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Hypoplastic left heart

MedGen UID:
505616
Concept ID:
CN003882
Finding
Synonyms: Underdeveloped left heart
 

Definition

Underdevelopment of the left side of the heart. May include atresia of the aortic or mitral orifice and hypoplasia of the ascending aorta. [from HPO]

Recent clinical studies

Etiology

Lloyd DF, Rutherford MA, Simpson JM, Razavi R
Cardiol Young 2017 Mar;27(2):217-223. Epub 2016 Nov 8 doi: 10.1017/S1047951116001645. PMID: 27821206
Yerebakan C, Valeske K, Elmontaser H, Yörüker U, Mueller M, Thul J, Mann V, Latus H, Villanueva A, Hofmann K, Schranz D, Akintuerk H
J Thorac Cardiovasc Surg 2016 Apr;151(4):1112-21, 1123.e1-5. Epub 2015 Oct 27 doi: 10.1016/j.jtcvs.2015.10.066. PMID: 26704055
Kobayashi D, Natarajan G, Turner DR, Forbes TJ, Delius RE, Walters HL, Aggarwal S
Cardiol Young 2016 Jun;26(5):867-75. Epub 2015 Sep 8 doi: 10.1017/S1047951115001419. PMID: 26345472
Voges I, Jerosch-Herold M, Wegner P, Hart C, Gabbert D, Al Bulushi A, Fischer G, Andrade AC, Pham HM, Kristo I, Kramer HH, Rickers C
J Am Heart Assoc 2015 Oct 5;4(10):e002107. doi: 10.1161/JAHA.115.002107. PMID: 26438562Free PMC Article
Arai S, Fujii Y, Kotani Y, Kuroko Y, Kasahara S, Sano S
Asian Cardiovasc Thorac Ann 2015 Nov;23(9):1034-8. Epub 2015 Sep 23 doi: 10.1177/0218492315606581. PMID: 26405018

Diagnosis

Lloyd DF, Rutherford MA, Simpson JM, Razavi R
Cardiol Young 2017 Mar;27(2):217-223. Epub 2016 Nov 8 doi: 10.1017/S1047951116001645. PMID: 27821206
Yerebakan C, Valeske K, Elmontaser H, Yörüker U, Mueller M, Thul J, Mann V, Latus H, Villanueva A, Hofmann K, Schranz D, Akintuerk H
J Thorac Cardiovasc Surg 2016 Apr;151(4):1112-21, 1123.e1-5. Epub 2015 Oct 27 doi: 10.1016/j.jtcvs.2015.10.066. PMID: 26704055
Voges I, Jerosch-Herold M, Wegner P, Hart C, Gabbert D, Al Bulushi A, Fischer G, Andrade AC, Pham HM, Kristo I, Kramer HH, Rickers C
J Am Heart Assoc 2015 Oct 5;4(10):e002107. doi: 10.1161/JAHA.115.002107. PMID: 26438562Free PMC Article
Arai S, Fujii Y, Kotani Y, Kuroko Y, Kasahara S, Sano S
Asian Cardiovasc Thorac Ann 2015 Nov;23(9):1034-8. Epub 2015 Sep 23 doi: 10.1177/0218492315606581. PMID: 26405018
Malik S, Bird TM, Jaquiss RD, Morrow WR, Robbins JM
J Thorac Cardiovasc Surg 2015 Sep;150(3):474-80.e2. Epub 2015 Jul 4 doi: 10.1016/j.jtcvs.2015.06.071. PMID: 26242838

Therapy

Ohye RG, Schranz D, D'Udekem Y
Circulation 2016 Oct 25;134(17):1265-1279. doi: 10.1161/CIRCULATIONAHA.116.022816. PMID: 27777296Free PMC Article
Yerebakan C, Valeske K, Elmontaser H, Yörüker U, Mueller M, Thul J, Mann V, Latus H, Villanueva A, Hofmann K, Schranz D, Akintuerk H
J Thorac Cardiovasc Surg 2016 Apr;151(4):1112-21, 1123.e1-5. Epub 2015 Oct 27 doi: 10.1016/j.jtcvs.2015.10.066. PMID: 26704055
Arai S, Fujii Y, Kotani Y, Kuroko Y, Kasahara S, Sano S
Asian Cardiovasc Thorac Ann 2015 Nov;23(9):1034-8. Epub 2015 Sep 23 doi: 10.1177/0218492315606581. PMID: 26405018
Malik S, Bird TM, Jaquiss RD, Morrow WR, Robbins JM
J Thorac Cardiovasc Surg 2015 Sep;150(3):474-80.e2. Epub 2015 Jul 4 doi: 10.1016/j.jtcvs.2015.06.071. PMID: 26242838
Ishigami S, Ohtsuki S, Tarui S, Ousaka D, Eitoku T, Kondo M, Okuyama M, Kobayashi J, Baba K, Arai S, Kawabata T, Yoshizumi K, Tateishi A, Kuroko Y, Iwasaki T, Sato S, Kasahara S, Sano S, Oh H
Circ Res 2015 Feb 13;116(4):653-64. Epub 2014 Nov 17 doi: 10.1161/CIRCRESAHA.116.304671. PMID: 25403163

