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Bronze diabetes

MedGen UID:
5492
•Concept ID:
C0018995
•
Disease or Syndrome
Synonyms: Bronze Diabetes; Bronzed Cirrhoses; Bronzed Cirrhosis; Cirrhoses, Bronzed; Cirrhoses, Pigmentary; Cirrhosis, Bronzed; Cirrhosis, Pigmentary; Diabetes, Bronze; Disease, Von Recklenhausen-Applebaum; Diseases, Von Recklenhausen-Applebaum; Disorder, Iron Storage; Disorders, Iron Storage; Haemochromatoses; Haemochromatosis; Hemochromatose; Hemochromatoses; Hemochromatosis; Iron Storage Disorder; Iron Storage Disorders; Pigmentary Cirrhoses; Pigmentary Cirrhosis; Recklenhausen-Applebaum Disease, Von; Recklenhausen-Applebaum Diseases, Von; Storage Disorder, Iron; Storage Disorders, Iron; Syndrome, Troisier-Hanot-Chauffard; Syndromes, Troisier-Hanot-Chauffard; Troisier Hanot Chauffard Syndrome; Troisier-Hanot-Chauffard Syndrome; Troisier-Hanot-Chauffard Syndromes; Von Recklenhausen Applebaum Disease; Von Recklenhausen-Applebaum Disease; Von Recklenhausen-Applebaum Diseases
SNOMED CT: Bronze diabetes (399144008); Hemochromatosis (399187006); Bronzed diabetes (399144008); Iron storage disease (399187006)

Definition

Accumulation of iron in internal organs. [from NCI]

Professional guidelines

PubMed

EASL Clinical Practice Guidelines on haemochromatosis.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2022 Aug;77(2):479-502. Epub 2022 Jun 1 doi: 10.1016/j.jhep.2022.03.033. PMID: 35662478
ACG Clinical Guideline: Hereditary Hemochromatosis.
Kowdley KV, Brown KE, Ahn J, Sundaram V
Am J Gastroenterol 2019 Aug;114(8):1202-1218. doi: 10.14309/ajg.0000000000000315. PMID: 31335359
ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.
Kwo PY, Cohen SM, Lim JK
Am J Gastroenterol 2017 Jan;112(1):18-35. Epub 2016 Dec 20 doi: 10.1038/ajg.2016.517. PMID: 27995906

Recent clinical studies

Etiology

Bronze Diabetes:The "Silent" Diabetes. Little-known condition signals hemochromatosis.
Wiley F
Diabetes Self Manag 2016 Mar-Apr;33(2):32, 35. PMID: 27086398
Cerebrovascular accident in beta-thalassemia major (beta-TM) and beta-thalassemia intermedia (beta-TI).
Karimi M, Khanlari M, Rachmilewitz EA
Am J Hematol 2008 Jan;83(1):77-9. doi: 10.1002/ajh.20938. PMID: 17696211
The HLA-A1-B8 haplotype hitchhiking with the hemochromatosis mutation: does it affect the phenotype?
Olsson KS, Ritter B, Hansson N
Eur J Haematol 2007 Nov;79(5):429-34. doi: 10.1111/j.1600-0609.2007.00953.x. PMID: 17924859

Diagnosis

An unusual presentation of seborrheic keratoses in a man with hereditary hemochromatosis.
Loh TY, Cohen PR
Dermatol Online J 2017 Apr 15;23(4) PMID: 28541873
Bronze Diabetes:The "Silent" Diabetes. Little-known condition signals hemochromatosis.
Wiley F
Diabetes Self Manag 2016 Mar-Apr;33(2):32, 35. PMID: 27086398
Revisiting hereditary hemochromatosis: current concepts and progress.
Yen AW, Fancher TL, Bowlus CL
Am J Med 2006 May;119(5):391-9. doi: 10.1016/j.amjmed.2005.10.041. PMID: 16651049
Update on hereditary hemochromatosis and the HFE gene.
Brandhagen DJ, Fairbanks VF, Batts KP, Thibodeau SN
Mayo Clin Proc 1999 Sep;74(9):917-21. doi: 10.4065/74.9.917. PMID: 10488796
Determination of gene frequencies for two common haemochromatosis mutations in the Danish population by a novel polymerase chain reaction with sequence-specific primers.
Steffensen R, Varming K, Jersild C
Tissue Antigens 1998 Sep;52(3):230-5. doi: 10.1111/j.1399-0039.1998.tb03037.x. PMID: 9802602

Therapy

Determination of gene frequencies for two common haemochromatosis mutations in the Danish population by a novel polymerase chain reaction with sequence-specific primers.
Steffensen R, Varming K, Jersild C
Tissue Antigens 1998 Sep;52(3):230-5. doi: 10.1111/j.1399-0039.1998.tb03037.x. PMID: 9802602

Prognosis

Revisiting hereditary hemochromatosis: current concepts and progress.
Yen AW, Fancher TL, Bowlus CL
Am J Med 2006 May;119(5):391-9. doi: 10.1016/j.amjmed.2005.10.041. PMID: 16651049

Clinical prediction guides

An unusual presentation of seborrheic keratoses in a man with hereditary hemochromatosis.
Loh TY, Cohen PR
Dermatol Online J 2017 Apr 15;23(4) PMID: 28541873

Supplemental Content

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