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Atypical autism

MedGen UID:
572882
•Concept ID:
C0338986
•
Mental or Behavioral Dysfunction
Synonyms: atypical autism; Atypical autistic syndrome
SNOMED CT: Atypical autistic syndrome (231536004); Atypical autism (231536004)
 
Monarch Initiative: MONDO:0016052
Orphanet: ORPHA199627

Definition

A rare, pervasive developmental disorder that does not fit the diagnosis for the other specific autistic spectrum disorders (autism, Asperger syndrome, Rett syndrome or childhood disintegrative disorder) and is characterized by usually milder developmental and social delay and less stereotypical autistic behavior. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical autism
Follow this link to review classifications for Atypical autism in Orphanet.

Professional guidelines

PubMed

Diagnosing autism spectrum disorders in primary care.
Allely CS, Wilson P
Practitioner 2011 Nov;255(1745):27-30, 3. PMID: 22235552
Genetic and neurological evaluation in a sample of individuals with pervasive developmental disorders.
Steiner CE, Guerreiro MM, Marques-de-Faria AP
Arq Neuropsiquiatr 2003 Jun;61(2A):176-80. Epub 2003 Jun 9 doi: 10.1590/s0004-282x2003000200003. PMID: 12806492

Recent clinical studies

Etiology

Atypical Autism: Causes, Diagnosis and Support.
Jagadapillai R
Medicina (Kaunas) 2024 Jul 18;60(7) doi: 10.3390/medicina60071163. PMID: 39064592Free PMC Article
Early diagnosis of autism and other developmental disorders, Brazil, 2013-2019.
Girianelli VR, Tomazelli J, Silva CMFPD, Fernandes CS
Rev Saude Publica 2023;57:21. Epub 2023 Apr 14 doi: 10.11606/s1518-8787.2023057004710. PMID: 37075404Free PMC Article
Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014.
Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, Kurzius-Spencer M, Zahorodny W, Robinson Rosenberg C, White T, Durkin MS, Imm P, Nikolaou L, Yeargin-Allsopp M, Lee LC, Harrington R, Lopez M, Fitzgerald RT, Hewitt A, Pettygrove S, Constantino JN, Vehorn A, Shenouda J, Hall-Lande J, Van Naarden Braun K, Dowling NF
MMWR Surveill Summ 2018 Apr 27;67(6):1-23. doi: 10.15585/mmwr.ss6706a1. PMID: 29701730Free PMC Article
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Christensen J, Grønborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard M
JAMA 2013 Apr 24;309(16):1696-703. doi: 10.1001/jama.2013.2270. PMID: 23613074Free PMC Article
Autism and known medical conditions: myth and substance.
Rutter M, Bailey A, Bolton P, Le Couteur A
J Child Psychol Psychiatry 1994 Feb;35(2):311-22. doi: 10.1111/j.1469-7610.1994.tb01164.x. PMID: 8188801

Diagnosis

Atypical Autism: Causes, Diagnosis and Support.
Jagadapillai R
Medicina (Kaunas) 2024 Jul 18;60(7) doi: 10.3390/medicina60071163. PMID: 39064592Free PMC Article
Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014.
Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, Kurzius-Spencer M, Zahorodny W, Robinson Rosenberg C, White T, Durkin MS, Imm P, Nikolaou L, Yeargin-Allsopp M, Lee LC, Harrington R, Lopez M, Fitzgerald RT, Hewitt A, Pettygrove S, Constantino JN, Vehorn A, Shenouda J, Hall-Lande J, Van Naarden Braun K, Dowling NF
MMWR Surveill Summ 2018 Apr 27;67(6):1-23. doi: 10.15585/mmwr.ss6706a1. PMID: 29701730Free PMC Article
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Christensen J, Grønborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard M
JAMA 2013 Apr 24;309(16):1696-703. doi: 10.1001/jama.2013.2270. PMID: 23613074Free PMC Article
Autism spectrum disorders and mastocytosis.
Theoharides TC
Int J Immunopathol Pharmacol 2009 Oct-Dec;22(4):859-65. doi: 10.1177/039463200902200401. PMID: 20074449
Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association.
Taylor B, Miller E, Farrington CP, Petropoulos MC, Favot-Mayaud I, Li J, Waight PA
Lancet 1999 Jun 12;353(9169):2026-9. doi: 10.1016/s0140-6736(99)01239-8. PMID: 10376617

