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Myelomeningocele

MedGen UID:
505247
Concept ID:
CN002248
Finding
Synonyms: Meningomyelocele; Spina bifida cystica
 

Definition

Protrusion of the meninges and portions of the spinal cord through a defect of the vertebral column. [from HPO]

Recent clinical studies

Etiology

Tauheed J, Sanchez-Guerra M, Lee JJ, Paul L, Ibne Hasan MOS, Quamruzzaman Q, Selhub J, Wright RO, Christiani DC, Coull BA, Baccarelli AA, Mazumdar M
Epigenetics 2017 Jun 3;12(6):484-491. Epub 2017 Apr 7 doi: 10.1080/15592294.2017.1312238. PMID: 28387569Free PMC Article
Yasmeh P, Mueske NM, Yasmeh S, Ryan DD, Wren TAL
Disabil Rehabil 2017 Jul;39(14):1422-1427. Epub 2016 Jul 6 doi: 10.1080/09638288.2016.1198429. PMID: 27384911Free PMC Article
Van Speybroeck A, Mueske NM, Mittelman SD, Kremer RK, Ryan DD, Wren TA
J Spinal Cord Med 2017 Mar;40(2):193-200. Epub 2015 Dec 14 doi: 10.1080/10790268.2015.1101983. PMID: 26666357Free PMC Article
Cherian J, Staggers KA, Pan IW, Lopresti M, Jea A, Lam S
J Neurosurg Pediatr 2016 Oct;18(4):416-422. Epub 2016 Jun 3 doi: 10.3171/2016.1.PEDS15674. PMID: 27258591
Soni S, Moldenhauer JS, Spinner SS, Rendon N, Khalek N, Martinez-Poyer J, Johnson MP, Adzick NS
Am J Obstet Gynecol 2016 May;214(5):647.e1-7. Epub 2015 Dec 12 doi: 10.1016/j.ajog.2015.12.003. PMID: 26692177

Diagnosis

Heuer GG, Moldenhauer JS, Scott Adzick N
Childs Nerv Syst 2017 Jul;33(7):1149-1155. Epub 2017 May 17 doi: 10.1007/s00381-017-3440-z. PMID: 28516217
Elbabaa SK, Gildehaus AM, Pierson MJ, Albers JA, Vlastos EJ
Childs Nerv Syst 2017 Jul;33(7):1157-1168. Epub 2017 May 3 doi: 10.1007/s00381-017-3428-8. PMID: 28470384
Soni S, Moldenhauer JS, Spinner SS, Rendon N, Khalek N, Martinez-Poyer J, Johnson MP, Adzick NS
Am J Obstet Gynecol 2016 May;214(5):647.e1-7. Epub 2015 Dec 12 doi: 10.1016/j.ajog.2015.12.003. PMID: 26692177
Carreras E, Maroto A, Illescas T, Meléndez M, Arévalo S, Peiró JL, García-Fontecha CG, Belfort M, Cuxart A
Ultrasound Obstet Gynecol 2016 Feb;47(2):162-7. Epub 2016 Jan 13 doi: 10.1002/uog.15732. PMID: 26306897
Patel DM, Rocque BG, Hopson B, Arynchyna A, Bishop ER, Lozano D, Blount JP
J Neurosurg Pediatr 2015 Jul;16(1):30-5. Epub 2015 Apr 3 doi: 10.3171/2014.11.PEDS14314. PMID: 25837889

Therapy

Kancherla V, Ibne Hasan MOS, Hamid R, Paul L, Selhub J, Oakley G, Quamruzzaman Q, Mazumdar M
PLoS One 2017;12(11):e0188726. Epub 2017 Nov 30 doi: 10.1371/journal.pone.0188726. PMID: 29190654Free PMC Article
Tauheed J, Sanchez-Guerra M, Lee JJ, Paul L, Ibne Hasan MOS, Quamruzzaman Q, Selhub J, Wright RO, Christiani DC, Coull BA, Baccarelli AA, Mazumdar M
Epigenetics 2017 Jun 3;12(6):484-491. Epub 2017 Apr 7 doi: 10.1080/15592294.2017.1312238. PMID: 28387569Free PMC Article
Cherian J, Staggers KA, Pan IW, Lopresti M, Jea A, Lam S
J Neurosurg Pediatr 2016 Oct;18(4):416-422. Epub 2016 Jun 3 doi: 10.3171/2016.1.PEDS15674. PMID: 27258591
Mazumdar M, Valeri L, Rodrigues EG, Ibne Hasan MO, Hamid R, Paul L, Selhub J, Silva F, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC
Birth Defects Res A Clin Mol Teratol 2015 Sep;103(9):754-62. Epub 2015 Aug 6 doi: 10.1002/bdra.23399. PMID: 26250961Free PMC Article
Patel DM, Rocque BG, Hopson B, Arynchyna A, Bishop ER, Lozano D, Blount JP
J Neurosurg Pediatr 2015 Jul;16(1):30-5. Epub 2015 Apr 3 doi: 10.3171/2014.11.PEDS14314. PMID: 25837889

