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Epithelial metaplasia

MedGen UID:
473395
•Concept ID:
C1317977
•
Cell or Molecular Dysfunction
Synonym: Epithelial Metaplasia
SNOMED CT: Epithelial metaplasia (54725001)

Definition

A morphologic finding that refers to the replacement of a group of one type of epithelial cells (e.g., glandular epithelial cells) to another type of epithelial cells (e.g., squamous epithelial cells). [from NCI]

Professional guidelines

PubMed

Clinical implications of morular metaplasia in fertility-preserving treatment for atypical endometrial hyperplasia and early endometrial carcinoma patients.
Wu P, Lv Q, Guan J, Shan W, Chen X, Zhu Q, Luo X
Arch Gynecol Obstet 2022 Oct;306(4):1135-1146. Epub 2022 Mar 4 doi: 10.1007/s00404-021-06382-3. PMID: 35246715Free PMC Article
Barrett's Oesophagus and Bariatric/Metabolic Surgery-IFSO 2020 Position Statement.
Fisher OM, Chan DL, Talbot ML, Ramos A, Bashir A, Herrera MF, Himpens J, Shikora S, Higa KD, Kow L, Brown WA
Obes Surg 2021 Mar;31(3):915-934. Epub 2021 Jan 18 doi: 10.1007/s11695-020-05143-6. PMID: 33460005
Differential diagnosis of IgG4-related sialadenitis, primary Sjögren syndrome, and chronic obstructive submandibular sialadenitis.
Hong X, Li W, Xie XY, Zhang ZY, Chen Y, Gao Y, Peng X, Su JZ, Zhang YY, Wang Z, Cai ZG, Zhang L, Liu YY, He J, Ren LM, Li ZG, Yu GY
Br J Oral Maxillofac Surg 2017 Feb;55(2):179-184. Epub 2016 Nov 17 doi: 10.1016/j.bjoms.2016.10.021. PMID: 27866757

Recent clinical studies

Etiology

Natural history and mechanisms of COPD.
Lange P, Ahmed E, Lahmar ZM, Martinez FJ, Bourdin A
Respirology 2021 Apr;26(4):298-321. Epub 2021 Jan 28 doi: 10.1111/resp.14007. PMID: 33506971
Dystrophic calcification and respiratory metaplasia in the epithelial lining of odontogenic cysts: a study of 362 odontogenic cysts in a Brazilian population and literature review.
Stuepp RT, Scotti FM, Poletto AG, Rivero ERC, Modolo F
Pathol Res Pract 2020 Jun;216(6):152975. Epub 2020 Apr 18 doi: 10.1016/j.prp.2020.152975. PMID: 32360248
Mucinous metaplasia of the endometrium: current concepts.
Turashvili G, Childs T
Gynecol Oncol 2015 Feb;136(2):389-93. Epub 2014 Dec 6 doi: 10.1016/j.ygyno.2014.12.003. PMID: 25485781
Long-term outcome of esophageal anastomosis.
Rintala RJ, Pakarinen MP
Eur J Pediatr Surg 2013 Jun;23(3):219-25. Epub 2013 Jun 4 doi: 10.1055/s-0033-1347912. PMID: 23737132
Barrett's esophagus and adenocarcinoma.
Reid BJ, Weinstein WM
Annu Rev Med 1987;38:477-92. doi: 10.1146/annurev.me.38.020187.002401. PMID: 3555308

Diagnosis

Natural history and mechanisms of COPD.
Lange P, Ahmed E, Lahmar ZM, Martinez FJ, Bourdin A
Respirology 2021 Apr;26(4):298-321. Epub 2021 Jan 28 doi: 10.1111/resp.14007. PMID: 33506971
Dystrophic calcification and respiratory metaplasia in the epithelial lining of odontogenic cysts: a study of 362 odontogenic cysts in a Brazilian population and literature review.
Stuepp RT, Scotti FM, Poletto AG, Rivero ERC, Modolo F
Pathol Res Pract 2020 Jun;216(6):152975. Epub 2020 Apr 18 doi: 10.1016/j.prp.2020.152975. PMID: 32360248
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934
Epithelial metaplasia and the development of cancer.
Quinlan JM, Colleypriest BJ, Farrant M, Tosh D
Biochim Biophys Acta 2007 Sep;1776(1):10-21. Epub 2007 May 26 doi: 10.1016/j.bbcan.2007.05.005. PMID: 17618050
Barrett's esophagus and adenocarcinoma.
Reid BJ, Weinstein WM
Annu Rev Med 1987;38:477-92. doi: 10.1146/annurev.me.38.020187.002401. PMID: 3555308

