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Mood changes

MedGen UID:
640670
Concept ID:
C0554980
Finding
Synonyms: Mood alterations; Moody
SNOMED CT: Moody (286641001)
 
HPO: HP:0001575

Conditions with this feature

Pituitary dependent hypercortisolism
MedGen UID:
66381
Concept ID:
C0221406
Disease or Syndrome
AIP-related isolated familial pituitary adenoma (AIP-related FIPA) is defined as the presence of an AIP germline pathogenic variant in an individual with a pituitary adenoma (regardless of family history). The most commonly occurring pituitary adenomas in this disorder are growth hormone-secreting adenomas (somatotropinoma), followed by prolactin-secreting adenomas (prolactinoma), growth hormone and prolactin co-secreting adenomas (somatomammotropinoma), and non-functioning pituitary adenomas (NFPA). Rarely TSH- or ACTH-secreting adenomas (thyrotropinoma and corticotropinoma) are observed. Clinical findings result from excess hormone secretion, lack of hormone secretion, and/or mass effects (e.g., headaches, visual field loss). Within the same family, pituitary adenomas can be of the same or different type. Age of onset in AIP-related FIPA is around 20-24 years (age range: 6-66 years).
Choreoacanthocytosis
MedGen UID:
98277
Concept ID:
C0393576
Disease or Syndrome
Chorea-acanthocytosis (ChAc) is characterized by a progressive movement disorder, cognitive and behavior changes, a myopathy that can be subclinical, and chronic hyperCKemia in serum. Although the disorder is named for acanthocytosis of the red blood cells, this feature is variable. The movement disorder is mostly limb chorea, but some individuals present with parkinsonism. Dystonia is common and affects the oral region and especially the tongue, causing dysarthria and serious dysphagia with resultant weight loss. Habitual tongue and lip biting are characteristic, as well as tongue protrusion dystonia. Progressive cognitive and behavioral changes resemble those in a frontal lobe syndrome. Seizures are observed in almost half of affected individuals and can be the initial manifestation. Myopathy results in progressive distal muscle wasting and weakness. Mean age of onset in ChAc is about 30 years, although ChAc can develop as early as the first decade or as late as the seventh decade. It runs a chronic progressive course and may lead to major disability within a few years. Life expectancy is reduced, with age of death ranging from 28 to 61 years.
Cushing syndrome
MedGen UID:
347456
Concept ID:
C1857451
Disease or Syndrome
ACTH-independent macronodular adrenal hyperplasia (AIMAH) is an endogenous form of adrenal Cushing syndrome characterized by multiple bilateral adrenocortical nodules that cause a striking enlargement of the adrenal glands. Although some familial cases have been reported, the vast majority of AIMAH cases are sporadic. Patients typically present in the fifth and sixth decades of life, approximately 10 years later than most patients with other causes of Cushing syndrome (Swain et al., 1998; Christopoulos et al., 2005). Approximately 10 to 15% of adrenal Cushing syndrome is due to primary bilateral ACTH-independent adrenocortical pathology. The 2 main subtypes are AIMAH and primary pigmented nodular adrenocortical disease (PPNAD, see 610489), which is often a component of the Carney complex (160980) and associated with mutations in the PRKAR1A gene (188830) on chromosome 17q23-q24. AIMAH is rare, representing less than 1% of endogenous causes of Cushing syndrome (Swain et al., 1998; Christopoulos et al., 2005). See also ACTH-independent Cushing syndrome (615830) due to somatic mutation in the PRKACA gene (601639). Cushing 'disease' (219090) is an ACTH-dependent disorder caused in most cases by pituitary adenomas that secrete excessive ACTH. Genetic Heterogeneity of ACTH-Independent Macronodular Adrenal Hyperplasia AIMAH2 (615954) is caused by germline mutation of 1 allele of the ARMC5 gene (615549) coupled with a somatic mutation in the other allele.
Pigmented nodular adrenocortical disease, primary, 1
MedGen UID:
400627
Concept ID:
C1864846
Disease or Syndrome
Primary pigmented micronodular adrenocortical disease is a form of ACTH-independent adrenal hyperplasia resulting in Cushing syndrome. It is usually seen as a manifestation of the Carney complex (CNC1; 160980), a multiple neoplasia syndrome. However, PPNAD can also occur in isolation (Groussin et al., 2002). Genetic Heterogeneity of Primary Pigmented Micronodular Adrenocortical Disease See also PPNAD2 (610475), caused by mutation in the PDE11A gene (604961) on chromosome 2q31; PPNAD3 (614190), caused by mutation in the PDE8B gene (603390) on chromosome 5q13; and PPNAD4 (615830), caused by a duplication on chromosome 19p13 that includes the PRKACA gene (601639).
Pigmented nodular adrenocortical disease, primary, 2
MedGen UID:
355843
Concept ID:
C1864851
Disease or Syndrome

