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Paralysis due to lesion of spinal cord

MedGen UID:
508428
•Concept ID:
C0149780
•
Disease or Syndrome
Synonym: Spinal paralysis
SNOMED CT: Paralysis due to lesion of spinal cord (372310001); Spinal paralysis (372310001)

Professional guidelines

PubMed

Cardiovascular Autonomic Dysfunction in Spinal Cord Injury: Epidemiology, Diagnosis, and Management.
Wecht JM, Harel NY, Guest J, Kirshblum SC, Forrest GF, Bloom O, Ovechkin AV, Harkema S
Semin Neurol 2020 Oct;40(5):550-559. Epub 2020 Sep 9 doi: 10.1055/s-0040-1713885. PMID: 32906175
Treatment of neuromyelitis optica: state-of-the-art and emerging therapies.
Papadopoulos MC, Bennett JL, Verkman AS
Nat Rev Neurol 2014 Sep;10(9):493-506. Epub 2014 Aug 12 doi: 10.1038/nrneurol.2014.141. PMID: 25112508Free PMC Article
Spinal cord tumours: advances in genetics and their implications for treatment.
Zadnik PL, Gokaslan ZL, Burger PC, Bettegowda C
Nat Rev Neurol 2013 May;9(5):257-66. Epub 2013 Mar 26 doi: 10.1038/nrneurol.2013.48. PMID: 23528542Free PMC Article

Recent clinical studies

Etiology

Emerging trends and insights in acute flaccid myelitis: a comprehensive review of neurologic manifestations.
Singh B, Arora S, Sandhu N
Infect Dis (Lond) 2023 Oct;55(10):653-663. Epub 2023 Jun 27 doi: 10.1080/23744235.2023.2228407. PMID: 37368373
Psychophysiological impact of spinal cord injury: Depression, coping and heart rate variability.
Singh V, Mitra S
J Spinal Cord Med 2023 May;46(3):441-449. Epub 2022 Mar 30 doi: 10.1080/10790268.2022.2052503. PMID: 35353026Free PMC Article
Spinal lesions caused by abusive trauma in young children.
Vinchon M, Noulé N, Toubol A, Karnoub MA
Childs Nerv Syst 2022 Dec;38(12):2349-2355. Epub 2022 Dec 13 doi: 10.1007/s00381-022-05778-z. PMID: 36512049
Exercise recommendations for individuals with spinal cord injury.
Jacobs PL, Nash MS
Sports Med 2004;34(11):727-51. doi: 10.2165/00007256-200434110-00003. PMID: 15456347
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.
Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM
Neuron 2002 May 16;34(4):521-33. doi: 10.1016/s0896-6273(02)00682-7. PMID: 12062037

Diagnosis

Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials.
Zipser CM, Cragg JJ, Guest JD, Fehlings MG, Jutzeler CR, Anderson AJ, Curt A
Lancet Neurol 2022 Jul;21(7):659-670. Epub 2022 May 12 doi: 10.1016/S1474-4422(21)00464-6. PMID: 35569486
Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222).
Román GC, Gracia F, Torres A, Palacios A, Gracia K, Harris D
Front Immunol 2021;12:653786. Epub 2021 Apr 26 doi: 10.3389/fimmu.2021.653786. PMID: 33981305Free PMC Article
Myelopathy: chameleons and mimics.
Ginsberg L
Pract Neurol 2017 Jan;17(1):6-12. Epub 2016 Nov 21 doi: 10.1136/practneurol-2016-001485. PMID: 27872169
Neuroschistosomiasis.
Carod-Artal FJ
Expert Rev Anti Infect Ther 2010 Nov;8(11):1307-18. doi: 10.1586/eri.10.111. PMID: 21073294
Exercise recommendations for individuals with spinal cord injury.
Jacobs PL, Nash MS
Sports Med 2004;34(11):727-51. doi: 10.2165/00007256-200434110-00003. PMID: 15456347

Therapy

A mechanistic overview of spinal cord injury, oxidative DNA damage repair and neuroprotective therapies.
Kaur J, Mojumdar A
Int J Neurosci 2023 Mar;133(3):307-321. Epub 2021 Apr 28 doi: 10.1080/00207454.2021.1912040. PMID: 33789065
Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222).
Román GC, Gracia F, Torres A, Palacios A, Gracia K, Harris D
Front Immunol 2021;12:653786. Epub 2021 Apr 26 doi: 10.3389/fimmu.2021.653786. PMID: 33981305Free PMC Article
Spinal cord injury after thoracic endovascular aortic aneurysm repair.
Awad H, Ramadan ME, El Sayed HF, Tolpin DA, Tili E, Collard CD
Can J Anaesth 2017 Dec;64(12):1218-1235. Epub 2017 Oct 10 doi: 10.1007/s12630-017-0974-1. PMID: 29019146Free PMC Article
Neuroschistosomiasis.
Carod-Artal FJ
Expert Rev Anti Infect Ther 2010 Nov;8(11):1307-18. doi: 10.1586/eri.10.111. PMID: 21073294
Neurosurgery for spasticity.
Sindou MP, Mertens P
Stereotact Funct Neurosurg 2000;74(3-4):217-21. doi: 10.1159/000056483. PMID: 11279361

