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Anovulatory

MedGen UID:
607333
•Concept ID:
C0429468
•
Disease or Syndrome
Synonyms: Anovular cycle; Anovulatory Cycle; Anovulatory cycle
SNOMED CT: Anovulatory (251663001); Anovulatory cycle (251663001); Anovular cycle (266609001)

Definition

A menstrual cycle in which no ovulation occurs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnovulatory

Professional guidelines

PubMed

Evaluation and management of abnormal uterine bleeding.
Achanna KS, Nanda J
Med J Malaysia 2022 May;77(3):374-383. PMID: 35638495
Clinical management of pregnancy in women with polycystic ovary syndrome: An expert opinion.
Bahri Khomami M, Teede HJ, Joham AE, Moran LJ, Piltonen TT, Boyle JA
Clin Endocrinol (Oxf) 2022 Aug;97(2):227-236. Epub 2022 Apr 5 doi: 10.1111/cen.14723. PMID: 35383999Free PMC Article
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855

Recent clinical studies

Etiology

Obesity and menopause.
Palacios S, Chedraui P, Sánchez-Borrego R, Coronado P, Nappi RE
Gynecol Endocrinol 2024 Dec;40(1):2312885. Epub 2024 Feb 11 doi: 10.1080/09513590.2024.2312885. PMID: 38343134
The Influence of Diet on Ovulation Disorders in Women-A Narrative Review.
Jurczewska J, Szostak-Węgierek D
Nutrients 2022 Apr 8;14(8) doi: 10.3390/nu14081556. PMID: 35458118Free PMC Article
Exercise and Polycystic Ovary Syndrome.
Woodward A, Klonizakis M, Broom D
Adv Exp Med Biol 2020;1228:123-136. doi: 10.1007/978-981-15-1792-1_8. PMID: 32342454
Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome.
Franik S, Eltrop SM, Kremer JA, Kiesel L, Farquhar C
Cochrane Database Syst Rev 2018 May 24;5(5):CD010287. doi: 10.1002/14651858.CD010287.pub3. PMID: 29797697Free PMC Article
The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance.
Balen AH, Morley LC, Misso M, Franks S, Legro RS, Wijeyaratne CN, Stener-Victorin E, Fauser BC, Norman RJ, Teede H
Hum Reprod Update 2016 Nov;22(6):687-708. Epub 2016 Aug 10 doi: 10.1093/humupd/dmw025. PMID: 27511809

Diagnosis

Evaluation and management of abnormal uterine bleeding.
Achanna KS, Nanda J
Med J Malaysia 2022 May;77(3):374-383. PMID: 35638495
Exercise and Polycystic Ovary Syndrome.
Woodward A, Klonizakis M, Broom D
Adv Exp Med Biol 2020;1228:123-136. doi: 10.1007/978-981-15-1792-1_8. PMID: 32342454
The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions.
Munro MG, Critchley HOD, Fraser IS; FIGO Menstrual Disorders Committee
Int J Gynaecol Obstet 2018 Dec;143(3):393-408. Epub 2018 Oct 10 doi: 10.1002/ijgo.12666. PMID: 30198563
Abnormal Uterine Bleeding in Adolescents.
Elmaoğulları S, Aycan Z
J Clin Res Pediatr Endocrinol 2018 Jul 31;10(3):191-197. Epub 2018 Feb 28 doi: 10.4274/jcrpe.0014. PMID: 29537383Free PMC Article
Insulin and the polycystic ovary syndrome.
Macut D, Bjekić-Macut J, Rahelić D, Doknić M
Diabetes Res Clin Pract 2017 Aug;130:163-170. Epub 2017 Jun 12 doi: 10.1016/j.diabres.2017.06.011. PMID: 28646699

Therapy

Ovulation induction in polycystic ovary syndrome.
Tanbo T, Mellembakken J, Bjercke S, Ring E, Åbyholm T, Fedorcsak P
Acta Obstet Gynecol Scand 2018 Oct;97(10):1162-1167. Epub 2018 Jul 24 doi: 10.1111/aogs.13395. PMID: 29889977
Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome.
Franik S, Eltrop SM, Kremer JA, Kiesel L, Farquhar C
Cochrane Database Syst Rev 2018 May 24;5(5):CD010287. doi: 10.1002/14651858.CD010287.pub3. PMID: 29797697Free PMC Article
Transfer of Fresh versus Frozen Embryos in Ovulatory Women.
Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro RS, Chen ZJ
N Engl J Med 2018 Jan 11;378(2):126-136. doi: 10.1056/NEJMoa1705334. PMID: 29320646
Insulin and the polycystic ovary syndrome.
Macut D, Bjekić-Macut J, Rahelić D, Doknić M
Diabetes Res Clin Pract 2017 Aug;130:163-170. Epub 2017 Jun 12 doi: 10.1016/j.diabres.2017.06.011. PMID: 28646699
The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance.
Balen AH, Morley LC, Misso M, Franks S, Legro RS, Wijeyaratne CN, Stener-Victorin E, Fauser BC, Norman RJ, Teede H
Hum Reprod Update 2016 Nov;22(6):687-708. Epub 2016 Aug 10 doi: 10.1093/humupd/dmw025. PMID: 27511809

