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Lip freckle

MedGen UID:
507325
•Concept ID:
C0406814
•
Finding; Neoplastic Process
Synonyms: Ephelis of lip; Labial lentigo; Lentigo of lip; Lip lentigo
SNOMED CT: Lentigo of lip (788632005)
 
HPO: HP:0010798

Definition

Increased focal pigmentation of the vermilion of the lips. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip freckle

Professional guidelines

PubMed

Q-switched alexandrite laser treatment of oral labial lentigines in Chinese subjects with Peutz-Jeghers syndrome.
Xi Z, Hui Q, Zhong L
Dermatol Surg 2009 Jul;35(7):1084-8. Epub 2009 Apr 28 doi: 10.1111/j.1524-4725.2009.01192.x. PMID: 19438690
Q-switched ruby laser in the treatment of labial melanotic macules.
Gupta G, MacKay IR, MacKie RM
Lasers Surg Med 1999;25(3):219-22. doi: 10.1002/(sici)1096-9101(1999)25:3<219::aid-lsm5>3.0.co;2-k. PMID: 10495298
Successful treatment of mucosal melanosis of the lip with normal pulsed ruby laser.
Hanada K, Baba T, Sasaki C, Hashimoto I
J Dermatol 1996 Apr;23(4):263-6. doi: 10.1111/j.1346-8138.1996.tb04010.x. PMID: 8935342

Recent clinical studies

Etiology

Dermatological manifestations in Costello syndrome: A prospective multicentric study of 31 HRAS-positive variant patients.
Bessis D, Bursztejn AC, Morice-Picard F, Capri Y, Barbarot S, Aubert H, Bodet D, Bourrat E, Chiaverini C, Poujade L, Willems M, Rouanet J, Dompmartin-Blanchère A, Geneviève D, Gerard M, Ginglinger E, Hadj-Rabia S, Martin L, Mazereeuw-Hautier J, Bibas N, Molinari N, Herman F, Phan A, Rod J, Roger H, Sigaudy S, Ziegler A, Vial Y, Verloes A, Cavé H, Lacombe D
J Eur Acad Dermatol Venereol 2024 Sep;38(9):1818-1827. Epub 2024 Apr 10 doi: 10.1111/jdv.19996. PMID: 38595321
A review of craniofacial and dental findings of the RASopathies.
Cao H, Alrejaye N, Klein OD, Goodwin AF, Oberoi S
Orthod Craniofac Res 2017 Jun;20 Suppl 1(Suppl 1):32-38. doi: 10.1111/ocr.12144. PMID: 28643916Free PMC Article
In Vivo Reflectance Confocal Microscopy for the Diagnosis of Melanoma and Melanotic Macules of the Lip.
Uribe P, Collgros H, Scolyer RA, Menzies SW, Guitera P
JAMA Dermatol 2017 Sep 1;153(9):882-891. doi: 10.1001/jamadermatol.2017.0504. PMID: 28467525Free PMC Article
Interventions for photodamaged skin.
Samuel M, Brooke RC, Hollis S, Griffiths CE
Cochrane Database Syst Rev 2005 Jan 25;(1):CD001782. doi: 10.1002/14651858.CD001782.pub2. PMID: 15674885
The labial melanotic macule.
Weathers DR, Corio RL, Crawford BE, Giansanti JS, Page LR
Oral Surg Oral Med Oral Pathol 1976 Aug;42(2):196-205. doi: 10.1016/0030-4220(76)90124-9. PMID: 1066601

Diagnosis

Dermatological manifestations in Costello syndrome: A prospective multicentric study of 31 HRAS-positive variant patients.
Bessis D, Bursztejn AC, Morice-Picard F, Capri Y, Barbarot S, Aubert H, Bodet D, Bourrat E, Chiaverini C, Poujade L, Willems M, Rouanet J, Dompmartin-Blanchère A, Geneviève D, Gerard M, Ginglinger E, Hadj-Rabia S, Martin L, Mazereeuw-Hautier J, Bibas N, Molinari N, Herman F, Phan A, Rod J, Roger H, Sigaudy S, Ziegler A, Vial Y, Verloes A, Cavé H, Lacombe D
J Eur Acad Dermatol Venereol 2024 Sep;38(9):1818-1827. Epub 2024 Apr 10 doi: 10.1111/jdv.19996. PMID: 38595321
Laser therapy and light sources for labial lentigines in patients with Peutz-Jeghers syndrome.
Medeiros YL, Faria LV, Chandretti PCS, Mainenti P
Dermatol Ther 2022 Jul;35(7):e15519. Epub 2022 Apr 20 doi: 10.1111/dth.15519. PMID: 35426222
Xeroderma pigmentosum in Yemen.
Khatri ML
Int J Dermatol 2021 Mar;60(3):314-320. Epub 2021 Feb 4 doi: 10.1111/ijd.15395. PMID: 33538348
Peutz-Jeghers syndrome in dermatology.
Nevozinskaya Z, Korsunskaya I, Sakaniya L, Perlamutrov Y, Sobolev V
Acta Dermatovenerol Alp Pannonica Adriat 2019 Sep;28(3):135-137. PMID: 31545393
A review of craniofacial and dental findings of the RASopathies.
Cao H, Alrejaye N, Klein OD, Goodwin AF, Oberoi S
Orthod Craniofac Res 2017 Jun;20 Suppl 1(Suppl 1):32-38. doi: 10.1111/ocr.12144. PMID: 28643916Free PMC Article

