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Adult Pure Erythroid Leukemia

MedGen UID:
417053
•Concept ID:
C2347753
•
Neoplastic Process

Definition

A pure erythroid leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Pure Erythroid Leukemia

Professional guidelines

PubMed

Pure (acute) erythroid leukemia: morphology, immunophenotype, cytogenetics, mutations, treatment details, and survival data among 41 Mayo Clinic cases.
Reichard KK, Tefferi A, Abdelmagid M, Orazi A, Alexandres C, Haack J, Greipp PT
Blood Cancer J 2022 Nov 2;12(11):147. doi: 10.1038/s41408-022-00746-x. PMID: 36323674Free PMC Article
The uniqueness of morphological features of pure erythroid leukemia in myeloid neoplasm with erythroid predominance: A reassessment using criteria revised in the 2016 World Health Organization classification.
Ko PS, Liu YC, Yeh CM, Gau JP, Yu YB, Hsiao LT, Tzeng CH, Chen PM, Chiou TJ, Liu CJ, Liu JH
PLoS One 2017;12(2):e0172029. Epub 2017 Feb 14 doi: 10.1371/journal.pone.0172029. PMID: 28196090Free PMC Article
Pure red cell aplasia: clinical features and treatment results in 16 cases.
Kwong YL, Wong KF, Liang RH, Chu YC, Chan LC, Chan TK
Ann Hematol 1996 Mar;72(3):137-40. doi: 10.1007/s002770050151. PMID: 8766255

Recent clinical studies

Etiology

De novo pure erythroid leukemia: refining the clinicopathologic and cytogenetic characteristics of a rare entity.
Reinig EF, Greipp PT, Chiu A, Howard MT, Reichard KK
Mod Pathol 2018 May;31(5):705-717. Epub 2018 Jan 12 doi: 10.1038/modpathol.2017.175. PMID: 29327715
Pure Erythroid Leukemia and Erythroblastic Sarcoma Evolving From Chronic Myeloid Neoplasms.
Li H, Hasserjian RP, Kroft SH, Harrington AM, Wheaton SE, Pildain A, Ewalt MD, Gratzinger D, Hosking P, Olteanu H
Am J Clin Pathol 2016 Apr;145(4):538-51. Epub 2016 Apr 22 doi: 10.1093/ajcp/aqw033. PMID: 27124944
Pure erythroid leukemia: a reassessment of the entity using the 2008 World Health Organization classification.
Liu W, Hasserjian RP, Hu Y, Zhang L, Miranda RN, Medeiros LJ, Wang SA
Mod Pathol 2011 Mar;24(3):375-83. Epub 2010 Nov 19 doi: 10.1038/modpathol.2010.194. PMID: 21102413
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Aplastic anemia and pure red cell aplasia.
Dessypris EN
Curr Opin Hematol 1994 Mar;1(2):157-61. PMID: 9371275

Diagnosis

Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia.
Takeda J, Yoshida K, Nakagawa MM, Nannya Y, Yoda A, Saiki R, Ochi Y, Zhao L, Okuda R, Qi X, Mori T, Kon A, Chiba K, Tanaka H, Shiraishi Y, Kuo MC, Kerr CM, Nagata Y, Morishita D, Hiramoto N, Hangaishi A, Nakazawa H, Ishiyama K, Miyano S, Chiba S, Miyazaki Y, Kitano T, Usuki K, Sezaki N, Tsurumi H, Miyawaki S, Maciejewski JP, Ishikawa T, Ohyashiki K, Ganser A, Heuser M, Thol F, Shih LY, Takaori-Kondo A, Makishima H, Ogawa S
Blood Cancer Discov 2022 Sep 6;3(5):410-427. doi: 10.1158/2643-3230.BCD-21-0192. PMID: 35839275Free PMC Article
Pure erythroid leukemia subsequent to acute myelomonocytic leukemia: A case report.
Ji J, Li Y, Fan L, Lu H, Qu X
Medicine (Baltimore) 2021 Apr 16;100(15):e25528. doi: 10.1097/MD.0000000000025528. PMID: 33847676Free PMC Article
Diagnosis of rare subtypes of acute myeloid leukaemia and related neoplasms.
George TI, Bajel A
Pathology 2021 Apr;53(3):312-327. Epub 2021 Mar 4 doi: 10.1016/j.pathol.2021.02.001. PMID: 33676766
De novo pure erythroid leukemia: refining the clinicopathologic and cytogenetic characteristics of a rare entity.
Reinig EF, Greipp PT, Chiu A, Howard MT, Reichard KK
Mod Pathol 2018 May;31(5):705-717. Epub 2018 Jan 12 doi: 10.1038/modpathol.2017.175. PMID: 29327715
Pure erythroid leukemia.
Huang Q
Arch Pathol Lab Med 2004 Feb;128(2):241-2. doi: 10.5858/2004-128-241-PEL. PMID: 14736271

