
Clin Exp Dermatol 2026 May 26;51(6):1066-1069. doi: 10.1093/ced/llag006. PMID: 41503662
Vitamin C and Benzoic Acid Intake in Patients with Kidney Disease: Is There Risk of Benzene Exposure?
Yepes-Calderón M, Doorenbos CSE, Corpeleijn E, Franssen CFM, Vos MJ, Touw DJ, Mariat C, de Weerd AE, Bakker SJL
Nutrients 2025 Dec 31;18(1) doi: 10.3390/nu18010132. PMID: 41515248Free PMC Article
Sodium Benzoate as an Emerging but Problematic Allergen: Retrospective Analysis of Patch Test Results in 3198 Cases Underlines the Need for an Improved Test Preparation, as Even Dubious Reactions May Be Clinically Relevant.
Lawrance NJ, Holden CR, Gawkrodger DJ
Contact Dermatitis 2025 Aug;93(2):114-118. Epub 2025 May 7 doi: 10.1111/cod.14803. PMID: 40342057Free PMC Article
Quantification of Free Radicals from Vaping Electronic Cigarettes Containing Nicotine Salt Solutions with Different Organic Acid Types and Concentrations.
Tran LN, Rao G, Robertson NE, Hunsaker HC, Chiu EY, Poulin BA, Madl AK, Pinkerton KE, Britt RD, Nguyen TB
Chem Res Toxicol 2024 Jun 17;37(6):991-999. Epub 2024 May 22 doi: 10.1021/acs.chemrestox.4c00065. PMID: 38778043Free PMC Article

Prognosis

A theoretical study on toluene oxidization by OH radical.
Mao Y, Yang L, Liu S, Song Y, Luo M, Guo Y
BMC Chem 2024 Apr 12;18(1):72. doi: 10.1186/s13065-024-01163-w. PMID: 38609951Free PMC Article
Adverse reactions to food additives in children: A retrospective study and a prospective survey.
Lemoine A, Pauliat-Desbordes S, Challier P, Tounian P
Arch Pediatr 2020 Oct;27(7):368-371. Epub 2020 Aug 15 doi: 10.1016/j.arcped.2020.07.005. PMID: 32807620
Structure-activity relationships for the degradation reaction of 1-beta-O-acyl glucuronides. Part 3: Electronic and steric descriptors predicting the reactivity of aralkyl carboxylic acid 1-beta-O-acyl glucuronides.
Baba A, Yoshioka T
Chem Res Toxicol 2009 Dec;22(12):1998-2008. doi: 10.1021/tx9002963. PMID: 19902937
Structure-activity relationships for degradation reaction of 1-beta-o-acyl glucuronides: kinetic description and prediction of intrinsic electrophilic reactivity under physiological conditions.
Baba A, Yoshioka T
Chem Res Toxicol 2009 Jan;22(1):158-72. doi: 10.1021/tx800292m. PMID: 19105593
The complex problem of sensitive skin.
Marriott M, Holmes J, Peters L, Cooper K, Rowson M, Basketter DA
Contact Dermatitis 2005 Aug;53(2):93-9. doi: 10.1111/j.0105-1873.2005.00653.x. PMID: 16033403

Clinical prediction guides

Beyond antimicrobial efficacy: Complex interactions of sodium benzoate, potassium sorbate, and citrate alter the rat gut microbiome.
Rezaei A, Habibabad FS, Bina S, Khoshnoud MJ, Haghshenas M, Rashedinia M
J Sci Food Agric 2026 Aug 15;106(10):5903-5909. Epub 2026 May 1 doi: 10.1002/jsfa.70703. PMID: 42066053
Quantification of Free Radicals from Vaping Electronic Cigarettes Containing Nicotine Salt Solutions with Different Organic Acid Types and Concentrations.
Tran LN, Rao G, Robertson NE, Hunsaker HC, Chiu EY, Poulin BA, Madl AK, Pinkerton KE, Britt RD, Nguyen TB
Chem Res Toxicol 2024 Jun 17;37(6):991-999. Epub 2024 May 22 doi: 10.1021/acs.chemrestox.4c00065. PMID: 38778043Free PMC Article
A theoretical study on toluene oxidization by OH radical.
Mao Y, Yang L, Liu S, Song Y, Luo M, Guo Y
BMC Chem 2024 Apr 12;18(1):72. doi: 10.1186/s13065-024-01163-w. PMID: 38609951Free PMC Article
Variabilities in Primary N-Containing Aromatic Compound Emissions from Residential Solid Fuel Combustion and Implications for Source Tracers.
Zhang L, Hu B, Liu X, Luo Z, Xing R, Li Y, Xiong R, Li G, Cheng H, Lu Q, Shen G, Tao S
Environ Sci Technol 2022 Oct 4;56(19):13622-13633. Epub 2022 Sep 21 doi: 10.1021/acs.est.2c03000. PMID: 36129490
Comparison of diclofenac transformation in enriched nitrifying sludge and heterotrophic sludge: Transformation rate, pathway, and role exploration.
Wu G, Geng J, Shi Y, Wang L, Xu K, Ren H
Water Res 2020 Oct 1;184:116158. Epub 2020 Jul 6 doi: 10.1016/j.watres.2020.116158. PMID: 32755734

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