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Familial hypertrophic cardiomyopathy 14(CMH14)

MedGen UID:
442484
Concept ID:
C2750467
Disease or Syndrome
Synonyms: CMH14
 
Gene (location): MYH6 (14q11.2)
OMIM®: 613251

Clinical features

Hypertrophic cardiomyopathy
MedGen UID:
2881
Concept ID:
C0007194
Disease or Syndrome
A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Pinto YM, Wilde AA, van Rijsingen IA, Christiaans I, Deprez RH, Elliott PM
Eur J Hum Genet 2011 Aug;19(8) Epub 2011 Jan 26 doi: 10.1038/ejhg.2010.243. PMID: 21267010Free PMC Article

Recent clinical studies

Etiology

Pacileo G, Salerno G, Gravino R, Calabrò R, Elliott PM
J Cardiovasc Med (Hagerstown) 2013 May;14(5):319-25. doi: 10.2459/JCM.0b013e328357739e. PMID: 22885536
Gandjbakhch E, Gackowski A, Tezenas du Montcel S, Isnard R, Hamroun A, Richard P, Komajda M, Charron P
Eur Heart J 2010 Jul;31(13):1599-607. Epub 2010 May 3 doi: 10.1093/eurheartj/ehq101. PMID: 20439259
Posch MG, Thiemann L, Tomasov P, Veselka J, Cardim N, Garcia-Castro M, Coto E, Perrot A, Geier C, Dietz R, Haverkamp W, Ozcelik C
Med Sci Monit 2008 Jul;14(7):CR372-4. PMID: 18591919
Kounas S, Demetrescu C, Pantazis AA, Keren A, Lee PJ, Hughes D, Mehta A, Elliott PM
J Am Coll Cardiol 2008 May 27;51(21):2058-61. doi: 10.1016/j.jacc.2008.02.046. PMID: 18498962
Tsoutsman T, Kelly M, Ng DC, Tan JE, Tu E, Lam L, Bogoyevitch MA, Seidman CE, Seidman JG, Semsarian C
Circulation 2008 Apr 8;117(14):1820-31. Epub 2008 Mar 24 doi: 10.1161/CIRCULATIONAHA.107.755777. PMID: 18362229

Diagnosis

Ntusi NA, Shaboodien G, Badri M, Gumedze F, Mayosi BM
Cardiovasc J Afr 2016 May/Jun;27(3):152-158. doi: 10.5830/CVJA-2015-075. PMID: 27841901Free PMC Article
Pacileo G, Salerno G, Gravino R, Calabrò R, Elliott PM
J Cardiovasc Med (Hagerstown) 2013 May;14(5):319-25. doi: 10.2459/JCM.0b013e328357739e. PMID: 22885536
Maron MS
J Cardiovasc Magn Reson 2012 Feb 1;14:13. doi: 10.1186/1532-429X-14-13. PMID: 22296938Free PMC Article
Gandjbakhch E, Gackowski A, Tezenas du Montcel S, Isnard R, Hamroun A, Richard P, Komajda M, Charron P
Eur Heart J 2010 Jul;31(13):1599-607. Epub 2010 May 3 doi: 10.1093/eurheartj/ehq101. PMID: 20439259
Kounas S, Demetrescu C, Pantazis AA, Keren A, Lee PJ, Hughes D, Mehta A, Elliott PM
J Am Coll Cardiol 2008 May 27;51(21):2058-61. doi: 10.1016/j.jacc.2008.02.046. PMID: 18498962