Prognosis

Sathanandam SK, Philip R, Gamboa D, Van Bergen A, Ilbawi MN, Knott-Craig C, Waller BR, Javois AJ, Cuneo BF
Cardiol Young 2016 Aug;26(6):1072-81. Epub 2015 Sep 8 doi: 10.1017/S1047951115001791. PMID: 26346529
Voges I, Jerosch-Herold M, Wegner P, Hart C, Gabbert D, Al Bulushi A, Fischer G, Andrade AC, Pham HM, Kristo I, Kramer HH, Rickers C
J Am Heart Assoc 2015 Oct 5;4(10):e002107. doi: 10.1161/JAHA.115.002107. PMID: 26438562Free PMC Article
Malik S, Bird TM, Jaquiss RD, Morrow WR, Robbins JM
J Thorac Cardiovasc Surg 2015 Sep;150(3):474-80.e2. Epub 2015 Jul 4 doi: 10.1016/j.jtcvs.2015.06.071. PMID: 26242838
Theis JL, Zimmermann MT, Evans JM, Eckloff BW, Wieben ED, Qureshi MY, O'Leary PW, Olson TM
Circ Cardiovasc Genet 2015 Aug;8(4):564-71. Epub 2015 Jun 17 doi: 10.1161/CIRCGENETICS.115.001070. PMID: 26085007
Schlangen J, Petko C, Hansen JH, Michel M, Hart C, Uebing A, Fischer G, Becker K, Kramer HH
Circ Cardiovasc Imaging 2014 Nov;7(6):880-6. Epub 2014 Sep 30 doi: 10.1161/CIRCIMAGING.114.002110. PMID: 25270741

Clinical prediction guides

Sathanandam SK, Philip R, Gamboa D, Van Bergen A, Ilbawi MN, Knott-Craig C, Waller BR, Javois AJ, Cuneo BF
Cardiol Young 2016 Aug;26(6):1072-81. Epub 2015 Sep 8 doi: 10.1017/S1047951115001791. PMID: 26346529
Voges I, Jerosch-Herold M, Wegner P, Hart C, Gabbert D, Al Bulushi A, Fischer G, Andrade AC, Pham HM, Kristo I, Kramer HH, Rickers C
J Am Heart Assoc 2015 Oct 5;4(10):e002107. doi: 10.1161/JAHA.115.002107. PMID: 26438562Free PMC Article
Malik S, Bird TM, Jaquiss RD, Morrow WR, Robbins JM
J Thorac Cardiovasc Surg 2015 Sep;150(3):474-80.e2. Epub 2015 Jul 4 doi: 10.1016/j.jtcvs.2015.06.071. PMID: 26242838
Theis JL, Zimmermann MT, Evans JM, Eckloff BW, Wieben ED, Qureshi MY, O'Leary PW, Olson TM
Circ Cardiovasc Genet 2015 Aug;8(4):564-71. Epub 2015 Jun 17 doi: 10.1161/CIRCGENETICS.115.001070. PMID: 26085007
Schlangen J, Petko C, Hansen JH, Michel M, Hart C, Uebing A, Fischer G, Becker K, Kramer HH
Circ Cardiovasc Imaging 2014 Nov;7(6):880-6. Epub 2014 Sep 30 doi: 10.1161/CIRCIMAGING.114.002110. PMID: 25270741

Recent systematic reviews

Saul D, Degenhardt K, Iyoob SD, Surrey LF, Johnson AM, Johnson MP, Rychik J, Victoria T
Pediatr Radiol 2016 Apr;46(4):483-9. Epub 2015 Dec 21 doi: 10.1007/s00247-015-3514-6. PMID: 26691156
Danford DA, Karels Q, Kulkarni A, Hussain A, Xiao Y, Kutty S
Orphanet J Rare Dis 2015 Oct 22;10:137. doi: 10.1186/s13023-015-0355-1. PMID: 26494006Free PMC Article
Miller-Tate H, Stewart J, Allen R, Husain N, Rosen K, Cheatham JP, Galantowicz M, Cua CL
Congenit Heart Dis 2013 May-Jun;8(3):228-33. Epub 2012 Sep 25 doi: 10.1111/chd.12007. PMID: 23006134
Slicker J, Hehir DA, Horsley M, Monczka J, Stern KW, Roman B, Ocampo EC, Flanagan L, Keenan E, Lambert LM, Davis D, Lamonica M, Rollison N, Heydarian H, Anderson JB; Feeding Work Group of the National Pediatric Cardiology Quality Improvement Collaborative.
Congenit Heart Dis 2013 Mar-Apr;8(2):89-102. Epub 2012 Aug 14 doi: 10.1111/j.1747-0803.2012.00705.x. PMID: 22891735Free PMC Article
Photiadis J, Sinzobahamvya N, Hraška V, Asfour B
Thorac Cardiovasc Surg 2012 Apr;60(3):181-8. Epub 2012 Jan 3 doi: 10.1055/s-0031-1295569. PMID: 22215495

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