Prognosis

Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome.
Xing J, Qiao G, Luo X, Liu S, Chen S, Ye G, Zhang C, Yi J
Clin Sci (Lond) 2023 Mar 31;137(6):453-468. doi: 10.1042/CS20220408. PMID: 36752638
Polycystic ovary syndrome, amenorrhea and the diagnostic role of anti-Müllerian hormone.
Capuzzo M, Donno V, La Marca A
Minerva Endocrinol 2020 Dec;45(4):376-380. doi: 10.23736/S0391-1977.20.03390-8. PMID: 33478206
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Ovarian antral folliculogenesis during the human menstrual cycle: a review.
Baerwald AR, Adams GP, Pierson RA
Hum Reprod Update 2012 Jan-Feb;18(1):73-91. Epub 2011 Nov 8 doi: 10.1093/humupd/dmr039. PMID: 22068695
Polycystic ovarian syndrome--prognosis and outcomes.
Hart R, Norman R
Best Pract Res Clin Obstet Gynaecol 2006 Oct;20(5):751-78. Epub 2006 Jun 12 doi: 10.1016/j.bpobgyn.2006.04.006. PMID: 16766228

Clinical prediction guides

Catamenial epilepsy occurrence and patterns in a mixed population of women with epilepsy.
Voinescu PE, Kelly M, French JA, Harden C, Davis A, Lau C, Ehlert A, Allien S, Osterhaus E, Barnard S, Jain R, Pennell PB
Epilepsia 2023 Sep;64(9):e194-e199. Epub 2023 Jul 25 doi: 10.1111/epi.17718. PMID: 37452790
Dietary energy intake across the menstrual cycle: a narrative review.
Rogan MM, Black KE
Nutr Rev 2023 Jun 9;81(7):869-886. doi: 10.1093/nutrit/nuac094. PMID: 36367830Free PMC Article
Thyroid disorders in polycystic ovary syndrome.
Kowalczyk K, Franik G, Kowalczyk D, Pluta D, Blukacz Ł, Madej P
Eur Rev Med Pharmacol Sci 2017 Jan;21(2):346-360. PMID: 28165551
Changes in macronutrient, micronutrient, and food group intakes throughout the menstrual cycle in healthy, premenopausal women.
Gorczyca AM, Sjaarda LA, Mitchell EM, Perkins NJ, Schliep KC, Wactawski-Wende J, Mumford SL
Eur J Nutr 2016 Apr;55(3):1181-8. Epub 2015 Jun 5 doi: 10.1007/s00394-015-0931-0. PMID: 26043860Free PMC Article
Ovarian antral folliculogenesis during the human menstrual cycle: a review.
Baerwald AR, Adams GP, Pierson RA
Hum Reprod Update 2012 Jan-Feb;18(1):73-91. Epub 2011 Nov 8 doi: 10.1093/humupd/dmr039. PMID: 22068695

Recent systematic reviews

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Franik S, Le QK, Kremer JA, Kiesel L, Farquhar C
Cochrane Database Syst Rev 2022 Sep 27;9(9):CD010287. doi: 10.1002/14651858.CD010287.pub4. PMID: 36165742Free PMC Article
Curcumin and Polycystic Ovary Syndrome: a Systematic Review.
Shojaei-Zarghani S, Molani-Gol R, Rafraf M
Reprod Sci 2022 Aug;29(8):2105-2118. Epub 2022 Feb 14 doi: 10.1007/s43032-021-00826-6. PMID: 35157259
Acupuncture for polycystic ovarian syndrome.
Lim CED, Ng RWC, Cheng NCL, Zhang GS, Chen H
Cochrane Database Syst Rev 2019 Jul 2;7(7):CD007689. doi: 10.1002/14651858.CD007689.pub4. PMID: 31264709Free PMC Article
Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome.
Franik S, Eltrop SM, Kremer JA, Kiesel L, Farquhar C
Cochrane Database Syst Rev 2018 May 24;5(5):CD010287. doi: 10.1002/14651858.CD010287.pub3. PMID: 29797697Free PMC Article
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Morley LC, Tang T, Yasmin E, Norman RJ, Balen AH
Cochrane Database Syst Rev 2017 Nov 29;11(11):CD003053. doi: 10.1002/14651858.CD003053.pub6. PMID: 29183107Free PMC Article

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