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Zenker diverticulum

MedGen UID:
43132
•Concept ID:
C0085232
•
Disease or Syndrome
Synonyms: Diverticula, Esophago-Pharyngeal; Diverticula, Pharyngeal; Diverticula, Pharyngo-Esophageal; Diverticula, Pharyngoesophageal; Diverticula, Pharyngoesophageal Pulsion; Diverticula, Zenker's; Diverticulum, Esophago-Pharyngeal; Diverticulum, Esophagopharyngeal; Diverticulum, Pharyngeal; Diverticulum, Pharyngo-Esophageal; Diverticulum, Pharyngoesophageal; Diverticulum, Pharyngoesophageal Pulsion; Diverticulum, Zenker; Diverticulum, Zenker's; Esophago Pharyngeal Diverticula; Esophago Pharyngeal Diverticulum; Esophago-Pharyngeal Diverticula; Esophago-Pharyngeal Diverticulum; Esophagopharyngeal Diverticulum; Esophagopharyngeal Diverticulums; Pharyngeal Diverticula; Pharyngeal Diverticulum; Pharyngo Esophageal Diverticula; Pharyngo Esophageal Diverticulum; Pharyngo-Esophageal Diverticula; Pharyngo-Esophageal Diverticulum; Pharyngoesophageal Diverticula; Pharyngoesophageal Diverticulum; Pharyngoesophageal Pulsion Diverticula; Pharyngoesophageal Pulsion Diverticulum; Pulsion Diverticula, Pharyngoesophageal; Pulsion Diverticulum, Pharyngoesophageal; Zenker Diverticula; Zenker Diverticulum; Zenker's Diverticula; Zenker's Diverticulum; Zenkers Diverticula; Zenkers Diverticulum
SNOMED CT: Zenker's diverticulum (399291005); Zenker's hypopharyngeal diverticulum (399291005); Zenker diverticulum (399291005); Hypopharyngeal diverticulum (399291005); Acquired pharyngoesophageal diverticulum (399291005); Pharyngoesophageal diverticulum (399291005); Pharyngo-oesophageal diverticulum (399291005)

Definition

A diverticulum of the posterior pharyngeal wall opening, which is located just posterior the cricoid cartilage, between the inferior pharyngeal constrictor and the cricopharyngeus muscles. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVZenker diverticulum

Professional guidelines

PubMed

Epidemiology and Management of Zenker Diverticulum in a Low-Threshold Single-payer Health Care System.
Uoti S, Andersson SE, Robinson E, Räsänen J, Kytö V, Ilonen I
JAMA Otolaryngol Head Neck Surg 2022 Mar 1;148(3):235-242. doi: 10.1001/jamaoto.2021.3671. PMID: 34913965Free PMC Article
Zenker Diverticulum Treatment: Endoscopic or Surgical?
Ciuc D, Birlă R, Panaitescu E, Tanţău M, Constantinoiu S
Chirurgia (Bucur) 2018 Mar-Apr;113(2):234-243. doi: 10.21614/chirurgia.113.2.234. PMID: 29733017
Current trends in management of Zenker diverticulum.
Veenker E, Cohen JI
Curr Opin Otolaryngol Head Neck Surg 2003 Jun;11(3):160-5. doi: 10.1097/00020840-200306000-00006. PMID: 12923356

Recent clinical studies

Etiology

Surgical Nonresponders in Zenker Diverticulum and Lower Esophageal Pathology (POUCH Collaborative).
Brown J, McCoy N, Allen J, Altaye M, Amin M, Bayan S, Belafsky P, DeSilva B, Dion G, Ekbom D, Friedman A, Fritz M, Giliberto JP, Guardiani E, Johnson C, Kasperbauer J, Kim B, Krekeler BN, Kuhn M, Kwak P, Ma Y, Madden LL, Matrka L, Mayerhoff R, Piraka C, Rosen CA, Tabangin M, Wahab S, Wilson K, Wright C, Young VN, Postma G, Howell RJ
Laryngoscope 2024 Dec;134(12):4897-4902. Epub 2024 Jul 9 doi: 10.1002/lary.31619. PMID: 38979706
Modern approaches to treating Zenker's diverticulum.
Fair L, Ward MA
Curr Opin Gastroenterol 2023 Jul 1;39(4):333-339. Epub 2023 Apr 25 doi: 10.1097/MOG.0000000000000941. PMID: 37278290
Transcervical pharyngeal pouch stapling.
Brimioulle M, Corbridge R, Elsayed M
Eur Arch Otorhinolaryngol 2023 Jan;280(1):487-490. Epub 2022 Aug 30 doi: 10.1007/s00405-022-07603-4. PMID: 36040518
Zenker's Diverticulum: Readability and Quality of Online Written Education Materials.
Shneyderman M, Davis R, Snow G, Dhar S, Akst LM
Dysphagia 2022 Dec;37(6):1461-1467. Epub 2022 Jan 29 doi: 10.1007/s00455-022-10406-8. PMID: 35092487
The role of peroral endoscopic myotomy for Zenker's diverticulum: a systematic review and meta-analysis.
Zhang H, Huang S, Xia H, Shi L, Zeng X, Jiang J, Ren W, Peng Y, Lü M, Tang X
Surg Endosc 2022 May;36(5):2749-2759. Epub 2022 Jan 12 doi: 10.1007/s00464-022-09021-3. PMID: 35020054