Therapy

Increased risk for an atypical autism diagnosis following Thimerosal-containing vaccine exposure in the United States: A prospective longitudinal case-control study in the Vaccine Safety Datalink.
Geier DA, Kern JK, Geier MR
J Trace Elem Med Biol 2017 Jul;42:18-24. Epub 2017 Mar 9 doi: 10.1016/j.jtemb.2017.03.005. PMID: 28595786
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Christensen J, Grønborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard M
JAMA 2013 Apr 24;309(16):1696-703. doi: 10.1001/jama.2013.2270. PMID: 23613074Free PMC Article
CHARGE association in Sweden: malformations and functional deficits.
Strömland K, Sjögreen L, Johansson M, Ekman Joelsson BM, Miller M, Danielsson S, Billstedt E, Gillberg C, Jacobsson C, Norinder JA, Granström G
Am J Med Genet A 2005 Mar 15;133A(3):331-9. doi: 10.1002/ajmg.a.30563. PMID: 15633180
Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study.
Taylor B, Miller E, Lingam R, Andrews N, Simmons A, Stowe J
BMJ 2002 Feb 16;324(7334):393-6. doi: 10.1136/bmj.324.7334.393. PMID: 11850369Free PMC Article
Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association.
Taylor B, Miller E, Farrington CP, Petropoulos MC, Favot-Mayaud I, Li J, Waight PA
Lancet 1999 Jun 12;353(9169):2026-9. doi: 10.1016/s0140-6736(99)01239-8. PMID: 10376617

Prognosis

SYMPTOM PRESENTATIONS AND CLASSIFICATION OF AUTISM SPECTRUM DISORDER IN EARLY CHILDHOOD: APPLICATION TO THE DIAGNOSTIC CLASSIFICATION OF MENTAL HEALTH AND DEVELOPMENTAL DISORDERS OF INFANCY AND EARLY CHILDHOOD (DC:0-5).
Soto T, Giserman Kiss I, Carter AS
Infant Ment Health J 2016 Sep;37(5):486-97. Epub 2016 Aug 24 doi: 10.1002/imhj.21589. PMID: 27556740Free PMC Article
Incontinence in children with autism spectrum disorder.
von Gontard A, Pirrung M, Niemczyk J, Equit M
J Pediatr Urol 2015 Oct;11(5):264.e1-7. Epub 2015 May 22 doi: 10.1016/j.jpurol.2015.04.015. PMID: 26052001
The frequency and risk factors of allergy and asthma in children with autism--case-control study.
Mrozek-Budzyn D, Majewska R, Kiełyka A, Augustyniak M
Przegl Epidemiol 2013;67(4):675-9, 761-4. PMID: 24741916
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Christensen J, Grønborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard M
JAMA 2013 Apr 24;309(16):1696-703. doi: 10.1001/jama.2013.2270. PMID: 23613074Free PMC Article
Autism and epilepsy: a retrospective follow-up study.
Hara H
Brain Dev 2007 Sep;29(8):486-90. Epub 2007 Feb 26 doi: 10.1016/j.braindev.2006.12.012. PMID: 17321709

Clinical prediction guides

Familial Molecular Burden in Autism Spectrum Disorder: A Next-Generation Sequencing Study of Polish Affected Families.
Wawszczak-Kasza M, Rachuna J, Madej Ł, Lewitowicz W, Lewitowicz P, Horecka-Lewitowicz A
Int J Mol Sci 2025 Oct 3;26(19) doi: 10.3390/ijms26199672. PMID: 41096937Free PMC Article
Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors.
Bhandari R, Paliwal JK, Kuhad A
Adv Neurobiol 2020;24:97-141. doi: 10.1007/978-3-030-30402-7_4. PMID: 32006358
Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014.
Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, Kurzius-Spencer M, Zahorodny W, Robinson Rosenberg C, White T, Durkin MS, Imm P, Nikolaou L, Yeargin-Allsopp M, Lee LC, Harrington R, Lopez M, Fitzgerald RT, Hewitt A, Pettygrove S, Constantino JN, Vehorn A, Shenouda J, Hall-Lande J, Van Naarden Braun K, Dowling NF
MMWR Surveill Summ 2018 Apr 27;67(6):1-23. doi: 10.15585/mmwr.ss6706a1. PMID: 29701730Free PMC Article
Communication, interventions, and scientific advances in autism: a commentary.
Llaneza DC, DeLuke SV, Batista M, Crawley JN, Christodulu KV, Frye CA
Physiol Behav 2010 Jun 1;100(3):268-76. Epub 2010 Jan 21 doi: 10.1016/j.physbeh.2010.01.003. PMID: 20093134Free PMC Article
Autism and epilepsy: a retrospective follow-up study.
Hara H
Brain Dev 2007 Sep;29(8):486-90. Epub 2007 Feb 26 doi: 10.1016/j.braindev.2006.12.012. PMID: 17321709

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