Recent clinical studies

Etiology

Lorefice L, Fenu G, Fois M, Frau J, Coghe G, Marrosu MG, Cocco E
Mult Scler Relat Disord 2018 Feb;20:104-108. Epub 2018 Jan 31 doi: 10.1016/j.msard.2018.01.012. PMID: 29360061
Taneja R, Hunter K, Burakgazi-Dalkilic E, Carran M
Epilepsy Behav 2017 Oct;75:237-240. Epub 2017 Aug 18 doi: 10.1016/j.yebeh.2017.07.038. PMID: 28827040
Grilo NM, Correia MJ, Sequeira C, Harjivan SG, Caixas U, Diogo LN, Marques MM, Monteiro EC, Antunes AM, Pereira SA
Toxicol Lett 2016 Oct 17;260:28-35. Epub 2016 Aug 16 doi: 10.1016/j.toxlet.2016.08.009. PMID: 27543169
Lewis CJ, Maier F, Horstkötter N, Zywczok A, Witt K, Eggers C, Meyer TD, Dembek TA, Maarouf M, Moro E, Zurowski M, Woopen C, Kuhn J, Timmermann L
Psychol Med 2015 Jan;45(1):73-85. Epub 2014 May 12 doi: 10.1017/S0033291714001081. PMID: 25066623
Ekholm UB, Turkmen S, Hammarbäck S, Bäckström T
Acta Obstet Gynecol Scand 2014 Mar;93(3):248-55. doi: 10.1111/aogs.12327. PMID: 24387812

Diagnosis

Kamada Y, Sakamoto A, Kotani S, Masuyama H
J Obstet Gynaecol Res 2018 Apr;44(4):797-800. Epub 2018 Jan 23 doi: 10.1111/jog.13578. PMID: 29359527
Grilo NM, Correia MJ, Sequeira C, Harjivan SG, Caixas U, Diogo LN, Marques MM, Monteiro EC, Antunes AM, Pereira SA
Toxicol Lett 2016 Oct 17;260:28-35. Epub 2016 Aug 16 doi: 10.1016/j.toxlet.2016.08.009. PMID: 27543169
Arkin L, Talasila S, Paller AS
Pediatr Dermatol 2016 May;33(3):e216-7. Epub 2016 Apr 13 doi: 10.1111/pde.12845. PMID: 27071734
Acquaye AA, Lin L, Vera-Bolanos E, Gilbert MR, Armstrong TS
Neuro Oncol 2016 Jan;18(1):119-25. Epub 2015 Jun 23 doi: 10.1093/neuonc/nov101. PMID: 26109686Free PMC Article
Cheniaux E, Filgueiras A, Silva Rde A, Silveira LA, Nunes AL, Landeira-Fernandez J
J Affect Disord 2014 Jan;152-154:256-61. Epub 2013 Oct 3 doi: 10.1016/j.jad.2013.09.021. PMID: 24140225

Therapy

Kamada Y, Sakamoto A, Kotani S, Masuyama H
J Obstet Gynaecol Res 2018 Apr;44(4):797-800. Epub 2018 Jan 23 doi: 10.1111/jog.13578. PMID: 29359527
Taneja R, Hunter K, Burakgazi-Dalkilic E, Carran M
Epilepsy Behav 2017 Oct;75:237-240. Epub 2017 Aug 18 doi: 10.1016/j.yebeh.2017.07.038. PMID: 28827040
Grilo NM, Correia MJ, Sequeira C, Harjivan SG, Caixas U, Diogo LN, Marques MM, Monteiro EC, Antunes AM, Pereira SA
Toxicol Lett 2016 Oct 17;260:28-35. Epub 2016 Aug 16 doi: 10.1016/j.toxlet.2016.08.009. PMID: 27543169
Lewis CJ, Maier F, Horstkötter N, Zywczok A, Witt K, Eggers C, Meyer TD, Dembek TA, Maarouf M, Moro E, Zurowski M, Woopen C, Kuhn J, Timmermann L
Psychol Med 2015 Jan;45(1):73-85. Epub 2014 May 12 doi: 10.1017/S0033291714001081. PMID: 25066623
Shakerinejad G, Hidarnia A, Motlagh ME, Karami K, Niknami S, Montazeri A
Reprod Health 2013 Sep 9;10:45. doi: 10.1186/1742-4755-10-45. PMID: 24015872Free PMC Article