Therapy

Efficacy of cysteamine and methimazole in treating melasma: A comparative narrative review.
Niazi S, Gheisari M, Moravvej H, Doroodgar F, Niazi F
J Cosmet Dermatol 2022 Sep;21(9):3867-3875. Epub 2022 Jul 19 doi: 10.1111/jocd.15180. PMID: 35751542
Laser therapy and light sources for labial lentigines in patients with Peutz-Jeghers syndrome.
Medeiros YL, Faria LV, Chandretti PCS, Mainenti P
Dermatol Ther 2022 Jul;35(7):e15519. Epub 2022 Apr 20 doi: 10.1111/dth.15519. PMID: 35426222
Melasma--updated treatments.
Situm M, Kolić M, Bolanca Z, Ljubicić I, Misanović B
Coll Antropol 2011 Sep;35 Suppl 2:315-8. PMID: 22220462
A randomized, double-blind, placebo-controlled trial of oral procyanidin with vitamins A, C, E for melasma among Filipino women.
Handog EB, Galang DA, de Leon-Godinez MA, Chan GP
Int J Dermatol 2009 Aug;48(8):896-901. doi: 10.1111/j.1365-4632.2009.04130.x. PMID: 19659873
Doxorubicin-induced hyperpigmentation.
Abbasi NR, Wang N
Dermatol Online J 2008 Oct 15;14(10):18. PMID: 19061617

Prognosis

A novel missense mutation of the STK11 gene in a Chinese family with Peutz-Jeghers syndrome.
Yu Z, Liu L, Jiang F, Ji Y, Wang X, Liu L
BMC Gastroenterol 2022 Dec 22;22(1):536. doi: 10.1186/s12876-022-02617-y. PMID: 36550395Free PMC Article
Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma.
Sarkar R, Garg V, Bansal S, Sethi S, Gupta C
Dermatol Surg 2016 Mar;42(3):384-91. doi: 10.1097/DSS.0000000000000642. PMID: 26859648
Dermoscopic features of mucosal melanosis.
Mannone F, De Giorgi V, Cattaneo A, Massi D, De Magnis A, Carli P
Dermatol Surg 2004 Aug;30(8):1118-23. doi: 10.1111/j.1524-4725.2004.30337.x. PMID: 15274702
The labial melanotic macule.
Weathers DR, Corio RL, Crawford BE, Giansanti JS, Page LR
Oral Surg Oral Med Oral Pathol 1976 Aug;42(2):196-205. doi: 10.1016/0030-4220(76)90124-9. PMID: 1066601
Malignant melanoma with adjacent intraepidermal proliferation.
Seiji M, Takahashi M
Tohoku J Exp Med 1974 Oct;114(2):93-107. doi: 10.1620/tjem.114.93. PMID: 4612877

Clinical prediction guides

Xeroderma pigmentosum in Yemen.
Khatri ML
Int J Dermatol 2021 Mar;60(3):314-320. Epub 2021 Feb 4 doi: 10.1111/ijd.15395. PMID: 33538348
Prevalence of lip and perioral Ephelides in beach workers.
Lucena EE, Castro AC, Farias DB, Lima PT, Silveira EJ, Lima KC
An Bras Dermatol 2013 Jan-Feb;88(1):56-63. doi: 10.1590/s0365-05962013000100006. PMID: 23539004Free PMC Article
A randomized, double-blind, placebo-controlled trial of oral procyanidin with vitamins A, C, E for melasma among Filipino women.
Handog EB, Galang DA, de Leon-Godinez MA, Chan GP
Int J Dermatol 2009 Aug;48(8):896-901. doi: 10.1111/j.1365-4632.2009.04130.x. PMID: 19659873
Chloasma--the mask of pregnancy.
Bolanca I, Bolanca Z, Kuna K, Vuković A, Tuckar N, Herman R, Grubisić G
Coll Antropol 2008 Oct;32 Suppl 2:139-41. PMID: 19140277
Interventions for photodamaged skin.
Samuel M, Brooke RC, Hollis S, Griffiths CE
Cochrane Database Syst Rev 2005 Jan 25;(1):CD001782. doi: 10.1002/14651858.CD001782.pub2. PMID: 15674885

Recent systematic reviews

Interventions for photodamaged skin.
Samuel M, Brooke RC, Hollis S, Griffiths CE
Cochrane Database Syst Rev 2005 Jan 25;(1):CD001782. doi: 10.1002/14651858.CD001782.pub2. PMID: 15674885

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