Therapy

Forsey J, Benson L, Rozenblyum E, Friedberg MK, Mertens L
J Am Soc Echocardiogr 2014 Feb;27(2):215-21. Epub 2013 Dec 8 doi: 10.1016/j.echo.2013.10.012. PMID: 24325958
Lopes LR, Rahman MS, Elliott PM
Heart 2013 Dec;99(24):1800-11. Epub 2013 May 14 doi: 10.1136/heartjnl-2013-303939. PMID: 23674365
Spoladore R, Maron MS, D'Amato R, Camici PG, Olivotto I
Eur Heart J 2012 Jul;33(14):1724-33. Epub 2012 Jun 19 doi: 10.1093/eurheartj/ehs150. PMID: 22719025
Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Otsuka H, Arimura T, Kimura A, Doi YL
Circ J 2011;75(11):2654-9. Epub 2011 Jul 29 PMID: 21799269
Kounas S, Demetrescu C, Pantazis AA, Keren A, Lee PJ, Hughes D, Mehta A, Elliott PM
J Am Coll Cardiol 2008 May 27;51(21):2058-61. doi: 10.1016/j.jacc.2008.02.046. PMID: 18498962

Prognosis

Ntusi NA, Shaboodien G, Badri M, Gumedze F, Mayosi BM
Cardiovasc J Afr 2016 May/Jun;27(3):152-158. doi: 10.5830/CVJA-2015-075. PMID: 27841901Free PMC Article
Forsey J, Benson L, Rozenblyum E, Friedberg MK, Mertens L
J Am Soc Echocardiogr 2014 Feb;27(2):215-21. Epub 2013 Dec 8 doi: 10.1016/j.echo.2013.10.012. PMID: 24325958
Pacileo G, Salerno G, Gravino R, Calabrò R, Elliott PM
J Cardiovasc Med (Hagerstown) 2013 May;14(5):319-25. doi: 10.2459/JCM.0b013e328357739e. PMID: 22885536
Noureldin RA, Liu S, Nacif MS, Judge DP, Halushka MK, Abraham TP, Ho C, Bluemke DA
J Cardiovasc Magn Reson 2012 Feb 20;14:17. doi: 10.1186/1532-429X-14-17. PMID: 22348519Free PMC Article
Maron MS
J Cardiovasc Magn Reson 2012 Feb 1;14:13. doi: 10.1186/1532-429X-14-13. PMID: 22296938Free PMC Article

Clinical prediction guides

Ntusi NA, Shaboodien G, Badri M, Gumedze F, Mayosi BM
Cardiovasc J Afr 2016 May/Jun;27(3):152-158. doi: 10.5830/CVJA-2015-075. PMID: 27841901Free PMC Article
Pacileo G, Salerno G, Gravino R, Calabrò R, Elliott PM
J Cardiovasc Med (Hagerstown) 2013 May;14(5):319-25. doi: 10.2459/JCM.0b013e328357739e. PMID: 22885536
Gandjbakhch E, Gackowski A, Tezenas du Montcel S, Isnard R, Hamroun A, Richard P, Komajda M, Charron P
Eur Heart J 2010 Jul;31(13):1599-607. Epub 2010 May 3 doi: 10.1093/eurheartj/ehq101. PMID: 20439259
Kounas S, Demetrescu C, Pantazis AA, Keren A, Lee PJ, Hughes D, Mehta A, Elliott PM
J Am Coll Cardiol 2008 May 27;51(21):2058-61. doi: 10.1016/j.jacc.2008.02.046. PMID: 18498962
Tsoutsman T, Kelly M, Ng DC, Tan JE, Tu E, Lam L, Bogoyevitch MA, Seidman CE, Seidman JG, Semsarian C
Circulation 2008 Apr 8;117(14):1820-31. Epub 2008 Mar 24 doi: 10.1161/CIRCULATIONAHA.107.755777. PMID: 18362229

Recent systematic reviews

Lopes LR, Rahman MS, Elliott PM
Heart 2013 Dec;99(24):1800-11. Epub 2013 May 14 doi: 10.1136/heartjnl-2013-303939. PMID: 23674365
Spoladore R, Maron MS, D'Amato R, Camici PG, Olivotto I
Eur Heart J 2012 Jul;33(14):1724-33. Epub 2012 Jun 19 doi: 10.1093/eurheartj/ehs150. PMID: 22719025

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