Prognosis

Acute flaccid myelitis and enterovirus D68: lessons from the past and present.
Helfferich J, Knoester M, Van Leer-Buter CC, Neuteboom RF, Meiners LC, Niesters HG, Brouwer OF
Eur J Pediatr 2019 Sep;178(9):1305-1315. Epub 2019 Jul 23 doi: 10.1007/s00431-019-03435-3. PMID: 31338675Free PMC Article
Concepts of aging with paralysis: implications for recovery and treatment.
Wirz M, Dietz V
Handb Clin Neurol 2012;109:77-84. doi: 10.1016/B978-0-444-52137-8.00005-X. PMID: 23098707
Neuroschistosomiasis.
Carod-Artal FJ
Expert Rev Anti Infect Ther 2010 Nov;8(11):1307-18. doi: 10.1586/eri.10.111. PMID: 21073294
Fractures in myelomeningocele.
Akbar M, Bresch B, Raiss P, Fürstenberg CH, Bruckner T, Seyler T, Carstens C, Abel R
J Orthop Traumatol 2010 Sep;11(3):175-82. Epub 2010 Aug 19 doi: 10.1007/s10195-010-0102-2. PMID: 20721596Free PMC Article
Exercise recommendations for individuals with spinal cord injury.
Jacobs PL, Nash MS
Sports Med 2004;34(11):727-51. doi: 10.2165/00007256-200434110-00003. PMID: 15456347

Clinical prediction guides

Spinal lesions caused by abusive trauma in young children.
Vinchon M, Noulé N, Toubol A, Karnoub MA
Childs Nerv Syst 2022 Dec;38(12):2349-2355. Epub 2022 Dec 13 doi: 10.1007/s00381-022-05778-z. PMID: 36512049
Concepts of aging with paralysis: implications for recovery and treatment.
Wirz M, Dietz V
Handb Clin Neurol 2012;109:77-84. doi: 10.1016/B978-0-444-52137-8.00005-X. PMID: 23098707
A new age for rehabilitation.
Edgerton VR, Roy RR
Eur J Phys Rehabil Med 2012 Mar;48(1):99-109. Epub 2012 Mar 12 PMID: 22407010
Neuroschistosomiasis.
Carod-Artal FJ
Expert Rev Anti Infect Ther 2010 Nov;8(11):1307-18. doi: 10.1586/eri.10.111. PMID: 21073294
Fractures in myelomeningocele.
Akbar M, Bresch B, Raiss P, Fürstenberg CH, Bruckner T, Seyler T, Carstens C, Abel R
J Orthop Traumatol 2010 Sep;11(3):175-82. Epub 2010 Aug 19 doi: 10.1007/s10195-010-0102-2. PMID: 20721596Free PMC Article

Recent systematic reviews

Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222).
Román GC, Gracia F, Torres A, Palacios A, Gracia K, Harris D
Front Immunol 2021;12:653786. Epub 2021 Apr 26 doi: 10.3389/fimmu.2021.653786. PMID: 33981305Free PMC Article
Physical Training and Upper-Limb Strength of People With Paraplegia: A Systematic Review.
Melo FCM, de Lima KKF, Silveira APKF, de Azevedo KPM, Dos Santos IK, de Medeiros HJ, Leitão JC, Knackfuss MI
J Sport Rehabil 2019 Mar 1;28(3):288-293. Epub 2018 Dec 4 doi: 10.1123/jsr.2017-0062. PMID: 29364066
Survival after spinal cord injury: a systematic review.
van den Berg ME, Castellote JM, de Pedro-Cuesta J, Mahillo-Fernandez I
J Neurotrauma 2010 Aug;27(8):1517-28. doi: 10.1089/neu.2009.1138. PMID: 20486810
Reorganization and preservation of motor control of the brain in spinal cord injury: a systematic review.
Kokotilo KJ, Eng JJ, Curt A
J Neurotrauma 2009 Nov;26(11):2113-26. doi: 10.1089/neu.2008.0688. PMID: 19604097Free PMC Article
Efficacy of electrical stimulation to increase muscle strength in people with neurological conditions: a systematic review.
Glinsky J, Harvey L, Van Es P
Physiother Res Int 2007 Sep;12(3):175-94. doi: 10.1002/pri.375. PMID: 17624871

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