Therapy

Pure erythroid leukemia with hemophagocytosis.
Kitagawa J, Hara T, Tsurumi H, Oyama M, Moriwaki H
Intern Med 2009;48(18):1695-8. Epub 2009 Sep 15 doi: 10.2169/internalmedicine.48.1798. PMID: 19755777
Epistaxis and severe weakness in a patient with multiple myeloma. Therapy-related acute myeloid leukemia, pure erythroid leukemia.
Guo C, Inghirami G, Ibrahim S, Sen F
Arch Pathol Lab Med 2006 Jul;130(7):1075-6. doi: 10.5858/2006-130-1075-EASWIA. PMID: 16831041
Pure red cell aplasia developing into myeloproliferation with myelodysplasia and subsequent leukemia after cyclosporin A therapy.
Yamauchi T, Shirasaki H, Kuwata A, Yamashita T, Imamura S, Tsutani H, Ueda T
Int J Hematol 2002 Jun;75(5):514-8. doi: 10.1007/BF02982116. PMID: 12095153
Pure red cell aplasia: clinical features and treatment results in 16 cases.
Kwong YL, Wong KF, Liang RH, Chu YC, Chan LC, Chan TK
Ann Hematol 1996 Mar;72(3):137-40. doi: 10.1007/s002770050151. PMID: 8766255
Pure red cell aplasia and hypogammaglobulinemia associated with Tr-cell chronic lymphocytic leukemia.
Nagasawa T, Abe T, Nakagawa T
Blood 1981 Jun;57(6):1025-31. PMID: 6971663

Prognosis

Pure (acute) erythroid leukemia: morphology, immunophenotype, cytogenetics, mutations, treatment details, and survival data among 41 Mayo Clinic cases.
Reichard KK, Tefferi A, Abdelmagid M, Orazi A, Alexandres C, Haack J, Greipp PT
Blood Cancer J 2022 Nov 2;12(11):147. doi: 10.1038/s41408-022-00746-x. PMID: 36323674Free PMC Article
Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia.
Takeda J, Yoshida K, Nakagawa MM, Nannya Y, Yoda A, Saiki R, Ochi Y, Zhao L, Okuda R, Qi X, Mori T, Kon A, Chiba K, Tanaka H, Shiraishi Y, Kuo MC, Kerr CM, Nagata Y, Morishita D, Hiramoto N, Hangaishi A, Nakazawa H, Ishiyama K, Miyano S, Chiba S, Miyazaki Y, Kitano T, Usuki K, Sezaki N, Tsurumi H, Miyawaki S, Maciejewski JP, Ishikawa T, Ohyashiki K, Ganser A, Heuser M, Thol F, Shih LY, Takaori-Kondo A, Makishima H, Ogawa S
Blood Cancer Discov 2022 Sep 6;3(5):410-427. doi: 10.1158/2643-3230.BCD-21-0192. PMID: 35839275Free PMC Article
Diagnosis of rare subtypes of acute myeloid leukaemia and related neoplasms.
George TI, Bajel A
Pathology 2021 Apr;53(3):312-327. Epub 2021 Mar 4 doi: 10.1016/j.pathol.2021.02.001. PMID: 33676766
De novo pure erythroid leukemia: refining the clinicopathologic and cytogenetic characteristics of a rare entity.
Reinig EF, Greipp PT, Chiu A, Howard MT, Reichard KK
Mod Pathol 2018 May;31(5):705-717. Epub 2018 Jan 12 doi: 10.1038/modpathol.2017.175. PMID: 29327715
Pure Erythroid Leukemia and Erythroblastic Sarcoma Evolving From Chronic Myeloid Neoplasms.
Li H, Hasserjian RP, Kroft SH, Harrington AM, Wheaton SE, Pildain A, Ewalt MD, Gratzinger D, Hosking P, Olteanu H
Am J Clin Pathol 2016 Apr;145(4):538-51. Epub 2016 Apr 22 doi: 10.1093/ajcp/aqw033. PMID: 27124944

Clinical prediction guides

The uniqueness of morphological features of pure erythroid leukemia in myeloid neoplasm with erythroid predominance: A reassessment using criteria revised in the 2016 World Health Organization classification.
Ko PS, Liu YC, Yeh CM, Gau JP, Yu YB, Hsiao LT, Tzeng CH, Chen PM, Chiou TJ, Liu CJ, Liu JH
PLoS One 2017;12(2):e0172029. Epub 2017 Feb 14 doi: 10.1371/journal.pone.0172029. PMID: 28196090Free PMC Article
How unique is pure erythroid leukaemia? A retrospective analysis of seven cases and review of the literature.
Wong E, Ling V, Westerman D, Morgan S, Juneja S
J Clin Pathol 2015 Apr;68(4):301-5. Epub 2015 Jan 21 doi: 10.1136/jclinpath-2014-202740. PMID: 25609576
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Pure red cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities.
Lacy MQ, Kurtin PJ, Tefferi A
Blood 1996 Apr 1;87(7):3000-6. PMID: 8639922
Aplastic anemia and pure red cell aplasia.
Dessypris EN
Curr Opin Hematol 1994 Mar;1(2):157-61. PMID: 9371275

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