Prognosis

Elbabaa SK, Gildehaus AM, Pierson MJ, Albers JA, Vlastos EJ
Childs Nerv Syst 2017 Jul;33(7):1157-1168. Epub 2017 May 3 doi: 10.1007/s00381-017-3428-8. PMID: 28470384
Borgstedt-Bakke JH, Fenger-Grøn M, Rasmussen MM
J Neurosurg Pediatr 2017 Feb;19(2):227-231. Epub 2016 Dec 2 doi: 10.3171/2016.8.PEDS1654. PMID: 27911247
Cherian J, Staggers KA, Pan IW, Lopresti M, Jea A, Lam S
J Neurosurg Pediatr 2016 Oct;18(4):416-422. Epub 2016 Jun 3 doi: 10.3171/2016.1.PEDS15674. PMID: 27258591
Carreras E, Maroto A, Illescas T, Meléndez M, Arévalo S, Peiró JL, García-Fontecha CG, Belfort M, Cuxart A
Ultrasound Obstet Gynecol 2016 Feb;47(2):162-7. Epub 2016 Jan 13 doi: 10.1002/uog.15732. PMID: 26306897
Kshettry VR, Kelly ML, Rosenbaum BP, Seicean A, Hwang L, Weil RJ
J Neurosurg Pediatr 2014 Jun;13(6):666-78. Epub 2014 Apr 4 doi: 10.3171/2014.3.PEDS13597. PMID: 24702620

Clinical prediction guides

Elbabaa SK, Gildehaus AM, Pierson MJ, Albers JA, Vlastos EJ
Childs Nerv Syst 2017 Jul;33(7):1157-1168. Epub 2017 May 3 doi: 10.1007/s00381-017-3428-8. PMID: 28470384
Matar HE, Beirne P, Garg NK
J Pediatr Orthop B 2017 Mar;26(2):133-136. doi: 10.1097/BPB.0000000000000352. PMID: 27386794
Cherian J, Staggers KA, Pan IW, Lopresti M, Jea A, Lam S
J Neurosurg Pediatr 2016 Oct;18(4):416-422. Epub 2016 Jun 3 doi: 10.3171/2016.1.PEDS15674. PMID: 27258591
Carreras E, Maroto A, Illescas T, Meléndez M, Arévalo S, Peiró JL, García-Fontecha CG, Belfort M, Cuxart A
Ultrasound Obstet Gynecol 2016 Feb;47(2):162-7. Epub 2016 Jan 13 doi: 10.1002/uog.15732. PMID: 26306897
Kshettry VR, Kelly ML, Rosenbaum BP, Seicean A, Hwang L, Weil RJ
J Neurosurg Pediatr 2014 Jun;13(6):666-78. Epub 2014 Apr 4 doi: 10.3171/2014.3.PEDS13597. PMID: 24702620

Recent systematic reviews

Committee on Obstetric Practice, Society for Maternal–Fetal Medicine.
Obstet Gynecol 2017 Sep;130(3):e164-e167. doi: 10.1097/AOG.0000000000002303. PMID: 28832491
Obstet Gynecol 2017 Sep;130(3):672-673. doi: 10.1097/AOG.0000000000002294. PMID: 28832482
Chan YY, Sandlin SK, Kurzrock EA
Curr Urol Rep 2017 May;18(5):35. doi: 10.1007/s11934-017-0684-9. PMID: 28285380
Soni S, Moldenhauer JS, Spinner SS, Rendon N, Khalek N, Martinez-Poyer J, Johnson MP, Adzick NS
Am J Obstet Gynecol 2016 May;214(5):647.e1-7. Epub 2015 Dec 12 doi: 10.1016/j.ajog.2015.12.003. PMID: 26692177
Cohen AR, Couto J, Cummings JJ, Johnson A, Joseph G, Kaufman BA, Litman RS, Menard MK, Moldenhauer JS, Pringle KC, Schwartz MZ, Walker WO Jr, Warf BC, Wax JR; MMC Maternal-Fetal Management Task Force.
Am J Obstet Gynecol 2014 Feb;210(2):107-11. Epub 2013 Sep 18 doi: 10.1016/j.ajog.2013.09.016. PMID: 24055581

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