Diagnosis

Upper Esophageal Dysphagia.
Chheda NN
Surg Clin North Am 2022 Apr;102(2):199-207. Epub 2022 Mar 4 doi: 10.1016/j.suc.2021.12.002. PMID: 35344692
Zenker's Diverticulum.
Law R, Katzka DA, Baron TH
Clin Gastroenterol Hepatol 2014 Nov;12(11):1773-82; quiz e111-2. Epub 2013 Sep 18 doi: 10.1016/j.cgh.2013.09.016. PMID: 24055983
Zenker's diverticulum.
Mohan P, Narasimhan M, Ardhanari R
Indian J Gastroenterol 2014 Nov;33(6):578. doi: 10.1007/s12664-013-0404-4. PMID: 24037767
Zenker diverticulum.
Prisman E, Genden EM
Otolaryngol Clin North Am 2013 Dec;46(6):1101-11. Epub 2013 Oct 10 doi: 10.1016/j.otc.2013.08.011. PMID: 24262962
Zenker's diverticulum: reappraisal.
Watemberg S, Landau O, Avrahami R
Am J Gastroenterol 1996 Aug;91(8):1494-8. PMID: 8759648

Therapy

Zenker's peroral endoscopic myotomy for management of large Zenker's diverticulum.
Zhang LY, Hernández Mondragón O, Pioche M, Steinway SN, Nieto J, Ujiki MB, VanDruff VN, Kim RE, Canakis A, Tantau M, Tantau A, Pop A, Jacques J, Lajin M, Desai P, Shrigiriwar A, Bejjani M, Kumta NA, Khashab MA
Endoscopy 2023 Jun;55(6):501-507. Epub 2023 Feb 24 doi: 10.1055/a-2025-0715. PMID: 36827992
Endoscopic stapler versus laser diverticulotomy for Zenker's diverticulum: a systematic review and meta-analysis.
Edwards D, Prades E, Thorne C, Harris A
J Laryngol Otol 2023 Jul;137(7):718-724. Epub 2022 Nov 16 doi: 10.1017/S0022215122002377. PMID: 36382425
Transcervical pharyngeal pouch stapling.
Brimioulle M, Corbridge R, Elsayed M
Eur Arch Otorhinolaryngol 2023 Jan;280(1):487-490. Epub 2022 Aug 30 doi: 10.1007/s00405-022-07603-4. PMID: 36040518
The role of peroral endoscopic myotomy for Zenker's diverticulum: a systematic review and meta-analysis.
Zhang H, Huang S, Xia H, Shi L, Zeng X, Jiang J, Ren W, Peng Y, Lü M, Tang X
Surg Endosc 2022 May;36(5):2749-2759. Epub 2022 Jan 12 doi: 10.1007/s00464-022-09021-3. PMID: 35020054
Neopharyngeal diverticulum.
Howell RJ, Postma GN
Ear Nose Throat J 2014 Aug;93(8):297. doi: 10.1177/014556131409300804. PMID: 25181656

Prognosis

Natural History of Cricopharyngeus Muscle Dysfunction Symptomatology.
Randall DR, Chan R, Gomes D, Walker K
Dysphagia 2022 Aug;37(4):937-945. Epub 2021 Sep 8 doi: 10.1007/s00455-021-10355-8. PMID: 34495387
Adverse Events after Rigid and Flexible Endoscopic Repair of Zenker's Diverticula: A Systematic Review and Meta-analysis.
Crawley B, Dehom S, Tamares S, Marghalani A, Ongkasuwan J, Reder L, Ivey C, Amin M, Fritz M, Pitman M, Tulunay-Ugur O, Weissbrod P
Otolaryngol Head Neck Surg 2019 Sep;161(3):388-400. Epub 2019 Apr 23 doi: 10.1177/0194599819839991. PMID: 31010403
New and emerging techniques for endoscopic treatment of Zenker's diverticulum: State-of-the-art review.
Ishaq S, Sultan H, Siau K, Kuwai T, Mulder CJ, Neumann H
Dig Endosc 2018 Jul;30(4):449-460. Epub 2018 Mar 7 doi: 10.1111/den.13035. PMID: 29423955
Respiratory Symptoms and Complications of Zenker Diverticulum: Effect of Trans-Oral Septum Stapling.
Siboni S, Asti E, Sozzi M, Bonitta G, Melloni M, Bonavina L
J Gastrointest Surg 2017 Sep;21(9):1391-1395. Epub 2017 May 3 doi: 10.1007/s11605-017-3435-9. PMID: 28470561
Functional results in endoscopic Zenker's diverticulum surgery.
Dissard A, Gilain L, Pastourel R, Mom T, Saroul N
Eur Ann Otorhinolaryngol Head Neck Dis 2017 Oct;134(5):309-313. Epub 2017 Mar 22 doi: 10.1016/j.anorl.2017.02.009. PMID: 28341539