Prognosis

Taneja R, Hunter K, Burakgazi-Dalkilic E, Carran M
Epilepsy Behav 2017 Oct;75:237-240. Epub 2017 Aug 18 doi: 10.1016/j.yebeh.2017.07.038. PMID: 28827040
Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TLS, Fagan AM, Morris JC, Roe CM
Am J Geriatr Psychiatry 2016 Nov;24(11):1095-1104. Epub 2016 Apr 19 doi: 10.1016/j.jagp.2016.04.004. PMID: 27426238Free PMC Article
Acquaye AA, Lin L, Vera-Bolanos E, Gilbert MR, Armstrong TS
Neuro Oncol 2016 Jan;18(1):119-25. Epub 2015 Jun 23 doi: 10.1093/neuonc/nov101. PMID: 26109686Free PMC Article
Lewis CJ, Maier F, Horstkötter N, Zywczok A, Witt K, Eggers C, Meyer TD, Dembek TA, Maarouf M, Moro E, Zurowski M, Woopen C, Kuhn J, Timmermann L
Psychol Med 2015 Jan;45(1):73-85. Epub 2014 May 12 doi: 10.1017/S0033291714001081. PMID: 25066623
Shakerinejad G, Hidarnia A, Motlagh ME, Karami K, Niknami S, Montazeri A
Reprod Health 2013 Sep 9;10:45. doi: 10.1186/1742-4755-10-45. PMID: 24015872Free PMC Article

Clinical prediction guides

Lorefice L, Fenu G, Fois M, Frau J, Coghe G, Marrosu MG, Cocco E
Mult Scler Relat Disord 2018 Feb;20:104-108. Epub 2018 Jan 31 doi: 10.1016/j.msard.2018.01.012. PMID: 29360061
Tan O, Metin B, Ünsalver BÖ, Sayar GH
Psychiatry Res 2017 Dec;258:166-170. Epub 2016 Jun 16 doi: 10.1016/j.psychres.2016.04.088. PMID: 27979316
Grilo NM, Correia MJ, Sequeira C, Harjivan SG, Caixas U, Diogo LN, Marques MM, Monteiro EC, Antunes AM, Pereira SA
Toxicol Lett 2016 Oct 17;260:28-35. Epub 2016 Aug 16 doi: 10.1016/j.toxlet.2016.08.009. PMID: 27543169
Lewis CJ, Maier F, Horstkötter N, Zywczok A, Witt K, Eggers C, Meyer TD, Dembek TA, Maarouf M, Moro E, Zurowski M, Woopen C, Kuhn J, Timmermann L
Psychol Med 2015 Jan;45(1):73-85. Epub 2014 May 12 doi: 10.1017/S0033291714001081. PMID: 25066623
Shakerinejad G, Hidarnia A, Motlagh ME, Karami K, Niknami S, Montazeri A
Reprod Health 2013 Sep 9;10:45. doi: 10.1186/1742-4755-10-45. PMID: 24015872Free PMC Article

Recent systematic reviews

Perich T, Ussher J, Meade T
Bipolar Disord 2017 Sep;19(6):434-443. Epub 2017 Aug 10 doi: 10.1111/bdi.12530. PMID: 28796389
Leo RJ, Singh J
Scand J Pain 2016 Apr;11:136-145. Epub 2016 Feb 23 doi: 10.1016/j.sjpain.2015.12.002. PMID: 28850455
Schaffir J, Worly BL, Gur TL
Eur J Contracept Reprod Health Care 2016 Oct;21(5):347-55. Epub 2016 Aug 15 doi: 10.1080/13625187.2016.1217327. PMID: 27636867
Caldwell PH, Sureshkumar P, Wong WC
Cochrane Database Syst Rev 2016 Jan 20;(1):CD002117. doi: 10.1002/14651858.CD002117.pub2. PMID: 26789925
Battleday RM, Brem AK
Eur Neuropsychopharmacol 2015 Nov;25(11):1865-81. Epub 2015 Aug 20 doi: 10.1016/j.euroneuro.2015.07.028. PMID: 26381811

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