Therapy

Natural history and mechanisms of COPD.
Lange P, Ahmed E, Lahmar ZM, Martinez FJ, Bourdin A
Respirology 2021 Apr;26(4):298-321. Epub 2021 Jan 28 doi: 10.1111/resp.14007. PMID: 33506971
Autologous serum eye drops for dry eye.
Pan Q, Angelina A, Zambrano A, Marrone M, Stark WJ, Heflin T, Tang L, Akpek EK
Cochrane Database Syst Rev 2013 Aug 27;8(8):CD009327. doi: 10.1002/14651858.CD009327.pub2. PMID: 23982997Free PMC Article
Pathogenesis of and unifying hypothesis for idiopathic pouchitis.
Coffey JC, Rowan F, Burke J, Dochery NG, Kirwan WO, O'Connell PR
Am J Gastroenterol 2009 Apr;104(4):1013-23. Epub 2009 Mar 3 doi: 10.1038/ajg.2008.127. PMID: 19259080
Role of estrogens in development of prostate cancer.
Härkönen PL, Mäkelä SI
J Steroid Biochem Mol Biol 2004 Nov;92(4):297-305. Epub 2004 Dec 19 doi: 10.1016/j.jsbmb.2004.10.016. PMID: 15663993
Hormonal pathology of the endometrium.
Deligdisch L
Mod Pathol 2000 Mar;13(3):285-94. doi: 10.1038/modpathol.3880050. PMID: 10757339

Prognosis

Natural history and mechanisms of COPD.
Lange P, Ahmed E, Lahmar ZM, Martinez FJ, Bourdin A
Respirology 2021 Apr;26(4):298-321. Epub 2021 Jan 28 doi: 10.1111/resp.14007. PMID: 33506971
Preinflammatory Signs in Established Reusable and Disposable Contact Lens Wearers.
Chao C, Stapleton F, Willcox MDP, Golebiowski B, Richdale K
Optom Vis Sci 2017 Nov;94(11):1003-1008. doi: 10.1097/OPX.0000000000001129. PMID: 28858005
Mucinous metaplasia of the endometrium: current concepts.
Turashvili G, Childs T
Gynecol Oncol 2015 Feb;136(2):389-93. Epub 2014 Dec 6 doi: 10.1016/j.ygyno.2014.12.003. PMID: 25485781
Long-term outcome of esophageal anastomosis.
Rintala RJ, Pakarinen MP
Eur J Pediatr Surg 2013 Jun;23(3):219-25. Epub 2013 Jun 4 doi: 10.1055/s-0033-1347912. PMID: 23737132
Long-term results of esophageal atresia: Helsinki experience and review of literature.
Sistonen SJ, Pakarinen MP, Rintala RJ
Pediatr Surg Int 2011 Nov;27(11):1141-9. Epub 2011 Sep 30 doi: 10.1007/s00383-011-2980-7. PMID: 21960312

Clinical prediction guides

Dystrophic calcification and respiratory metaplasia in the epithelial lining of odontogenic cysts: a study of 362 odontogenic cysts in a Brazilian population and literature review.
Stuepp RT, Scotti FM, Poletto AG, Rivero ERC, Modolo F
Pathol Res Pract 2020 Jun;216(6):152975. Epub 2020 Apr 18 doi: 10.1016/j.prp.2020.152975. PMID: 32360248
Origins of Metaplasia in Barrett's Esophagus: Is this an Esophageal Stem or Progenitor Cell Disease?
Zhang W, Wang DH
Dig Dis Sci 2018 Aug;63(8):2005-2012. doi: 10.1007/s10620-018-5069-5. PMID: 29675663Free PMC Article
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934
Epithelial metaplasia: adult stem cell reprogramming and (pre)neoplastic transformation mediated by inflammation?
Herfs M, Hubert P, Delvenne P
Trends Mol Med 2009 Jun;15(6):245-53. Epub 2009 May 18 doi: 10.1016/j.molmed.2009.04.002. PMID: 19457719
Differences in airway remodeling between asthma and chronic obstructive pulmonary disease.
Aoshiba K, Nagai A
Clin Rev Allergy Immunol 2004 Aug;27(1):35-43. doi: 10.1385/CRIAI:27:1:035. PMID: 15347849

Recent systematic reviews

Autologous serum eye drops for dry eye.
Pan Q, Angelina A, Zambrano A, Marrone M, Stark WJ, Heflin T, Tang L, Akpek EK
Cochrane Database Syst Rev 2013 Aug 27;8(8):CD009327. doi: 10.1002/14651858.CD009327.pub2. PMID: 23982997Free PMC Article

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