Clinical prediction guides

Surgical Nonresponders in Zenker Diverticulum and Lower Esophageal Pathology (POUCH Collaborative).
Brown J, McCoy N, Allen J, Altaye M, Amin M, Bayan S, Belafsky P, DeSilva B, Dion G, Ekbom D, Friedman A, Fritz M, Giliberto JP, Guardiani E, Johnson C, Kasperbauer J, Kim B, Krekeler BN, Kuhn M, Kwak P, Ma Y, Madden LL, Matrka L, Mayerhoff R, Piraka C, Rosen CA, Tabangin M, Wahab S, Wilson K, Wright C, Young VN, Postma G, Howell RJ
Laryngoscope 2024 Dec;134(12):4897-4902. Epub 2024 Jul 9 doi: 10.1002/lary.31619. PMID: 38979706
Zenker's peroral endoscopic myotomy for management of large Zenker's diverticulum.
Zhang LY, Hernández Mondragón O, Pioche M, Steinway SN, Nieto J, Ujiki MB, VanDruff VN, Kim RE, Canakis A, Tantau M, Tantau A, Pop A, Jacques J, Lajin M, Desai P, Shrigiriwar A, Bejjani M, Kumta NA, Khashab MA
Endoscopy 2023 Jun;55(6):501-507. Epub 2023 Feb 24 doi: 10.1055/a-2025-0715. PMID: 36827992
Upper Esophageal Dysphagia.
Chheda NN
Surg Clin North Am 2022 Apr;102(2):199-207. Epub 2022 Mar 4 doi: 10.1016/j.suc.2021.12.002. PMID: 35344692
Zenker's Diverticulum: Readability and Quality of Online Written Education Materials.
Shneyderman M, Davis R, Snow G, Dhar S, Akst LM
Dysphagia 2022 Dec;37(6):1461-1467. Epub 2022 Jan 29 doi: 10.1007/s00455-022-10406-8. PMID: 35092487
Efficacy and Safety of Flexible Endoscopic Management of Zenker's Diverticulum.
Jain D, Sharma A, Shah M, Patel U, Thosani N, Singhal S
J Clin Gastroenterol 2018 May/Jun;52(5):369-385. doi: 10.1097/MCG.0000000000000977. PMID: 29283905

Recent systematic reviews

Endoscopic stapler versus laser diverticulotomy for Zenker's diverticulum: a systematic review and meta-analysis.
Edwards D, Prades E, Thorne C, Harris A
J Laryngol Otol 2023 Jul;137(7):718-724. Epub 2022 Nov 16 doi: 10.1017/S0022215122002377. PMID: 36382425
The role of peroral endoscopic myotomy for Zenker's diverticulum: a systematic review and meta-analysis.
Zhang H, Huang S, Xia H, Shi L, Zeng X, Jiang J, Ren W, Peng Y, Lü M, Tang X
Surg Endosc 2022 May;36(5):2749-2759. Epub 2022 Jan 12 doi: 10.1007/s00464-022-09021-3. PMID: 35020054
Submucosal tunnelling techniques for Zenker's diverticulum: a systematic review of early outcomes with pooled analysis.
Spadaccini M, Maselli R, Chandrasekar VT, Patel HK, Fugazza A, Galtieri PA, Pellegatta G, Attardo S, Carrara S, Anderloni A, Desai P, Alkandari A, Sharma P, Khashab MA, Repici A
Eur J Gastroenterol Hepatol 2021 Dec 1;33(1S Suppl 1):e78-e83. doi: 10.1097/MEG.0000000000002318. PMID: 34907984
Comparison of Surgical Treatments for Zenker Diverticulum: A Systematic Review and Network Meta-analysis.
Bhatt NK, Mendoza J, Kallogjeri D, Hardi AC, Bradley JP
JAMA Otolaryngol Head Neck Surg 2021 Feb 1;147(2):190-196. doi: 10.1001/jamaoto.2020.4091. PMID: 33270099Free PMC Article
Open Versus Endoscopic Surgery of Zenker's Diverticula: A Systematic Review and Meta-analysis.
Howell RJ, Giliberto JP, Harmon J, Masch J, Khosla S, Postma GN, Meinzen-Derr J
Dysphagia 2019 Dec;34(6):930-938. Epub 2019 Mar 12 doi: 10.1007/s00455-019-09994-9. PMID: 30863914

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